Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.

Abstract:

:Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.

journal_name

J Virol

journal_title

Journal of virology

authors

Singh BK,Koromyslova A,Hefele L,Gürth C,Hansman GS

doi

10.1128/JVI.03119-15

subject

Has Abstract

pub_date

2015-12-23 00:00:00

pages

2710-5

issue

5

eissn

0022-538X

issn

1098-5514

pii

JVI.03119-15

journal_volume

90

pub_type

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