Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.


:Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.


J Virol


Journal of virology


Singh BK,Koromyslova A,Hefele L,Gürth C,Hansman GS




Has Abstract


2015-12-23 00:00:00














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    abstract::Herpesvirus nucleocapsids traverse the nuclear envelope into the cytoplasm in a process called nuclear egress that includes disruption of the nuclear lamina. In several herpesviruses, a key player in nuclear egress is a complex of two proteins, whose homologs in human cytomegalovirus (HCMV) are UL50 and UL53. However,...

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    authors: Sharma M,Kamil JP,Coughlin M,Reim NI,Coen DM

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    abstract::Herpesviruses encode a set of core proteins essential for lytic replication of their genomes. Three of these proteins form a tripartite helix-primase complex that, in the case of Epstein-Barr virus (EBV), consists of the helicase BBLF4, the primase BSLF1, and the linker protein BBLF2/3. BBLF2/3 and its homologs in the...

    journal_title:Journal of virology

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    authors: Liao G,Huang J,Fixman ED,Hayward SD

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  • Advancing Our Understanding of Protective Maternal Immunity as a Guide for Development of Vaccines To Reduce Congenital Cytomegalovirus Infections.

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    pub_type: 杂志文章


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    journal_title:Journal of virology

    pub_type: 杂志文章


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    journal_title:Journal of virology

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    更新日期:2016-01-20 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Journal of virology

    pub_type: 杂志文章


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    journal_title:Journal of virology

    pub_type: 杂志文章


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    journal_title:Journal of virology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Journal of virology

    pub_type: 杂志文章


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