Effects of viral strain, transgene position, and target cell type on replication kinetics, genomic stability, and transgene expression of replication-competent murine leukemia virus-based vectors.

abstract：:Innate immunity provides an immediate defense against infection after host cells sense danger signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of misfolded/unfolded proteins when protein load overwhelms the ER folding capacity, which activates the unfolded protein response (UPR) to res...

journal_title：Journal of virology

authors： Frabutt DA,Wang B,Riaz S,Schwartz RC,Zheng YH

更新日期：2017-12-14 00:00:00

abstract：:Analysis of purified simian rotavirus has shown that it contains fewer structural polypeptide classes than previously reported. Two polypeptides (molecular weights, 62,000 and 28,000) commonly found in purified rotaviruses were, in fact, produced by cleavage of a larger structural polypeptide (molecular weight, about ...

journal_title：Journal of virology

authors： Espejo RT,López S,Arias C

更新日期：1981-01-01 00:00:00

abstract：:All hepatitis B viruses replicate by protein-primed reverse transcription, employing a specialized reverse transcriptase, P protein, that carries a unique terminal protein (TP) domain. To initiate reverse transcription, P protein must bind to a stem-loop, epsilon, on the pregenomic RNA template. TP then provides a Y r...

journal_title：Journal of virology

authors： Stahl M,Beck J,Nassal M

更新日期：2007-12-01 00:00:00

abstract：:Polyomavirus small t antigen was purified from genetically engineered Escherichia coli and used as the immunogen for the production of polyclonal and monoclonal antibodies. A new series of plasmids for increased expression of polyomavirus T antigens or a T antigen-beta-galactosidase fusion protein was constructed by r...

journal_title：Journal of virology

authors： Pallas DC,Schley C,Mahoney M,Harlow E,Schaffhausen BS,Roberts TM

更新日期：1986-12-01 00:00:00

abstract：:Cell-to-cell spread of tobacco mosaic virus is facilitated by the virus-encoded 30-kDa movement protein (MP). This process involves interaction of viral proteins with host components, including the cytoskeleton and the endoplasmic reticulum (ER). During virus infection, high-molecular-weight forms of MP were detected ...

journal_title：Journal of virology

authors： Reichel C,Beachy RN

更新日期：2000-04-01 00:00:00

abstract：UNLABELLED:The four serotypes of dengue virus (DENV) cause the most important and rapidly emerging arboviral diseases in humans. The recent phase 2b and 3 studies of a tetravalent dengue vaccine reported a moderate efficacy despite the presence of neutralizing antibodies, highlighting the need for a better understandin...

journal_title：Journal of virology

authors： Tsai WY,Durbin A,Tsai JJ,Hsieh SC,Whitehead S,Wang WK

更新日期：2015-07-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several neoplastic diseases: Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV replicates actively, via a controlled gene expression program, but can also remain latent. It had been thought that the transition...

journal_title：Journal of virology

authors： Prasad A,Lu M,Lukac DM,Zeichner SL

更新日期：2012-04-01 00:00:00

abstract：:There are no known RNA viruses that infect Archaea. Filling this gap in our knowledge of viruses will enhance our understanding of the relationships between RNA viruses from the three domains of cellular life and, in particular, could shed light on the origin of the enormous diversity of RNA viruses infecting eukaryot...

journal_title：Journal of virology

authors： Bolduc B,Shaughnessy DP,Wolf YI,Koonin EV,Roberto FF,Young M

更新日期：2012-05-01 00:00:00

abstract：:A porcine rotavirus (prv), variant 4F, isolated in tissue culture from the feces of a Chinese pig with diarrhea, was found to have become highly pathogenic when passaged in gnotobiotic piglets (J. C. Bridger, B. Burke, G. M. Beards, and U. Desselberger, J. Gen. Virol. 73:3011-3015, 1992). Comparison with the closely r...

journal_title：Journal of virology

authors： Tauscher GI,Desselberger U

更新日期：1997-01-01 00:00:00

abstract：:Panicum mosaic virus (PMV) is a recently molecularly characterized RNA virus with the unique feature of supporting the replication of two subviral RNAs in a few species of the family Gramineae. The subviral agents include a satellite RNA (satRNA) that is devoid of a coding region and the unrelated satellite panicum mo...

journal_title：Journal of virology

authors： Qiu W,Scholthof KB

更新日期：2001-06-01 00:00:00

abstract：:It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E prot...

