Cell-cell fusion induced by measles virus amplifies the type I interferon response.

abstract：:Some retroviruses contain monoubiquitinated Gag and do not bud efficiently from cells treated with proteasome inhibitors, suggesting an interaction between the ubiquitin-proteasome system and retrovirus assembly. We examined equine infectious anemia virus (EIAV) particles and found that approximately 2% of the p9(Gag)...

journal_title：Journal of virology

authors： Ott DE,Coren LV,Sowder RC 2nd,Adams J,Nagashima K,Schubert U

更新日期：2002-03-01 00:00:00

abstract：UNLABELLED:A hallmark of Ebola virus (EBOV) infection is the formation of viral inclusions in the cytoplasm of infected cells. These viral inclusions contain the EBOV nucleocapsids and are sites of viral replication and nucleocapsid maturation. Although there is growing evidence that viral inclusions create a protected...

journal_title：Journal of virology

authors： Nelson EV,Schmidt KM,Deflubé LR,Doğanay S,Banadyga L,Olejnik J,Hume AJ,Ryabchikova E,Ebihara H,Kedersha N,Ha T,Mühlberger E

更新日期：2016-07-27 00:00:00

abstract：:Experiments were conducted to investigate the roles of Marek's disease virus serotype 1 (MDV-1) major tegument proteins VP11/12, VP13/14, VP16, and VP22 in viral growth in cultured cells. Based on a bacterial artificial chromosome clone of MDV-1 (BAC20), mutant viruses were constructed in which the MDV-1 homologs of U...

journal_title：Journal of virology

authors： Dorange F,Tischer BK,Vautherot JF,Osterrieder N

更新日期：2002-02-01 00:00:00

abstract：:The sheep genome harbors approximately 20 endogenous retroviruses (enJSRVs) highly related to the exogenous Jaagsiekte sheep retrovirus (JSRV). One of the enJSRV loci, enJS56A1, acts as a unique restriction factor by blocking JSRV in a transdominant fashion at a late stage of the retroviral cycle. To better understand...

journal_title：Journal of virology

authors： Murcia PR,Arnaud F,Palmarini M

更新日期：2007-02-01 00:00:00

abstract：:Recently, we demonstrated that inverted repeat sequences inserted into first-generation adenovirus (Ad) vector genomes mediate precise genomic rearrangements resulting in vector genomes devoid of all viral genes that are efficiently packaged into functional Ad capsids. As a specific application of this finding, we gen...

journal_title：Journal of virology

authors： Lieber A,Steinwaerder DS,Carlson CA,Kay MA

更新日期：1999-11-01 00:00:00

abstract：:The uncoating of adenovirus type 2 and a temperature-sensitive mutant, tsl, was studied. HEp-2 cells were infected with 32P- OR 125I-labeled purified virions for various lengths of time, and the nuclear and cytoplasmic fractions were analyzed by sucrose gradient velocity sedimentation and sodium dodecyl sulfate-polyac...

journal_title：Journal of virology

authors： Mirza MA,Weber J

更新日期：1979-05-01 00:00:00

abstract：:The rescue of influenza viruses by reverse genetics has been described only for the influenza A and B viruses. Based on a similar approach, we developed a reverse-genetics system that allows the production of influenza C viruses entirely from cloned cDNA. The complete sequences of the 3' and 5' noncoding regions of ty...

journal_title：Journal of virology

authors： Crescenzo-Chaigne B,van der Werf S

更新日期：2007-10-01 00:00:00

abstract：:We identified the transcriptional coactivator FHL2 as a novel target of the human papillomavirus type 16 (HPV-16) E7 oncoprotein, which plays a major role in cell transformation. The interaction with FHL2 is abolished by mutations in conserved regions 1 and 2 and in the C-terminal zinc finger domain of E7, all require...

journal_title：Journal of virology

authors： Campo-Fernández B,Morandell D,Santer FR,Zwerschke W,Jansen-Dürr P

更新日期：2007-01-01 00:00:00

abstract：:Many viruses induce type I interferon responses by activating cytoplasmic RNA sensors, including the RIG-I-like receptors (RLRs). Although two members of the RLR family, RIG-I and MDA5, have been implicated in host control of virus infection, the relative role of each RLR in restricting pathogenesis in vivo remains un...

journal_title：Journal of virology

authors： Lazear HM,Pinto AK,Ramos HJ,Vick SC,Shrestha B,Suthar MS,Gale M Jr,Diamond MS

