Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.

abstract：:The M2-2 protein of respiratory syncytial virus (RSV) is involved in regulation of viral RNA transcription and replication. Encoded by the next-to-last gene of RSV, the M2-2 open reading frame (ORF) overlaps with the upstream M2-1 ORF, suggesting that the production of the M2-2 protein might be tightly regulated durin...

journal_title：Journal of virology

authors： Cheng X,Park H,Zhou H,Jin H

更新日期：2005-11-01 00:00:00

abstract：:A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. In this study, we assessed the immunogenicity of the CAP256 superinfecting viral envelope (CAP256 SU) protein delivered by modified vaccinia virus Ankara (MVA) and DNA vaccines in different prime-boost com...

journal_title：Journal of virology

authors： van Diepen MT,Chapman R,Douglass N,Galant S,Moore PL,Margolin E,Ximba P,Morris L,Rybicki EP,Williamson AL

更新日期：2019-04-03 00:00:00

abstract：:Efforts to develop a vaccine against human immunodeficiency virus type 1 (HIV-1) are complicated by resistance of virus to neutralization. The neutralization resistance phenotype of HIV-1 has been linked to high infectivity. We studied the mechanisms determining this phenotype using clones of the T-cell-line-adapted (...

journal_title：Journal of virology

authors： Leavitt M,Park EJ,Sidorov IA,Dimitrov DS,Quinnan GV Jr

更新日期：2003-01-01 00:00:00

abstract：:Coxsackievirus B3 (CB3) firmly attaches to HeLa cells, forming a specific complex between the virus and its receptor on the cell surface. We extracted this virus-receptor complex (VRC) with the detergents sodium deoxycholate and Triton X-100. The VRC was identified by its sedimentation coefficient (140S), which was le...

journal_title：Journal of virology

authors： Mapoles JE,Krah DL,Crowell RL

更新日期：1985-09-01 00:00:00

abstract：:Although the genetic organization of tobacco mosaic virus (TMV) differs considerably from that of the tripartite viruses (alfalfa mosaic virus [AlMV] and brome mosaic virus [BMV]), all of these RNA plant viruses share three domains of homology among their nonstructural proteins. One such domain, common to the AlMV and...

journal_title：Journal of virology

authors： Ahlquist P,Strauss EG,Rice CM,Strauss JH,Haseloff J,Zimmern D

更新日期：1985-02-01 00:00:00

abstract：:Longitudinal studies of T cell immune responses during viral infections in humans are essential for our understanding of how effector T cell responses develop, clear infection, and provide long-lasting immunity. Here, following an outbreak of a Puumala hantavirus infection in the human population, we longitudinally an...

journal_title：Journal of virology

authors： Lindgren T,Ahlm C,Mohamed N,Evander M,Ljunggren HG,Björkström NK

更新日期：2011-10-01 00:00:00

abstract：UNLABELLED:An altered intestinal microbiome during chronic human immunodeficiency virus (HIV) infection is associated with mucosal dysfunction, inflammation, and disease progression. We performed a preclinical evaluation of the safety and efficacy of fecal microbiota transplantation (FMT) as a potential therapeutic in ...

journal_title：Journal of virology

authors： Hensley-McBain T,Zevin AS,Manuzak J,Smith E,Gile J,Miller C,Agricola B,Katze M,Reeves RK,Kraft CS,Langevin S,Klatt NR

更新日期：2016-04-29 00:00:00

abstract：:The immediate-early 1 and 2 (IE1 and IE2, respectively) proteins of human cytomegalovirus are known transcription factors, which regulate the expression of viral and cellular genes. Transcriptional activation by IE2 is dependent on the presence of a TATA motif in target promoters, and IE2 can interact directly with th...

journal_title：Journal of virology

authors： Caswell R,Bryant L,Sinclair J

更新日期：1996-06-01 00:00:00

abstract：:Vaccine-induced memory T cells localized at mucosal sites can provide rapid protection from viral infection. All-trans-retinoic acid (ATRA) has been shown to act physiologically to induce the expression of gut-homing receptors on lymphocytes. We tested whether the administration of exogenous ATRA during a systemic vac...

journal_title：Journal of virology

authors： Tan X,Sande JL,Pufnock JS,Blattman JN,Greenberg PD

更新日期：2011-08-01 00:00:00

abstract：:The role of nitric oxide after poliovirus infection of the human HeLa (carcinoma) and U937 (promonocytic) cell lines has been analyzed. Both types of cells produced detectable levels of nitric oxide after poliovirus infection. However, this production was not sufficient to limit viral productivity. On the other hand, ...

