Abstract:
:Trigeminal ganglia (TG) from rabbits latently infected with either wild-type herpes simplex virus type 1 (HSV-1) or the latency-associated transcript (LAT) promoter deletion mutant 17DeltaPst were assessed for their viral chromatin profile and transcript abundance. The wild-type 17syn+ genomes were more enriched in the transcriptionally permissive mark dimethyl H3 K4 than were the 17DeltaPst genomes at the 5' exon and ICP0 and ICP27 promoters. Reverse transcription-PCR analysis revealed significantly more ICP4, tk, and glycoprotein C lytic transcripts in 17syn+ than in 17DeltaPst. These results suggest that, for efficient reactivation from latency in rabbits, the LAT is important for increased transcription of lytic genes during latency.
journal_name
J Viroljournal_title
Journal of virologyauthors
Giordani NV,Neumann DM,Kwiatkowski DL,Bhattacharjee PS,McAnany PK,Hill JM,Bloom DCdoi
10.1128/JVI.02661-07subject
Has Abstractpub_date
2008-06-01 00:00:00pages
6056-60issue
12eissn
0022-538Xissn
1098-5514pii
JVI.02661-07journal_volume
82pub_type
杂志文章abstract::Hepatitis C virus (HCV) is a major causative agent of posttransfusion non-A, non-B hepatitis, which often develops into malignant chronic diseases, including liver cirrhosis and hepatocellular carcinoma. We have cloned from human carriers overlapping cDNAs (9,416 bp) covering the entire coding region of the HCV genome...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.3.1105-1113.1991
更新日期:1991-03-01 00:00:00
abstract::Understanding how HIV-1 persists during effective antiretroviral therapy (ART) should inform strategies to cure HIV-1 infection. We hypothesize that proliferation of HIV-1-infected cells contributes to persistence of HIV-1 infection during suppressive ART. This predicts that identical or monotypic HIV-1 DNA sequences ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01985-12
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abstract::Human parainfluenza type 2 virus (hPIV-2)-infected HeLa (HeLa-CA) cells and hPIV-2 V-expressing HeLa (HeLa-V) cells show high resistance to alpha/beta interferons (IFN-alpha/beta) irrespective of whether vesicular stomatitis virus or Sindbis virus is used as a challenge virus. When Sindbis virus is used, these cells s...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.19.9165-9176.2001
更新日期:2001-10-01 00:00:00
abstract::The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel vi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00638-09
更新日期:2009-12-01 00:00:00
abstract::Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally due to antibodies directed toward a hypervariable region of gp120 between cysteine residues 302 and 337 and is virus isol...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.11.4195-4200.1988
更新日期:1988-11-01 00:00:00
abstract::The recent advent of genome sequences as the only source available to classify many newly discovered viruses challenges the development of virus taxonomy by expert virologists who traditionally rely on extensive virus characterization. In this proof-of-principle study, we address this issue by presenting a computation...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.07173-11
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abstract::Mature dendritic cells (DCs) are potent antigen-presenting cells essential for initiating successful antiviral immune responses and would therefore serve as an ideal target for viruses seeking to evade or delay the immune response by disrupting their function. We have previously reported that VZV productively infects ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.8.4950-4959.2003
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abstract::Enhancins are metalloproteinases, first identified in granuloviruses, that can enhance nucleopolyhedrovirus (NPV) potency. We had previously identified two enhancin genes (E1 and E2) in the Lymantria dispar multinucleocapsid NPV (LdMNPV) and showed that both were functional. For this study, we have extended our analys...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.16.10578-10588.2005
更新日期:2005-08-01 00:00:00
abstract::The gene encoding glycoprotein F (gF) of herpes simplex virus type 2 (HSV-2) was mapped to the region of the viral genome from 0.62 to 0.64 map units. This region is colinear with, and partially homologous to, the region of the HSV-1 genome previously shown to encode gC. Mapping of the gF gene was done by insertion of...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.49.3.741-747.1984
更新日期:1984-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.10.5173-5176.1990
更新日期:1990-10-01 00:00:00
abstract::The innate and adaptive immune responses have evolved distinct strategies for controlling different viral pathogens. Encephalomyocarditis virus (EMCV) is a picornavirus that can cause paralysis, diabetes, and myocarditis within days of infection. The optimal innate immune response against EMCV in vivo requires CD1d. I...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02745-05
更新日期:2006-07-01 00:00:00
abstract::Pestiviruses prevent alpha/beta interferon (IFN-alpha/beta) production by promoting proteasomal degradation of interferon regulatory factor 3 (IRF3) by means of the viral N(pro) nonstructural protein. N(pro) is also an autoprotease, and its amino-terminal coding sequence is involved in translation initiation. We previ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01509-08
更新日期:2009-01-01 00:00:00
abstract::ICP0, an alpha (immediate-early) protein of herpes simplex virus 1, performs at least two key functions. It blocks inhibition of viral-gene expression by interferon, a function dependent on the degradation of the ND10 components PML and SP100 by the ubiquitin ligase expressed by the RING finger (RF), and it blocks sil...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01940-08
更新日期:2009-01-01 00:00:00
abstract::RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W site by the host RNA adenosine deaminase ADAR1 is a critical step in the HDV replication cycle. Editing is required for production of the viral protein hepatitis delta antigen long form (HDAg-L), which is necessary for viral particle production b...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.17.11187-11193.2005
更新日期:2005-09-01 00:00:00