更新日期：2013-11-01 00:00:00

abstract：:Heterologous viral infections have been shown to impact the preexisting memory CD8(+)-T-cell repertoire. Bacterial superantigens are products of common human pathogenic bacteria, including staphylococci and streptococci, that are potent T-cell-stimulatory molecules. In this report, we show that exposure to staphylococ...

journal_title：Journal of virology

authors： Huang CC,Shah S,Nguyen P,Altman JD,Blackman MA

更新日期：2002-07-01 00:00:00

abstract：:Simian virus 40 mutants lacking sequences in the late leader region are viable but produce smaller plaques than does wild-type virus. Within three passages at low multiplicities of infection, virus stocks of several such mutants accumulated variants that synthesized an altered form of the major virion protein, VP1, ha...

journal_title：Journal of virology

authors： Barkan A,Welch RC,Mertz JE

更新日期：1987-10-01 00:00:00

abstract：UNLABELLED:The Nairovirus genus of the Bunyaviridae family contains serious human and animal pathogens classified within multiple serogroups and species. Of these serogroups, the Crimean-Congo hemorrhagic fever virus (CCHFV) serogroup comprises sole members CCHFV and Hazara virus (HAZV). CCHFV is an emerging zoonotic v...

journal_title：Journal of virology

authors： Surtees R,Dowall SD,Shaw A,Armstrong S,Hewson R,Carroll MW,Mankouri J,Edwards TA,Hiscox JA,Barr JN

更新日期：2016-09-29 00:00:00

abstract：:A marked virus-inhibiting potency is obtained in the serum after intraperitoneal injection of polyacrylic acid (PAA) and polymethacrylic acid (PMAA) in mice. Much higher antiviral levels were reached than for other related polymers including dextran sulfate, heparin, polyvinyl sulfate, pyran copolymer, polystyrene sul...

journal_title：Journal of virology

authors： De Somer P,De Clercq E,Billiau A,Schonne E,Claesen M

更新日期：1968-09-01 00:00:00

abstract：:The innate and adaptive immune responses have evolved distinct strategies for controlling different viral pathogens. Encephalomyocarditis virus (EMCV) is a picornavirus that can cause paralysis, diabetes, and myocarditis within days of infection. The optimal innate immune response against EMCV in vivo requires CD1d. I...

journal_title：Journal of virology

authors： Ilyinskii PO,Wang R,Balk SP,Exley MA

更新日期：2006-07-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) play an important role in recovery from a number of viral infections. They are also implicated in virus-induced immunopathology as best demonstrated in lymphocytic choriomeningitis virus (LCMV) infection of adult immunocompetent mice. In the present study, the structure of the T-cell rece...

journal_title：Journal of virology

authors： Yanagi Y,Maekawa R,Cook T,Kanagawa O,Oldstone MB

更新日期：1990-12-01 00:00:00

abstract：:Macrophage adherence, an important regulatory signal, has the potential to affect human immunodeficiency virus (HIV) production either directly or by priming monocytes to respond to other activating signals. We have investigated the role of adherence as an activator of HIV-1 transcription and release. The effects of a...

journal_title：Journal of virology

authors： Shattock RJ,Friedland JS,Griffin GE

更新日期：1993-06-01 00:00:00

abstract：:Immunization of mice with DNA encoding the influenza virus hemagglutinin (HA) affords complete protection against lethal influenza virus infection and the means to investigate the mechanisms of B-cell responsiveness to virus challenge. Using a single-cell enzyme-linked immunospot assay, we sought to determine the loca...

journal_title：Journal of virology

authors： Justewicz DM,Morin MJ,Robinson HL,Webster RG

更新日期：1995-12-01 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit th...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Collins PL

更新日期：2005-05-01 00:00:00

abstract：:The tetrameric paramyxovirus hemagglutinin-neuraminidase (HN) protein mediates attachment to sialic acid-containing receptors as well as cleavage of the same moiety via its neuraminidase (NA) activity. The X-ray crystallographic structure of an HN dimer from Newcastle disease virus (NDV) suggests that a single site in...

journal_title：Journal of virology

authors： Corey EA,Mirza AM,Levandowsky E,Iorio RM

更新日期：2003-06-01 00:00:00

abstract：:We have shown previously that processing of the Sindbis virus envelope protein precursor PE2 to envelope protein E2 is not required for virus maturation in cultured vertebrate fibroblast cells and that unprocessed PE2 can be incorporated into infectious virus in place of E2 (J. F. Presley and D. T. Brown, J. Virol. 63...

