Early infection of the central nervous system by the GDVII and DA strains of Theiler's virus.

Abstract:

:The DA strain of Theiler's virus, a murine picornavirus, causes a persistent infection of glial cells of the white matter of the spinal cord, associated with chronic inflammation and primary demyelination. The GDVII strain causes an acute fatal grey matter encephalomyelitis. We characterized the target cells of GDVII and DA viruses 4 days following intracerebral inoculation, and we compared the levels of viral RNA within these cells. GDVII virus infected approximately 10 times more cells than DA virus. Whereas GDVII virus infected neurons exclusively, DA virus infected also astrocytes and possible macrophage-microglial cells. The levels of viral RNA in neurons infected with GDVII and DA viruses were of the same order. These results show that DA virus infects glial cells already at the beginning of the disease and that the more efficient spread of GDVII virus is probably not due to a higher level of RNA replication per cell.

journal_name

J Virol

journal_title

Journal of virology

authors

Aubert C,Brahic M

doi

10.1128/JVI.69.5.3197-3200.1995

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

3197-200

issue

5

eissn

0022-538X

issn

1098-5514

journal_volume

69

pub_type

杂志文章
  • Single-dose vaccination of a recombinant parainfluenza virus 5 expressing NP from H5N1 virus provides broad immunity against influenza A viruses.

    abstract::Influenza viruses often evade host immunity via antigenic drift and shift despite previous influenza virus infection and/or vaccination. Vaccines that match circulating virus strains are needed for optimal protection. Development of a universal influenza virus vaccine providing broadly cross-protective immunity will b...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00120-13

    authors: Li Z,Gabbard JD,Mooney A,Gao X,Chen Z,Place RJ,Tompkins SM,He B

    更新日期:2013-05-01 00:00:00

  • Constitutive phosphorylation of the vesicular stomatitis virus P protein modulates polymerase complex formation but is not essential for transcription or replication.

    abstract::As a subunit of both the P-L polymerase complex and the P-N assembly complex, the vesicular stomatitis virus (VSV) P protein plays a pivotal role in transcription and replication of the viral genome. Constitutive phosphorylation of this protein is currently thought to be essential for formation of the P-L complex. We ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.70.7.4538-4548.1996

    authors: Spadafora D,Canter DM,Jackson RL,Perrault J

    更新日期:1996-07-01 00:00:00

  • Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine.

    abstract::The extracellular virion form (EV) of vaccinia virus (VACV) is essential for viral pathogenesis and is difficult to neutralize with antibodies. Why this is the case and how the smallpox vaccine overcomes this challenge remain incompletely understood. We previously showed that high concentrations of anti-B5 antibodies ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02152-12

    authors: Benhnia MR,Maybeno M,Blum D,Aguilar-Sino R,Matho M,Meng X,Head S,Felgner PL,Zajonc DM,Koriazova L,Kato S,Burton DR,Xiang Y,Crowe JE Jr,Peters B,Crotty S

    更新日期:2013-02-01 00:00:00

  • The selection of low envelope glycoprotein reactivity to soluble CD4 and cold during simian-human immunodeficiency virus infection of rhesus macaques.

    abstract::Envelope glycoprotein (Env) reactivity (ER) describes the propensity of human immunodeficiency virus type 1 (HIV-1) Env to change conformation from the metastable unliganded state in response to the binding of ligands (antibodies and soluble CD4 [sCD4]) or incubation in the cold. To investigate Env properties that fav...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01558-13

    authors: McGee K,Haim H,Korioth-Schmitz B,Espy N,Javanbakht H,Letvin N,Sodroski J

    更新日期:2014-01-01 00:00:00

  • Restriction endonuclease mapping of unintegrated proviral DNA of Snyder-Theilen feline sarcoma virus: localization of sarcoma-specific sequences.

    abstract::Extrachromosomal DNA purified from mink cells acutely infected with the Snyder-Theilen strain of feline sarcoma virus (FeSV) was digested with restriction endonucleases, and the DNA fragments were electrophoretically separated, transferred to a solid substrate, and hybridized with radiolabeled DNA transcripts compleme...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.32.3.860-875.1979

    authors: Sherr CJ,Fedele LA,Donner L,Turek LP

    更新日期:1979-12-01 00:00:00

  • Cortactin Interacts with Hepatitis C Virus Core and NS5A Proteins: Implications for Virion Assembly.

    abstract::Hepatitis C virus (HCV) exploits cellular proteins to facilitate viral propagation. To identify the cellular factors involved in the HCV life cycle, we previously performed protein microarray assays using either HCV nonstructural 5A (NS5A) protein or core protein as a probe. Interestingly, cellular cortactin strongly ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01306-20

    authors: Nguyen LP,Nguyen TTT,Nguyen HC,Pham HT,Han KM,Choi DH,Park EM,Kang SM,Tark D,Lim YS,Hwang SB