journal_title：Journal of virology

authors： López-Guerrero JA,Carrasco L

更新日期：1998-03-01 00:00:00

abstract：:DNA of the avian hepadnavirus, duck hepatitis B virus, was found to be integrated at low abundance into the cellular DNA extracted from the livers of infected ducklings. The frequency of integration was estimated to be at least one viral genome per 10(3) to 10(4) cells by 6 days postinfection. The structures of virus-...

journal_title：Journal of virology

authors： Yang W,Summers J

更新日期：1999-12-01 00:00:00

abstract：:Human hepatitis B virus (HBV) HBx protein is a multifunctional protein that activates cellular signaling pathways and is thought to be essential for viral infection. Woodchuck HBV mutants that lack HBx are unable to replicate in vivo or are severely impaired. HBV replication in HepG2 cells, a human hepatoblastoma cell...

journal_title：Journal of virology

authors： Bouchard MJ,Puro RJ,Wang L,Schneider RJ

更新日期：2003-07-01 00:00:00

abstract：:The transcriptional activities of the four hepatitis B virus promoters were compared in three differentiated hepatoma cell lines, HepG2, Hep3B, and PLC/PRF/5; a dedifferentiated subline of HepG2, HepG2.1; a human cervical carcinoma cell line, HeLa S3; and a mouse fibroblast cell line, NIH 3T3. The plasmid constructs, ...

journal_title：Journal of virology

authors： Raney AK,Milich DR,Easton AJ,McLachlan A

更新日期：1990-05-01 00:00:00

abstract：:Carcinogenic progression of a human papillomavirus (HPV)-infected cell is often associated with integration of the viral genome in a manner which results in the loss of expression of the viral regulatory protein E2. One function of E2 is the regulation of expression of the viral oncogenes, E6 and E7. Introduction of t...

journal_title：Journal of virology

authors： Dowhanick JJ,McBride AA,Howley PM

更新日期：1995-12-01 00:00:00

abstract：:In this study, we have identified an internal ribosome entry site (IRES) from the highly infectious herpesvirus Marek's disease virus (MDV). The IRES was mapped to the intercistronic region (ICR) of a bicistronic mRNA that we cloned from the MDV-transformed CD4(+) T-cell line MSB-1. The transcript is a member of a fam...

journal_title：Journal of virology

authors： Tahiri-Alaoui A,Smith LP,Baigent S,Kgosana L,Petherbridge LJ,Lambeth LS,James W,Nair V

更新日期：2009-06-01 00:00:00

abstract：:Varicella-zoster virus (VZV), an alphaherpesvirus restricted to humans, infects differentiated cells in vivo, including T lymphocytes, keratinocytes, and neurons, and spreads rapidly in confluent cultured dermal fibroblasts (HFFs). In VZV-infected HFFs, atypical expression of cyclins D3 and B1 occurs along with the in...

journal_title：Journal of virology

authors： Leisenfelder SA,Kinchington PR,Moffat JF

更新日期：2008-12-01 00:00:00

abstract：:Poliovirus-specific T lymphocytes were isolated from virus-immunized mice of different H-2 haplotypes. Immunological characterization of this population indicates that the effector population involved in the observed poliovirus-specific proliferative response was that of CD4-positive T-helper cells. Proliferative resp...

journal_title：Journal of virology

authors： Kutubuddin M,Simons J,Chow M

更新日期：1992-05-01 00:00:00

abstract：:Replication of flock house virus (FHV) RNA1 and production of subgenomic RNA3 in the yeast Saccharomyces cerevisiae provide a useful tool for the dissection of FHV molecular biology and host-encoded functions involved in RNA replication. The replication template activity of RNA1 can be separated from its coding potent...

journal_title：Journal of virology

authors： Lindenbach BD,Sgro JY,Ahlquist P

更新日期：2002-04-01 00:00:00

abstract：:The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection. The temporal and spatial distribution of viral antigen, known as the transneuronal spread phenotype, has not previously been described; nor is it ...

journal_title：Journal of virology

authors： Engel JP,Madigan TC,Peterson GM

更新日期：1997-03-01 00:00:00

abstract：:Pestiviruses prevent alpha/beta interferon (IFN-alpha/beta) production by promoting proteasomal degradation of interferon regulatory factor 3 (IRF3) by means of the viral N(pro) nonstructural protein. N(pro) is also an autoprotease, and its amino-terminal coding sequence is involved in translation initiation. We previ...

journal_title：Journal of virology

authors： Ruggli N,Summerfield A,Fiebach AR,Guzylack-Piriou L,Bauhofer O,Lamm CG,Waltersperger S,Matsuno K,Liu L,Gerber M,Choi KH,Hofmann MA,Sakoda Y,Tratschin JD

