Viral determinants of rotavirus pathogenicity in pigs: production of reassortants by asynchronous coinfection.

abstract：:We followed the dynamics of capsid amino acid replacement among 403 Nigerian outbreak isolates of type 2 circulating vaccine-derived poliovirus (cVDPV2) from 2005 through 2011. Four different functional domains were analyzed: (i) neutralizing antigenic (NAg) sites, (ii) residues binding the poliovirus receptor (PVR), ...

journal_title：Journal of virology

authors： Shaw J,Jorba J,Zhao K,Iber J,Chen Q,Adu F,Adeniji A,Bukbuk D,Baba M,Henderson E,Dybdahl-Sissoko N,McDonald S,Weldon WC,Gumede N,Oberste MS,Kew OM,Burns CC

更新日期：2018-04-13 00:00:00

abstract：:Noroviruses are the causative agents of the majority of viral gastroenteritis outbreaks in humans. During the past 15 years, noroviruses of genotype GGII.4 have caused four epidemic seasons of viral gastroenteritis, during which four novel variants (termed epidemic variants) emerged and displaced the resident viruses....

journal_title：Journal of virology

authors： Siebenga JJ,Vennema H,Renckens B,de Bruin E,van der Veer B,Siezen RJ,Koopmans M

更新日期：2007-09-01 00:00:00

abstract：:Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection ...

journal_title：Journal of virology

authors： Hao X,Kim TS,Braciale TJ

更新日期：2008-05-01 00:00:00

abstract：:Affinity-purified medium T antigen encoded by NG59, a nontransforming mutant of polyomavirus, is specifically associated with a protein of 72,000 daltons (72K protein). Medium T antigens of wild-type polyomavirus and the transformation-competent mutant dl8 are not associated with the 72K protein. Instead, they form a ...

journal_title：Journal of virology

authors： Walter G,Carbone A,Welch WJ

更新日期：1987-02-01 00:00:00

abstract：:The synthesis of closed circular simian virus 40 (SV40) deoxyribonucleic acid (DNA) containing sequences homologous to host cell DNA depends upon the conditions under which the cells are infected. When BS-C-1 monkey cells were infected with non-plaque-purified virus at low multiplicity of infection [MOI, 0.032 plaque-...

journal_title：Journal of virology

authors： Lavi S,Winocour E

更新日期：1972-02-01 00:00:00

abstract：:Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in...

journal_title：Journal of virology

authors： Miura T,Brumme CJ,Brockman MA,Brumme ZL,Pereyra F,Block BL,Trocha A,John M,Mallal S,Harrigan PR,Walker BD

更新日期：2009-04-01 00:00:00

abstract：:Natural killer (NK) cells serve as a crucial first-line defense against tumors and virus-infected cells. We previously showed that lysis of influenza virus (IV)-infected cells is mediated by the interaction between the NK receptor, NKp46, and the IV hemagglutinin (HA) type 1 expressed by the infected cells. This inter...

journal_title：Journal of virology

authors： Mendelson M,Tekoah Y,Zilka A,Gershoni-Yahalom O,Gazit R,Achdout H,Bovin NV,Meningher T,Mandelboim M,Mandelboim O,David A,Porgador A

更新日期：2010-04-01 00:00:00

abstract：:Pretreatment with two biological response modifiers (BRM), OK-432 and PS-K, protected mice from lethal infection by murine cytomegalovirus (MCMV). This was evidenced by an increase in 50% lethal doses and a decrease in titers of infectious viruses replicated in the liver and spleen. Spleen cells from the BRM-treated m...

journal_title：Journal of virology

authors： Ebihara K,Minamishima Y

更新日期：1984-07-01 00:00:00

abstract：:Aichi virus, a member of the family Picornaviridae, encodes a leader (L) protein of 170 amino acids (aa). The Aichi virus L protein exhibits no significant sequence homology to those of other picornaviruses. In this study, we investigated the function of the Aichi virus L protein in virus growth. In vitro translation ...

journal_title：Journal of virology

authors： Sasaki J,Nagashima S,Taniguchi K

更新日期：2003-10-01 00:00:00

abstract：:We have previously described several human immunodeficiency virus type 1 (HIV-1) mutants that are characterized by an excessive-RNA-splicing phenotype and reduced virus particle production. In one of these mutants (NLD2up), the sequence of 5' splice site D2 was changed to a consensus splice donor site. This splice sit...

