A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication.

abstract：:Chronic HIV infection is characterized by chronic immune activation and dysfunctional T cells with elevated intracellular cyclic AMP (cAMP), which inhibits the T cell activation capability. cAMP may be induced by prostaglandin E(2) following lipopolysaccharide (LPS)-induced upregulation of cyclooxygenase type 2 (COX-2...

journal_title：Journal of virology

authors： Pettersen FO,Torheim EA,Dahm AE,Aaberge IS,Lind A,Holm M,Aandahl EM,Sandset PM,Taskén K,Kvale D

更新日期：2011-07-01 00:00:00

abstract：:The intracellular assembly site for flaviviruses in currently not known but is presumed to be located within the lumen of the rough endoplasmic reticulum (RER). Building on previous studies involving immunofluorescence (IF) and cryoimmunoelectron microscopy of Kunjin virus (KUN)-infected cells, we sought to identify t...

journal_title：Journal of virology

authors： Mackenzie JM,Westaway EG

更新日期：2001-11-01 00:00:00

abstract：:To study the tissue specificity of mouse mammary tumor virus (MMTV) gene expression, we developed two series of transgenic mice, containing the MMTV proviral DNA of mammary (GR) and kidney (C3H-K) origin. The expression pattern in the MMTV(GR) transgenic mice is very similar to that observed in infected animals, e.g.,...

journal_title：Journal of virology

authors： Rollini P,Billotte J,Kolb E,Diggelmann H

更新日期：1992-07-01 00:00:00

abstract：:We have devised an enrichment scheme for the isolation of export-competent derivatives of pseudorabies virus glycoprotein gIII signal peptide mutants. Enrichment is based upon a growth advantage imparted upon gIII-containing virions compared with virions lacking the glycoprotein. Each of identified derivatives suppres...

journal_title：Journal of virology

authors： Powers L,Ryan P

更新日期：1994-05-01 00:00:00

abstract：:While cytomegalovirus (CMV) infections are often limited in host range by lengthy coevolution with a single host species, a few CMVs are known to deviate from this rule. For example, rhesus macaque CMV (RhCMV), a model for human CMV (HCMV) pathogenesis and vaccine development, can replicate in human cells, as well as ...

journal_title：Journal of virology

authors： Child SJ,Hickson SE,Bayer A,Malouli D,Früh K,Geballe AP

更新日期：2018-02-26 00:00:00

abstract：:Foot-and-mouth disease (FMD), which is caused by FMD virus (FMDV), remains a major plague among cloven-hoofed animals worldwide, and its outbreak often has disastrous socioeconomic consequences. A live-attenuated FMDV vaccine will greatly facilitate the global control and eradication of FMD, but a safe and effective a...

journal_title：Journal of virology

authors： Yang D,Sun C,Gao R,Wang H,Liu W,Yu K,Zhou G,Zhao B,Yu L

更新日期：2020-07-30 00:00:00

abstract：:Adenovirus (Ad) gene transfer vectors can be used to transfer and express antigens and function as strong adjuvants and thus are useful platforms for the development of genetic vaccines. Based on the hypothesis that Ad vectors with enhanced infectibility of dendritic cells (DC) may be able to evoke enhanced immune res...

journal_title：Journal of virology

authors： Worgall S,Busch A,Rivara M,Bonnyay D,Leopold PL,Merritt R,Hackett NR,Rovelink PW,Bruder JT,Wickham TJ,Kovesdi I,Crystal RG

更新日期：2004-03-01 00:00:00

abstract：:Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into...

journal_title：Journal of virology

authors： Bonham L,Wolgamot G,Miller AD

更新日期：1997-06-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68) establishes a lifelong infection in mice and is used as a model pathogen to study the role of viral and host factors in chronic infection. The maintenance of chronic MHV68 infection, at least in some latency reservoirs, appears to be dependent on the capacity of the virus to reactiva...

journal_title：Journal of virology

authors： Gargano LM,Forrest JC,Speck SH

更新日期：2009-02-01 00:00:00

abstract：:Influenza A virus encodes M2, a proton channel that has been shown to be important during virus entry and assembly. In order to systematically investigate the role of the membrane-proximal residues in the M2 cytoplasmic tail in virus replication, we utilized scanning and directed alanine mutagenesis in combination wit...

