Regulation of toxinogenesis in Corynebacterium diphtheriae. II. Genetic mapping of a tox regulatory mutation in bacteriophage beta.

abstract：:High rates of genetic variation ensure the survival of RNA viruses. Although this variation is thought to result from error-prone replication, RNA viruses must also maintain highly conserved genomic segments. A balance between conserved and variable viral elements is especially important in order for viruses to avoid ...

journal_title：Journal of virology

authors： Contreras AM,Hiasa Y,He W,Terella A,Schmidt EV,Chung RT

更新日期：2002-09-01 00:00:00

abstract：:The effects of human papillomavirus type 18 (HPV-18) E6 and E7 proteins on global patterns of host gene expression in primary human keratinocytes grown in organotypic raft culture system were assessed. Primary human keratinocytes were infected with retroviruses that express the wild-type HPV-18 E6 and E7 genes from th...

journal_title：Journal of virology

authors： Garner-Hamrick PA,Fostel JM,Chien WM,Banerjee NS,Chow LT,Broker TR,Fisher C

更新日期：2004-09-01 00:00:00

abstract：UNLABELLED:Inhibitor-of-apoptosis (IAP) proteins are key regulators of the innate antiviral response by virtue of their capacity to respond to signals affecting cell survival. In insects, wherein the host IAP provides a primary restriction to apoptosis, diverse viruses trigger rapid IAP depletion that initiates caspase...

journal_title：Journal of virology

authors： Vandergaast R,Mitchell JK,Byers NM,Friesen PD

更新日期：2015-04-01 00:00:00

abstract：:Natural killer (NK) cells derived from the human female reproductive tract (FRT) are phenotypically and functionally distinct from those obtained from peripheral blood. Because the FRT is a primary site of human immunodeficiency virus type 1 (HIV-1) infection in women, we determined whether soluble factors secreted by...

journal_title：Journal of virology

authors： Mselle TF,Howell AL,Ghosh M,Wira CR,Sentman CL

更新日期：2009-11-01 00:00:00

abstract：:The transcriptional activities of the four hepatitis B virus promoters were compared in three differentiated hepatoma cell lines, HepG2, Hep3B, and PLC/PRF/5; a dedifferentiated subline of HepG2, HepG2.1; a human cervical carcinoma cell line, HeLa S3; and a mouse fibroblast cell line, NIH 3T3. The plasmid constructs, ...

journal_title：Journal of virology

authors： Raney AK,Milich DR,Easton AJ,McLachlan A

更新日期：1990-05-01 00:00:00

abstract：UNLABELLED:Hepatitis B, which caused by hepatitis B virus (HBV) infection, remains a major health threat worldwide. Hepatic injury and regeneration from chronic inflammation are the main driving factors of liver fibrosis and cirrhosis in chronic hepatitis B. Proinflammatory tumor necrosis factor alpha (TNF-α) has been ...

journal_title：Journal of virology

authors： Jia B,Guo M,Li G,Yu D,Zhang X,Lan K,Deng Q

更新日期：2015-02-01 00:00:00

abstract：:Using 3'-end-labeled genome probes, cells infected with vesicular stomatitis virus Chandipura, Cocal, and Piry serotypes were shown to contain (+) leader RNAs of approximately 50 nucleotides in length. The nucleotide sequence of the leader RNA regions of these genomes was determined and compared with the previously re...

journal_title：Journal of virology

authors： Giorgi C,Blumberg B,Kolakofsky D

更新日期：1983-04-01 00:00:00

abstract：:The effect of bacteriophage SPO1 infection of Bacillus subtilis and a deoxyribonucleic acid (DNA) polymerase-deficient (pol(-)) mutant of this microorganism on the synthesis of DNA has been examined. Soon after infection, the incorporation of deoxyribonucleoside triphosphates into acid-insoluble material by cell lysat...

journal_title：Journal of virology

authors： Yehle CO,Ganesan AT

更新日期：1972-02-01 00:00:00

abstract：:Interferon-induced transmembrane protein 3 (IFITM3) is a cellular factor that reduces HIV-1 infectivity by an incompletely understood mechanism. We show here that viruses differing only in the envelope glycoprotein (Env) expressed on their surface have different sensitivities to IFITM3. Measurements of the sensitivity...

journal_title：Journal of virology

authors： Drouin A,Migraine J,Durand MA,Moreau A,Burlaud-Gaillard J,Beretta M,Roingeard P,Bouvin-Pley M,Braibant M