journal_title：Journal of virology

authors： Mandal D,Feng Z,Stoltzfus CM

更新日期：2008-02-01 00:00:00

abstract：:Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that is a major cause of lower-respiratory-tract disease. hMPV is associated with more severe disease in infants and persons with underlying medical conditions. Animal studies have shown that the hMPV fusion (F) protein alone is capable of inducing pr...

journal_title：Journal of virology

authors： Williams JV,Chen Z,Cseke G,Wright DW,Keefer CJ,Tollefson SJ,Hessell A,Podsiad A,Shepherd BE,Sanna PP,Burton DR,Crowe JE Jr,Williamson RA

更新日期：2007-08-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) infects a number of different cell types, including mammary gland and lymphoid cells, in vivo. To identify the cellular receptor for this virus, a mouse cDNA expression library was transfected into Cos-7 monkey kidney cells, and those transfected cells able to bind virus were selected ...

journal_title：Journal of virology

authors： Golovkina TV,Dzuris J,van den Hoogen B,Jaffe AB,Wright PC,Cofer SM,Ross SR

更新日期：1998-04-01 00:00:00

abstract：:Grasshoppers, Melanoplus sanguinipes (F.), infected with the grasshopper inclusion body virus (GIBV) showed a general torpor, took longer to develop, and had abnormally high rates of mortality. Infection was found only in the fat body, and developing viruses and inclusion bodies were observed in the nuclei and cytopla...

journal_title：Journal of virology

authors： Henry JE,Nelson BP,Jutila JW

更新日期：1969-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) play an important role in the immune response against respiratory syncytial virus (RSV) infection. The cell surface molecule lymphocyte function-associated antigen 1 (LFA-1) is an important contributor to CTL activation, CTL-mediated direct cell lysis, and lymphocyte migration. In an att...

journal_title：Journal of virology

authors： Rutigliano JA,Johnson TR,Hollinger TN,Fischer JE,Aung S,Graham BS

更新日期：2004-03-01 00:00:00

abstract：:Inbred LSH hamster brain cells were transformed in vitro by the GS strain of BK virus (BKV), and transplantable tumors classified as undifferentiated glioblastomas were induced in the syngeneic host. The viral status in the transformed cells, designated LSH-BR-BK, was established. About 46 genome equivalents per cell ...

journal_title：Journal of virology

authors： Beth E,Giraldo G,Schmidt-Ullrich R,Pater MM,Pater A,di Mayorca G

更新日期：1981-10-01 00:00:00

abstract：:We have analyzed the mechanism by which the matrix (M1) protein associates with cellular membranes during influenza A virus assembly. Interaction of the M1 protein with the viral hemagglutinin (HA) or neuraminidase (NA) glycoprotein was extensively analyzed by using wild-type and transfectant influenza viruses as well...

journal_title：Journal of virology

authors： Enami M,Enami K

更新日期：1996-10-01 00:00:00

abstract：:We previously demonstrated that polyhedron formation (PF) mutants arise at a high frequency during serial passage of the Lymantria dispar nucleopolyhedrovirus (LdMNPV) in the L. dispar 652Y cell line (J. M. Slavicek, N. Hayes-Plazolles, and M. E. Kelly, Biol. Control 5:251-261, 1995). Most of these PF mutants exhibite...

journal_title：Journal of virology

authors： Bischoff DS,Slavicek JM

更新日期：1997-02-01 00:00:00

abstract：:We have previously described the expression of the major nonstructural protein (NS-1) of Aleutian mink disease parvovirus (ADV) in insect cells by using a baculovirus vector (J. Christensen, T. Storgaard, B. Bloch, S. Alexandersen, and B. Aasted, J. Virol. 67:229-238, 1993). To study its biochemical properties, ADV NS...

journal_title：Journal of virology

authors： Christensen J,Pedersen M,Aasted B,Alexandersen S

更新日期：1995-03-01 00:00:00

abstract：:A uniform nomenclature has been agreed upon for monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus. Blocks of numbers from PAb1 to PAb999 have been allocated to workers involved in the isolation of monoclonal antibodies of this type. The correspondence between PAb numbers ...

journal_title：Journal of virology

authors： Crawford L,Harlow E

更新日期：1982-02-01 00:00:00

abstract：:Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectru...

