Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylated.

abstract：:The hepatitis C virus (HCV) causes chronic hepatitis in most infected individuals by evading host immune defenses. In this investigation, we show that HCV-infected cells may go undetected in the immune system by suppressing major histocompatibility complex (MHC) class I antigen presentation to cytotoxic T lymphocytes....

journal_title：Journal of virology

authors： Tardif KD,Siddiqui A

更新日期：2003-11-01 00:00:00

abstract：:A nucleotide phosphohydrolase is firmly associated with a purified polyhedral cytoplasmic deoxyvirus, frog virus 3. This adenosine triphosphatase is distinguishable from known mammalian cell adenosine triphosphatases and from adenosine triphosphatase of an unrelated cytoplasmic replicating virus grown in the same host...

journal_title：Journal of virology

authors： Vilagines R,McAuslan BR

更新日期：1971-05-01 00:00:00

abstract：:In coliphage 186, 22 essential genes were defined by complementation studies with amber mutants. Eighteen genes were associated with phage morphogenesis: 11 with phage tail formation, and 7 with phage head formation. The remaining four genes are discussed in the accompanying paper (S. M. Hocking and J. B. Egan, J. Vir...

journal_title：Journal of virology

authors： Hocking SM,Egan JB

更新日期：1982-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) is an enveloped DNA virus that presumably buds at intracellular membranes of infected cells. HBV budding involves two endocytic host proteins, the ubiquitin-interacting adaptor gamma 2-adaptin and the Nedd4 ubiquitin ligase. Here, we demonstrate that HBV release also requires the cellular machi...

journal_title：Journal of virology

authors： Lambert C,Döring T,Prange R

更新日期：2007-09-01 00:00:00

abstract：:Mouse mammary tumor virus (MTV) was isolated from the milk of RIII mice by density-gradient centrifugation in Ficoll. The homogeneity of the preparation was demonstrated in electron micrographs. The nucleic acid was extracted with phenol in the presence of Pronase. Its viral origin was attested by failure of ribo-nucl...

journal_title：Journal of virology

authors： Sarkar NH,Moore DH

更新日期：1970-02-01 00:00:00

abstract：:The envelope of class I viruses can be a target for potent viral inhibitors, such as the human immunodeficiency virus type 1 (HIV-1) inhibitor enfuvirtide, which are derived from the C-terminal heptad repeat (HR2) of the transmembrane (TM) subunit. Resistance to an HR2-based peptide inhibitor of a model retrovirus, su...

journal_title：Journal of virology

authors： Amberg SM,Netter RC,Simmons G,Bates P

更新日期：2006-01-01 00:00:00

abstract：:An in vitro poliovirus RNA-synthesizing system derived from a crude membrane fraction of infected HeLa cells was used to analyze the mechanism of initiation of poliovirus plus-strand RNA synthesis. This system contains an activity that synthesizes the nucleotidyl proteins VPg-pU and VPg-pUpU. These molecules represent...

journal_title：Journal of virology

authors： Takeda N,Kuhn RJ,Yang CF,Takegami T,Wimmer E

更新日期：1986-10-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of B lymphocytes in vitro. EBNA-3C can inhibit transcription through an association with the cellular DNA-binding protein Jkappa, a function sh...

journal_title：Journal of virology

authors： Zhao B,Sample CE

更新日期：2000-06-01 00:00:00

abstract：:We have investigated the mechanism of duck hepatitis B virus (DHBV) entry into susceptible primary duck hepatocytes (PDHs), using mutants of carboxypeptidase D (gp180), a transmembrane protein shown to act as the primary cellular receptor for avian hepatitis B virus uptake. The variant proteins were abundantly produce...

journal_title：Journal of virology

authors： Breiner KM,Schaller H

更新日期：2000-03-01 00:00:00

abstract：:Vaccines preventing HIV-1 infection will likely elicit antibodies that neutralize diverse strains. However, the capacity for lentiviruses to escape broadly neutralizing antibodies (NAbs) is not completely understood, nor is it known whether NAbs alone can control heterologous infection. Here, we determined that conval...

journal_title：Journal of virology

authors： Taylor SD,Leib SR,Carpenter S,Mealey RH

更新日期：2010-07-01 00:00:00

abstract：:Defective interfering (DI) RNAs of Tomato bushy stunt virus (TBSV), a plus-sense RNA virus, comprise four conserved noncontiguous regions (I through IV) derived from the viral genome. Region III, a 70-nucleotide-long sequence corresponding to a genomic segment located 378 nucleotides upstream of the 3' terminus of the...

