The amino-terminal one-third of pseudorabies virus glycoprotein gIII contains a functional attachment domain, but this domain is not required for the efficient penetration of Vero cells.

abstract：:Streptomyces coelicolor is a model system for the study of Streptomyces, a genus of bacteria responsible for the production of many clinically important antibiotics. Here we report the genome sequence of ΦCAM, a new S. coelicolor generalized transducing bacteriophage, isolated from a soil sample originating from Linco...

journal_title：Journal of virology

authors： Monson R,Salmond GP

更新日期：2012-12-01 00:00:00

abstract：:The smallpox vaccine is the prototypic vaccine, yet the viral targets critical for vaccine-mediated protection remain unclear in humans. We have produced protein microarrays of a near-complete vaccinia proteome and used them to determine the major antigen specificities of the human humoral immune response to the small...

journal_title：Journal of virology

authors： Davies DH,McCausland MM,Valdez C,Huynh D,Hernandez JE,Mu Y,Hirst S,Villarreal L,Felgner PL,Crotty S

更新日期：2005-09-01 00:00:00

abstract：:Deletion mutants of simian virus 40 (SV40) with lesions at the three DdeI sites near the 3' end of the early region were constructed. Mutants with deletions at 0.203 and 0.219 map units (mu) which did not change the large T antigen reading frame were viable. This extends slightly the upstream boundary for the location...

journal_title：Journal of virology

authors： Tornow J,Cole CN

更新日期：1983-09-01 00:00:00

abstract：:A promoter-trap retrovirus has been constructed in which a promoterless polyomavirus middle T antigen gene was inserted in the U3 region of the long terminal repeat of a replication-competent Moloney murine leukemia virus. The resulting virus, designated PyT, was used to infect mouse mammary glands in situ. As expecte...

journal_title：Journal of virology

authors： Coulombe J,Avis Y,Gray DA

更新日期：1996-10-01 00:00:00

abstract：:A single phosphorylation event at T-antigen residue Thr124 regulates initiation of simian virus 40 DNA replication. To explore this regulatory process, a series of peptides were synthesized, centered on Thr124. These peptides contain a nuclear localization signal (NLS) and a recognition site for cyclin/Cdk kinases. Wh...

journal_title：Journal of virology

authors： Kim RJ,Moine S,Reese DK,Bullock PA

更新日期：2002-12-01 00:00:00

abstract：:Shrimp subcuticular epithelial cells are the initial and major targets of white spot syndrome virus (WSSV) infection. Proteomic studies of WSSV-infected subcuticular epithelium of Penaeus monodon were performed through two approaches, namely, subcellular fractionation coupled with shotgun proteomics to identify viral ...

journal_title：Journal of virology

authors： Wu J,Lin Q,Lim TK,Liu T,Hew CL

更新日期：2007-11-01 00:00:00

abstract：:Hepatitis delta virus (HDV), a single-stranded RNA virus, bears a single coding region whose product, the hepatitis delta antigen (HDAg), is expressed in two isoforms, small (S-HDAg) and large (L-HDAg). S-HDAg is required for replication of HDV, while L-HDAg inhibits viral replication and is required for the envelopme...

journal_title：Journal of virology

authors： Bell P,Brazas R,Ganem D,Maul GG

更新日期：2000-06-01 00:00:00

abstract：:Oligonucleotide-directed mutagenesis was used to construct a nonsense mutation in open reading frame (ORF) E2 of bovine papillomavirus DNA. A single base substitution mutation was constructed which converted a TAC codon into a TAG amber stop codon at a position in the ORF that did not overlap with any other viral ORFs...

journal_title：Journal of virology

authors： DiMaio D

更新日期：1986-02-01 00:00:00

abstract：:The coding capacity of human cytomegalovirus (HCMV) for glycoproteins by far exceeds that of other herpesviruses. Few of these proteins have been characterized so far. We have investigated the gene product of reading frame UL132. The putative protein product of UL132 is a glycoprotein with a theoretical mass of 29.8 k...

journal_title：Journal of virology

authors： Spaderna S,Kropff B,Ködel Y,Shen S,Coley S,Lu S,Britt W,Mach M

更新日期：2005-09-01 00:00:00

abstract：:The role of cellular genes in West Nile virus (WNV) replication is not well understood. Examination of cellular transcripts upregulated during WNV infection revealed an increase in the expression of the src family kinase (SFK) c-Yes. WNV-infected cell lines treated with the SFK inhibitor PP2 demonstrated a 2- to 4-log...

