Abstract:
:Growth kinetics in lymphocytic H9 and M8166 cells of two mutants of human immunodeficiency virus type 1 (HIV-1) with deleted gp41 cytoplasmic tails were examined. While the mutant viruses designated CTdel-44 and CTdel-144 were able to grow in M8166 cells, they were unable to grow in H9 cells. Transfection and single-round infectivity assays demonstrated that they are defective in the early phase of viral replication in H9 cells. Analysis of the mutant virions revealed drastically reduced incorporation of Env gp120 (compared with the incorporation of wild-type virions) in H9 cells but normal incorporation in M8166 cells. These results indicate that the HIV-1 cytoplasmic tail of gp41 determines virus infectivity in a cell-dependent manner by affecting incorporation of Env into virions and suggest the involvement of a host cell factor(s) in the Env incorporation.
journal_name
J Viroljournal_title
Journal of virologyauthors
Akari H,Fukumori T,Adachi Adoi
10.1128/jvi.74.10.4891-4893.2000subject
Has Abstractpub_date
2000-05-01 00:00:00pages
4891-3issue
10eissn
0022-538Xissn
1098-5514journal_volume
74pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.56.3.969-977.1985
更新日期:1985-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.69.9.5445-5454.1995
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00540-19
更新日期:2019-07-17 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.4.2916-2920.1999
更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.69.10.6487-6497.1995
更新日期:1995-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.13.7319-7329.2003
更新日期:2003-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.25.3.923-927.1978
更新日期:1978-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.11.6127-6137.2003
更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/jvi.78.5.2572-2580.2004
更新日期:2004-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1971-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.5.2764-2773.1996
更新日期:1996-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2017-08-24 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.52.3.1011-1012.1984
更新日期:1984-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.50.2.615-618.1984
更新日期:1984-05-01 00:00:00
abstract::Nonenveloped gastrointestinal viruses, such as human rotavirus, can exit infected cells from the apical surface without cell lysis. The mechanism of such nonlytic exit is poorly understood. The nonenveloped Orsay virus is an RNA virus infecting the intestine cells of the nematode Caenorhabditis elegans Dye staining re...
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pub_type: 杂志文章
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更新日期:2018-06-29 00:00:00