journal_title：Journal of virology

authors： To J,Surya W,Fung TS,Li Y,Verdià-Bàguena C,Queralt-Martin M,Aguilella VM,Liu DX,Torres J

更新日期：2017-02-14 00:00:00

abstract：:A novel phage lambda mutation, called dc10, which interferes with proper lambda head assembly has been isolated and characterized. Phage lambda carrying this mutation is (i) unable to form plaques at 30 or 37 degrees C but does so at 42 degrees C and (ii) unable to form plaques at 42 degrees C on pN-constitutive hosts...

journal_title：Journal of virology

authors： Georgopoulos CP,Bisig R,Magazin M,Eisen H,Court D

更新日期：1979-02-01 00:00:00

abstract：:Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics, representing a serious public health concern. It has been described that one mechanism used by some IAV strains to escape the host innate immune responses and modulate virus pathogenicity involves the ability of the PA-X and NS1 proteins to ...

journal_title：Journal of virology

authors： Nogales A,Rodriguez L,DeDiego ML,Topham DJ,Martínez-Sobrido L

更新日期：2017-08-10 00:00:00

abstract：:Vaccinia virus DNA fragments that have been denatured by alkali and then neutralized contain a fraction that rapidly reforms duplex structures. The fraction is enriched by fractionating on hydroxyapatite columns and serves as as substrate for digestion by two restriction endonucleases isolated from Hemophilus parainfl...

journal_title：Journal of virology

authors： DeFilippes F

更新日期：1975-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection causes substantial morbidity and some deaths in the young and elderly worldwide. There is no safe and effective vaccine available, although it is possible to reduce the hospitalization rate for high-risk children by anti-RSV antibody prophylaxis. RSV has been shown to modify...

journal_title：Journal of virology

authors： Zhang W,Choi Y,Haynes LM,Harcourt JL,Anderson LJ,Jones LP,Tripp RA

更新日期：2010-01-01 00:00:00

abstract：:The synthesis of minus-strand RNA was studied in cell cultures infected with the heat-resistant strain of Sindbis virus and with temperature-sensitive (ts) belonging to complementation groups A, B, F, and G, all of which exhibited an RNA-negative (RNA-) phenotype when infection was initiated and maintained at 39 degre...

journal_title：Journal of virology

authors： Sawicki DL,Sawicki SG,Keränen S,Kääriäinen L

更新日期：1981-08-01 00:00:00

abstract：:Although combination therapy allows the suppression of human immunodeficiency virus type 1 (HIV-1) viremia to undetectable levels, eradication has not been achieved because the virus persists in cellular reservoirs, particularly the latent reservoir in resting CD4(+) T lymphocytes. We previously established a simian i...

journal_title：Journal of virology

authors： Shen A,Yang HC,Zhou Y,Chase AJ,Boyer JD,Zhang H,Margolick JB,Zink MC,Clements JE,Siliciano RF

更新日期：2007-02-01 00:00:00

abstract：UNLABELLED:The risk of transmission of transmissible spongiform encephalopathies (TSE) between different species has been notoriously unpredictable because the mechanisms of transmission are not fully understood. A transmission barrier between species often prevents infection of a new host with a TSE agent. Nonetheless...

journal_title：Journal of virology

authors： Wiseman FK,Cancellotti E,Piccardo P,Iremonger K,Boyle A,Brown D,Ironside JW,Manson JC,Diack AB

更新日期：2015-05-01 00:00:00

abstract：:The phenotypic properties of ICP27 temperature-sensitive and deletion mutants and the results of transient expression assays have demonstrated that ICP27 has a modulatory effect on viral gene expression induced by ICPs 0 and 4. In order to identify the regions of the ICP27 molecule that are responsible for its enhanci...

journal_title：Journal of virology

authors： McMahan L,Schaffer PA

更新日期：1990-07-01 00:00:00

abstract：:Type III interferons (IFNs) (interleukin-28/29 or lambda interferon [IFN-lambda]) are cytokines with IFN-like activities. Here we show that several classes of viruses induce expression of IFN-lambda1 and -lambda2/3 in similar patterns. The IFN-lambdas were-unlike alpha/beta interferon (IFN-alpha/beta)-induced directly...

journal_title：Journal of virology

authors： Ank N,West H,Bartholdy C,Eriksson K,Thomsen AR,Paludan SR

更新日期：2006-05-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Tat protein binds to an RNA stem-loop structure called TAR which is present at the 5' end of all human immunodeficiency virus type 1 transcripts. This binding is centered on a bulge within the stem of TAR and is an essential step in the trans-activation process which results in ...