    更新日期:2020-09-15 00:00:00

  • Mapping and ordering of fragments of BK virus DNA produced by restriction endonucleases.

    abstract::A total of 51 restriction sites were recognized within the BK virus genome by the combination of 10 different restriction endonucleases. These sites were mapped and oriented relative to one another as well as to the five fragments generated by the digestion of BK virus DNA with HindIII and EcoRI. The result was a comp...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.29.3.915-925.1979

    authors: Freund J,di Mayorca G,Subramanian KN

    更新日期:1979-03-01 00:00:00

  • West Nile Virus-Inclusive Single-Cell RNA Sequencing Reveals Heterogeneity in the Type I Interferon Response within Single Cells.

    abstract::West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus of global importance. Neuroinvasive WNV infection results in encephalitis and can lead to prolonged neurological impairment or death. Type I interferon (IFN-I) is crucial for promoting antiviral defenses through the induction of antiviral effectors, whic...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01778-18

    authors: O'Neal JT,Upadhyay AA,Wolabaugh A,Patel NB,Bosinger SE,Suthar MS

    更新日期:2019-03-05 00:00:00

  • Ribonucleic acid synthesis in cells infected with herpes simplex virus. VI. Polyadenylic acid sequences in viral messenger ribonucleic acid.

    abstract::Evidence is presented by use of radiolabeling and pancreatic and T1 ribonuclease digestion that some of the ribonucleic acid specified by herpes simplex virus contains polyadenylic acid sequences. The polyadenylic sequences are not transcribed from viral DNA. ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.10.4.875-879.1972

    authors: Bachenheimer SL,Roizman B

    更新日期:1972-10-01 00:00:00

  • Cross-presentation of human cytomegalovirus pp65 (UL83) to CD8+ T cells is regulated by virus-induced, soluble-mediator-dependent maturation of dendritic cells.

    abstract::Cytotoxic CD8+ T lymphocytes (CTL) directed against the matrix protein pp65 are major effectors in controlling infection against human cytomegalovirus (HCMV), a persistent virus of the Betaherpesvirus family. We previously suggested that cross-presentation of pp65 by nonpermissive dendritic cells (DCs) could overcome ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.76.1.142-150.2002

    authors: Arrode G,Boccaccio C,Abastado JP,Davrinche C

    更新日期:2002-01-01 00:00:00

  • Antigenic and receptor binding properties of enterovirus 68.

    abstract:UNLABELLED:Increased detection of enterovirus 68 (EV68) among patients with acute respiratory infections has been reported from different parts of the world in the late 2000s since its first detection in pediatric patients with lower-respiratory-tract infections in 1962. However, the underlying molecular mechanisms for...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.03070-13

    authors: Imamura T,Okamoto M,Nakakita S,Suzuki A,Saito M,Tamaki R,Lupisan S,Roy CN,Hiramatsu H,Sugawara KE,Mizuta K,Matsuzaki Y,Suzuki Y,Oshitani H

    更新日期:2014-03-01 00:00:00

  • Identification of a receptor-binding pocket on the envelope protein of friend murine leukemia virus.

    abstract::Based on previous structural and functional studies, a potential receptor-binding site composed of residues that form a pocket at one end of the two long antiparallel helices in the receptor-binding domain of Friend 57 murine leukemia virus envelope protein (RBD) has been proposed. To test this hypothesis, directed su...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.73.5.3758-3763.1999

    authors: Davey RA,Zuo Y,Cunningham JM

    更新日期:1999-05-01 00:00:00

  • Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system.

    abstract::The small-ruminant lentiviruses ovine maedi-visna virus (MVV) and caprine arthritis-encephalitis virus (CAEV) cause encephalitis, progressive pneumonia, arthritis, and mastitis in sheep and goats. Icelandic MVV strains, which are lytic in tissue culture, have a wide species distribution of functional receptors, which ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.75.16.7384-7391.2001

    authors: Hötzel I,Cheevers WP

    更新日期:2001-08-01 00:00:00

  • A novel type of defective viral genome suggests a unique strategy to establish and maintain persistent lymphocytic choriomeningitis virus infections.

    abstract::Defective interfering RNAs have long been thought to be a causal factor of persistent RNA virus infections. Here we describe a novel type of defective genome of lymphocytic choriomeningitis virus and the unique mechanism by which these RNAs appear to contribute to the establishment and maintenance of persistent infect...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.71.9.6757-6764.1997

    authors: Meyer BJ,Southern PJ

    更新日期:1997-09-01 00:00:00

  • Human papillomavirus types 16, 31, and 58 use different endocytosis pathways to enter cells.