journal_title：Journal of virology

authors： Stewart SM,Pekosz A

更新日期：2011-12-01 00:00:00

abstract：:Influenza causes significant morbidity in tropical regions; however, unlike in temperate zones, influenza in the tropics is not strongly associated with a given season. We have recently shown that influenza virus transmission in the guinea pig model is most efficient under cold, dry conditions, which are rare in the t...

journal_title：Journal of virology

authors： Lowen AC,Steel J,Mubareka S,Palese P

更新日期：2008-06-01 00:00:00

abstract：:The synthesis of Sendai virus RNA species was examined after UV irradiation of cells late in infection. Compared with the inactivation of 50S genomic RNA synthesis, the synthesis of the group of mRNA species that sediments at 18S was inactivated at an average rate consistent with a process of sequential transcription ...

journal_title：Journal of virology

authors： Glazier K,Raghow R,Kingsbury DW

更新日期：1977-03-01 00:00:00

abstract：:Group I host range (hr) mutants of adenovirus type 5 are unable to transform rat embryo or rat embryo brain cells but induce an abnormal transformation of baby rat kidney cells. We established several transformed rat kidney cell lines and characterized them with respect to the transformed phenotype and the structure o...

journal_title：Journal of virology

authors： Ruben M,Bacchetti S,Graham FL

更新日期：1982-02-01 00:00:00

abstract：:This study identifies memory cytotoxic T lymphocyte (CTL) epitopes to respiratory syncytial virus (RSV) in healthy South African adults and demonstrates the conservation of those epitopes in circulating field strains of RSV in South Africa. Thirty-seven healthy adults from a population with diverse HLA backgrounds wer...

journal_title：Journal of virology

authors： Venter M,Rock M,Puren AJ,Tiemessen CT,Crowe JE Jr

更新日期：2003-07-01 00:00:00

abstract：UNLABELLED:Viral myocarditis, which is most prevalently caused by coxsackievirus B3 (CVB3), is a serious clinical condition characterized by excessive myocardial inflammation. Recent studies suggest that regulation of protein acetylation levels by inhibiting histone deacetylase (HDAC) activity modulates inflammatory re...

journal_title：Journal of virology

authors： Zhou L,He X,Gao B,Xiong S

更新日期：2015-10-01 00:00:00

abstract：:Lysyl-tRNA synthetase (LysRS) is packaged into human immunodeficiency virus type 1 (HIV-1) via its interaction with Gag, and this enzyme facilitates the selective packaging of tRNA(3)(Lys), the primer for initiating reverse transcription, into HIV-1. The Gag/LysRS interaction is detected at detergent-resistant membran...

journal_title：Journal of virology

authors： Halwani R,Cen S,Javanbakht H,Saadatmand J,Kim S,Shiba K,Kleiman L

更新日期：2004-07-01 00:00:00

abstract：:The first morphological evidence of African swine fever virus (ASFV) assembly is the appearance of precursor viral membranes, thought to derive from the endoplasmic reticulum, within the assembly sites. We have shown previously that protein p54, a viral structural integral membrane protein, is essential for the genera...

journal_title：Journal of virology

authors： Suárez C,Gutiérrez-Berzal J,Andrés G,Salas ML,Rodríguez JM

更新日期：2010-08-01 00:00:00

abstract：:The physical map locations of 62 temperature-sensitive mutations of vaccinia virus WR have been determined by marker rescue experiments, using cloned HindIII fragments of wild-type DNA. Since vaccinia virus DNA is not infectious, marker rescue was performed by infecting monolayers of cells at the nonpermissive tempera...

journal_title：Journal of virology

authors： Ensinger MJ,Rovinsky M

更新日期：1983-11-01 00:00:00

abstract：:West Nile virus (WNV), currently the cause of a serious U.S. epidemic, is a mosquito-borne flavivirus and member of the Japanese encephalitis (JE) serocomplex. There is currently no approved human WNV vaccine, and treatment options remain limited, resulting in significant mortality and morbidity from human infection. ...

journal_title：Journal of virology

authors： Petrovsky N,Larena M,Siddharthan V,Prow NA,Hall RA,Lobigs M,Morrey J

更新日期：2013-09-01 00:00:00

abstract：:We have found that the burst size of bacteriophage T7 was decreased in two Escherichia coli temperature-sensitive gyrase mutants incubated at the restrictive temperature. This reduction in burst size indicates that gyrase may be required for T7 growth. ...

