An internally located RNA hairpin enhances replication of Tomato bushy stunt virus RNAs.

abstract：:In coliphage 186, 22 essential genes were defined by complementation studies with amber mutants. Eighteen genes were associated with phage morphogenesis: 11 with phage tail formation, and 7 with phage head formation. The remaining four genes are discussed in the accompanying paper (S. M. Hocking and J. B. Egan, J. Vir...

journal_title：Journal of virology

authors： Hocking SM,Egan JB

更新日期：1982-12-01 00:00:00

abstract：:We describe respiratory syncytial virus (RSV)-specific cytotoxic T-cell (CTL) lines and clones developed from the spleens of C57BL/6 and BALB/c mice. Line 7 and clones derived from it were H-2Kb restricted, whereas line 12 had both Kb and Db components. Both lines, and all the clones except one, could lyse targets inf...

journal_title：Journal of virology

authors： Muñoz JL,McCarthy CA,Clark ME,Hall CB

更新日期：1991-08-01 00:00:00

abstract：:Dengue virus (DEN) causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome, which are major public health problems worldwide. The immune factors that control DEN infection or contribute to severe disease are neither well understood nor easy to examine in humans. In this study, we used wild-type and cong...

journal_title：Journal of virology

authors： Shresta S,Kyle JL,Snider HM,Basavapatna M,Beatty PR,Harris E

更新日期：2004-03-01 00:00:00

abstract：:Herpesviruses establish latency in suitable host cells after primary infection and persist in their host organisms for life. Most of the viral genes are silenced during latency, also enabling the virus to escape from an immune response. This study addresses the control of viral gene silencing by epigenetic mechanisms,...

journal_title：Journal of virology

authors： Alberter B,Vogel B,Lengenfelder D,Full F,Ensser A

更新日期：2011-06-01 00:00:00

abstract：:Both circulating and mucosal antibodies are considered important for protection against infection by influenza virus in humans and animals. However, current inactivated vaccines administered by intramuscular injection using a syringe and needle elicit primarily circulating antibodies. In this study, we report that epi...

journal_title：Journal of virology

authors： Chen D,Periwal SB,Larrivee K,Zuleger C,Erickson CA,Endres RL,Payne LG

更新日期：2001-09-01 00:00:00

abstract：:Walleye dermal sarcoma virus (WDSV) is a complex retrovirus associated with dermal sarcomas in walleye fish. A WDSV accessory gene encodes a cyclin homolog or retroviral cyclin (rv-cyclin). WDSV rv-cyclin was found to be associated with transcription complexes and to affect transcription in a cell-type and promoter-de...

journal_title：Journal of virology

authors： Rovnak J,Quackenbush SL

更新日期：2006-12-01 00:00:00

abstract：UNLABELLED:Following retrovirus entry, the viral capsid (CA) disassembles into its component capsid proteins. The rate of this uncoating process, which is regulated by CA-CA interactions and by the association of the capsid with host cell factors like cyclophilin A (CypA), can influence the efficiency of reverse transc...

journal_title：Journal of virology

authors： Tipper C,Sodroski JG

更新日期：2014-09-01 00:00:00

abstract：:Poliovirus inactivation by ammonia causes a slight reduction in the sedimentation coefficients of viral particles, but has no detectable effect on either the electrophoretic pattern of viral capsid proteins or the isoelectric points of inactivated particles. These virions still attach to cells, but are unable to repre...

journal_title：Journal of virology

authors： Ward RL

更新日期：1978-05-01 00:00:00

abstract：:The regulation of murine cytomegalovirus early (E) gene expression was studied in the cell line B25, which is stably transfected with the immediate-early ie1/ie3 gene complex. Infection of B25 cells in the presence of the protein synthesis inhibitor cycloheximide resulted in the expression of some E genes, whereas for...

journal_title：Journal of virology

authors： Bühler B,Keil GM,Weiland F,Koszinowski UH

更新日期：1990-05-01 00:00:00

abstract：:The bacteriophage PRD1 is a lipid-bearing phage that infects a wide variety of gram-negative bacteria, including Escherichia coli and Salmonella typhimurium when they contain the appropriate plasmid. It contains a linear duplex DNA molecule that is covalently bound by its 5' ends to a terminal protein. We report here ...

