Characterization of stable Chinese hamster ovary cells expressing wild-type, secreted, and glycosylphosphatidylinositol-anchored human immunodeficiency virus type 1 envelope glycoprotein.

abstract：:The novel low-pathogenic avian influenza A H7N9 viruses (LPAI H7N9 viruses) have been a threat to public health since their emergence in 2013 because of the high rates of mortality and morbidity that they cause. Recently, highly pathogenic variants of these avian influenza A H7N9 viruses (HPAI H7N9 viruses) have emerg...

journal_title：Journal of virology

authors： Yang L,Zhu W,Li X,Chen M,Wu J,Yu P,Qi S,Huang Y,Shi W,Dong J,Zhao X,Huang W,Li Z,Zeng X,Bo H,Chen T,Chen W,Liu J,Zhang Y,Liang Z,Shi W,Shu Y,Wang D

更新日期：2017-11-14 00:00:00

abstract：:We previously established a genetic assay for retroviral Gag polyprotein multimerization (J. Luban, K. B. Alin, K. L. Bossolt, T. Humaran, and S. P. Goff, J. Virol. 66:5157-5160, 1992). Here we use this assay to demonstrate homomeric interactions between Gag polyproteins encoded by six different retroviruses. Of the G...

journal_title：Journal of virology

authors： Franke EK,Yuan HE,Bossolt KL,Goff SP,Luban J

更新日期：1994-08-01 00:00:00

abstract：:Current L1 virus-like particle (VLP) vaccines provide type-restricted protection against a small subset of the human papillomavirus (HPV) genotypes associated with cervical cancer, necessitating continued cytologic screening of vaccinees. Cervical cancer is most problematic in countries that lack the resources for scr...

journal_title：Journal of virology

authors： Gambhira R,Jagu S,Karanam B,Gravitt PE,Culp TD,Christensen ND,Roden RB

更新日期：2007-11-01 00:00:00

abstract：:Human group C adenoviruses cause an acute infection in respiratory epithelia and establish a long-term or persistent infection, possibly in lymphocytes. The mechanism by which this persistence is maintained is unknown; however, it would require that persistently infected lymphocytes not be deleted. The adenovirus geno...

journal_title：Journal of virology

authors： McNees AL,Garnett CT,Gooding LR

更新日期：2002-10-01 00:00:00

abstract：:We showed previously that retrovirus vector particles can encapsidate RNAs without retroviral cis-acting sequences, that such RNAs are reverse transcribed in infected target cells, and that the cDNA copies are inserted into the host genome resulting in cDNA genes (R. Dornburg and H. M. Temin, Mol. Cell. Biol. 8:2328-2...

journal_title：Journal of virology

authors： Dornburg R,Temin HM

更新日期：1990-02-01 00:00:00

abstract：:To investigate the relation between the polyoma tumor-specific transplantation antigen and the virus-coded proteins, mice were immunized by inoculation of a variety of viable polyoma virus mutants and then challenged with polyoma virus-induced tumors. Two classes of early region mutants were used. One class produces a...

journal_title：Journal of virology

authors： Dalianis T,Magnusson G,Ito Y,Klein G

更新日期：1982-09-01 00:00:00

abstract：:An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgium. Although the virus shared a number of the same biological and morphological properties as human immunodeficiency retrovirus type 1 (HIV-1)...

journal_title：Journal of virology

authors： De Leys R,Vanderborght B,Vanden Haesevelde M,Heyndrickx L,van Geel A,Wauters C,Bernaerts R,Saman E,Nijs P,Willems B

更新日期：1990-03-01 00:00:00

abstract：:Beyond their role in cellular RNA metabolism, DExD/H-box RNA helicases are hijacked by various RNA viruses in order to assist replication of the viral genome. Here, we identify the DExH-box RNA helicase 9 (DHX9) as a binding partner of chikungunya virus (CHIKV) nsP3 mainly interacting with the C-terminal hypervariable...

journal_title：Journal of virology

authors： Matkovic R,Bernard E,Fontanel S,Eldin P,Chazal N,Hassan Hersi D,Merits A,Péloponèse JM Jr,Briant L

更新日期：2019-02-05 00:00:00

abstract：:Purified nuclei from polyoma-infected mouse (3T3) cells were found to be greatly reduced in their ability to synthesize viral DNA in vitro when compared with a crude system consisting of an unfractionated hypotonic lysate of the infected cells. The synthetic capacity of the nuclei could be fully reconstituted when a h...

journal_title：Journal of virology

authors： Francke B,Hunter T

更新日期：1975-01-01 00:00:00

abstract：:Mitogenic activities of simian virus 40 large T and small t antigens were studied in serum-deprived human diploid fibroblasts. Wild-type large T and small t cooperated in stimulating DNA synthesis and in inducing hyperphosphorylation of the Rb gene product (pRb). In contrast, a T antigen mutant defective for pRb bindi...