journal_title：Journal of virology

authors： Ray D,White KA

更新日期：2003-01-01 00:00:00

abstract：:Prior studies demonstrated that immunization of macaques with simian immunodeficiency virus (SIV) Gag-Pol and Env recombinants of the attenuated poxvirus modified vaccinia virus Ankara (MVA) provided protection from high levels of viremia and AIDS following challenge with a pathogenic strain of SIV (V. M. Hirsch et al...

journal_title：Journal of virology

authors： Ourmanov I,Brown CR,Moss B,Carroll M,Wyatt L,Pletneva L,Goldstein S,Venzon D,Hirsch VM

更新日期：2000-03-01 00:00:00

abstract：:Our study was designed to investigate the nature of an antigen-specific suppressor factor generated by antigen-stimulated herpes simplex virus (HSV)-immune splenocytes. Factor SF-200, a 90,000- to 100,000-dalton fraction obtained after Sephacryl gel filtration, suppressed the generation of HSV-specific cytotoxic T-lym...

journal_title：Journal of virology

authors： Horohov DW,Wyckoff JH 3rd,Moore RN,Rouse BT

更新日期：1986-05-01 00:00:00

abstract：UNLABELLED:The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from ...

journal_title：Journal of virology

authors： Koel BF,Mögling R,Chutinimitkul S,Fraaij PL,Burke DF,van der Vliet S,de Wit E,Bestebroer TM,Rimmelzwaan GF,Osterhaus AD,Smith DJ,Fouchier RA,de Graaf M

更新日期：2015-04-01 00:00:00

abstract：:Little is known about the mechanisms used by enveloped viruses to separate themselves from the cell surface at the final step of budding. However, small sequences in the Gag proteins of several retroviruses (L domains) have been implicated in this process. A sequence has been identified in the M proteins of rhabdoviru...

journal_title：Journal of virology

authors： Craven RC,Harty RN,Paragas J,Palese P,Wills JW

更新日期：1999-04-01 00:00:00

abstract：:A hydrophilic region consisting of strikingly clustered charged amino acids is present at the center of human immunodeficiency virus type 1 (HIV-1) Vif. In this study, the role for this central hydrophilic region (E(88)WRKKR(93)) in the virus replication in nonpermissive H9 cells was investigated by extensive deletion...

journal_title：Journal of virology

authors： Fujita M,Sakurai A,Yoshida A,Miyaura M,Koyama AH,Sakai K,Adachi A

更新日期：2003-01-01 00:00:00

abstract：UNLABELLED:An understanding of the antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines, but it has not been possible to examine these cells directly because HA binds to sialic acid (SA) on most cell types. Here, we use structure-based...

journal_title：Journal of virology

authors： Whittle JR,Wheatley AK,Wu L,Lingwood D,Kanekiyo M,Ma SS,Narpala SR,Yassine HM,Frank GM,Yewdell JW,Ledgerwood JE,Wei CJ,McDermott AB,Graham BS,Koup RA,Nabel GJ

更新日期：2014-04-01 00:00:00

abstract：:The virus-encoded proteins of tobacco etch virus (TEV), a plant potyvirus, arise by proteolytic processing of a large polyprotein precursor. The TEV genome codes for two proteinases, a 49-kilodalton proteinase and helper component proteinase (HC-Pro), which cleave the polyprotein at specific sites. The only known clea...

journal_title：Journal of virology

authors： Carrington JC,Freed DD,Sanders TC

更新日期：1989-10-01 00:00:00

abstract：:Infectious cDNA corresponding to the entire genome of the attenuated Sabin strain of type 1 poliovirus has been inserted into EcoRI site of bacterial plasmid pBR325. Two consecutive PstI fragments (nucleotide positions 1814 to 3421) of the infectious cDNA of the Sabin 1 strain were replaced by the corresponding DNA fr...

journal_title：Journal of virology

authors： Kohara M,Omata T,Kameda A,Semler BL,Itoh H,Wimmer E,Nomoto A

更新日期：1985-03-01 00:00:00

abstract：:A fresh inoculum of human adenovirus type 12 (Ad12) was obtained from the American Type Culture Collection and passaged once on human embryonic kidney cells, and Ad12 DNA was prepared from the first-passage yield to avoid higher passages which might have generated host-virus DNA recombinants. The 18 PstI fragments of ...