journal_title：Journal of virology

authors： Sumner-Smith M,Roy S,Barnett R,Reid LS,Kuperman R,Delling U,Sonenberg N

更新日期：1991-10-01 00:00:00

abstract：:Fanconi anemia (FA) patients have an increased risk for squamous cell carcinomas (SCCs) at sites of predilection for infection with high-risk human papillomavirus (HPV) types, including the oral cavity and the anogenital tract. We show here that activation of the FA pathway is a frequent event in cervical SCCs. We fou...

journal_title：Journal of virology

authors： Spardy N,Duensing A,Charles D,Haines N,Nakahara T,Lambert PF,Duensing S

更新日期：2007-12-01 00:00:00

abstract：:The inhibition of multilineage hematopoiesis which occurs in the severe combined immunodeficiency mouse with transplanted human fetal thymus and liver tissues (SCID-hu Thy/Liv) due to human immunodeficiency virus type 1 (HIV-1) infection is also accompanied by a severe loss of c-Mpl expression on these progenitor cell...

journal_title：Journal of virology

authors： Koka PS,Kitchen CM,Reddy ST

更新日期：2004-10-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) against the rubella virion were used to locate epitopes involved in hemagglutination and neutralization. The MAbs exhibiting high-level hemagglutination-inhibiting activity were shown by Western blot analysis to be specific for the E1 polypeptide; this is consistent with the presence of th...

journal_title：Journal of virology

authors： Green KY,Dorsett PH

更新日期：1986-03-01 00:00:00

abstract：:Extracellular murine leukemia virus (MLV) reverse transcriptase activity was decreased by interferon treatment in four interferon-sensitive mouse cell lines which were chronic MLV producers. In three cell lines which were relatively insensitive to interferon, extracellular enzyme activity remained unchanged by interfe...

journal_title：Journal of virology

authors： Friedman RM,Chang EH,Ramseur JM,Myers MW

更新日期：1975-09-01 00:00:00

abstract：:The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin (HA) vaccine-mediated protection after vaccination. Using a C3 knockout (C3 KO) mouse model, we found that ...

journal_title：Journal of virology

authors： Kim YJ,Kim KH,Ko EJ,Kim MC,Lee YN,Jung YJ,Lee YT,Kwon YM,Song JM,Kang SM

更新日期：2018-09-26 00:00:00

abstract：:Hantavirus pulmonary syndrome (HPS) is a severe respiratory disease which is thought to result from a dysregulated immune response to infection with pathogenic hantaviruses, such as Sin Nombre virus or Andes virus (ANDV). Other New World hantaviruses, such as Prospect Hill virus (PHV), have not been associated with hu...

journal_title：Journal of virology

authors： Spiropoulou CF,Albariño CG,Ksiazek TG,Rollin PE

更新日期：2007-03-01 00:00:00

abstract：:The transcription map of the Aedes albopictus densovirus (AalDNV) brevidensovirus was identified by Northern blotting, rapid amplification of cDNA ends (RACE) analysis, and RNase protection assays. AalDNV produced mRNAs of 3,359 (NS1), 3,345 (NS2), and 1,246 (VP) nucleotides. The two overlapping P7/7.4 NS promoters em...

journal_title：Journal of virology

authors： Pham HT,Jousset FX,Perreault J,Shike H,Szelei J,Bergoin M,Tijssen P

更新日期：2013-09-01 00:00:00

abstract：:The VP7 and VP4 genes of seven antigenic mutants of simian rotavirus SA11 4fM (serotype 3) selected after 39 passages in the presence of SA11 4fM hyperimmune antiserum, were sequenced. Nucleotide sequence analysis indicated the following. (i) Twice as many amino acid substitutions occurred in the VP7 protein than in V...

journal_title：Journal of virology

authors： Gorziglia M,Larralde G,Ward RL

更新日期：1990-09-01 00:00:00

abstract：:Historically, the adenoviral E3 region was found to be nonessential for viral replication in vitro. In addition, adenoviruses whose genome was more than approximately 105% the size of the native genome were inefficiently packaged. These profound observations were used experimentally to insert transgenes into the adeno...

journal_title：Journal of virology

authors： Zhu M,Bristol JA,Xie Y,Mina M,Ji H,Forry-Schaudies S,Ennist DL

更新日期：2005-05-01 00:00:00