Spontaneous variation and synthesis in the U3 region of the long terminal repeat of an avian retrovirus.

abstract：:Human immunodeficiency virus type 1 (HIV-1) gp41 plays a critical role in the viral fusion process, and its N- and C-terminal heptad repeat domains serve as important targets for developing anti-HIV-1 drugs, like T-20 (generic name, enfuvirtide; brand name, Fuzeon). Here, we conducted a yeast two-hybrid screening on a...

journal_title：Journal of virology

authors： Zhu Y,Lu L,Xu L,Yang H,Jiang S,Chen YH

更新日期：2010-09-01 00:00:00

abstract：:Five gibbon ape leukemia virus substrains (two from gibbons with lymphocytic leukemia and three from gibbons with myelogenous leukemia) were examined for unique genomic sequences specific for each form of leukemia. By using sequential adsorption procedures, the genome from each gibbon ape leukemia virus was fractionat...

journal_title：Journal of virology

authors： Sun L,Kawakami TG

更新日期：1980-08-01 00:00:00

abstract：:Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting patients infected with virus bearing the T215Y/F amino acid substitution associated with zidovudine (ZDV) resistance. A...

journal_title：Journal of virology

authors： Yerly S,Rakik A,De Loes SK,Hirschel B,Descamps D,Brun-Vézinet F,Perrin L

更新日期：1998-05-01 00:00:00

abstract：:The RNA produced in vivo from bacteriophage phiX174 DNA has been analyzed by polyacrylamide-agarose gel electrophoresis and sedimentation in dimethyl sulfoxide gradients, and the results of Hayashi and Hayashi (1970) have been confirmed and extended. An efficient procedure for recovery of RNA from gels, followed by a ...

journal_title：Journal of virology

authors： Clements JB,Sinsheimer RL

更新日期：1975-01-01 00:00:00

abstract：:Cells of Mus minutoides, an African pygmy mouse of the subgenus Nannomys, are susceptible to ecotropic Moloney and Friend mouse leukemia viruses (MLVs) but not to AKV-type MLVs. Transfected MA139 ferret cells expressing the mCAT-1 cell surface receptor, with the minCAT-1 substitutions K222Q and V233L, did not restrict...

journal_title：Journal of virology

authors： Yan Y,Kozak CA

更新日期：2008-07-01 00:00:00

abstract：:Reciprocal three-factor crosses and the use of a partial revertant of a putative ribonucleotide reductase mutant of Escherichia coli B/5 as indicator have made it possible to map denA (deficient in endonuclease II) between nrd-11 (ribonucleotide reductase gene B) and amM69 (gene 63) on the bacteriophage T4 chromosome....

journal_title：Journal of virology

authors： Ray P,Sinha NK,Warner HR,Snustad DP

更新日期：1972-01-01 00:00:00

abstract：:We investigated the use of infectious cDNA for the production of poliovirus type 1-type 3 recombinants. One such recombinant virus was produced, but a second construct involving the transfer of part of the capsid protein region was not infectious. Our results suggest that the approach may prove valuable but that not a...

journal_title：Journal of virology

authors： Stanway G,Hughes PJ,Westrop GD,Evans DM,Dunn G,Minor PD,Schild GC,Almond JW

更新日期：1986-03-01 00:00:00

abstract：:HVEM (for herpesvirus entry mediator) is a member of the tumor necrosis factor receptor superfamily and mediates entry of many strains of herpes simplex virus (HSV) into normally nonpermissive Chinese hamster ovary (CHO) cells. We used sucrose density centrifugation to demonstrate that purified HSV-1 KOS virions bind ...

journal_title：Journal of virology

authors： Nicola AV,Ponce de Leon M,Xu R,Hou W,Whitbeck JC,Krummenacher C,Montgomery RI,Spear PG,Eisenberg RJ,Cohen GH

更新日期：1998-05-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three discrete activities that each affect the ability of HN to promote viral fusion and entry: receptor binding, receptor cleaving (neuraminidase), and triggering of the fusion protein. The interrelationship between the receptor binding and f...

journal_title：Journal of virology

authors： Porotto M,Fornabaio M,Kellogg GE,Moscona A

更新日期：2007-04-01 00:00:00

abstract：:Animals that naturally acquire the prion diseases have a well-developed olfactory sense that they utilize for a variety of basic behaviors. To assess the potential for the nasal cavity to serve as a point of entry for prion diseases, a small amount of prion-infected brain homogenate was placed inferior to the nostrils...

journal_title：Journal of virology

authors： Kincaid AE,Bartz JC

更新日期：2007-05-01 00:00:00

abstract：:Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver dis...

