VP3, a structural protein of infectious pancreatic necrosis virus, interacts with RNA-dependent RNA polymerase VP1 and with double-stranded RNA.

abstract：:The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and th...

journal_title：Journal of virology

authors： Xiao H,Killip MJ,Staeheli P,Randall RE,Jackson D

更新日期：2013-12-01 00:00:00

abstract：UNLABELLED:Increased detection of enterovirus 68 (EV68) among patients with acute respiratory infections has been reported from different parts of the world in the late 2000s since its first detection in pediatric patients with lower-respiratory-tract infections in 1962. However, the underlying molecular mechanisms for...

journal_title：Journal of virology

authors： Imamura T,Okamoto M,Nakakita S,Suzuki A,Saito M,Tamaki R,Lupisan S,Roy CN,Hiramatsu H,Sugawara KE,Mizuta K,Matsuzaki Y,Suzuki Y,Oshitani H

更新日期：2014-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection leads to lifelong viral persistence through its latency in B cells. EBV-specific T cells control reactivations and prevent the development of EBV-associated malignancies in most healthy carriers, but infection can sometimes cause chronic disease and malignant transformation. Epstein-...

journal_title：Journal of virology

authors： Leskowitz RM,Zhou XY,Villinger F,Fogg MH,Kaur A,Lieberman PM,Wang F,Ertl HC

更新日期：2013-08-01 00:00:00

abstract：:To examine the contribution of the transmembrane envelope glycoprotein (TM) to the infectivity of the human T-cell leukemia virus type 1 (HTLV-1), single amino acid substitutions were introduced throughout its ectodomain. The mutated envelopes were tested for intracellular maturation and for functions, including abili...

journal_title：Journal of virology

authors： Rosenberg AR,Delamarre L,Pique C,Pham D,Dokhélar MC

更新日期：1997-10-01 00:00:00

abstract：:Retrovirus assembly involves a complex series of events in which a large number of proteins must be targeted to a point on the plasma membrane where immature viruses bud from the cell. Gag polyproteins of most retroviruses assemble an immature capsid on the cytoplasmic side of the plasma membrane during the budding pr...

journal_title：Journal of virology

authors： Parker SD,Hunter E

更新日期：2000-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common opportunistic infection in immunosuppressed individuals, such as transplant recipients or people living with HIV/AIDS, and congenital CMV is the leading viral cause of developmental disabilities in infants. Due to the highly species-specific nature of CMV, animal mode...

journal_title：Journal of virology

authors： Marsh AK,Willer DO,Ambagala AP,Dzamba M,Chan JK,Pilon R,Fournier J,Sandstrom P,Brudno M,MacDonald KS

更新日期：2011-12-01 00:00:00

abstract：UNLABELLED:We searched The Cancer Genome Atlas (TCGA) database for viruses by comparing non-human reads present in transcriptome sequencing (RNA-Seq) and whole-exome sequencing (WXS) data to viral sequence databases. Human papillomavirus 18 (HPV18) is an etiologic agent of cervical cancer, and as expected, we found rob...

journal_title：Journal of virology

authors： Cantalupo PG,Katz JP,Pipas JM

更新日期：2015-04-01 00:00:00

abstract：:Although several virologic and immunologic factors associated with an increased risk of perinatal human immunodeficiency virus type 1 (HIV-1) transmission have been described, the mechanism of mother-to-child transmission is still unclear. More specifically, the question of whether selective pressures influence the tr...

journal_title：Journal of virology

authors： Verhofstede C,Demecheleer E,De Cabooter N,Gaillard P,Mwanyumba F,Claeys P,Chohan V,Mandaliya K,Temmerman M,Plum J

更新日期：2003-03-01 00:00:00

abstract：:In response to viral infection, host cells elicit a number of responses, including the expression of alpha/beta interferon (IFN-alpha/beta). In these cells, IFN regulatory factor-3 (IRF-3) undergoes a sequence of posttranslational modifications that allow it to act as a potent transcriptional coactivator of specific I...

journal_title：Journal of virology

authors： Melroe GT,DeLuca NA,Knipe DM

更新日期：2004-08-01 00:00:00

abstract：:Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce...

journal_title：Journal of virology

authors： Cladel NM,Budgeon LR,Cooper TK,Balogh KK,Hu J,Christensen ND

更新日期：2013-08-01 00:00:00

abstract：UNLABELLED:The increasing number of zoonotic infections caused by influenza A virus (IAV) subtypes of avian origin (e.g., H5N1 and H7N9) in recent years underscores the need to better understand the factors driving IAV evolution and diversity. To evaluate the current feasibility of global analyses to contribute to this...

