Initiation of poliovirus plus-strand RNA synthesis in a membrane complex of infected HeLa cells.

abstract：:Hemagglutinin (HA) of influenza virus must be activated by proteolysis before the virus can become infectious. Previous studies indicated that HA cleavage is driven by membrane-bound or extracellular serine proteases in the respiratory tract. However, there is still uncertainty as to which proteases are critical for a...

journal_title：Journal of virology

authors： Magnen M,Gueugnon F,Guillon A,Baranek T,Thibault VC,Petit-Courty A,de Veer SJ,Harris J,Humbles AA,Si-Tahar M,Courty Y

更新日期：2017-07-27 00:00:00

abstract：:A thorough understanding of the diversity of viruses in wildlife provides epidemiological baseline information about potential pathogens. Metagenomic analysis of the enteric viral flora revealed a new anellovirus and bocavirus species in pine martens and a new circovirus-like virus and geminivirus-related DNA virus in...

journal_title：Journal of virology

authors： van den Brand JM,van Leeuwen M,Schapendonk CM,Simon JH,Haagmans BL,Osterhaus AD,Smits SL

更新日期：2012-02-01 00:00:00

abstract：:We have demonstrated that a liposomal array of well-ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2 autologous neutralizing antibodies. Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids int...

journal_title：Journal of virology

authors： Bale S,Goebrecht G,Stano A,Wilson R,Ota T,Tran K,Ingale J,Zwick MB,Wyatt RT

更新日期：2017-07-27 00:00:00

abstract：:Relative to wild-type herpes simplex virus type 1 (HSV-1), ICP0-null mutant viruses reactivate inefficiently from explanted, latently infected mouse trigeminal ganglia (TG), indicating that ICP0 is not essential for reactivation but plays a central role in enhancing the efficiency of reactivation. The validity of thes...

journal_title：Journal of virology

authors： Halford WP,Schaffer PA

更新日期：2001-04-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-...

journal_title：Journal of virology

authors： Karsten CB,Buettner FF,Cajic S,Nehlmeier I,Neumann B,Klippert A,Sauermann U,Reichl U,Gerardy-Schahn R,Rapp E,Stahl-Hennig C,Pöhlmann S

更新日期：2015-11-01 00:00:00

abstract：:Human papillomaviruses (HPV) link their life cycles to epithelial differentiation and induce productive replication of viral DNA in suprabasal cells. Viral-DNA amplification requires cells to remain active in the cell cycle upon differentiation. This is in contrast to normal cells, which lose proliferative capability ...

journal_title：Journal of virology

authors： Melar-New M,Laimins LA

更新日期：2010-05-01 00:00:00

abstract：:Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1 production was impaired in patients with chronic infections of hepatitis C virus (HCV), implying that IL-1 may play a role in viral clearance. Using an HCV subgenomic replicon cell line, we demonstrate th...

journal_title：Journal of virology

authors： Zhu H,Liu C

更新日期：2003-05-01 00:00:00

abstract：:Activated microglia and astroglia are known to be involved in a variety of neurodegenerative diseases, including prion diseases. In the present experiments, we studied activation of astroglia and microglia after intraocular scrapie infection in transgenic mice expressing prion protein (PrP) in multiple cell types (tg7...

journal_title：Journal of virology

authors： Kercher L,Favara C,Striebel JF,LaCasse R,Chesebro B

更新日期：2007-10-01 00:00:00

abstract：:Cylindrical projections surrounding the fivefold-symmetry axes in minute virus of mice (MVM) harbor central pores that penetrate through the virion shell. In newly released DNA-containing particles, these pores contain residues 28 to 38 belonging to a single copy of VP2, disposed so that its extreme N-terminal domain ...

journal_title：Journal of virology

authors： Farr GA,Cotmore SF,Tattersall P

更新日期：2006-01-01 00:00:00

abstract：:The segment of simian virus 40 (SV40) genome which is recognized as the BC domain encodes for the COOH-terminal end of the SV40 major capsid protein VP1. Mutations in this domain lead to the synthesis of a thermosensitive VP1 which fails to assemble mature SV40 at the nonpermissive temperature. We determined the DNA s...