journal_title：Journal of virology

authors： Gerendasy DD,Ito J

更新日期：1987-02-01 00:00:00

abstract：:Major histocompatibility complex class I (MHC I) molecules present antigenic peptides for CD8(+) T-cell recognition. Prior to cell surface expression, proper MHC I loading is conducted by the peptide-loading complex (PLC), composed of the MHC I heavy chain (HC) and β(2)-microglobulin (β(2)m), the peptide transporter T...

journal_title：Journal of virology

authors： Halenius A,Hauka S,Dölken L,Stindt J,Reinhard H,Wiek C,Hanenberg H,Koszinowski UH,Momburg F,Hengel H

更新日期：2011-04-01 00:00:00

abstract：:Brome mosaic virus (BMV) RNA replication is directed by two virus-encoded proteins, 1a and 2a. The amino-terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1, which has been implicated in capping viral RNAs. In this study, we examined the enzymatic activities of BMV 1a expressed in yeast, ...

journal_title：Journal of virology

authors： Ahola T,Ahlquist P

更新日期：1999-12-01 00:00:00

abstract：:Swine influenza viruses (SIV) naturally infect pigs and can be transmitted to humans. In the pig, genetic reassortment to create novel influenza subtypes by mixing avian, human, and swine influenza viruses is possible. An SIV vaccine inducing cross-protective immunity between different subtypes and strains circulating...

journal_title：Journal of virology

authors： Richt JA,Lekcharoensuk P,Lager KM,Vincent AL,Loiacono CM,Janke BH,Wu WH,Yoon KJ,Webby RJ,Solórzano A,García-Sastre A

更新日期：2006-11-01 00:00:00

abstract：:The activity and epithelial tropism of the human papillomavirus type 18 P105 early promoter, which directs the synthesis of the E6 and E7 transforming genes, are controlled by cis elements included in the viral long control region. To identify potential cellular regulators of this promoter, we mutagenized one or both ...

journal_title：Journal of virology

authors： Thierry F,Spyrou G,Yaniv M,Howley P

更新日期：1992-06-01 00:00:00

abstract：:The replication of porcine circovirus type 1 (PCV1) is thought to occur by rolling-circle replication (RCR), whereby the introduction of a single-strand break generates a free 3'-hydroxyl group serving as a primer for subsequent DNA synthesis. The covalently closed, single-stranded genome of PCV1 replicates via a doub...

journal_title：Journal of virology

authors： Steinfeldt T,Finsterbusch T,Mankertz A

更新日期：2006-07-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) BMRF1 protein is a DNA polymerase processivity factor. We have deleted the BMRF1 open reading frame from the EBV genome and assessed the DeltaBMRF1 EBV phenotype. DeltaBMRF1 viruses were replication deficient, but the wild-type phenotype could be restored by BMRF1 trans-complementation. Th...

journal_title：Journal of virology

authors： Neuhierl B,Delecluse HJ

更新日期：2006-05-01 00:00:00

abstract：:It is well established that chronic viral infections can cause immune suppression, resulting in increased susceptibility to other infectious diseases. However, the effects of chronic viral infection on T-cell responses and vaccination against highly pathogenic viruses are not well understood. We have recently shown th...

journal_title：Journal of virology

authors： Alves-Peixoto P,Férez M,Knudson CJ,Melo-Silva CR,Stotesbury C,Wong EB,Correia-Neves M,Sigal LJ

更新日期：2020-02-14 00:00:00

abstract：:Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune responses through the actions of their V proteins. The V protein mediates interference with the interferon regulatory RNA helicase MDA5 to avoid cellular antiviral responses. Analysis of the interaction i...

journal_title：Journal of virology

authors： Parisien JP,Bamming D,Komuro A,Ramachandran A,Rodriguez JJ,Barber G,Wojahn RD,Horvath CM

更新日期：2009-07-01 00:00:00

abstract：:Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 H1N1 pandemic. This pathology is induced by IAV-specific memory CD8(+) T cells cr...

journal_title：Journal of virology

authors： Kraft AR,Wlodarczyk MF,Kenney LL,Selin LK

更新日期：2013-12-01 00:00:00

abstract：:A distinct clinical presentation of respiratory syncytial virus (RSV) infection of humans is bronchiolitis, which has clinical features similar to those of asthma. Substance P (SP), a tachykinin neuropeptide, has been associated with neurogenic inflammation and asthma; therefore, we chose to examine SP-induced inflamm...