journal_title：Journal of virology

authors： Rejmanek D,Hosseini PR,Mazet JA,Daszak P,Goldstein T

更新日期：2015-11-01 00:00:00

abstract：:The rapid and accurate identification of pathogens is critical in the control of infectious disease. To this end, we analyzed the capacity for viral detection and identification of a newly described high-density resequencing microarray (RMA), termed PathogenID, which was designed for multiple pathogen detection using ...

journal_title：Journal of virology

authors： Dacheux L,Berthet N,Dissard G,Holmes EC,Delmas O,Larrous F,Guigon G,Dickinson P,Faye O,Sall AA,Old IG,Kong K,Kennedy GC,Manuguerra JC,Cole ST,Caro V,Gessain A,Bourhy H

更新日期：2010-09-01 00:00:00

abstract：:The human herpes simplex virus (HSV) protein VP16 induces formation of a transcriptional regulatory complex with two cellular factors-the POU homeodomain transcription factor Oct-1 and the cell proliferation factor HCF-1-to activate viral immediate-early-gene transcription. Although the cellular role of Oct-1 in trans...

journal_title：Journal of virology

authors： Lee S,Herr W

更新日期：2001-12-01 00:00:00

abstract：:To assess the possible contribution of host immune responses to the exertion of Fv2-associated resistance to Friend virus (FV)-induced disease development, we inoculated C57BL/6 (B6) mice that lacked various subsets of lymphocytes with FV containing no lactate dehydrogenase-elevating virus. Fv2(r) B6 mice lacking CD4(...

journal_title：Journal of virology

authors： Tsuji-Kawahara S,Kawabata H,Matsukuma H,Kinoshita S,Chikaishi T,Sakamoto M,Kawasaki Y,Miyazawa M

更新日期：2013-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-specific T-cell lines generated by repeated stimulation with EBV-immortalized lymphoblastoid B-cell lines (LCL) have been successfully used to treat EBV-associated posttransplant lymphoproliferative disease (PTLD) in hematopoietic stem cell transplant recipients. However, PTLD in solid-organ t...

journal_title：Journal of virology

authors： Adhikary D,Behrends U,Feederle R,Delecluse HJ,Mautner J

更新日期：2008-04-01 00:00:00

abstract：:The major envelope glycoproteins gp120 and gp41 of human immunodeficiency virus type 1, the causative agent for human AIDS, contain numerous N-linked oligosaccharides. We report here our discovery that N-acetylglucosamine residues within the complex-type N-linked oligosaccharides of both gp120 and its precursor, gp160...

journal_title：Journal of virology

authors： Shilatifard A,Merkle RK,Helland DE,Welles JL,Haseltine WA,Cummings RD

更新日期：1993-02-01 00:00:00

abstract：:In order to study cell tropism and attenuation of hepatitis A virus (HAV), the genome of HAV wild-type GBM and two cell culture-adapted variants, GBM/FRhK and GBM/HFS, were cloned and sequenced after amplification by reverse transcriptase-PCR. During virus cultivation, the HAV variant GBM/FRhK had a strict host range ...

journal_title：Journal of virology

authors： Graff J,Normann A,Feinstone SM,Flehmig B

更新日期：1994-01-01 00:00:00

abstract：:The combination of an amino acid deletion at codon 67 (delta 67) and Thr-to-Gly change at codon 69 (T69G) in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is associated with high-level resistance to multiple RT inhibitors. To determine the relative contributions of the delta 67 and T69G...

journal_title：Journal of virology

authors： Imamichi T,Berg SC,Imamichi H,Lopez JC,Metcalf JA,Falloon J,Lane HC

更新日期：2000-12-01 00:00:00

abstract：:The recent finding that the E1 glycoproteins of murine coronaviruses contain only O-linked oligosaccharides suggested that this unusual modification might be a distinguishing feature of coronaviruses and might play an essential role in the life cycle of this family of viruses. To examine these possibilities, we analyz...

journal_title：Journal of virology

authors： Stern DF,Sefton BM

更新日期：1982-12-01 00:00:00

abstract：:We identified the transcriptional coactivator FHL2 as a novel target of the human papillomavirus type 16 (HPV-16) E7 oncoprotein, which plays a major role in cell transformation. The interaction with FHL2 is abolished by mutations in conserved regions 1 and 2 and in the C-terminal zinc finger domain of E7, all require...

