Transcription factor AP-1 modulates the activity of the human foamy virus long terminal repeat.


:The human foamy virus (HFV) contains within the U3 region of its long terminal repeat (LTR) three perfect consensus sequences for the binding of the inducible transcription factor AP-1. Results of DNase I footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK-21 cells as well as bacterially expressed Jun and Fos proteins bind to these AP-1 sites. By conducting transient expression assays using chloramphenicol acetyltransferase plasmids carrying LTR sequences with point-mutated AP-1 sites, it was found that the three AP-1 sites contribute to the optimal activity of the HFV promoter. It is shown that induction of the HFV LTR by 12-O-tetradecanoylphorbol-13-acetate (TPA) and serum factors is mediated through the AP-1 sites.


J Virol


Journal of virology


Maurer B,Serfling E,ter Meulen V,Rethwilm A




Has Abstract


1991-11-01 00:00:00












  • Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro.

    abstract::An E1-E3-deleted recombinant adenovirus vector expressing the hybrid protein TetR-KRAB has been produced. In this virus, AdTG9562, the E2 transcription is regulated by TetR-KRAB and tetO sequences inserted in cis. In the absence of tetracycline, a strong reduction in E2A gene expression, viral DNA replication, and lat...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Rittner K,Schultz H,Pavirani A,Mehtali M

    更新日期:1997-04-01 00:00:00

  • High mutant frequency in populations of a DNA virus allows evasion from antibody therapy in an immunodeficient host.

    abstract::The degree of genetic heterogeneity of DNA virus populations in nature and its consequences for disease control are virtually unknown. The parvovirus minute virus of mice (MVMi) was used here to investigate (i) the frequency of antibody-escape mutants in populations of a DNA virus and (ii) the ability of a DNA virus t...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: López-Bueno A,Mateu MG,Almendral JM

    更新日期:2003-02-01 00:00:00

  • Cell cycle perturbations induced by infection with the coronavirus infectious bronchitis virus and their effect on virus replication.

    abstract::In eukaryotic cells, cell growth and division occur in a stepwise, orderly fashion described by a process known as the cell cycle. The relationship between positive-strand RNA viruses and the cell cycle and the concomitant effects on virus replication are not clearly understood. We have shown that infection of asynchr...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Dove B,Brooks G,Bicknell K,Wurm T,Hiscox JA

    更新日期:2006-04-01 00:00:00

  • A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus strains.

    abstract::The affinity of human immunodeficiency virus (HIV) envelope for CD4 and CCR5 appears to be associated with aspects of R5 virus (virus using the CCR5 coreceptor) pathogenicity. However, entry efficiency results from complex interactions between the viral envelope glycoprotein and both CD4 and CCR5, which limits attempt...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Johnston SH,Lobritz MA,Nguyen S,Lassen K,Delair S,Posta F,Bryson YJ,Arts EJ,Chou T,Lee B

    更新日期:2009-11-01 00:00:00

  • Immunoglobulin G is the main protective antibody in mouse vaginal secretions after vaginal immunization with attenuated herpes simplex virus type 2.

    abstract::We investigated the protective role of antibodies in vaginal secretions of mice that were immune to vaginal challenge with herpes simplex virus type 2 (HSV-2). Unfractionated vaginal immunoglobulins from immune and nonimmune mice and affinity-purified immunoglobulin G (IgG) and secretory IgA (S-IgA) from immune secret...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Parr EL,Parr MB

    更新日期:1997-11-01 00:00:00

  • Characterization of murine-specific leukemia virus receptor from L cells.

    abstract::The host cell receptor for Moloney murine leukemia virus was solubilized from murine L-cell membranes and characterized. In initial studies designed to identify a receptor-rich cell line, different mouse cells were screened for binding to Moloney gp70, the viral envelope glycoprotein which determines host cell-binding...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Johnson PA,Rosner MR

    更新日期:1986-06-01 00:00:00

  • Canine adenovirus vectors: an alternative for adenovirus-mediated gene transfer.

    abstract::Preclinical studies have shown that gene transfer following readministration of viral vectors is often inefficient due to the presence of neutralizing antibodies. Vectors derived from ubiquitous human adenoviruses may have limited clinical use because preexisting humoral and cellular immunity is found in 90% of the po...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kremer EJ,Boutin S,Chillon M,Danos O

    更新日期:2000-01-01 00:00:00

  • Endoplasmic reticulum chaperones are involved in the morphogenesis of rotavirus infectious particles.

    abstract::The final assembly of rotavirus particles takes place in the endoplasmic reticulum (ER). In this work, we evaluated by RNA interference the relevance to rotavirus assembly and infectivity of grp78, protein disulfide isomerase (PDI), grp94, calnexin, calreticulin, and ERp57, members of the two ER folding systems descri...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Maruri-Avidal L,López S,Arias CF