更新日期：2020-12-09 00:00:00

abstract：:Alphavirus expression systems based on suicidal virus particles carrying recombinant replicons have proven to be a very efficient way to deliver genes for heterologous protein expression. However, present strategies for production of such particles have biosafety limitations due to the generation, by RNA recombination...

journal_title：Journal of virology

authors： Smerdou C,Liljeström P

更新日期：1999-02-01 00:00:00

abstract：:Sequences from the 5' end of type 1 human immunodeficiency virus RNA dimerize spontaneously in vitro in a reaction thought to mimic the initial step of genomic dimerization in vivo. Dimer initiation has been proposed to occur through a "kissing-loop" interaction involving a specific RNA stem-loop element designated SL...

journal_title：Journal of virology

authors： Clever JL,Wong ML,Parslow TG

更新日期：1996-09-01 00:00:00

abstract：:The region of the UL component of the herpes simplex virus type 1 genome between nucleotides 17,793 and 25,150 includes three open reading frames that code for the protein products of the UL8, UL9, and UL10 genes (D.J. McGeogh, M.A. Dalrymple, A.J. Davison, A. Dolan, M.C. Frame, D. McNab, L.J. Perry, J.E. Scott, and P...

journal_title：Journal of virology

authors： Baradaran K,Dabrowski CE,Schaffer PA

更新日期：1994-07-01 00:00:00

abstract：:The nodavirus flock house virus (FHV) has a bipartite, positive-sense, RNA genome that encodes the catalytic subunit of the RNA replicase and the viral capsid protein precursor on separate genomic segments (RNA1 and RNA2, respectively). RNA1 can replicate autonomously when transfected into permissive cells, allowing s...

journal_title：Journal of virology

authors： Johnson KL,Ball LA

更新日期：1999-10-01 00:00:00

abstract：:Neurotropic herpesviruses depend on long-distance axon transport for the initial establishment of latency in peripheral ganglia (retrograde transport) and for viral spread in axons to exposed body surfaces following reactivation (anterograde transport). Images of neurons infected with herpes simplex virus type 1 (HSV-...

journal_title：Journal of virology

authors： Antinone SE,Zaichick SV,Smith GA

更新日期：2010-12-01 00:00:00

abstract：:Primary sympathetic neuronal cultures were maintained for up to 5 weeks after inoculation with herpes simplex virus (HSV) without evidence of viral infection. Upon deprivation of nerve growth factor, the cultures produced infectious HSV, indicating that the cultures harbored latent HSV. This study demonstrates a funct...

journal_title：Journal of virology

authors： Wilcox CL,Johnson EM Jr

更新日期：1987-07-01 00:00:00

abstract：:R325-beta TK+, a herpes simplex virus 1 mutant carrying a 500-base-pair deletion in the alpha 22 gene and the wild-type (beta) thymidine kinase (TK) gene, was previously shown to grow efficiently in HEp-2 and Vero cell lines. We report that in rodent cell lines exemplified by the Rat-1 line, plating efficiency was red...

journal_title：Journal of virology

authors： Sears AE,Halliburton IW,Meignier B,Silver S,Roizman B

更新日期：1985-08-01 00:00:00

abstract：:Functional defects in cytotoxic CD8(+) T cell responses arise in chronic human viral infections, but the mechanisms involved are not well understood. In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the maintenance of CD8(+) T cell function and control of persistent viral infections. To in...

journal_title：Journal of virology

authors： Chevalier MF,Jülg B,Pyo A,Flanders M,Ranasinghe S,Soghoian DZ,Kwon DS,Rychert J,Lian J,Muller MI,Cutler S,McAndrew E,Jessen H,Pereyra F,Rosenberg ES,Altfeld M,Walker BD,Streeck H

更新日期：2011-01-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：:The temperature-sensitive defects of virus mutants isolated from L cells persistently infected with Newcastle disease virus (NDV) were analyzed. Genetic grouping of the mutants by complementation tests was attempted by using several different methods, including yield analysis, RNA synthesis, and heterozygote formation...

journal_title：Journal of virology

authors： Preble OT,Youngner JS

更新日期：1973-09-01 00:00:00

abstract：:The genome of bacteriophage phi 6 contains three segments of double-stranded RNA. Procapsid structures whose formation was directed by cDNA copies of the large genomic segment are capable of packaging the three viral message sense RNAs in the presence of ATP. Addition of UTP, CTP, and GTP results in the synthesis of m...

journal_title：Journal of virology

authors： Gottlieb P,Strassman J,Qiao X,Frilander M,Frucht A,Mindich L

更新日期：1992-05-01 00:00:00

abstract：:T-even bacteriophages were grown and purified in bulk quantities. The protein coats were disrupted into their component substructures by treatment with 67% dimethyl sulfoxide (DMSO). Tail fibers and tubes were purified on glycerol-CsCl-D(2)O gradients and examined with respect to sedimentation properties, subunit mole...