journal_title：Journal of virology

authors： Hirsch AJ,Medigeshi GR,Meyers HL,DeFilippis V,Früh K,Briese T,Lipkin WI,Nelson JA

更新日期：2005-09-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is a retrovirus which induces a strong immune response and a dramatic increase in the number of infected cells through the expression of a superantigen (SAg). Many cytokines are likely to be involved in the interaction between MMTV and the immune system. In particular, alpha/beta inter...

journal_title：Journal of virology

authors： Maillard I,Launois P,Xenarios I,Louis JA,Acha-Orbea H,Diggelmann H

更新日期：1998-04-01 00:00:00

abstract：:The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to ...

journal_title：Journal of virology

authors： Yu X,Shah S,Atanasov I,Lo P,Liu F,Britt WJ,Zhou ZH

更新日期：2005-01-01 00:00:00

abstract：:Cellular annexin II has been shown to specifically bind human cytomegalovirus (HCMV) and be a component of highly purified virions. In this report, we characterize the interaction of annexin II with HCMV. We found that the binding of annexin II to the HCMV envelope occurs partially through the calcium-dependent phosph...

journal_title：Journal of virology

authors： Pietropaolo RL,Compton T

更新日期：1997-12-01 00:00:00

abstract：:Human hepatitis B virus (HBV) HBx protein is a multifunctional protein that activates cellular signaling pathways and is thought to be essential for viral infection. Woodchuck HBV mutants that lack HBx are unable to replicate in vivo or are severely impaired. HBV replication in HepG2 cells, a human hepatoblastoma cell...

journal_title：Journal of virology

authors： Bouchard MJ,Puro RJ,Wang L,Schneider RJ

更新日期：2003-07-01 00:00:00

abstract：:Transcription and replication signals within the negative-sense genomic RNA of vesicular stomatitis virus (VSV) are located at the 3' terminus. To identify these signals, we have used a transcription- and replication-competent minigenome of VSV to generate a series of deletions spanning the first 47 nucleotides at the...

journal_title：Journal of virology

authors： Li T,Pattnaik AK

更新日期：1999-01-01 00:00:00

abstract：:The US3 protein kinase of herpes simplex virus 1 blocks apoptosis induced by replication-incompetent virus mutants, proapoptotic members of the Bcl-2 family of proteins, and by a variety of other agents that act at the premitochondrial level in the proapoptotic cascade. To define the role of US3 in blocking apoptosis ...

journal_title：Journal of virology

authors： Benetti L,Roizman B

更新日期：2007-10-01 00:00:00

abstract：:We have constructed a series of vectors based on simian foamy virus type 1 (SFV-1) to define the minimum cis-acting elements required for gene transfer. To characterize these vectors, we inserted the coding sequence of the bacterial lacZ gene linked to the cytomegalovirus immediate-early gene promoter. Introduction of...

journal_title：Journal of virology

authors： Wu M,Chari S,Yanchis T,Mergia A

更新日期：1998-04-01 00:00:00

abstract：:West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infect...

journal_title：Journal of virology

authors： Gould LH,Sui J,Foellmer H,Oliphant T,Wang T,Ledizet M,Murakami A,Noonan K,Lambeth C,Kar K,Anderson JF,de Silva AM,Diamond MS,Koski RA,Marasco WA,Fikrig E

更新日期：2005-12-01 00:00:00

abstract：:We have examined the transcriptional utilization of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) under differentiating conditions by using the embryonal carcinoma cell line NTERA-2. NTERA-2 cells undergo two distinct pathways of terminal differentiation, to a neuronal phenotype in respons...

journal_title：Journal of virology

authors： Zeichner SL,Hirka G,Andrews PW,Alwine JC

更新日期：1992-04-01 00:00:00

abstract：:Theiler's virus infection of the central nervous system (CNS) induces an immune-mediated demyelinating disease in susceptible mouse strains, such as SJL/J, and serves as a relevant infectious model for human multiple sclerosis. It has been previously suggested that susceptible SJL/J mice do not mount an efficient cyto...

journal_title：Journal of virology

authors： Kang BS,Lyman MA,Kim BS

更新日期：2002-07-01 00:00:00

abstract：:Infection with human papillomavirus (HPV) is a critical factor in the pathogenesis of most cervical cancers and some aerodigestive cancers. The HPV E6 oncoprotein from high-risk HPV types contributes to the immortalization and transformation of cells by multiple mechanisms, including degradation of p53, transcriptiona...

