In vitro polyoma DNA synthesis: requirement for cytoplasmic factors.

abstract：:Several viruses, including members of the gammaherpesvirus family, encode proteins that are secreted into the extracellular environment. We have identified an abundant 44-kDa secreted protein that is present in the supernatant of fibroblasts infected with murine gammaherpesvirus 68 (gammaHV68; also referred to as MHV-...

journal_title：Journal of virology

authors： van Berkel V,Preiter K,Virgin HW 4th,Speck SH

更新日期：1999-05-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified residue serine 900 (Ser900) as a unique site of reversible casein kinase 2 phosphorylation in the cytoplasmic domain of HCMV g...

journal_title：Journal of virology

authors： Jarvis MA,Jones TR,Drummond DD,Smith PP,Britt WJ,Nelson JA,Baldick CJ

更新日期：2004-01-01 00:00:00

abstract：:We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/gammac(null) (NOG) mice. This model is very useful for investigating the mechanism of tumorigenesis and malignant cell growth of adult T-cell leukemia (ATL)/lymphoma, which still remains unclear. Nine...

journal_title：Journal of virology

authors： Dewan MZ,Terashima K,Taruishi M,Hasegawa H,Ito M,Tanaka Y,Mori N,Sata T,Koyanagi Y,Maeda M,Kubuki Y,Okayama A,Fujii M,Yamamoto N

更新日期：2003-05-01 00:00:00

abstract：:Defective interfering RNAs have long been thought to be a causal factor of persistent RNA virus infections. Here we describe a novel type of defective genome of lymphocytic choriomeningitis virus and the unique mechanism by which these RNAs appear to contribute to the establishment and maintenance of persistent infect...

journal_title：Journal of virology

authors： Meyer BJ,Southern PJ

更新日期：1997-09-01 00:00:00

abstract：:Through their hemagglutinin-neuraminidase glycoprotein, parainfluenza viruses bind to sialic acid-containing glycoconjugates to initiate infection. Although the virus-receptor interaction is a key factor of infection, the exact nature of the receptors that human parainfluenza viruses recognize has not been determined....

journal_title：Journal of virology

authors： Suzuki T,Portner A,Scroggs RA,Uchikawa M,Koyama N,Matsuo K,Suzuki Y,Takimoto T

更新日期：2001-05-01 00:00:00

abstract：UNLABELLED:The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an endoplasmic reticulum (ER)-resident enzyme that synthesizes phosphatidylinositol 4-phosphate (PI4P). PI4KIIIα is an essential host factor for hepatitis C virus (HCV) replication. Interaction with HCV nonstructural protein 5A (NS5A) lea...

journal_title：Journal of virology

authors： Harak C,Radujkovic D,Taveneau C,Reiss S,Klein R,Bressanelli S,Lohmann V

更新日期：2014-09-01 00:00:00

abstract：:Despite the long-standing observation that herpes simplex virus (HSV) latency-associated transcript (LAT) promoter deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. We constructed and evaluated four mutant HSV...

journal_title：Journal of virology

authors： Kawamura Y,Bosch-Marce M,Tang S,Patel A,Krause PR

更新日期：2018-06-29 00:00:00

abstract：:The development of vaccines against bluetongue, a prevalent livestock disease, has been focused on surface antigens that induce strong neutralizing antibody responses. Because of their antigenic variability, these vaccines are usually serotype restricted. We now show that a single highly conserved nonstructural protei...

journal_title：Journal of virology

authors： Marín-López A,Calvo-Pinilla E,Barriales D,Lorenzo G,Brun A,Anguita J,Ortego J

更新日期：2018-07-31 00:00:00

abstract：:Latency is an integral feature of the pathogenesis of cytomegalovirus infection and disease. Using in situ hybridization, we detected viral DNA in the splenic stroma of mice with acute murine cytomegalovirus (MCMV) infection but could not detect latent infection. By using enzymatic amplification of a 700-bp region of ...

journal_title：Journal of virology

authors： Pomeroy C,Hilleren PJ,Jordan MC

更新日期：1991-06-01 00:00:00

abstract：:The RNA of infectious bursal disease virus was reexamined in a detailed analysis. It could be established that its genome consists of two segments of double-stranded RNA. The RNA is RNase resistant and has a sedimentation coefficient of 14S and a buoyant density of 1.62 g/ml. The purine/pyrimidine ratio is nearly 1; t...