    更新日期:2008-06-01 00:00:00

  • RNA and protein requirements for incorporation of the Pol protein into foamy virus particles.

    abstract::Foamy viruses (FVs) generate their Pol protein precursor molecule independently of the Gag protein from a spliced mRNA. This mode of expression raises the question of the mechanism of Pol protein incorporation into the viral particle (capsid). We previously showed that the packaging of (pre)genomic RNA is essential fo...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Peters K,Wiktorowicz T,Heinkelein M,Rethwilm A

    更新日期:2005-06-01 00:00:00

  • Crystal structure of the avian reovirus inner capsid protein sigmaA.

    abstract::Avian reovirus, an important avian pathogen, expresses eight structural and four nonstructural proteins. The structural sigmaA protein is a major component of the inner capsid, clamping together lambdaA building blocks. sigmaA has also been implicated in the resistance of avian reovirus to the antiviral action of inte...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Guardado-Calvo P,Vazquez-Iglesias L,Martinez-Costas J,Llamas-Saiz AL,Schoehn G,Fox GC,Hermo-Parrado XL,Benavente J,van Raaij MJ

    更新日期:2008-11-01 00:00:00

  • Mimic Phosphorylation of a βC1 Protein Encoded by TYLCCNB Impairs Its Functions as a Viral Suppressor of RNA Silencing and a Symptom Determinant.

    abstract::Phosphorylation of the βC1 protein encoded by the betasatellite of tomato yellow leaf curl China virus (TYLCCNB-βC1) by SNF1-related protein kinase 1 (SnRK1) plays a critical role in defense of host plants against geminivirus infection in Nicotiana benthamiana However, how phosphorylation of TYLCCNB-βC1 impacts its pa...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Zhong X,Wang ZQ,Xiao R,Cao L,Wang Y,Xie Y,Zhou X

    更新日期:2017-07-27 00:00:00

  • Involvement of DNA gyrase in bacteriophage T7 growth.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Steck TR,Drlica K

    更新日期:1985-01-01 00:00:00

  • Regulation of polyomavirus late promoter activity by viral early proteins.

    abstract::To assess the effect of the polyomavirus (Py) early proteins, the large T (LT), middle T (MT), and small T (ST) antigens, on gene expression from the Py late promoter, replication-defective plasmid constructs with the bacterial chloramphenicol acetyltransferase (cat) gene linked to this promoter were cotransfected int...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kern FG,Pellegrini S,Cowie A,Basilico C

    更新日期:1986-10-01 00:00:00

  • Efficient Interaction between Arenavirus Nucleoprotein (NP) and RNA-Dependent RNA Polymerase (L) Is Mediated by the Virus Nucleocapsid (NP-RNA) Template.

    abstract::In this study, we document that efficient interaction between arenavirus nucleoprotein (NP) and RNA-dependent RNA polymerase (L protein), the two trans-acting viral factors required for both virus RNA replication and gene transcription, requires the presence of virus-specific RNA sequences located within the untransla...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Iwasaki M,Ngo N,Cubitt B,de la Torre JC

    更新日期:2015-05-01 00:00:00

  • Independent isolates of the emerging subgroup J avian leukosis virus derive from a common ancestor.

    abstract::A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between ex...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Benson SJ,Ruis BL,Garbers AL,Fadly AM,Conklin KF

    更新日期:1998-12-01 00:00:00

  • Extracellular vaccinia virus envelope glycoprotein encoded by the A33R gene.

    abstract::With the aid of three monoclonal antibodies (MAbs), a glycoprotein specifically localized to the outer envelope of vaccinia virus was shown to be encoded by the A33R gene. These MAbs reacted with a glycosylated protein that migrated as 23- to 28-kDa and 55-kDa species under reducing and nonreducing conditions, respect...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Roper RL,Payne LG,Moss B

    更新日期:1996-06-01 00:00:00

  • Movement protein of a closterovirus is a type III integral transmembrane protein localized to the endoplasmic reticulum.

    abstract::Cell-to-cell movement of beet yellows closterovirus requires four structural proteins and a 6-kDa protein (p6) that is a conventional, nonstructural movement protein. Here we demonstrate that either virus infection or p6 overexpression results in association of p6 with the rough endoplasmic reticulum. The p6 protein p...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Peremyslov VV,Pan YW,Dolja VV

    更新日期:2004-04-01 00:00:00

  • Dephosphorylation of eIF2alpha mediated by the gamma134.5 protein of herpes simplex virus 1 facilitates viral neuroinvasion.

    abstract::The gamma(1)34.5 protein, a virulence factor of herpes simplex viruses, redirects protein phosphatase 1 to dephosphorylate the alpha subunit of translation initiation factor 2 (eIF2alpha). Additionally, it inhibits the induction of antiviral genes by TANK-binding kinase 1. Nevertheless, its precise role in vivo remain...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Verpooten D,Feng Z,Valyi-Nagy T,Ma Y,Jin H,Yan Z,Zhang C,Cao Y,He B