abstract:UNLABELLED:Susceptibility or resistance to prion infection in humans and animals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's modulating role has not been well investigated. Compared to disease incubation times in wild-type homozygous ARQ/ARQ (where each triplet represents...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02316-15
更新日期:2015-10-28 00:00:00
abstract::The human T-cell leukemia virus type 1 (HTLV-1) transmembrane glycoprotein has a 24-amino-acid cytoplasmic domain whose function in the viral life cycle is poorly understood. We introduced premature-stop mutations and 18 single-amino-acid substitutions into this domain and studied their effects on cell-to-cell transmi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.11.9659-9663.1999
更新日期:1999-11-01 00:00:00
abstract::Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The majority of the isolat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02444-09
更新日期:2010-08-01 00:00:00
abstract::Although several virologic and immunologic factors associated with an increased risk of perinatal human immunodeficiency virus type 1 (HIV-1) transmission have been described, the mechanism of mother-to-child transmission is still unclear. More specifically, the question of whether selective pressures influence the tr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.5.3050-3057.2003
更新日期:2003-03-01 00:00:00
abstract::Early in infection by bacteriophage T4, before replication has commenced, one can detect the presence of newly synthesized DNA which cosediments with parental phage DNA on sucrose gradients. As shown earlier (R. E. Murray and C. K. Mathews, 1969), some of this represents covalent attachment of new material to parental...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.4.847-857.1974
更新日期:1974-04-01 00:00:00
abstract::Beyond their role in cellular RNA metabolism, DExD/H-box RNA helicases are hijacked by various RNA viruses in order to assist replication of the viral genome. Here, we identify the DExH-box RNA helicase 9 (DHX9) as a binding partner of chikungunya virus (CHIKV) nsP3 mainly interacting with the C-terminal hypervariable...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01764-18
更新日期:2019-02-05 00:00:00
abstract::Rabies virus (RV) of the Rhabdoviridae family grows in alpha/beta interferon (IFN)-competent cells, suggesting the existence of viral mechanisms preventing IFN gene expression. We here identify the viral phosphoprotein P as the responsible IFN antagonist. The critical involvement of P was first suggested by the observ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.12.7673-7681.2005
更新日期:2005-06-01 00:00:00
abstract::The stimulation of host macromolecular synthesis and induction into the cell cycle of serum-deprived G0-G1-arrested mouse embryo fibroblasts were examined after infection of resting cells with wild-type simian virus 40 or with viral mutants affecting T antigen (tsA58) or small t antigen (dl884). At various times after...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.37.2.802-812.1981
更新日期:1981-02-01 00:00:00
abstract::Human herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) is a cytokine that is poorly secreted and localized largely to the endoplasmic reticulum (ER). It has been implicated, along with other HHV-8 proinflammatory and/or angiogenic viral proteins, in HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00909-20
更新日期:2020-09-15 00:00:00
abstract::Far-upstream element-binding protein 2 (FBP2) is an internal ribosomal entry site (IRES) trans-acting factor (ITAF) that negatively regulates enterovirus 71 (EV71) translation. This study shows that EV71 infection cleaved FBP2. Live EV71 and the EV71 replicon (but not UV-inactivated virus particles) induced FBP2 cleav...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02278-12
更新日期:2013-04-01 00:00:00
abstract::Antisera were prepared against the amino acid sequences encoded within the N-terminal half of the adenovirus 12 (Ad12) early region 1A (E1A) gene. This was accomplished by construction of a plasmid vector which encoded the N-terminal 131 amino acids of Ad12 E1A joined in frame to the coding sequence of beta-galactosid...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.3.895-903.1984
更新日期:1984-06-01 00:00:00
abstract::Herpes simplex virus (HSV) entry requires the interaction between the envelope glycoprotein D (gD) and a cellular receptor such as nectin-1 (also named herpesvirus entry mediator C [HveC]) or HveA/HVEM. Nectin-1 is a cell adhesion molecule found at adherens junctions associated with the cytoplasmic actin-binding prote...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.5.2424-2433.2002
更新日期:2002-03-01 00:00:00
abstract::The DA strain of Theiler's virus, a murine picornavirus, causes a persistent infection of glial cells of the white matter of the spinal cord, associated with chronic inflammation and primary demyelination. The GDVII strain causes an acute fatal grey matter encephalomyelitis. We characterized the target cells of GDVII ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.5.3197-3200.1995
更新日期:1995-05-01 00:00:00
abstract::A potentially powerful approach for in vivo gene delivery is to target retrovirus to specific cells through interactions between cell surface receptors and appropriately modified viral envelope proteins. Previously, relatively large (>100 residues) protein ligands to cell surface receptors have been inserted at or nea...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.7.3558-3563.2002
更新日期:2002-04-01 00:00:00
abstract::The Epstein-Barr Virus (EBV) immediate-early protein BRLF1 is one of two transactivators which mediate the switch from latent to lytic replication in EBV-infected cells. DNA viruses often modulate the function of critical cell cycle proteins to maximize the efficiency of virus replication. Here we have examined the ef...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.8.6540-6550.1999
更新日期:1999-08-01 00:00:00
abstract::Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient for primary effusion lymphoma (PEL) development. Alterations in cellular signaling pathways are also a characteristic of PEL. Other B cell lymphomas have acquired an oncogenic mutation in the myeloid differentiation primary response 88 (MYD88...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02123-19
更新日期:2020-05-04 00:00:00