Human uterine natural killer cells but not blood natural killer cells inhibit human immunodeficiency virus type 1 infection by secretion of CXCL12.

abstract：:The Epstein-Barr virus (EBV) is an oncogenic human herpesvirus. EBV latent membrane protein 1 (LMP-1) is a viral oncogene that manifests its oncogenic phenotype through activation of cellular signaling pathways involved in cell growth, survival, differentiation, and transformation. Lytic LMP-1 (lyLMP-1) is a related E...

journal_title：Journal of virology

authors： Pandya J,Walling DM

更新日期：2006-08-01 00:00:00

abstract：:Circulating leukocytes are important in dissemination of cytomegalovirus (CMV) infection in humans. In the mouse model of murine CMV infection (MCMV), it has been shown that infection peaks on days 5 to 7 after experimental infection, when 0.01 to 0.1% of the circulating leukocytes contain viral DNA. In our laboratory...

journal_title：Journal of virology

authors： Collins TM,Quirk MR,Jordan MC

更新日期：1994-10-01 00:00:00

abstract：:The majority of HIV-1 infections around the world result from non-B clade HIV-1 strains. The CRF01_AE (AE) strain is seen principally in Southeast Asia. AE protease differs by approximately 10% in amino acid sequence from clade B protease and carries several naturally occurring polymorphisms that are associated with d...

journal_title：Journal of virology

authors： Bandaranayake RM,Kolli M,King NM,Nalivaika EA,Heroux A,Kakizawa J,Sugiura W,Schiffer CA

更新日期：2010-10-01 00:00:00

abstract：:Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype...

journal_title：Journal of virology

authors： de Jong JJ,Goudsmit J,Keulen W,Klaver B,Krone W,Tersmette M,de Ronde A

更新日期：1992-02-01 00:00:00

abstract：:Semlike forest virus capsid protein cosedimented with the large ribosomal subunit at 60S in sucrose gradients after treatment of cytoplasm from infected cells with Triton X-100 and EDTA. In CsCl gradients the capsid protein banded with the subunit at a density of 1.56 to 1.57 g/cm3. Most of the capsid protein could be...

journal_title：Journal of virology

authors： Ulmanen I,Söderlund H,Kääriäinen L

更新日期：1976-10-01 00:00:00

abstract：:T-cell responses of pigs to hog cholera virus (HCV) have reportedly been absent or difficult to detect. Therefore, little is known about cellular immunity to HCV. In this study, we used an attenuated strain of pseudorabies virus expressing the envelope glycoprotein E1 of HCV and purified recombinant E1 to examine whet...

journal_title：Journal of virology

authors： Kimman TG,Bianchi AT,Wensvoort G,de Bruin TG,Meliefste C

更新日期：1993-05-01 00:00:00

abstract：:Experimental evidence from the simian immunodeficiency virus (SIV) model of AIDS has shown that the nef gene is critical in the pathogenesis of AIDS. Consequently, nef is of considerable interest in both antiviral drug and vaccine development. Preliminary findings in two rhesus macaques indicated that a deletion of on...

journal_title：Journal of virology

authors： Whatmore AM,Cook N,Hall GA,Sharpe S,Rud EW,Cranage MP

更新日期：1995-08-01 00:00:00

abstract：:Eleven highly conserved proteins comprise the poxvirus entry-fusion complex (EFC). We focused on vaccinia virus (VACV) O3, a 35-amino acid, largely hydrophobic component of unknown specific function. Experimental evolution was carried out by blindly passaging a virus that was severely impaired in entry due to deletion...

journal_title：Journal of virology

authors： Tak AI,Americo JL,Diesterbeck US,Moss B

更新日期：2021-01-27 00:00:00

abstract：:Previous work demonstrated that a herpes simplex virus type 1 (HSV-1) immediate-early function up-regulates beta interferon but not chloramphenicol acetyltransferase reporter genes driven by the strong simian virus 40 (SV40) or cytomegalovirus promoter-enhancer regions in both transient assays and stable cell lines. T...

journal_title：Journal of virology

authors： Brown CR,Nakamura MS,Mosca JD,Hayward GS,Straus SE,Perera LP

更新日期：1995-11-01 00:00:00

abstract：:We have previously shown for the paramyxovirus simian virus 5 (SV5) that a functional promoter for RNA replication requires proper spacing between two discontinuous elements: a 19-base segment at the 3' terminus (conserved region I [CRI]) and an 18-base internal region (CRII) that is contained within the coding region...