    abstract::The early steps of the intracellular trafficking of human papillomavirus type 16 (HPV-16), -31, and -58 pseudovirions were studied by investigating the effects of drugs acting at defined points of endocytosis pathways on virus-like particle-mediated pseudoinfection by overexpression of a dominant-negative form of the ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.77.6.3846-3850.2003

    authors: Bousarghin L,Touzé A,Sizaret PY,Coursaget P

    更新日期:2003-03-01 00:00:00

  • rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells.

    abstract::In cell-free systems, 2-5A [ppp(A2'p)nA, n = 2 to greater than or equal to 4] activates a latent endoribonuclease, the 2-5A-dependent RNase, which cleaves rRNA in intact ribosomes into discrete and characteristic products (D. H. Wreschner et al., Nucleic Acids Res. 9:1571-1581, 1981). Here we present Northern blots wh...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.46.3.1051-1055.1983

    authors: Silverman RH,Skehel JJ,James TC,Wreschner DH,Kerr IM

    更新日期:1983-06-01 00:00:00

  • Galectin-9 functionally impairs natural killer cells in humans and mice.

    abstract::Galectin-9 is a pleiotropic immune modulator affecting numerous cell types of innate and adaptive immunity. Patients with chronic infection with either hepatitis C virus (HCV) or HIV have elevated circulating levels. Limited data exist on the regulation of natural killer (NK) cell function through interaction with gal...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01085-12

    authors: Golden-Mason L,McMahan RH,Strong M,Reisdorph R,Mahaffey S,Palmer BE,Cheng L,Kulesza C,Hirashima M,Niki T,Rosen HR

    更新日期:2013-05-01 00:00:00

  • Integrins alpha2beta1 and alpha4beta1 can mediate SA11 rotavirus attachment and entry into cells.

    abstract::Most mammalian rotaviruses contain tripeptide amino acid sequences in outer capsid proteins VP4 and VP7 which have been shown to act as ligands for integrins alpha2beta1 and alpha4beta1. Peptides containing these sequences and monoclonal antibodies directed to these integrins block rotavirus infection of cells. Here w...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.1.228-236.2000

    authors: Hewish MJ,Takada Y,Coulson BS

    更新日期:2000-01-01 00:00:00

  • Measles virus ribonucleic acid and protein synthesis: effects of 6-azauridine and cycloheximide on viral replication.

    abstract::Cycloheximide and 6-azauridine were employed to study the time course of measles virus protein and nucleic acid syntheses in AV3 cells. Synthesis of ribonucleic acid (RNA) essential for infectivity was first detected at 6 hr and increased concurrently with the formation of essential protein. Maximum levels of virus-sp...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.11.1.46-53.1973

    authors: Portner A,Bussell RH

    更新日期:1973-01-01 00:00:00

  • Forms of pp60v-src isolated from Rous sarcoma virus-transformed cells.

    abstract::It has previously been shown that an electrophoretic variant form of the Rous sarcoma virus transforming protein, pp60v-src, exists in src-transformed cells. This variant, which was readily observed in vanadate-treated cells, was characterized as possessing extensive amino-terminal domain phosphotyrosine modification....

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.61.5.1593-1601.1987

    authors: Collett MS,Belzer SK

    更新日期:1987-05-01 00:00:00

  • The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus.

    abstract::The feline homolog of the alpha-chemokine receptor CXCR4 has recently been shown to support cell-cell fusion mediated by CXCR4-dependent strains of human immunodeficiency virus (HIV) and strains of feline immunodeficiency virus (FIV) that have been selected for growth in the Crandell feline kidney (CrFK) cell line. In...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.72.8.6475-6481.1998

    authors: Willett BJ,Adema K,Heveker N,Brelot A,Picard L,Alizon M,Turner JD,Hoxie JA,Peiper S,Neil JC,Hosie MJ

    更新日期:1998-08-01 00:00:00

  • Virus-like particles of a fish nodavirus display a capsid subunit domain organization different from that of insect nodaviruses.

    abstract::The structure of recombinant virus-like particles of malabaricus grouper nervous necrosis virus (MGNNV), a fish nodavirus isolated from the grouper Epinephelus malabaricus, was determined by electron cryomicroscopy (cryoEM) and three-dimensional reconstruction at 23-A resolution. The cryoEM structure, sequence compari...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.76.12.6370-6375.2002

    authors: Tang L,Lin CS,Krishna NK,Yeager M,Schneemann A,Johnson JE

    更新日期:2002-06-01 00:00:00

  • Incoming human cytomegalovirus pp65 (UL83) contained in apoptotic infected fibroblasts is cross-presented to CD8(+) T cells by dendritic cells.