journal_title：Journal of virology

authors： Presley JF,Polo JM,Johnston RE,Brown DT

更新日期：1991-04-01 00:00:00

abstract：:Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune responses through the actions of their V proteins. The V protein mediates interference with the interferon regulatory RNA helicase MDA5 to avoid cellular antiviral responses. Analysis of the interaction i...

journal_title：Journal of virology

authors： Parisien JP,Bamming D,Komuro A,Ramachandran A,Rodriguez JJ,Barber G,Wojahn RD,Horvath CM

更新日期：2009-07-01 00:00:00

abstract：:African swine fever virus (ASFV) is a complex, cytoplasmic double-stranded DNA (dsDNA) virus that is currently expanding throughout the world. Currently, circulating virulent genotype II Armenia/07-like viruses cause fatal disease in pigs and wild boar, whereas attenuated strains induce infections with various levels ...

journal_title：Journal of virology

authors： García-Belmonte R,Pérez-Núñez D,Pittau M,Richt JA,Revilla Y

更新日期：2019-05-29 00:00:00

abstract：:In vivo decay rates for the individual T7 early mRNA species were determined. The physical half-lives, measured at 37 C, range from 1.1 min for gene 0.7 RNA to 4.5 min for gene 0.3 RNA. Physical half-lives, as observed after rifampin inhibition of RNA synthesis and polyacylamide electrophoresis of RNAs, are approximat...

journal_title：Journal of virology

authors： Hercules K,Jovanovich S,Sauerbrier W

更新日期：1976-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV infections have been associated with chronic wheezing and asthma during childhood. However, the mechanism of RSV-induced airway inflammation and airway hyperresponsiveness (AHR) is poorly und...

journal_title：Journal of virology

authors： Zang N,Xie X,Deng Y,Wu S,Wang L,Peng C,Li S,Ni K,Luo Y,Liu E

更新日期：2011-12-01 00:00:00

abstract：:Deoxyribonucleic acid (DNA) synthesis was studied in poxvirus-infected cells by measuring (14)C-thymidine incorporation into viral and host cell DNA. A complete separation of the two species of DNA was achieved by combining the previously used "Dounce method" with a separation method based on different reannealing pro...

journal_title：Journal of virology

authors： Jungwirth C,Launer J

更新日期：1968-05-01 00:00:00

abstract：:The hepatitis B virus (HBV) core promoter regulates the transcription of two related RNA products named precore RNA and core RNA. Previous studies indicate that a double-nucleotide mutation that occurs frequently during chronic HBV infection converts a nuclear receptor binding site in the core promoter to the binding ...

journal_title：Journal of virology

authors： Li J,Xu Z,Zheng Y,Johnson DL,Ou JH

更新日期：2002-06-01 00:00:00

abstract：:Enhancins are metalloproteinases, first identified in granuloviruses, that can enhance nucleopolyhedrovirus (NPV) potency. We had previously identified two enhancin genes (E1 and E2) in the Lymantria dispar multinucleocapsid NPV (LdMNPV) and showed that both were functional. For this study, we have extended our analys...

journal_title：Journal of virology

authors： Slavicek JM,Popham HJ

更新日期：2005-08-01 00:00:00

abstract：:Efforts to develop a vaccine against human immunodeficiency virus type 1 (HIV-1) are complicated by resistance of virus to neutralization. The neutralization resistance phenotype of HIV-1 has been linked to high infectivity. We studied the mechanisms determining this phenotype using clones of the T-cell-line-adapted (...

journal_title：Journal of virology

authors： Leavitt M,Park EJ,Sidorov IA,Dimitrov DS,Quinnan GV Jr

更新日期：2003-01-01 00:00:00

abstract：:The synthesis of closed circular simian virus 40 (SV40) deoxyribonucleic acid (DNA) containing sequences homologous to host cell DNA depends upon the conditions under which the cells are infected. When BS-C-1 monkey cells were infected with non-plaque-purified virus at low multiplicity of infection [MOI, 0.032 plaque-...

journal_title：Journal of virology

authors： Lavi S,Winocour E

更新日期：1972-02-01 00:00:00

abstract：:In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allo...

journal_title：Journal of virology

authors： Castilla J,Brun A,Díaz-San Segundo F,Salguero FJ,Gutiérrez-Adán A,Pintado B,Ramírez MA,del Riego L,Torres JM

更新日期：2005-07-01 00:00:00