journal_title：Journal of virology

authors： Keller MA,Murphy SK,Parks GD

更新日期：2001-04-01 00:00:00

abstract：:Ebola virus (EBOV) causes severe hemorrhagic fever, for which therapeutic options are not available. Preventing the entry of EBOV into host cells is an attractive antiviral strategy, which has been validated for HIV by the FDA approval of the anti-HIV drug enfuvirtide. To identify inhibitors of EBOV entry, the EBOV en...

journal_title：Journal of virology

authors： Basu A,Li B,Mills DM,Panchal RG,Cardinale SC,Butler MM,Peet NP,Majgier-Baranowska H,Williams JD,Patel I,Moir DT,Bavari S,Ray R,Farzan MR,Rong L,Bowlin TL

更新日期：2011-04-01 00:00:00

abstract：:The sequence of the human immunodeficiency virus type 2 circle junction was determined. The most common sequence found between the conserved CA and TG dinucleotides at the ends of the integrated provirus was five bases long (GGTAC). This suggests that the integration of human immunodeficiency virus type 2 DNA is accom...

journal_title：Journal of virology

authors： Whitcomb JM,Hughes SH

更新日期：1991-07-01 00:00:00

abstract：:The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We ...

journal_title：Journal of virology

authors： Taylor JR Jr,Kimbrell KC,Scoggins R,Delaney M,Wu L,Camerini D

更新日期：2001-09-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV), a member of the Picornaviridae, is a pathogen of cloven-hoofed animals and causes a disease of major economic importance. Picornavirus-infected cells show changes in cell morphology and rearrangement of cytoplasmic membranes, which are a consequence of virus replication. We show he...

journal_title：Journal of virology

authors： Armer H,Moffat K,Wileman T,Belsham GJ,Jackson T,Duprex WP,Ryan M,Monaghan P

更新日期：2008-11-01 00:00:00

abstract：:Severe complications of Zika virus (ZIKV) infection might be caused by inflammation, but how ZIKV induces proinflammatory cytokines is not understood. In this study, we show opposite regulatory effects of the ZIKV NS5 protein on interferon (IFN) signaling. Whereas ZIKV and its NS5 protein were potent suppressors of ty...

journal_title：Journal of virology

authors： Chaudhary V,Yuen KS,Chan JF,Chan CP,Wang PH,Cai JP,Zhang S,Liang M,Kok KH,Chan CP,Yuen KY,Jin DY

更新日期：2017-06-26 00:00:00

abstract：:Fluorescent retroviral envelope (Env) proteins were developed for direct visualization of viral particles. By fusing the enhanced green fluorescent protein (eGFP) to the N terminus of the amphotropic 4070A envelope protein, extracellular presentation of eGFP was achieved. Viruses incorporated the modified Env protein ...

journal_title：Journal of virology

authors： Spitzer D,Dittmar KE,Rohde M,Hauser H,Wirth D

更新日期：2003-05-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC famil...

journal_title：Journal of virology

authors： Siu YT,Chin KT,Siu KL,Yee Wai Choy E,Jeang KT,Jin DY

更新日期：2006-07-01 00:00:00

abstract：:The varicella-zoster virus (VZV) open reading frame 54 (ORF54) gene encodes an 87-kDa monomer that oligomerizes to form the VZV portal protein, pORF54. pORF54 was hypothesized to perform a function similar to that of a previously described herpes simplex virus 1 (HSV-1) homolog, pUL6. pUL6 and the associated viral ter...

journal_title：Journal of virology

authors： Visalli MA,House BL,Selariu A,Zhu H,Visalli RJ

更新日期：2014-07-01 00:00:00

abstract：:The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin (HA) vaccine-mediated protection after vaccination. Using a C3 knockout (C3 KO) mouse model, we found that ...

journal_title：Journal of virology

authors： Kim YJ,Kim KH,Ko EJ,Kim MC,Lee YN,Jung YJ,Lee YT,Kwon YM,Song JM,Kang SM

更新日期：2018-09-26 00:00:00

abstract：:We have cloned several prototypic members of the family of human endogenous retroviruslike elements having a histidine tRNA primer-binding site (RTVL-H) and have determined the nucleotide sequence of one of these clones (RTVL-H2). The RTVL-H2 sequence is 5,813 nucleotides long, with long terminal repeats of 450 nucleo...