journal_title：Journal of virology

authors： Ng SC,Behm M,Bina M

更新日期：1985-05-01 00:00:00

abstract：UNLABELLED:Avian metapneumovirus (aMPV), also known as avian pneumovirus or turkey rhinotracheitis virus, is the causative agent of turkey rhinotracheitis and is associated with swollen head syndrome in chickens. Since its discovery in the 1970s, aMPV has been recognized as an economically important pathogen in the pou...

journal_title：Journal of virology

authors： Sun J,Wei Y,Rauf A,Zhang Y,Ma Y,Zhang X,Shilo K,Yu Q,Saif YM,Lu X,Yu L,Li J

更新日期：2014-11-01 00:00:00

abstract：:The three double-stranded ribonucleic acid (dsRNA) segments of the bacteriophage phi6 were isolated and shown to have similar melting temperatures and base compositions. RNA:RNA hybridization experiments with the isolated segments eliminate the possibility that the two smaller dsRNA segments arise from a cleavage of t...

journal_title：Journal of virology

authors： Van Etten JL,Vidaver AK,Koski RK,Burnett JP

更新日期：1974-06-01 00:00:00

abstract：:During the latent phase, Kaposi's sarcoma-associated herpes virus (KSHV) maintains itself inside the host by escaping the host immune surveillance mechanism through restricted protein expression. Latency-associated nuclear antigen (LANA), the most abundantly expressed protein, is essential for viral persistence, as it...

journal_title：Journal of virology

authors： Dabral P,Babu J,Zareie A,Verma SC

更新日期：2020-01-17 00:00:00

abstract：:The polypeptides of three paramyxoviruses (simian virus 5, Newcastle disease virus, and Sendai virus) were separated by polyacrylamide gel electrophoresis. Glycoproteins were identified by the use of radioactive glucosamine as a carbohydrate precursor. The protein patterns reveal similarities among the three viruses. ...

journal_title：Journal of virology

authors： Mountcastle WE,Compans RW,Choppin PW

更新日期：1971-01-01 00:00:00

abstract：:Viral infection induces production of type I interferons (IFNs), which stimulate the expression of a variety of antiviral factors to inhibit viral replication. To establish effective infection, viruses need to develop strategies to evade the immune responses. A neurovirulent Sindbis virus strain with neuroinvasive pro...

journal_title：Journal of virology

authors： Wang X,Li MMH,Zhao J,Li S,MacDonald MR,Rice CM,Gao X,Gao G

更新日期：2016-10-28 00:00:00

abstract：:The DNA of lymphomas from 12 AKXD recombinant inbred mouse strains was analyzed to determine the presence of somatically acquired ecotropic and mink cell focus-forming proviruses. Mink cell focus-forming proviruses were associated primarily with T-cell lymphomas, whereas ecotropic proviruses were associated with lymph...

journal_title：Journal of virology

authors： Mucenski ML,Taylor BA,Copeland NG,Jenkins NA

更新日期：1987-09-01 00:00:00

abstract：:The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein la...

journal_title：Journal of virology

authors： Tran EE,Simmons JA,Bartesaghi A,Shoemaker CJ,Nelson E,White JM,Subramaniam S

更新日期：2014-09-01 00:00:00

abstract：:Since parvoviruses apparently do not possess a DNA polymerase activity, one or more of the host cell DNA polymerases must be responsible for replicating the single-stranded DNA genome. We have focused on determining which polymerase, alpha, beta, or gamma (pol alpha, pol beta, or pol gamma, respectively), is responsib...

journal_title：Journal of virology

authors： Robertson AT,Stout ER,Bates RC

更新日期：1984-03-01 00:00:00

abstract：:The relative antigenicity of the individual herpes simplex virus type 1 (KOS) glycoproteins gC and gB was analyzed in BALB/c mice by using KOS mutants altered in their ability to present these antigens on cell surface membranes during infection. The mutants employed were as follows: syn LD70 , a non-temperature-sensit...

journal_title：Journal of virology

authors： Glorioso J,Schröder CH,Kumel G,Szczesiul M,Levine M

更新日期：1984-06-01 00:00:00

abstract：:N6-adenosine methylation (m6A) is the most common posttranscriptional RNA modification in mammalian cells. We found that most transcripts encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome undergo m6A modification. The levels of m6A-modified mRNAs increased substantially upon stimulation for lytic re...