journal_title：Journal of virology

authors： Ogryzko VV,Hirai TH,Shih CE,Howard BH

更新日期：1994-06-01 00:00:00

abstract：:Viral infection is associated with a vigorous inflammatory response characterized by cellular infiltration and release of the proinflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). In the present study, we identified a novel function of human cytomegalovirus (HCMV) that results in ...

journal_title：Journal of virology

authors： Jarvis MA,Borton JA,Keech AM,Wong J,Britt WJ,Magun BE,Nelson JA

更新日期：2006-06-01 00:00:00

abstract：:T7 early mRNA's are generated from a high-molecular-weight precursor RNA by site-specific RNase III cleavage. When T7 DNA is transcribed in vitro by Escherichia coli RNA polymerase, the transcript is a large, single-piece RNA equivalent to the in vivo precursor RNA. The T7 RNA synthesized in vitro can be translated as...

journal_title：Journal of virology

authors： Yamada Y,Nakada D

更新日期：1976-06-01 00:00:00

abstract：:GS-8374 is a potent HIV protease inhibitor (PI) with a unique diethyl-phosphonate moiety. Due to a balanced contribution of enthalpic and entropic components to its interaction with the protease (PR) active site, the compound retains activity against HIV mutants with high-level multi-PI resistance. We report here the ...

journal_title：Journal of virology

authors： Stray KM,Callebaut C,Glass B,Tsai L,Xu L,Müller B,Kräusslich HG,Cihlar T

更新日期：2013-01-01 00:00:00

abstract：:Equine infectious anemia virus (EIAV) provides a natural model system by which immunological control of lentivirus infections may be studied. To date, no detailed study addressing in parallel both the humoral and cellular immune responses induced in horses upon infection by EIAV has been conducted. Therefore, we initi...

journal_title：Journal of virology

authors： Hammond SA,Cook SJ,Lichtenstein DL,Issel CJ,Montelaro RC

更新日期：1997-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an important human pathogen associated with chronic liver disease. Recently, based on a genotype 2a isolate, tissue culture systems supporting complete replication and infectious virus production have been developed. In this study, we used cell culture-produced infectious HCV to analyze the ...

journal_title：Journal of virology

authors： Tscherne DM,Jones CT,Evans MJ,Lindenbach BD,McKeating JA,Rice CM

更新日期：2006-02-01 00:00:00

abstract：:Bacteriophages of the C3 morphotype, characterized by very long heads that exceed their width several times, are extremely rare among the Podoviridae family members and constitute only 0.5% of over 5,500 phages that have been examined by the electron microscope (H. W. Ackermann, Arch. Virol. 152:227-243, 2007; H. W. A...

journal_title：Journal of virology

authors： Li Y,Chen M,Tang F,Yao H,Lu C,Zhang W

更新日期：2012-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) exhibits a highly restricted host range. In this study, we sought to examine the relative significance of host and viral factors in activating early gene expression of the HCMV UL54 (DNA polymerase) promoter in murine cells. Appropriate activation of the UL54 promoter at early times is ess...

journal_title：Journal of virology

authors： García-Ramírez JJ,Ruchti F,Huang H,Simmen K,Angulo A,Ghazal P

更新日期：2001-01-01 00:00:00

abstract：:We have reported previously that ocular infection of different strains of mice with recombinant herpes simplex virus 1 (HSV-1) constitutively expressing interleukin-2 (IL-2) provokes central nervous system (CNS) demyelination and optic neuropathy, as determined by changes in visual evoked cortical potentials and patho...

journal_title：Journal of virology

authors： Mott KR,Zandian M,Allen SJ,Ghiasi H

更新日期：2013-11-01 00:00:00

abstract：:Herpes simplex virus (HSV) entry is dependent on the interaction of virion glycoprotein D (gD) with one of several cellular receptors. We previously showed that gD binds specifically to two structurally dissimilar receptors, HveA and HveC. We have continued our studies by using (i) a panel of baculovirus-produced gD m...

journal_title：Journal of virology

authors： Whitbeck JC,Muggeridge MI,Rux AH,Hou W,Krummenacher C,Lou H,van Geelen A,Eisenberg RJ,Cohen GH

更新日期：1999-12-01 00:00:00

abstract：:The large T antigen encoded by simian virus 40 (SV40) plays essential roles in the infection of permissive cells, leading to production of progeny virions, and in the infection of nonpermissive cells, leading to malignant transformation. Primary mouse embryo fibroblasts (MEFs) are nonpermissive for SV40, and infection...