    abstract::Human cytomegalovirus (HCMV) infection is well controlled mainly by cytotoxic CD8(+) T lymphocytes (CTL) directed against the matrix protein pp65 despite the numerous immune escape mechanisms developed by the virus. Dendritic cells (DCs) are key antigen-presenting cells for the generation of an immune response which h...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.21.10018-10024.2000

    authors: Arrode G,Boccaccio C,Lulé J,Allart S,Moinard N,Abastado JP,Alam A,Davrinche C

    更新日期:2000-11-01 00:00:00

  • Outcome of simian-human immunodeficiency virus strain 89.6p challenge following vaccination of rhesus macaques with human immunodeficiency virus Tat protein.

    abstract::The regulatory proteins Nef, Rev, and Tat of human immunodeficiency virus type 1 (HIV-1) are attractive targets for vaccine development, since induction of effective immune responses targeting these early proteins may best control virus replication. Here we investigated whether vaccination with biologically active Tat...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.76.8.3800-3809.2002

    authors: Silvera P,Richardson MW,Greenhouse J,Yalley-Ogunro J,Shaw N,Mirchandani J,Khalili K,Zagury JF,Lewis MG,Rappaport J

    更新日期:2002-04-01 00:00:00

  • Attachment of avidin-coupled spheres to linear and circular forms of mengovirus double-stranded RNA.

    abstract::Picornavirus-infected cells contain a double-stranded RNA (replicative form [RF] RNA), composed of viral genomic RNA hydrogen bonded to cRNA of similar nucleotide length. Mengovirus RF RNA reacted with a succinimide ester of biotin was shown by electron microscopy to bind avidin-coupled polymethacrylate spheres. These...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.39.1.229-237.1981

    authors: Thornton GB,Robberson DL,Arlinghaus RB

    更新日期:1981-07-01 00:00:00

  • A molecularly cloned Schwarz strain of measles virus vaccine induces strong immune responses in macaques and transgenic mice.

    abstract::Live attenuated RNA viruses make highly efficient vaccines. Among them, measles virus (MV) vaccine has been given to a very large number of children and has been shown to be highly efficacious and safe. Therefore, this vaccine might be a very promising vector to immunize children against both measles and other infecti...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.77.21.11546-11554.2003

    authors: Combredet C,Labrousse V,Mollet L,Lorin C,Delebecque F,Hurtrel B,McClure H,Feinberg MB,Brahic M,Tangy F

    更新日期:2003-11-01 00:00:00

  • Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes.

    abstract:UNLABELLED:Herpes simplex virus 1 (HSV-1) glycoprotein B (gB)-specific CD8(+) T cells protect mice from herpes infection and disease. However, whether and which HSV-1 gB-specific CD8(+) T cells play a key role in the "natural" protection seen in HSV-1-seropositive healthy asymptomatic (ASYMP) individuals (who have neve...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.03419-14

    authors: Khan AA,Srivastava R,Spencer D,Garg S,Fremgen D,Vahed H,Lopes PP,Pham TT,Hewett C,Kuang J,Ong N,Huang L,Scarfone VM,Nesburn AB,Wechsler SL,BenMohamed L

    更新日期:2015-04-01 00:00:00

  • Transcriptional activation function is not required for stimulation of DNA replication by bovine papillomavirus type 1 E2.

    abstract::Bovine papillomavirus type 1 replication was previously shown to require both the E1 initiator protein and the E2 transactivator protein. We show here that E1, in the absence of E2, is sufficient for low-level bovine papillomavirus type 1 DNA replication in C-33A cells. In addition, studies of genetically isolated E2 ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.70.10.7264-7269.1996

    authors: Grossel MJ,Sverdrup F,Breiding DE,Androphy EJ

    更新日期:1996-10-01 00:00:00

  • Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo.

    abstract::The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain. As an attempt to elucidate the function of nef, we characterized the nucleotide and corre...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.67.8.4639-4650.1993

    authors: Shugars DC,Smith MS,Glueck DH,Nantermet PV,Seillier-Moiseiwitsch F,Swanstrom R

    更新日期:1993-08-01 00:00:00

  • Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol.

    abstract::Influenza viruses resistant to the neuraminidase (NA) inhibitor oseltamivir arise under drug selection pressure both in vitro and in vivo. Several mutations in the active site of the viral NA are known to confer relative resistance to oseltamivir, and influenza viruses with certain oseltamivir resistance mutations hav...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01226-08

    authors: Bouvier NM,Lowen AC,Palese P

    更新日期:2008-10-01 00:00:00