Early events after infection of Escherichia coli by bacteriophage T5. III. Inhibition of uracil-DNA glycosylase activity.

abstract：:Influenza causes significant morbidity in tropical regions; however, unlike in temperate zones, influenza in the tropics is not strongly associated with a given season. We have recently shown that influenza virus transmission in the guinea pig model is most efficient under cold, dry conditions, which are rare in the t...

journal_title：Journal of virology

authors： Lowen AC,Steel J,Mubareka S,Palese P

更新日期：2008-06-01 00:00:00

abstract：:Previous studies in our laboratory showed that the RNA debranching enzyme (DBR1) is not required for early steps in HIV cDNA formation but is necessary for synthesis of intermediate and late cDNA products. To further characterize this effect, we evaluated the topology of the 5' end of the HIV-1 RNA genome during early...

journal_title：Journal of virology

authors： Galvis AE,Fisher HE,Fan H,Camerini D

更新日期：2017-11-14 00:00:00

abstract：:Growth kinetics in lymphocytic H9 and M8166 cells of two mutants of human immunodeficiency virus type 1 (HIV-1) with deleted gp41 cytoplasmic tails were examined. While the mutant viruses designated CTdel-44 and CTdel-144 were able to grow in M8166 cells, they were unable to grow in H9 cells. Transfection and single-r...

journal_title：Journal of virology

authors： Akari H,Fukumori T,Adachi A

更新日期：2000-05-01 00:00:00

abstract：:The Arabidopsis flowering locus T (FT) gene encodes the mobile florigen essential for floral induction. While movement of the FT protein has been shown to occur within plants, systemic spread of FT mRNA remains to be unequivocally demonstrated. Utilizing novel RNA mobility assay vectors based on two distinct movement-...

journal_title：Journal of virology

authors： Li C,Zhang K,Zeng X,Jackson S,Zhou Y,Hong Y

更新日期：2009-04-01 00:00:00

abstract：:The immediate-early 1 and 2 (IE1 and IE2, respectively) proteins of human cytomegalovirus are known transcription factors, which regulate the expression of viral and cellular genes. Transcriptional activation by IE2 is dependent on the presence of a TATA motif in target promoters, and IE2 can interact directly with th...

journal_title：Journal of virology

authors： Caswell R,Bryant L,Sinclair J

更新日期：1996-06-01 00:00:00

abstract：:JC virus (JCV), along with other members of the polyomavirus family, encodes a class of highly conserved proteins, T antigens, that are capable of inducing aneuploidy in cultured cells. We have previously isolated T-antigen DNA variants of JCV from both colon cancer tissues and the corresponding nonneoplastic gastroin...

journal_title：Journal of virology

authors： Ricciardiello L,Chang DK,Laghi L,Goel A,Chang CL,Boland CR

更新日期：2001-02-01 00:00:00

abstract：:The recent yellow fever virus (YFV) epidemic in Brazil in 2017 and Zika virus (ZIKV) epidemic in 2015 serve to remind us of the importance of flaviviruses as emerging human pathogens. With the current global flavivirus threat, there is an urgent need for antivirals and vaccines to curb the spread of these viruses. How...

journal_title：Journal of virology

authors： Miorin L,Laurent-Rolle M,Pisanelli G,Co PH,Albrecht RA,García-Sastre A,Morrison J

更新日期：2019-06-28 00:00:00

abstract：:Polyacrylamide gel electrophoretic analysis of purified preparations of human and calf diarrhea viruses indicated eight polypeptide components, or possibly nine in the case of the calf diarrhea virus. Thermal denaturation and analytical studies of the calf diarrhea virus genome showed it to consist of 11 double-strand...

journal_title：Journal of virology

authors： Rodger SM,Schnagl RD,Holmes IH

更新日期：1975-11-01 00:00:00

abstract：:In vitro studies have suggested an important role for the minor capsid protein (VP1) unique region and the junction between VP1 and the major capsid protein (VP2) in the neutralizing immune response to B19 parvovirus. We investigated the role of the NH2-terminal region of the major structural protein in capsid structu...