journal_title：Journal of virology

authors： Zhu JY,Abate M,Rice PW,Cole CN

更新日期：1991-12-01 00:00:00

abstract：:The NS3 protein of hepatitis C virus (HCV) possesses protease activity responsible for the proteolytic cleavage of the viral polyprotein at the junctions of nonstructural proteins downstream of NS3. The NS3 protein was also found to be internally cleaved. In this study, we demonstrated that internal cleavages occurred...

journal_title：Journal of virology

authors： Kou YH,Chang MF,Wang YM,Hung TM,Chang SC

更新日期：2007-08-01 00:00:00

abstract：:Prasinoviruses infecting unicellular green algae in the order Mamiellales (class Mamiellophyceae) are commonly found in coastal marine waters where their host species frequently abound. We tested 40 Ostreococcus tauri viruses on 13 independently isolated wild-type O. tauri strains, 4 wild-type O. lucimarinus strains, ...

journal_title：Journal of virology

authors： Clerissi C,Desdevises Y,Grimsley N

更新日期：2012-04-01 00:00:00

abstract：:High concentrations of either trypsin or chymotrypsin caused nearly complete cleavage of capsid protein VP2 of hepatitis A virus but did not significantly reduce the infectivity, thermostability, or antigenicity of the virus. Chymotrypsin also had a lesser effect on VP1. These findings indicate the presence of a prote...

journal_title：Journal of virology

authors： Lemon SM,Amphlett E,Sangar D

更新日期：1991-10-01 00:00:00

abstract：:T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4(+)-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decre...

journal_title：Journal of virology

authors： Hoffmann-Fezer G,Thum J,Ackley C,Herbold M,Mysliwietz J,Thefeld S,Hartmann K,Kraft W

更新日期：1992-03-01 00:00:00

abstract：UNLABELLED:Enteroviruses (EVs) are a genetically and antigenically diverse group of viruses infecting humans. A mostly distinct set of EV variants have additionally been documented to infect wild apes and several, primarily captive, Old World monkey (OWM) species. To investigate the prevalence and genetic characteristi...

journal_title：Journal of virology

authors： Van Nguyen D,Harvala H,Ngole EM,Delaporte E,Woolhouse ME,Peeters M,Simmonds P

更新日期：2014-06-01 00:00:00

abstract：:The sheep genome harbors approximately 20 endogenous retroviruses (enJSRVs) highly related to the exogenous Jaagsiekte sheep retrovirus (JSRV). One of the enJSRV loci, enJS56A1, acts as a unique restriction factor by blocking JSRV in a transdominant fashion at a late stage of the retroviral cycle. To better understand...

journal_title：Journal of virology

authors： Murcia PR,Arnaud F,Palmarini M

更新日期：2007-02-01 00:00:00

abstract：:The beginning of the second century of research in the field of virology (the first virus was discovered in 1898) was marked by its amalgamation with bioinformatics, resulting in the birth of a new domain--viroinformatics. The availability of more than 100 Web servers and databases embracing all or specific viruses (f...

journal_title：Journal of virology

authors： Sharma D,Priyadarshini P,Vrati S

更新日期：2015-02-01 00:00:00

abstract：:Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodies (Abs) elicited by influenza viruses target the head domain of the hemagglutinin (HA) protein. Anti-HA head Abs can be highly potent, but they have limited breadth since the HA head is variable. There is great interest...

journal_title：Journal of virology

authors： Christensen SR,Toulmin SA,Griesman T,Lamerato LE,Petrie JG,Martin ET,Monto AS,Hensley SE

更新日期：2019-04-03 00:00:00

abstract：:The regulatory proteins Nef, Rev, and Tat of human immunodeficiency virus type 1 (HIV-1) are attractive targets for vaccine development, since induction of effective immune responses targeting these early proteins may best control virus replication. Here we investigated whether vaccination with biologically active Tat...

journal_title：Journal of virology

authors： Silvera P,Richardson MW,Greenhouse J,Yalley-Ogunro J,Shaw N,Mirchandani J,Khalili K,Zagury JF,Lewis MG,Rappaport J

更新日期：2002-04-01 00:00:00

abstract：:The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to be active in at least patients infected with HCV of subtypes 1a and 1...

journal_title：Journal of virology

authors： Nyanguile O,Devogelaere B,Vijgen L,Van den Broeck W,Pauwels F,Cummings MD,De Bondt HL,Vos AM,Berke JM,Lenz O,Vandercruyssen G,Vermeiren K,Mostmans W,Dehertogh P,Delouvroy F,Vendeville S,VanDyck K,Dockx K,Cleiren E,R

更新日期：2010-03-01 00:00:00