journal_title：Journal of virology

authors： Cote PJ,Shapiro M,Engle RE,Popper H,Purcell RH,Gerin JL

更新日期：1986-12-01 00:00:00

abstract：:The feline homolog of the alpha-chemokine receptor CXCR4 has recently been shown to support cell-cell fusion mediated by CXCR4-dependent strains of human immunodeficiency virus (HIV) and strains of feline immunodeficiency virus (FIV) that have been selected for growth in the Crandell feline kidney (CrFK) cell line. In...

journal_title：Journal of virology

authors： Willett BJ,Adema K,Heveker N,Brelot A,Picard L,Alizon M,Turner JD,Hoxie JA,Peiper S,Neil JC,Hosie MJ

更新日期：1998-08-01 00:00:00

abstract：UNLABELLED:The measles virus (MeV) membrane fusion apparatus consists of a fusion protein trimer and an attachment protein tetramer. To trigger membrane fusion, the heads of the MeV attachment protein, hemagglutinin (H), bind cellular receptors while the 96-residue-long H stalk transmits the triggering signal. Structur...

journal_title：Journal of virology

authors： Navaratnarajah CK,Kumar S,Generous A,Apte-Sengupta S,Mateo M,Cattaneo R

更新日期：2014-06-01 00:00:00

abstract：:Hepatitis B virus (HBV) is an enveloped DNA virus that presumably buds at intracellular membranes of infected cells. HBV budding involves two endocytic host proteins, the ubiquitin-interacting adaptor gamma 2-adaptin and the Nedd4 ubiquitin ligase. Here, we demonstrate that HBV release also requires the cellular machi...

journal_title：Journal of virology

authors： Lambert C,Döring T,Prange R

更新日期：2007-09-01 00:00:00

abstract：:The major envelope glycoproteins gp120 and gp41 of human immunodeficiency virus type 1, the causative agent for human AIDS, contain numerous N-linked oligosaccharides. We report here our discovery that N-acetylglucosamine residues within the complex-type N-linked oligosaccharides of both gp120 and its precursor, gp160...

journal_title：Journal of virology

authors： Shilatifard A,Merkle RK,Helland DE,Welles JL,Haseltine WA,Cummings RD

更新日期：1993-02-01 00:00:00

abstract：:Synthetic peptides containing portions of a highly conserved region of retroviral transmembrane proteins of human and animal retroviruses were tested for their ability to inhibit lymphoproliferation to determine the minimum amino acid sequence required. The previously reported immunosuppression mediated by the peptide...

journal_title：Journal of virology

authors： Ruegg CL,Monell CR,Strand M

更新日期：1989-08-01 00:00:00

abstract：:Deoxyribonucleic acid (DNA) synthesis was studied in poxvirus-infected cells by measuring (14)C-thymidine incorporation into viral and host cell DNA. A complete separation of the two species of DNA was achieved by combining the previously used "Dounce method" with a separation method based on different reannealing pro...

journal_title：Journal of virology

authors： Jungwirth C,Launer J

更新日期：1968-05-01 00:00:00

abstract：:Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the seme...

journal_title：Journal of virology

authors： Whitney JB,Luedemann C,Hraber P,Rao SS,Mascola JR,Nabel GJ,Letvin NL

更新日期：2009-10-01 00:00:00

abstract：:Rhesus lymphocryptovirus (rLCV) and Epstein-Barr virus (EBV) are closely related gammaherpesviruses that infect and cause disease in rhesus monkeys and humans, respectively. Thus, rLCV is an important model system for EBV pathogenesis. Both rLCV and EBV express microRNAs (miRNAs), several conserved in sequence and gen...

journal_title：Journal of virology

authors： Riley KJ,Rabinowitz GS,Steitz JA

更新日期：2010-05-01 00:00:00

abstract：:Initial studies determined whether intraperitoneal (i.p.) injection of BALB/c mice with 0.1, 1.0, and 10 mg of adriamycin (a cardiotoxic anthracycline antibiotic) for times ranging between 1 and 9 weeks prior to i.p. injection of 10(5) PFU of coxsackievirus B3 (CVB3) would alter the severity of virus-induced myocardit...

journal_title：Journal of virology

authors： Huber SA,Moraska A,Choate M

更新日期：1992-11-01 00:00:00

abstract：:CH/S is a virulent porcine epidemic diarrhea virus (PEDV) strain and is used as the virulent strain to evaluate the protection rates of vaccines against PEDV infection in China. Here, we report the complete genome sequence of strain CH/S, which may aid in understanding the molecular characteristics of this strain. ...