journal_title：Journal of virology

authors： Kawase M,Momoeda M,Young NS,Kajigaya S

更新日期：1995-10-01 00:00:00

abstract：:This study examines the persistence and fitness of multidrug-resistant (MDR) viruses acquired during primary human immunodeficiency virus infection (PHI). In four individuals, MDR infections persisted over the entire study period, ranging from 36 weeks to 5 years, in the absence of antiretroviral therapy. In stark con...

journal_title：Journal of virology

authors： Brenner BG,Routy JP,Petrella M,Moisi D,Oliveira M,Detorio M,Spira B,Essabag V,Conway B,Lalonde R,Sekaly RP,Wainberg MA

更新日期：2002-02-01 00:00:00

abstract：:Certain chicken cells that do not spontaneously release virus particles have been shown to produce a subgroup E avian RNA tumor virus, Rous-associated virus 60 (RAV-60), after infection with viruses of other subgroups. The nucleic acids of RAV-60 were analyzed for sequence homologies with the viral nucleic acids conta...

journal_title：Journal of virology

authors： Hayward WS,Hanafusa H

更新日期：1975-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection of the human thymus results in depletion of CD4-bearing thymocytes. This depletion is initially manifested in the immature CD4+/CD8+ thymocyte subset. To determine cellular factors involved in HIV infection in the thymus, we examined the expression of the recently ...

journal_title：Journal of virology

authors： Kitchen SG,Zack JA

更新日期：1997-09-01 00:00:00

abstract：:Cultural changes that follow infection of rabbit kidney cells with fibroma virus were studied. Characteristic alterations of cell morphology and development of multilayered piles and cords of cells were found to occur in infected cultures in which cell division was blocked by gamma radiation or by cell crowding and se...

journal_title：Journal of virology

authors： Tompkins WA,Walker DL,Hinze HC

更新日期：1969-11-01 00:00:00

abstract：:Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense vacuolation of the central nervous system gray matter and vacuolation and hypomyelination of some white matter tracts. Bas...

journal_title：Journal of virology

authors： Carlson GA,Banks S,Lund D,Reichert C,Groth D,Torchia M,Dearmond SJ,Prusiner SB

更新日期：1997-03-01 00:00:00

abstract：:Cell fractionation and protein electrophoresis were used to study the intracellular sites of synthesis and intermediate structures in the assembly of the virion proteins of vesicular stomatitis virus. Each of the three major virion proteins assembled into virions through a separable pathway. The nucleocapsid (N) prote...

journal_title：Journal of virology

authors： Knipe DM,Baltimore D,Lodish HF

更新日期：1977-03-01 00:00:00

abstract：:The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motifs conserved in DEAD box proteins. In order to inspect the roles of in...

journal_title：Journal of virology

authors： Kim DW,Kim J,Gwack Y,Han JH,Choe J

更新日期：1997-12-01 00:00:00

abstract：:The development of vaccines against bluetongue, a prevalent livestock disease, has been focused on surface antigens that induce strong neutralizing antibody responses. Because of their antigenic variability, these vaccines are usually serotype restricted. We now show that a single highly conserved nonstructural protei...

journal_title：Journal of virology

authors： Marín-López A,Calvo-Pinilla E,Barriales D,Lorenzo G,Brun A,Anguita J,Ortego J

更新日期：2018-07-31 00:00:00

abstract：:The Duplan strain of murine leukemia virus induces murine AIDS in C57BL/6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells wer...

journal_title：Journal of virology

authors： Kubo Y,Nakagawa Y,Kakimi K,Matsui H,Iwashiro M,Kuribayashi K,Masuda T,Hiai H,Hirama T,Yanagawa S

更新日期：1992-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) has two envelope proteins, E1 and E2, which form a heterooligomer. During dissection of interacting regions of HCV E1 and E2, we found the presence of an interfering compound or compounds in skim milk. Here we report that human as well as bovine lactoferrin, a multifunctional immunomodulator, b...

journal_title：Journal of virology

authors： Yi M,Kaneko S,Yu DY,Murakami S

更新日期：1997-08-01 00:00:00

abstract：:The RNA genome of influenza virus is transcribed and replicated by the viral RNA polymerase complex in the cell nucleus. We have generated green fluorescent protein (GFP)-tagged polymerase subunits to study the assembly of the polymerase complex. Our results show that individually expressed polymerase basic protein 1 ...

journal_title：Journal of virology

authors： Fodor E,Smith M

更新日期：2004-09-01 00:00:00

abstract：:Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PM...