journal_title：Journal of virology

authors： Müller H,Scholtissek C,Becht H

更新日期：1979-09-01 00:00:00

abstract：:To determine the various roles of RNase H in reverse transcription, we generated a panel of mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase based on sequence alignments and the crystal structures of Escherichia coli and human immunodeficiency virus type 1 RNases H (S. W. Blain an...

journal_title：Journal of virology

authors： Blain SW,Goff SP

更新日期：1995-07-01 00:00:00

abstract：:We have examined the attachment and penetration phenotypes of several glycoprotein gIII mutants of pseudorabies virus (PRV) and have identified the first one-third of gIII as a region that mediates efficient virus attachment to PK15 and Vero cells. This portion of gIII, amino acids 25 through 157 of the wild-type sequ...

journal_title：Journal of virology

authors： Flynn SJ,Burgett BL,Stein DS,Wilkinson KS,Ryan P

更新日期：1993-05-01 00:00:00

abstract：:The ability of the 3A protein of coxsackievirus B (CVB) to inhibit protein secretion was investigated for this study. Here we show that the ectopic expression of CVB 3A blocked the transport of both the glycoprotein of vesicular stomatitis virus, a membrane-bound secretory marker, and the alpha-1 protease inhibitor, a...

journal_title：Journal of virology

authors： Wessels E,Duijsings D,Notebaart RA,Melchers WJ,van Kuppeveld FJ

更新日期：2005-04-01 00:00:00

abstract：:Host-virus interactions control disease progression in human immunodeficiency virus-infected human beings and in nonhuman primates infected with simian or simian/human immunodeficiency viruses (SHIV). These interactions evolve rapidly during acute infection and are key to the mechanisms of viral persistence and AIDS. ...

journal_title：Journal of virology

authors： Wallace M,Waterman PM,Mitchen JL,Djavani M,Brown C,Trivedi P,Horejsh D,Dykhuizen M,Kitabwalla M,Pauza CD

更新日期：1999-12-01 00:00:00

abstract：:We have developed a reconstituted system which models the events associated with human immunodeficiency virus type 1 (HIV-1) plus-strand transfer. These events include synthesis of plus-strand strong-stop DNA [(+) SSDNA] from a minus-strand DNA donor template covalently attached to human tRNA3Lys, tRNA primer removal,...

journal_title：Journal of virology

authors： Wu T,Guo J,Bess J,Henderson LE,Levin JG

更新日期：1999-06-01 00:00:00

abstract：:During lytic infection, herpes simplex virus subverts the host cell RNA polymerase II transcription machinery to efficiently express its own genome while repressing the expression of most cellular genes. The mechanism by which RNA polymerase II is directed to the viral delayed-early and late genes is still unresolved....

journal_title：Journal of virology

authors： Rice SA,Long MC,Lam V,Spencer CA

更新日期：1994-02-01 00:00:00

abstract：:Two types of geminate structures were purified from African cassava mosaic geminivirus (ACMV)-infected Nicotiana benthamiana plants and analyzed by electron cryomicroscopy and image reconstruction. After cesium sulfate density gradient centrifugation, they were separated into lighter top (T) and heavier bottom (B) com...

journal_title：Journal of virology

authors： Böttcher B,Unseld S,Ceulemans H,Russell RB,Jeske H

更新日期：2004-07-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cluster of 12 microRNAs (miRNAs) that are processed from a transcript that is embedded within the major latency control region. We have generated a deletion mutation that eliminates 10 of the 12 viral miRNAs from the KSHV bacmid by using recombineering methods. ...

journal_title：Journal of virology

authors： Lu F,Stedman W,Yousef M,Renne R,Lieberman PM

更新日期：2010-03-01 00:00:00

abstract：:Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced ...

journal_title：Journal of virology

authors： Kyuwa S,Cohen M,Nelson G,Tahara SM,Stohlman SA

更新日期：1994-10-01 00:00:00

abstract：:Live-attenuated vesicular stomatitis virus (VSV) vectors expressing foreign antigens induce potent immune responses and protect against viral diseases in animal models. Highly attenuated (VSV-CT1) or single-cycle VSV (VSVDeltaG) vectors induce immune responses lower than those generated by attenuated wild-type VSV vec...