journal_title：Journal of virology

authors： Cummings DJ,Kusy AR,Chapman VA,DeLong SS,Stone KR

更新日期：1970-10-01 00:00:00

abstract：:The recent yellow fever virus (YFV) epidemic in Brazil in 2017 and Zika virus (ZIKV) epidemic in 2015 serve to remind us of the importance of flaviviruses as emerging human pathogens. With the current global flavivirus threat, there is an urgent need for antivirals and vaccines to curb the spread of these viruses. How...

journal_title：Journal of virology

authors： Miorin L,Laurent-Rolle M,Pisanelli G,Co PH,Albrecht RA,García-Sastre A,Morrison J

更新日期：2019-06-28 00:00:00

abstract：:Protein P4, an early protein of double-stranded RNA bacteriophage phi 6, is a component of the virion-associated RNA polymerase complex and possesses a nucleoside triphosphate (NTP) phosphohydrolase activity. We have produced and characterized a panel of 20 P4-specific monoclonal antibodies. Epitope mapping using trun...

journal_title：Journal of virology

authors： Ojala PM,Juuti JT,Bamford DH

更新日期：1993-05-01 00:00:00

abstract：:The genome structure of a newly isolated sarcoma virus, Y73, was studied. Y73 is a defective, potent sarcomagenic virus and contains 4.8-kilobase (kb) RNA as its genome; in contrast, helper virus associated with Y73 had 8.5-kb RNA, similar to other avian leukemia viruses. Fingerprinting analysis these RNAs demonstrate...

journal_title：Journal of virology

authors： Yoshida M,Kawai S,Toyoshima K

更新日期：1981-05-01 00:00:00

abstract：:Interferon regulatory factor 7 (IRF-7) is implicated in the regulation of Epstein-Barr virus (EBV) latency. EBV transforms primary B cells, and the major EBV oncoprotein, latent membrane protein 1 (LMP-1), is required for the process. LMP-1 both induces the expression of IRF-7 and activates the IRF-7 protein by phosph...

journal_title：Journal of virology

authors： Zhang L,Zhang J,Lambert Q,Der CJ,Del Valle L,Miklossy J,Khalili K,Zhou Y,Pagano JS

更新日期：2004-12-01 00:00:00

abstract：:Members of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3 [A3]) family of DNA cytidine deaminases are intrinsic restriction factors against retroviruses. In felids such as the domestic cat (Felis catus), the A3 genes encode the A3Z2, A3Z3, and A3Z2Z3 antiviral cytidine deaminases. Only A3...

journal_title：Journal of virology

authors： Gu Q,Zhang Z,Gertzen CGW,Häussinger D,Gohlke H,Münk C

更新日期：2018-02-26 00:00:00

abstract：:Envelope glycoprotein E(rns) of classical swine fever virus (CSFV) has been shown to contain RNase activity and is involved in virus infection. Two short regions of amino acids in the sequence of E(rns) are responsible for RNase activity. In both regions, histidine residues appear to be essential for catalysis. They w...

journal_title：Journal of virology

authors： Hulst MM,Panoto FE,Hoekman A,van Gennip HG,Moormann RJ

更新日期：1998-01-01 00:00:00

abstract：:In order to study primate lentivirus evolution in the Colobinae subfamily, in which only one simian immunodeficiency virus (SIV) has been described to date, we screened additional species from the three different genera of African colobus monkeys for SIV infection. Blood was obtained from 13 West African colobids, and...

journal_title：Journal of virology

authors： Courgnaud V,Formenty P,Akoua-Koffi C,Noe R,Boesch C,Delaporte E,Peeters M

更新日期：2003-01-01 00:00:00

abstract：:Lymphocyte antigen 6E (LY6E) is a GPI-anchored, interferon-inducible protein that has been shown to modulate viral infection in a cell type-dependent manner. Our recent work showed that LY6E promotes HIV-1 infection in some high-CD4-expressing cells, including human peripheral blood mononuclear cells (PBMCs) and the S...

journal_title：Journal of virology

authors： Yu J,Liang C,Liu SL

更新日期：2019-03-21 00:00:00

abstract：:Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus ...

journal_title：Journal of virology

authors： Ren Y,Li C,Feng L,Pan W,Li L,Wang Q,Li J,Li N,Han L,Zheng X,Niu X,Sun C,Chen L

更新日期：2015-10-14 00:00:00