更新日期：2009-01-01 00:00:00

abstract：:We have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein. Nef triggered a rapid endocytosis and a degradation of CD4, while most of the p56lck was upheld at the cell membrane. In the presence of Nef, CD4 accumulated in acidic intracellular vesicles that were not...

journal_title：Journal of virology

authors： Schwartz O,Dautry-Varsat A,Goud B,Maréchal V,Subtil A,Heard JM,Danos O

更新日期：1995-01-01 00:00:00

abstract：:In an attempt to generate broadly cross-reactive, neutralizing monoclonal antibodies (MAbs) to simian immunodeficiency virus (SIV), we compared two immunization protocols using different preparations of oligomeric SIV envelope (Env) glycoproteins. In the first protocol, mice were immunized with soluble gp140 (sgp140) ...

journal_title：Journal of virology

authors： Edinger AL,Ahuja M,Sung T,Baxter KC,Haggarty B,Doms RW,Hoxie JA

更新日期：2000-09-01 00:00:00

abstract：:The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(-/-)), in IL-12 alone (p35(-/-)), and in IL-23 alone (p19(-/-)) revea...

journal_title：Journal of virology

authors： Kapil P,Atkinson R,Ramakrishna C,Cua DJ,Bergmann CC,Stohlman SA

更新日期：2009-06-01 00:00:00

abstract：:Humans chronically infected with hepatitis B virus (HBV) are at further risk of liver cancer upon exposure to dietary aflatoxin B1 (AFB1), a carcinogenic product of the mold Aspergillus flavus. For the present study, we utilized double-transgenic mice (ATX mice) that express the HBV X protein (HBx) and possess a bacte...

journal_title：Journal of virology

authors： Madden CR,Finegold MJ,Slagle BL

更新日期：2002-11-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) downregulates major histocompatibility complex (MHC) class I complexes from the plasma membrane via two of its genes, K3 and K5. The N termini of K3 and K5 contain a plant homeodomain (PHD) predicted to be structurally similar to RING domains found in E3 ubiquitin ligases. In view of the imp...

journal_title：Journal of virology

authors： Lorenzo ME,Jung JU,Ploegh HL

更新日期：2002-06-01 00:00:00

abstract：:Deer mice are the principal reservoir hosts of Sin Nombre virus, the etiologic agent of most hantavirus cardiopulmonary syndrome cases in North America. Infection of deer mice results in persistence without conspicuous pathology, and most, if not all, infected mice remain infected for life, with periods of viral shedd...

journal_title：Journal of virology

authors： Schountz T,Acuña-Retamar M,Feinstein S,Prescott J,Torres-Perez F,Podell B,Peters S,Ye C,Black WC 4th,Hjelle B

更新日期：2012-09-01 00:00:00

abstract：:Treatment of Friend erythroleukemia cells (FLC) with gamma interferon (IFN-gamma) in the presence of anti-IFN-beta antibodies reduces the effectiveness of the antiviral state and the induction of 2'-5'-oligoadenylate synthetase activity, indicating that the antiviral activity of IFN-gamma in FLC is in part mediated by...

journal_title：Journal of virology

authors： Marziali G,Fiorucci G,Coccia EM,Percario Z,Raber J,Battistini A,Rossi GB,Affabris E,Romeo G

更新日期：1991-08-01 00:00:00

abstract：:We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/gammac(null) (NOG) mice. This model is very useful for investigating the mechanism of tumorigenesis and malignant cell growth of adult T-cell leukemia (ATL)/lymphoma, which still remains unclear. Nine...

journal_title：Journal of virology

authors： Dewan MZ,Terashima K,Taruishi M,Hasegawa H,Ito M,Tanaka Y,Mori N,Sata T,Koyanagi Y,Maeda M,Kubuki Y,Okayama A,Fujii M,Yamamoto N

更新日期：2003-05-01 00:00:00

abstract：:The efficient attachment of pseudorabies virus to cultured cells is dependent on an electrostatic interaction between negatively charged cell surface heparan sulfate and the viral envelope glycoprotein gC. Deletion of the first one-third of gC severely impairs virus attachment, but the mutant virions are still capable...

journal_title：Journal of virology

authors： Flynn SJ,Ryan P

更新日期：1995-02-01 00:00:00

abstract：:Structural proteins designated p10gag, p21gag, p8gag, p3gag, p27gag, and p14gag from the C3H strain of mouse mammary tumor virus (MMTV) were purified by reversed-phase high-pressure liquid chromatography. The N- and C-terminal amino acid sequences and amino acid composition of each protein were determined and compared...

journal_title：Journal of virology

authors： Hizi A,Henderson LE,Copeland TD,Sowder RC,Krutzsch HC,Oroszlan S

更新日期：1989-06-01 00:00:00