journal_title：Journal of virology

authors： Simon ID,Publicover J,Rose JK

更新日期：2007-02-01 00:00:00

abstract：:Lipoxins are host anti-inflammatory molecules that play a vital role in restoring tissue homeostasis. The efficacy of lipoxins and their analog epilipoxins in treating inflammation and its associated diseases has been well documented. Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) are two well-known inflamm...

journal_title：Journal of virology

authors： Chandrasekharan JA,Huang XM,Hwang AC,Sharma-Walia N

更新日期：2016-11-28 00:00:00

abstract：:A large percentage of the repetitive elements in mammalian genomes are retroelements, which have been moved primarily by LINE-1 retrotransposons and endogenous retroviruses. Although LINE-1 elements have remained active throughout the mammalian radiation, specific groups of endogenous retroviruses generally remain act...

journal_title：Journal of virology

authors： Cantrell MA,Ederer MM,Erickson IK,Swier VJ,Baker RJ,Wichman HA

更新日期：2005-12-01 00:00:00

abstract：:Poliovirus proteinase 2A (2Apro) is autocatalytically released from the viral polyprotein by cleavage in cis of a Tyr-Gly dipeptide at its own amino terminus, resulting in separation of the P1 structural and P2-P3 nonstructural protein precursors. A second Ty-Gly dipeptide within 3D polymerase is cleaved by 2Apro in t...

journal_title：Journal of virology

authors： Hellen CU,Lee CK,Wimmer E

更新日期：1992-06-01 00:00:00

abstract：:Duck embryo fibroblast (DEF) and chicken embryo fibroblast (CEF) cultures infected with Marek's disease virus were studied by combined fluorescent antibody and electron microscopy techniques. In both DEF and CEF cultures, cells containing immunofluorescent (IF) antigen also contained herpesvirus particles; conversely,...

journal_title：Journal of virology

authors： Nazerian K,Purchase HG

更新日期：1970-01-01 00:00:00

abstract：:The paramyxoviral family contains many medically important viruses, including measles virus, mumps virus, parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and the deadly zoonotic henipaviruses Hendra and Nipah virus (NiV). To both enter host cells and spread from cell to cell within infected ...

journal_title：Journal of virology

authors： Stone JA,Vemulapati BM,Bradel-Tretheway B,Aguilar HC

更新日期：2016-11-14 00:00:00

abstract：:Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into...

journal_title：Journal of virology

authors： Bonham L,Wolgamot G,Miller AD

更新日期：1997-06-01 00:00:00

abstract：:Prasinoviruses infecting unicellular green algae in the order Mamiellales (class Mamiellophyceae) are commonly found in coastal marine waters where their host species frequently abound. We tested 40 Ostreococcus tauri viruses on 13 independently isolated wild-type O. tauri strains, 4 wild-type O. lucimarinus strains, ...

journal_title：Journal of virology

authors： Clerissi C,Desdevises Y,Grimsley N

更新日期：2012-04-01 00:00:00

abstract：:Efforts to develop adenovirus vectors suitable for genetic interventions in humans have identified three major limitations of the most frequently used vector prototype, human adenovirus serotype 5 (Ad5). These limitations--widespread preexisting anti-Ad5 immunity in humans, the high rate of transduction of normal nont...

journal_title：Journal of virology

authors： Belousova N,Mikheeva G,Xiong C,Soghomonian S,Young D,Le Roux L,Naff K,Bidaut L,Wei W,Li C,Gelovani J,Krasnykh V

更新日期：2010-10-01 00:00:00

abstract：:A distinct clinical presentation of respiratory syncytial virus (RSV) infection of humans is bronchiolitis, which has clinical features similar to those of asthma. Substance P (SP), a tachykinin neuropeptide, has been associated with neurogenic inflammation and asthma; therefore, we chose to examine SP-induced inflamm...

journal_title：Journal of virology

authors： Tripp RA,Moore D,Winter J,Anderson LJ

更新日期：2000-02-01 00:00:00

abstract：:Recent studies indicate that expansion of NKG2C-positive natural killer (NK) cells is associated with human cytomegalovirus (HCMV); however, their activity in response to HCMV-infected cells remains unclear. We show that NKG2C(hi) CD57(hi) NK cells gated on CD3(neg) CD56(dim) cells can be phenotypically identified as ...

journal_title：Journal of virology

authors： Wu Z,Sinzger C,Frascaroli G,Reichel J,Bayer C,Wang L,Schirmbeck R,Mertens T

更新日期：2013-07-01 00:00:00