journal_title：Journal of virology

authors： Scherer M,Stamminger T

更新日期：2016-06-10 00:00:00

abstract：:Two prion strains with identical incubation periods in mice exhibited distinct incubation periods and different neuropathological profiles upon serial transmission to transgenic mice expressing chimeric Syrian hamster/mouse (MH2M) prion protein (PrP) genes [Tg(MH2M) mice] and subsequent transmission to Syrian hamsters...

journal_title：Journal of virology

authors： Scott MR,Groth D,Tatzelt J,Torchia M,Tremblay P,DeArmond SJ,Prusiner SB

更新日期：1997-12-01 00:00:00

abstract：:The pathogenesis of Epstein-Barr virus (EBV) infection, including development of lymphomas and carcinomas, is dependent on the ability of the virus to transit from latency to the lytic phase. This conversion, and ultimately disease development, depends on the molecular switch protein, ZEBRA, a viral bZIP transcription...

journal_title：Journal of virology

authors： Weber E,Buzovetsky O,Heston L,Yu KP,Knecht KM,El-Guindy A,Miller G,Xiong Y

更新日期：2019-06-28 00:00:00

abstract：:The protein product of the v-myb oncogene of avian myeloblastosis virus, p48v-myb, differs structurally in several ways from its normal cellular homolog, p75c-myb. We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformat...

journal_title：Journal of virology

authors： Stober-Grässer U,Lipsick JS

更新日期：1988-03-01 00:00:00

abstract：:Homo-oligomeric runs were inserted into a spleen necrosis virus-based retrovirus vector to determine the nature and rate of mutations within runs of 10 to 12 identical nucleotides during a single replication cycle. Clones of helper cells containing integrated copies of retroviral vectors were used to produce virus for...

journal_title：Journal of virology

authors： Burns DP,Temin HM

更新日期：1994-07-01 00:00:00

abstract：:Four chimeric human immunodeficiency virus type 1 (HIV-1) env genes were constructed which encoded the extracellular domain of either the wild-type or a cleavage-defective HIV-1 envelope glycoprotein (gp160) fused at one of two different positions in env to a C-terminal glycosyl-phosphatidylinositol (GPI) attachment s...

journal_title：Journal of virology

authors： Salzwedel K,Johnston PB,Roberts SJ,Dubay JW,Hunter E

更新日期：1993-09-01 00:00:00

abstract：:The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration

journal_title：Journal of virology

authors： Leigh Brown AJ,Frost SD,Good B,Daar ES,Simon V,Markowitz M,Collier AC,Connick E,Conway B,Margolick JB,Routy JP,Corbeil J,Hellmann NS,Richman DD,Little SJ

更新日期：2004-03-01 00:00:00

abstract：:Although the envelope gene of human immunodeficiency virus type 1 shows considerable strain variability, cysteine residues of the envelope protein are strongly conserved, suggesting that they are important to the envelope structure. We constructed and analyzed mutants of a biologically active molecular clone of human ...

journal_title：Journal of virology

authors： Tschachler E,Buchow H,Gallo RC,Reitz MS Jr

更新日期：1990-05-01 00:00:00

abstract：:To combat emerging coronaviruses, developing safe and efficient platforms to evaluate viral protease activities and the efficacy of protease inhibitors is a high priority. Here, we exploit a biosafety level 2 (BSL-2) chimeric Sindbis virus system to evaluate protease activities and the efficacy of inhibitors directed ...

journal_title：Journal of virology

authors： Deng X,Agnihothram S,Mielech AM,Nichols DB,Wilson MW,StJohn SE,Larsen SD,Mesecar AD,Lenschow DJ,Baric RS,Baker SC

更新日期：2014-10-01 00:00:00

abstract：:Ebola virus (EBOV) continues to pose a significant threat to human health, as evidenced by the 2013-2016 epidemic in West Africa and the ongoing outbreak in the Democratic Republic of the Congo. EBOV causes hemorrhagic fever, organ damage, and shock culminating in death, with case fatality rates as high as 90%. This h...

journal_title：Journal of virology

authors： Jankeel A,Menicucci AR,Woolsey C,Fenton KA,Mendoza N,Versteeg K,Cross RW,Geisbert TW,Messaoudi I

更新日期：2020-05-18 00:00:00