Abstract:
:The gene encoding glycoprotein F (gF) of herpes simplex virus type 2 (HSV-2) was mapped to the region of the viral genome from 0.62 to 0.64 map units. This region is colinear with, and partially homologous to, the region of the HSV-1 genome previously shown to encode gC. Mapping of the gF gene was done by insertion of HSV-2 DNA fragments into the thymidine kinase gene of an HSV-1 virus and screening of the resultant recombinant viruses for the expression of gF. In this way, DNA sequences necessary for the expression of gF in infected cells were also delimited. Because several plaque morphology mutants (syncytial mutants) of HSV-1 have previously been shown to be gC-, a syncytial mutant of HSV-2 (GP) was tested for the expression of gF. It was found to be gF-, indicating that gF is not essential for replication of HSV-2 in cell culture, just as gC is not essential for replication of HSV-1. This result also suggests that the gF- and gC- phenotypes are related in the same, as yet undefined, way to the expression of a syncytial marker. A proposal to change the name of HSV-2 gF to gC (gC-2) is discussed.
journal_name
J Viroljournal_title
Journal of virologyauthors
Zezulak KM,Spear PGdoi
10.1128/JVI.49.3.741-747.1984subject
Has Abstractpub_date
1984-03-01 00:00:00pages
741-7issue
3eissn
0022-538Xissn
1098-5514journal_volume
49pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.8.3227-3233.1989
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.33.1.535-538.1980
更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/jvi.78.3.1256-1262.2004
更新日期:2004-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.3.1530-1542.1991
更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.34.3.764-771.1980
更新日期:1980-06-01 00:00:00
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更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.63.9.3661-3668.1989
更新日期:1989-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.37.1.372-382.1981
更新日期:1981-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.21.3.1247-1248.1977
更新日期:1977-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
abstract::TMC114, a newly designed human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is extremely potent against both wild-type (wt) and multidrug-resistant (MDR) viruses in vitro as well as in vivo. Although chemically similar to amprenavir (APV), the potency of TMC114 is substantially greater. To examine the bas...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.21.12012-12021.2004
更新日期:2004-11-01 00:00:00