journal_title：Journal of virology

authors： Sprengel J,Schmitz B,Heuss-Neitzel D,Zock C,Doerfler W

更新日期：1994-01-01 00:00:00

abstract：:Adeno-associated virus (AAV) codes for four related nonstructural Rep proteins. AAV both replicates and assembles in the nucleus and requires coinfection with a helper virus, either adenovirus (Ad) or herpesvirus, for a productive infection. Like other more complex DNA viruses, it is believed that AAV interacts or mod...

journal_title：Journal of virology

authors： Nash K,Chen W,Salganik M,Muzyczka N

更新日期：2009-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a betaherpesvirus that latently infects most adult humans worldwide and is a major cause of morbidity and mortality in immunocompromised hosts. Latent human CMV (HCMV) is believed to reside in precursors of myeloid-lineage leukocytes and monocytes, which give rise to macrophages and dendritic ...

journal_title：Journal of virology

authors： Kasmapour B,Kubsch T,Rand U,Eiz-Vesper B,Messerle M,Vondran FWR,Wiegmann B,Haverich A,Cicin-Sain L

更新日期：2017-12-14 00:00:00

abstract：:Among the five serine incorporator (SERINC) family members, SERINC5 (Ser5) was reported to strongly inhibit HIV-1 replication, which is counteracted by Nef. Ser5 produces 5 alternatively spliced isoforms: Ser5-001 has 10 putative transmembrane domains, whereas Ser5-004, -005, -008a, and -008b do not have the last one....

journal_title：Journal of virology

authors： Zhang X,Zhou T,Yang J,Lin Y,Shi J,Zhang X,Frabutt DA,Zeng X,Li S,Venta PJ,Zheng YH

更新日期：2017-04-28 00:00:00

abstract：:Multimerization of the Hantaan virus nucleocapsid protein (NP) in Hantaan virus-infected Vero E6 cells was observed in a competitive enzyme-linked immunosorbent assay (ELISA). Recombinant and truncated NPs of Hantaan, Seoul, and Dobrava viruses lacking the N-terminal 49 amino acids were also detected as multimers. Alt...

journal_title：Journal of virology

authors： Yoshimatsu K,Lee BH,Araki K,Morimatsu M,Ogino M,Ebihara H,Arikawa J

更新日期：2003-01-01 00:00:00

abstract：UNLABELLED:HIV-1 Vpu decreases the exposure of epitopes within the viral envelope glycoprotein (Env) on the surface of infected cells by downregulating both BST2 and CD4. To test the hypothesis that inhibiting Vpu activity would increase the exposure of these epitopes and sensitize infected cells to antibody-dependent ...

journal_title：Journal of virology

authors： Tokarev A,Stoneham C,Lewinski MK,Mukim A,Deshmukh S,Vollbrecht T,Spina CA,Guatelli J

更新日期：2015-12-16 00:00:00

abstract：:In vitro translation of the three single-stranded RNAs transcribed in vitro by bacteriophage phi 6 RNA polymerase revealed that the large RNA codes for phage proteins P1, P2, P4, and P7, the medium RNA codes for P3, P6, and P10, and the smaller RNA for P5, P8, and P9. ...

journal_title：Journal of virology

authors： Cuppels DA,Van Etten JL,Burbank DE,Lane LC,Vidaver AK

更新日期：1980-07-01 00:00:00

abstract：:Swainsonine, an inhibitor of glycoprotein processing, inhibits the formation of the normal oligosaccharide chain of the G protein of vesicular stomatitis virus. Thus, when vesicular stomatitis virus was grown in baby hamster kidney cells in the presence of swainsonine (15 to 500 ng/ml) and labeled with [2-(3)H]mannose...

journal_title：Journal of virology

authors： Kang MS,Elbein AD

更新日期：1983-04-01 00:00:00

abstract：:Claudins (CLDN) are a family of proteins that represent the most important components of tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between epithelial cells. Several types of viruses make full use of CLDN to facilitate entry into cells....

journal_title：Journal of virology

authors： Ding G,Liu J,Shao Q,Wang B,Feng J,Li Y,Li L,Cao S,Cong F,Zhao Y,Liu S,Xiao Y

更新日期：2020-09-29 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：:Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage t...

journal_title：Journal of virology

authors： Patterson S,Rae A,Hockey N,Gilmour J,Gotch F

更新日期：2001-07-01 00:00:00