journal_title：Journal of virology

authors： James MA,Lee JH,Klingelhutz AJ

更新日期：2006-06-01 00:00:00

abstract：UNLABELLED:Susceptibility or resistance to prion infection in humans and animals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's modulating role has not been well investigated. Compared to disease incubation times in wild-type homozygous ARQ/ARQ (where each triplet represents...

journal_title：Journal of virology

authors： Langeveld JP,Jacobs JG,Hunter N,van Keulen LJ,Lantier F,van Zijderveld FG,Bossers A

更新日期：2015-10-28 00:00:00

abstract：:We investigated properties of the rotavirus genome segment 11 protein. A rotavirus SA11 genome segment 11 cDNA which contains the entire coding region was sequenced and inserted into the baculovirus transfer vector pVL941. Recombinants containing gene 11 cDNA were selected, and the gene 11 product expressed in Spodopt...

journal_title：Journal of virology

authors： Welch SK,Crawford SE,Estes MK

更新日期：1989-09-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I region of humans, chimpanzees (Pan troglodytes), and bonobos (Pan paniscus) is highly similar, and orthologues of HLA-A, -B, and -C are present in both Pan species. Based on functional characteristics, the different HLA-A allotypes are classified into different supert...

journal_title：Journal of virology

authors： de Groot NG,Heijmans CMC,de Ru AH,Otting N,Koning F,van Veelen PA,Bontrop RE

更新日期：2020-04-16 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus (HIV) seizes control of cellular cullin-RING E3 ubiquitin ligases (CRLs) to promote viral replication. HIV-1 Vpr and HIV-2/simian immunodeficiency virus (SIV) Vpr and Vpx engage the cullin4 (CUL4)-containing ubiquitin ligase complex (CRL4) to cause polyubiquitination and proteaso...

journal_title：Journal of virology

authors： Sharifi HJ,Furuya AK,Jellinger RM,Nekorchuk MD,de Noronha CM

更新日期：2014-06-01 00:00:00

abstract：:Poliovirus infection of HeLa cells results in a rapid inhibition of host protein synthesis by a mechanism that does not affect the translation of poliovirus RNA. It has been suggested that this virus-induced translational control results from inactivation of the cap-binding protein complex, and it has been shown that ...

journal_title：Journal of virology

authors： Lloyd RE,Jense HG,Ehrenfeld E

更新日期：1987-08-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) is the prototype gamma-2 herpesvirus, which naturally infects the squirrel monkey Saimiri sciureus, causing an asymptomatic but persistent infection. The latent phase of gamma-2 herpesviruses is characterized by their ability to persist in a dividing cell population while expressing a limited...

journal_title：Journal of virology

authors： Griffiths R,Whitehouse A

更新日期：2007-04-01 00:00:00

abstract：UNLABELLED:MicroRNAs (miRNAs) are single-stranded small RNA molecules that regulate various cellular processes. miRNA 155 (miR-155) regulates various aspects of innate and adaptive immune responses and plays a key role in various viral infections and the resulting neuroinflammation. The present study evaluated the invo...

journal_title：Journal of virology

authors： Thounaojam MC,Kundu K,Kaushik DK,Swaroop S,Mahadevan A,Shankar SK,Basu A

更新日期：2014-05-01 00:00:00

abstract：:Human cytomegalovirus-induced DNA polymerase and cellular DNA polymerase alpha were purified by successive chromatography on DEAE-cellulose, phosphocellulose, heparin agarose, and single-stranded DNA agarose columns. The purified virus-induced DNA polymerase was resolved to consist of two polypeptides corresponding to...

journal_title：Journal of virology

authors： Mar EC,Chiou JF,Cheng YC,Huang ES

更新日期：1985-12-01 00:00:00

abstract：:The adenovirus fiber protein is used for attachment of the virus to a specific receptor on the cell surface. Structurally, the protein consists of a long, thin shaft that protrudes from the vertex of the virus capsid and terminates in a globular domain termed the knob. To verify that the knob is the domain which inter...

journal_title：Journal of virology

authors： Henry LJ,Xia D,Wilke ME,Deisenhofer J,Gerard RD

更新日期：1994-08-01 00:00:00