journal_title：Journal of virology

authors： Tripp RA,Moore D,Winter J,Anderson LJ

更新日期：2000-02-01 00:00:00

abstract：:Chronic infection by hepatitis C virus (HCV) can lead to severe hepatitis and cirrhosis and is closely associated with hepatocellular carcinoma. The replication cycle of HCV is poorly understood but is likely to involve interaction with host factors. In this report, we show that NS5B, the HCV RNA-dependent RNA polymer...

journal_title：Journal of virology

authors： Goh PY,Tan YJ,Lim SP,Tan YH,Lim SG,Fuller-Pace F,Hong W

更新日期：2004-05-01 00:00:00

abstract：:Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leading to the destruction of cellular signal transducer and activator of transcription (STAT) proteins. While many V proteins target the interferon-activated STA...

journal_title：Journal of virology

authors： Puri M,Lemon K,Duprex WP,Rima BK,Horvath CM

更新日期：2009-07-01 00:00:00

abstract：:Viral hemorrhagic septicemia virus (VHSV) infections cause high losses in cultured rainbow trout in Europe. Attempts to produce a recombinant vaccine based on the transmembrane glycoprotein (G protein) have indicated that proper folding is important for the antigenicity and immunogenicity of the protein. The present s...

journal_title：Journal of virology

authors： Einer-Jensen K,Krogh TN,Roepstorff P,Lorenzen N

更新日期：1998-12-01 00:00:00

abstract：:Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta). However, recombinant HRSV lacking the NS1 and NS2 genes (Delta NS1/2) induced high levels of IFN-alpha and -beta in human pulmonary epithelial cells (A549) as well as in macrophages derived from primary hum...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Chi B,Rabin RL,Collins PL

更新日期：2004-04-01 00:00:00

abstract：:When human A431 cells, which carry high numbers of epidermal growth factor (EGF) receptors, are exposed to EGF, the total content of phosphotyrosine in cell protein is increased, the EGF receptor becomes phosphorylated at tyrosine, and new phosphotyrosine-containing 36,000- and 81,000-dalton proteins are detected. We ...

journal_title：Journal of virology

authors： Cooper JA,Scolnick EM,Ozanne B,Hunter T

更新日期：1983-12-01 00:00:00

abstract：:Retroviral integration has recently been shown to be nonrandom, favoring transcriptionally active regions of chromatin. However, the mechanism for integration site selection by retroviruses is not clear. We show here the occurrence of Alu-like motifs in the sequences flanking the reported viral integration sites that ...

journal_title：Journal of virology

authors： Kumar PP,Mehta S,Purbey PK,Notani D,Jayani RS,Purohit HJ,Raje DV,Ravi DS,Bhonde RR,Mitra D,Galande S

更新日期：2007-06-01 00:00:00

abstract：:HIV-1 infectivity is strongly restricted by TRIM5α from certain primate species but has been described as being only marginally susceptible to human TRIM5α. In this study, we evaluated the effects of the modulation of human TRIM5α activity (pretreatment of target cells with alpha interferon, expression of a pre-miRNA ...

journal_title：Journal of virology

authors： Battivelli E,Lecossier D,Matsuoka S,Migraine J,Clavel F,Hance AJ

更新日期：2010-11-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) DNA fragments were cloned into M13 bacteriophage, and the single-stranded recombinant phage DNAs were used as strand-specific nucleic acid hybridization probes to measure synthesis of plus (genomic) and minus strands of MMTV RNA in cultured cell lines and in cell-free preparations of n...

journal_title：Journal of virology

authors： Prewitt RS,Washington LD,Stallcup MR

更新日期：1984-04-01 00:00:00

abstract：:The presence of cycloheximide, an inhibitor of protein synthesis, during the period 30 to 60 min after vaccinia infection produced an irreversible block in virus replication. In contrast (i) cycloheximide given at earlier or later times, even for prolonged periods, did not prevent continuation of the infectious cycle ...

journal_title：Journal of virology

authors： Mss B,Filler R

更新日期：1970-02-01 00:00:00

abstract：:Theiler's virus infection of the central nervous system (CNS) induces an immune-mediated demyelinating disease in susceptible mouse strains, such as SJL/J, and serves as a relevant infectious model for human multiple sclerosis. It has been previously suggested that susceptible SJL/J mice do not mount an efficient cyto...

journal_title：Journal of virology

authors： Kang BS,Lyman MA,Kim BS

更新日期：2002-07-01 00:00:00