journal_title：Journal of virology

authors： Chen J,Wang C,Shi H,Qiu HJ,Liu S,Shi D,Zhang X,Feng L

更新日期：2011-11-01 00:00:00

abstract：UNLABELLED:Due to a scarcity of immunocompetent animal models for viral hepatitis, little is known about the early innate immune responses in the liver. In various hepatotoxic models, both pro- and anti-inflammatory activities of recruited monocytes have been described. In this study, we compared the effect of liver in...

journal_title：Journal of virology

authors： Movita D,van de Garde MD,Biesta P,Kreefft K,Haagmans B,Zuniga E,Herschke F,De Jonghe S,Janssen HL,Gama L,Boonstra A,Vanwolleghem T

更新日期：2015-05-01 00:00:00

abstract：:Measles virus (MeV) infection is characterized by the formation of multinuclear giant cells (MGC). We report that beta interferon (IFN-beta) production is amplified in vitro by the formation of virus-induced MGC derived from human epithelial cells or mature conventional dendritic cells. Both fusion and IFN-beta respon...

journal_title：Journal of virology

authors： Herschke F,Plumet S,Duhen T,Azocar O,Druelle J,Laine D,Wild TF,Rabourdin-Combe C,Gerlier D,Valentin H

更新日期：2007-12-01 00:00:00

abstract：:The principal neutralizing epitope of the human immunodeficiency virus type 1 (HIV-1) lies between two invariant cysteines in the third variable region (V3) of the viral envelope (gp120), and its amino acid sequence varies among different HIV-1 isolates. HIV-2 carries an analogous amino acid sequence between two cyste...

journal_title：Journal of virology

authors： Boeri E,Giri A,Lillo F,Ferrari G,Varnier OE,Ferro A,Sabbatani S,Saxinger WC,Franchini G

更新日期：1992-07-01 00:00:00

abstract：:The small envelope protein (E) plays a role of central importance in the assembly of coronaviruses. This was initially established by studies demonstrating that cellular expression of only E protein and the membrane protein (M) was necessary and sufficient for the generation and release of virus-like particles. To inv...

journal_title：Journal of virology

authors： Kuo L,Hurst KR,Masters PS

更新日期：2007-03-01 00:00:00

abstract：:The promoter of the major immediate-early (MIE) genes of human cytomegalovirus (HCMV), also referred to as the CMV promoter, possesses a cis-acting element positioned downstream of the TATA box between positions -14 and -1 relative to the transcription start site (+1). We determined the role of the cis-acting element ...

journal_title：Journal of virology

authors： Isomura H,Stinski MF,Kudoh A,Nakayama S,Murata T,Sato Y,Iwahori S,Tsurumi T

更新日期：2008-01-01 00:00:00

abstract：:The 3'-untranslated region (3'-UTR) of mouse hepatitis virus (MHV) RNA regulates the replication of and transcription from the viral RNA. Several host cell proteins have previously been shown to interact with this regulatory region. By immunoprecipitation of UV-cross-linked cellular proteins and in vitro binding of th...

journal_title：Journal of virology

authors： Huang P,Lai MM

更新日期：2001-06-01 00:00:00

abstract：UNLABELLED:The expression of the antiviral host cell factor tetherin is induced by interferon and can inhibit the release of enveloped viruses from infected cells. The Vpu protein of HIV-1 antagonizes the antiviral activity of tetherin, and tetherin antagonists with Vpu-like activity have been identified in other virus...

journal_title：Journal of virology

authors： Gnirß K,Zmora P,Blazejewska P,Winkler M,Lins A,Nehlmeier I,Gärtner S,Moldenhauer AS,Hofmann-Winkler H,Wolff T,Schindler M,Pöhlmann S

更新日期：2015-09-01 00:00:00

abstract：:In varicella-zoster virus (VZV)-infected primary human brain vascular adventitial fibroblasts (BRAFs), levels of beta interferon (IFN-β,) STAT1, and STAT2 transcripts as well as STAT1 and STAT2 protein were decreased. IFN-α transcript levels were increased but not secreted IFN-α protein levels. Compared to IFN-α-treat...

journal_title：Journal of virology

authors： Nagel MA,James SF,Traktinskiy I,Wyborny A,Choe A,Rempel A,Baird NL,Gilden D

更新日期：2014-10-01 00:00:00

abstract：:A total of 51 restriction sites were recognized within the BK virus genome by the combination of 10 different restriction endonucleases. These sites were mapped and oriented relative to one another as well as to the five fragments generated by the digestion of BK virus DNA with HindIII and EcoRI. The result was a comp...

journal_title：Journal of virology

authors： Freund J,di Mayorca G,Subramanian KN

更新日期：1979-03-01 00:00:00