Abstract:
:In varicella-zoster virus (VZV)-infected primary human brain vascular adventitial fibroblasts (BRAFs), levels of beta interferon (IFN-β,) STAT1, and STAT2 transcripts as well as STAT1 and STAT2 protein were decreased. IFN-α transcript levels were increased but not secreted IFN-α protein levels. Compared to IFN-α-treated control results, in VZV-infected BRAFs, phosphorylated STAT1 did not translocate to the nucleus, resulting in impaired downstream expression of interferon-inducible antiviral Mx1. Overall, VZV interference with the type I interferon pathway may promote virus persistence in cerebral arteries.
journal_name
J Viroljournal_title
Journal of virologyauthors
Nagel MA,James SF,Traktinskiy I,Wyborny A,Choe A,Rempel A,Baird NL,Gilden Ddoi
10.1128/JVI.01945-14subject
Has Abstractpub_date
2014-10-01 00:00:00pages
11634-7issue
19eissn
0022-538Xissn
1098-5514pii
JVI.01945-14journal_volume
88pub_type
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