    更新日期:2009-12-01 00:00:00

  • The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle.

    abstract::As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. For example, human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they e...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kalejta RF,Shenk T

    更新日期:2003-03-01 00:00:00

  • Association of cap-binding protein with eucaryotic initiation factor 3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells.

    abstract::Extracts from poliovirus-infected HeLa cells are unable to translate vesicular stomatitis virus or cellular mRNAs in vitro, probably reflecting the poliovirus-induced inhibition of host cell protein synthesis which occurs in vivo. Crude initiation factors from uninfected HeLa cells are able to restore translation of v...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Hansen J,Etchison D,Hershey JW,Ehrenfeld E

    更新日期:1982-04-01 00:00:00

  • Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.

    abstract::Viruses in the family Coronaviridae, within the order Nidovirales, are etiologic agents of a range of human and animal diseases, including both mild and severe respiratory diseases in humans. These viruses encode conserved replicase and structural proteins as well as more diverse accessory proteins, encoded in the 3' ...

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    pub_type: 杂志文章


    authors: Goldstein SA,Thornbrough JM,Zhang R,Jha BK,Li Y,Elliott R,Quiroz-Figueroa K,Chen AI,Silverman RH,Weiss SR

    更新日期:2017-02-14 00:00:00

  • Infectivity and sedimentation of rhinovirus ribonucleic acid.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Nair CN,Lonberg-Holm KK

    更新日期:1971-02-01 00:00:00

  • Cell killing by spleen necrosis virus is correlated with a transient accumulation of spleen necrosis virus DNA.

    abstract::Spleen necrosis virus productively infects avian and rat cells. The average number of molecules of unintegrated and integrated viral DNA in cells at different times after infection was determined by hybridization and transfection assays. Shortly after infection, there was a transient accumulation of an average of abou...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Keshet E,Temin HM

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  • Initiation and direction of RNA transcription by vesicular stomatitis virus virion transcriptase.

    abstract::The initiation of RNA transcription by the virion-bound RNA transcriptase of vesicular stomatitis virus has been examined. Multiple initiation sequences have been observed, two of which have been characterized (pppApCpGp... and pppGpCp...) suggestive of a transcription process which can start at different sites along ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Roy P,Bishop DH

    更新日期:1973-04-01 00:00:00

  • Coding assignment and nucleotide sequence of simian rotavirus SA11 gene segment 10: location of glycosylation sites suggests that the signal peptide is not cleaved.

    abstract::A cloned DNA copy of simian rotavirus SA11 genomic segment 10 was used to confirm the assignment of the nonstructural glycoprotein NCVP5 to this gene. Determination of the nucleotide sequence for gene 10 indicated that NCVP5 is 175 amino acids in length and has an N-terminal hydrophobic region with the characteristics...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Both GW,Siegman LJ,Bellamy AR,Atkinson PH

    更新日期:1983-11-01 00:00:00

  • Host acyl coenzyme A binding protein regulates replication complex assembly and activity of a positive-strand RNA virus.

    abstract::All positive-strand RNA viruses reorganize host intracellular membranes to assemble their replication complexes. Similarly, brome mosaic virus (BMV) induces two alternate forms of membrane-bound RNA replication complexes: vesicular spherules and stacks of appressed double-membrane layers. The mechanisms by which these...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Zhang J,Diaz A,Mao L,Ahlquist P,Wang X

    更新日期:2012-05-01 00:00:00

  • Overexpression of the M2-2 protein of respiratory syncytial virus inhibits viral replication.

    abstract::The M2-2 protein of respiratory syncytial virus (RSV) is involved in regulation of viral RNA transcription and replication. Encoded by the next-to-last gene of RSV, the M2-2 open reading frame (ORF) overlaps with the upstream M2-1 ORF, suggesting that the production of the M2-2 protein might be tightly regulated durin...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Cheng X,Park H,Zhou H,Jin H

    更新日期:2005-11-01 00:00:00

  • The fitness of defective interfering murine coronavirus DI-a and its derivatives is decreased by nonsense and frameshift mutations.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: de Groot RJ,van der Most RG,Spaan WJ

    更新日期:1992-10-01 00:00:00

  • Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Giffin L,Yan F,Ben Major M,Damania B

    更新日期:2014-08-01 00:00:00

  • Infective substructures of measles virus from acutely and persistently infected cells.

    abstract::Ribonucleoprotein from cells acutely or persistently infected with measles virus were shown to be infectious by the calcium phosphate technique. Very little or no infectivity was obtained when calcium phosphate precipitation was omitted. Electron microscopy showed that the majority of ribonucleoprotein structures isol...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Rozenblatt S,Koch T,Pinhasi O,Bratosin S

    更新日期:1979-10-01 00:00:00