journal_title：Journal of virology

authors： Campo-Fernández B,Morandell D,Santer FR,Zwerschke W,Jansen-Dürr P

更新日期：2007-01-01 00:00:00

abstract：:The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta interferon (IFN-alpha/beta)- and IFN-gamma-induced nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) and to inhibit IFN-alpha/beta- and IFN-gamma-induced gene expression. These properties correlated with the ability of V...

journal_title：Journal of virology

authors： Reid SP,Valmas C,Martinez O,Sanchez FM,Basler CF

更新日期：2007-12-01 00:00:00

abstract：:Our previous studies showed that establishment of murine cytomegalovirus (MCMV) latency in vivo is associated with repression of immediate-early gene expression, deacetylation of histones bound to the major immediate-early promoter (MIEP), changes in patterns of methylation of histones, and recruitment of cellular rep...

journal_title：Journal of virology

authors： Liu XF,Yan S,Abecassis M,Hummel M

更新日期：2010-04-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional p...

journal_title：Journal of virology

authors： Ghez D,Lepelletier Y,Lambert S,Fourneau JM,Blot V,Janvier S,Arnulf B,van Endert PM,Heveker N,Pique C,Hermine O

更新日期：2006-07-01 00:00:00

abstract：:We have cloned several prototypic members of the family of human endogenous retroviruslike elements having a histidine tRNA primer-binding site (RTVL-H) and have determined the nucleotide sequence of one of these clones (RTVL-H2). The RTVL-H2 sequence is 5,813 nucleotides long, with long terminal repeats of 450 nucleo...

journal_title：Journal of virology

authors： Mager DL,Freeman JD

更新日期：1987-12-01 00:00:00

abstract：:Sensory neurons within trigeminal ganglia (TG) are the primary site for bovine herpesvirus 1 (BHV-1) latency. During latency, viral gene expression is restricted to the latency-related (LR) gene and the open reading frame ORF-E. We previously constructed an LR mutant virus that expresses LR RNA but not any of the know...

journal_title：Journal of virology

authors： Workman A,Perez S,Doster A,Jones C

更新日期：2009-09-01 00:00:00

abstract：:Toroviruses (family Coronaviridae, order Nidovirales) are enveloped, positive-stranded RNA viruses that have been implicated in enteric disease in cattle and possibly in humans. Despite their potential veterinary and clinical relevance, little is known about torovirus epidemiology and molecular genetics. Here, we pres...

journal_title：Journal of virology

authors： Smits SL,Lavazza A,Matiz K,Horzinek MC,Koopmans MP,de Groot RJ

更新日期：2003-09-01 00:00:00

abstract：:The vaccinia virus Western Reserve A38L protein is a hydrophobic integral membrane glycoprotein with amino acid similarity to mammalian integrin-associated protein. The protein has an N-terminal immunoglobulin superfamily domain, followed by five membrane-spanning domains and a short cytoplasmic tail. Deletion of the ...

journal_title：Journal of virology

authors： Sanderson CM,Parkinson JE,Hollinshead M,Smith GL

更新日期：1996-02-01 00:00:00

abstract：:The unique region of the capsid protein VP1 (VP1u) of human parvovirus B19 (B19) elicits a dominant immune response and has a phospholipase A(2) (PLA(2)) activity, which is necessary for the infection. In contrast to the rest of the parvoviruses, the VP1u of B19 is thought to occupy an external position in the virion,...

journal_title：Journal of virology

authors： Ros C,Gerber M,Kempf C

更新日期：2006-12-01 00:00:00

abstract：:Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct sub...

journal_title：Journal of virology

authors： Zhang L,Mohan PM,Padmanabhan R

更新日期：1992-12-01 00:00:00

abstract：:In wild aquatic birds and poultry around the world, influenza A viruses carrying 15 antigenic subtypes of hemagglutinin (HA) and 9 antigenic subtypes of neuraminidase (NA) have been described. Here we describe a previously unidentified antigenic subtype of HA (H16), detected in viruses circulating in black-headed gull...

journal_title：Journal of virology

authors： Fouchier RA,Munster V,Wallensten A,Bestebroer TM,Herfst S,Smith D,Rimmelzwaan GF,Olsen B,Osterhaus AD

更新日期：2005-03-01 00:00:00