journal_title：Journal of virology

authors： Mager DL,Freeman JD

更新日期：1987-12-01 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen 2 (EBNA-2) acidic domain is essential for B-lymphocyte growth transformation and can activate transcription when brought to a promoter by a sequence-specific DNA-binding domain. We now show that the EBNA-2 acidic domain has slightly less activity than the proteotypic acidic trans...

journal_title：Journal of virology

authors： Tong X,Wang F,Thut CJ,Kieff E

更新日期：1995-01-01 00:00:00

abstract：:Hepatitis A virus (HAV) is an enterically transmitted virus that replicates predominantly in hepatocytes within the liver before excretion via bile through feces. Hepatocytes are polarized epithelial cells, and it has been assumed that the virus load in bile results from direct export of HAV via the apical domain of p...

journal_title：Journal of virology

authors： Snooks MJ,Bhat P,Mackenzie J,Counihan NA,Vaughan N,Anderson DA

更新日期：2008-09-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) infects >90% of the population and establishes a latent infection with asymptomatic episodes of reactivation. However, HHV-6 reactivation is associated with morbidity and sometimes mortality in immunocompromised patients. To date, control of the virus in healthy virus carriers and the failu...

journal_title：Journal of virology

authors： Fastenackels S,Bayard C,Larsen M,Magnier P,Bonnafous P,Seddiki N,Appay V,Gautheret-Dejean A,Sauce D

更新日期：2019-06-14 00:00:00

abstract：:From purified linear and superhelical DNAs, the restriction endonuclease maps of four xenotropic murine leukemia virus DNAs from NFS, NZB, BALB/c, and AKR mice were determined with ten restriction endonucleases. Each xenotropic proviral DNA was found to be a unique restriction endonuclease map, with differences in the...

journal_title：Journal of virology

authors： Joseph DR

更新日期：1981-12-01 00:00:00

abstract：:We analyzed capsomeres of human papillomavirus type 16 (HPV16) consisting of the L1 major structural protein for their ability to trigger a cytotoxic T-cell (CTL) response. To this end, we immunized C57BL/6 mice and used the L1(165-173) peptide for ex vivo restimulation of splenocytes prior to analysis ((51)Cr release...

journal_title：Journal of virology

authors： Ohlschläger P,Osen W,Dell K,Faath S,Garcea RL,Jochmus I,Müller M,Pawlita M,Schäfer K,Sehr P,Staib C,Sutter G,Gissmann L

更新日期：2003-04-01 00:00:00

abstract：:From the results of transient plasmid-based replication assays, it has been postulated that homologous regions (hrs) of Autographa californica nuclear polyhedrosis virus (AcMNPV) function as origins of viral DNA replication. However, these assays vary in specificity according to the methodology used and may not be dep...

journal_title：Journal of virology

authors： Wu Y,Carstens EB

更新日期：1996-10-01 00:00:00

abstract：:The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) glycoprotein GP64 is the major envelope protein of the budded virus (BV). GP64 is a class III fusion protein that mediates BV attachment to the cell surface and low-pH-triggered membrane fusion between the BV envelope and the endosome membrane during en...

journal_title：Journal of virology

authors： Dong S,Blissard GW

更新日期：2012-09-01 00:00:00

abstract：:Alpha/beta interferon (IFN-alpha/beta) protects the host from virus infection by inhibition of lytic virus replication in infected cells and modulation of the antiviral cell-mediated immune response. To determine whether IFN-alpha/beta also modulates the virus-host interaction during latent virus infection, we infecte...

journal_title：Journal of virology

authors： Barton ES,Lutzke ML,Rochford R,Virgin HW 4th

更新日期：2005-11-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates very efficiently into a specific site (AAVS1) of human chromosome 19. Two elements of the AAV genome are sufficient: the inverted terminal repeats (ITRs) and the Rep78 or Rep68 protein. The incorporation of the AAV integration machinery in nonviral delivery systems is of great i...

journal_title：Journal of virology

authors： Lamartina S,Roscilli G,Rinaudo D,Delmastro P,Toniatti C

更新日期：1998-09-01 00:00:00

abstract：:For viruses with segmented genomes, genetic diversity is generated by genetic drift, reassortment, and recombination. Recombination produces RNA populations distinct from full-length gene segments and can influence viral population dynamics, persistence, and host immune responses. Viruses in the Reoviridae family, inc...

journal_title：Journal of virology

authors： Smith SC,Gribble J,Diller JR,Wiebe MA,Thoner TW Jr,Denison MR,Ogden KM

更新日期：2021-01-20 00:00:00