journal_title：Journal of virology

authors： Steck TR,Drlica K

更新日期：1985-01-01 00:00:00

abstract：:During the S phase of the eukaryotic cell cycle and in virus-infected cells, DNA replication takes place at discrete sites in the nucleus, although it is not clear how the proteins involved in the replicative process are directed to these sites. Nuclear factor I is a cellular, sequence-specific DNA-binding protein uti...

journal_title：Journal of virology

authors： Bosher J,Dawson A,Hay RT

更新日期：1992-05-01 00:00:00

abstract：:Human norovirus (HuNoV) is a leading cause of acute gastroenteritis in both developed and developing countries. Studies of HuNoV host cell interactions are limited by the lack of a simple, robust cell culture system. Due to their diverse HuNoV-like biological features, including histo-blood group antigen (HBGA) bindin...

journal_title：Journal of virology

authors： Farkas T,Yang K,Le Pendu J,Baines JD,Cardin RD

更新日期：2019-10-29 00:00:00

abstract：:Expression of the two bovine papillomavirus type 1 (BPV-1) late genes, L1 and L2, coding for the two capsid proteins, is limited to terminally differentiated keratinocytes in bovine fibropapillomas. This pattern of expression is determined both by the activity of the late promoter and by the inhibition of late region ...

journal_title：Journal of virology

authors： Furth PA,Baker CC

更新日期：1991-11-01 00:00:00

abstract：:Purified avian myeloblastosis virus was iodinated by the lactoperoxidase method. Disruption of the labeled virions and chromatography of the viral proteins showed that radioiodine was associated only with the glycoproteins of the viral envelope. Reaction of the radiolabeled virus with antiviral antibody followed by mi...

journal_title：Journal of virology

authors： Fritz RB

更新日期：1974-01-01 00:00:00

abstract：UNLABELLED:Semen enhances HIV infection in vitro, but how long it retains this activity has not been carefully examined. Immediately postejaculation, semen exists as a semisolid coagulum, which then converts to a more liquid form in a process termed liquefaction. We demonstrate that early during liquefaction, semen exh...

journal_title：Journal of virology

authors： Roan NR,Liu H,Usmani SM,Neidleman J,Müller JA,Avila-Herrera A,Gawanbacht A,Zirafi O,Chu S,Dong M,Kumar ST,Smith JF,Pollard KS,Fändrich M,Kirchhoff F,Münch J,Witkowska HE,Greene WC

更新日期：2014-07-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) infection eliminates production of type I interferons (IFNs) in host cells, which triggers an antiviral immune response through the induction of downstream IFN-stimulated genes (ISGs), thus escaping the fate of host-mediated clearance. The IFN-induced transme...

journal_title：Journal of virology

authors： Zhang A,Duan H,Zhao H,Liao H,Du Y,Li L,Jiang D,Wan B,Wu Y,Ji P,Zhou EM,Zhang G

更新日期：2020-11-23 00:00:00

abstract：:Human papillomaviruses (HPVs) infect keratinocytes and induce proliferative lesions. In infected cells, viral gene products alter the activities of cellular proteins, such as Rb and p53, resulting in altered cell cycle response. It is likely that HPV gene products also alter expression of cellular genes. In this study...

journal_title：Journal of virology

authors： Chang YE,Laimins LA

更新日期：2000-05-01 00:00:00

abstract：:Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma virus types 1, 2, 3, 4, 5, and 8 showed no homology under stringent hybridization conditions. Human papilloma virus type 6 D...

journal_title：Journal of virology

authors： Gissmann L,Diehl V,Schultz-Coulon HJ,zur Hausen H

更新日期：1982-10-01 00:00:00

abstract：:The level of RNase activity in human interferon preparations was examined. Although sequential purification of interferon resulted in nearly a 300-fold increase in specific activity, RNase-specific activity remained more or less constant. The implications of this finding for the analyses of the mode of action of inter...

journal_title：Journal of virology

authors： Winchurch RA,Karpetsky TP,Levy CC,Cantell K

更新日期：1977-03-01 00:00:00

abstract：:The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3' noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne fl...

journal_title：Journal of virology

authors： Men R,Bray M,Clark D,Chanock RM,Lai CJ

更新日期：1996-06-01 00:00:00