journal_title：Journal of virology

authors： O'Keefe BR,Giomarelli B,Barnard DL,Shenoy SR,Chan PK,McMahon JB,Palmer KE,Barnett BW,Meyerholz DK,Wohlford-Lenane CL,McCray PB Jr

更新日期：2010-03-01 00:00:00

abstract：:Massive infection of memory CD4 T cells is a hallmark of early simian immunodeficiency virus (SIV) infection, with viral infection peaking at day 10 postinfection (p.i.), when a majority of memory CD4 T cells in mucosal and peripheral tissues are infected. It is not clear if mononuclear cells from the monocyte and mac...

journal_title：Journal of virology

authors： Moore AC,Bixler SL,Lewis MG,Verthelyi D,Mattapallil JJ

更新日期：2012-01-01 00:00:00

abstract：:Proteolytic processing of the picornaviral polyprotein mediated by the differential action of virus-encoded proteinase(s) is pivotal to both RNA genome replication and capsid formation. Possibly to enlarge the array of viral proteins, picornaviral polyprotein processing results in intermediate and mature products whic...

journal_title：Journal of virology

authors： Probst C,Jecht M,Gauss-Müller V

更新日期：1998-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an important human pathogen associated with chronic liver disease. Recently, based on a genotype 2a isolate, tissue culture systems supporting complete replication and infectious virus production have been developed. In this study, we used cell culture-produced infectious HCV to analyze the ...

journal_title：Journal of virology

authors： Tscherne DM,Jones CT,Evans MJ,Lindenbach BD,McKeating JA,Rice CM

更新日期：2006-02-01 00:00:00

abstract：:The avian adenovirus CELO is a promising vector for gene transfer applications. In order to study this potentiality, we developed an improved method for construction of adenovirus vectors in cosmids that was used to engineer the CELO genome. For all the recombinant viruses constructed by this method, the ability to pr...

journal_title：Journal of virology

authors： François A,Eterradossi N,Delmas B,Payet V,Langlois P

更新日期：2001-06-01 00:00:00

abstract：:A number of avocado (Persea americana) cultivars are known to contain high-molecular-weight double-stranded RNA (dsRNA) molecules for which a viral nature has been suggested, although sequence data are not available. Here we report the cloning and complete sequencing of a 13.5-kbp dsRNA virus isolated from avocado and...

journal_title：Journal of virology

authors： Villanueva F,Sabanadzovic S,Valverde RA,Navas-Castillo J

更新日期：2012-01-01 00:00:00

abstract：:Most patients infected with hepatitis C virus (HCV) become chronic carriers. Viruses that efficiently establish persistent infections must have effective ways of evading host defenses. In the case of HCV, little is known about how chronic infections are established or maintained. Besides hepatocytes, several reports s...

journal_title：Journal of virology

authors： Bergqvist A,Rice CM

更新日期：2001-01-01 00:00:00

abstract：:A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between ex...

journal_title：Journal of virology

authors： Benson SJ,Ruis BL,Garbers AL,Fadly AM,Conklin KF

更新日期：1998-12-01 00:00:00

abstract：:Nearly 50 years ago, the discovery of interferon prompted the notion that host cells innately respond to viral invasion. Since that time, technological advances have allowed this response to be extensively characterized and dissected in vitro. However, these advances have only recently been applied to highly complex, ...

journal_title：Journal of virology

authors： Hartman ZC,Kiang A,Everett RS,Serra D,Yang XY,Clay TM,Amalfitano A

更新日期：2007-02-01 00:00:00

abstract：:Potyviruses express most of their proteins from a long open reading frame that is translated into a large polyprotein processed by three viral proteases. To understand the constraints on potyvirus genome organization, we relocated the viral RNA-dependent RNA polymerase (NIb) cistron to all possible intercistronic posi...

journal_title：Journal of virology

authors： Majer E,Salvador Z,Zwart MP,Willemsen A,Elena SF,Daròs JA

更新日期：2014-04-01 00:00:00

abstract：:To clarify the role of core protein phosphorylation in pregenomic-RNA encapsidation of human and duck hepatitis B viruses (HBV and DHBV, respectively), we have examined the phosphorylation states of different forms of intracellular HBV core protein and the phenotypic effects of mutations in the phosphorylation sites o...

journal_title：Journal of virology

authors： Gazina EV,Fielding JE,Lin B,Anderson DA

更新日期：2000-05-01 00:00:00