journal_title：Journal of virology

authors： Ye F,Chen ER,Nilsen TW

更新日期：2017-07-27 00:00:00

abstract：:Nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) possesses an RNA-dependent RNA polymerase activity responsible for viral genome RNA replication. Despite several reports on the characterization of this essential viral enzyme, little is known about the reaction pathway of NS5B-catalyzed nucleotide incorporati...

journal_title：Journal of virology

authors： Zhong W,Ferrari E,Lesburg CA,Maag D,Ghosh SK,Cameron CE,Lau JY,Hong Z

更新日期：2000-10-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect keratinocytes and induce proliferative lesions. In infected cells, viral gene products alter the activities of cellular proteins, such as Rb and p53, resulting in altered cell cycle response. It is likely that HPV gene products also alter expression of cellular genes. In this study...

journal_title：Journal of virology

authors： Chang YE,Laimins LA

更新日期：2000-05-01 00:00:00

abstract：:In contrast to humans, several primate species are believed to have harbored simian immunodeficiency viruses (SIVs) since ancient times. In particular, the geographically dispersed species of African green monkeys (AGMs) are all infected with highly diversified SIVagm viruses at high prevalences (greater than 50% of s...

journal_title：Journal of virology

authors： Kuhmann SE,Madani N,Diop OM,Platt EJ,Morvan J,Müller-Trutwin MC,Barré-Sinoussi F,Kabat D

更新日期：2001-09-01 00:00:00

abstract：:Activation of the interferon-inducible, double-stranded RNA-dependent protein kinase was monitored in monolayer cultures of control and interferon-treated HeLa cells infected with encephalomyocarditis virus. The extent of phosphorylation in the intact cell of the alpha-subunit of eucaryotic protein synthesis initiatio...

journal_title：Journal of virology

authors： Rice AP,Duncan R,Hershey JW,Kerr IM

更新日期：1985-06-01 00:00:00

abstract：:Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ass...

journal_title：Journal of virology

authors： Brass V,Pal Z,Sapay N,Deléage G,Blum HE,Penin F,Moradpour D

更新日期：2007-03-01 00:00:00

abstract：:Replication of the genomic RNA of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro). Previously, we showed that SARS-CoV PLpro processes the replicase polyprotein at three ...

journal_title：Journal of virology

authors： Barretto N,Jukneliene D,Ratia K,Chen Z,Mesecar AD,Baker SC

更新日期：2005-12-01 00:00:00

abstract：:The vast majority of studies with candidate immunogens based on the human immunodeficiency virus envelope (Env) have been conducted with Env proteins derived from clade B viruses isolated during chronic infection. Whether non-clade B Env protein immunogens will elicit antibodies with epitope specificities that are sim...

journal_title：Journal of virology

authors： Kraft Z,Strouss K,Sutton WF,Cleveland B,Tso FY,Polacino P,Overbaugh J,Hu SL,Stamatatos L

更新日期：2008-06-01 00:00:00

abstract：:HVEM (for herpesvirus entry mediator) is a member of the tumor necrosis factor receptor superfamily and mediates entry of many strains of herpes simplex virus (HSV) into normally nonpermissive Chinese hamster ovary (CHO) cells. We used sucrose density centrifugation to demonstrate that purified HSV-1 KOS virions bind ...

journal_title：Journal of virology

authors： Nicola AV,Ponce de Leon M,Xu R,Hou W,Whitbeck JC,Krummenacher C,Montgomery RI,Spear PG,Eisenberg RJ,Cohen GH

更新日期：1998-05-01 00:00:00

abstract：:The first 86 residues of the Rous sarcoma virus (RSV) Gag protein form a membrane-binding (M) domain that directs Gag to the plasma membrane during budding. Unlike other retroviral Gag proteins, RSV Gag is not myristylated; however, the RSV M domain does contain 11 basic residues that could potentially interact with a...

journal_title：Journal of virology

authors： Callahan EM,Wills JW

更新日期：2000-12-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three discrete activities that each affect the ability of HN to promote viral fusion and entry: receptor binding, receptor cleaving (neuraminidase), and triggering of the fusion protein. The interrelationship between the receptor binding and f...

journal_title：Journal of virology

authors： Porotto M,Fornabaio M,Kellogg GE,Moscona A

更新日期：2007-04-01 00:00:00