Characterization of intramolecular disulfide bonds and secondary modifications of the glycoprotein from viral hemorrhagic septicemia virus, a fish rhabdovirus.

abstract：:The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18 degrees C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesic...

journal_title：Journal of virology

authors： Vihinen-Ranta M,Kalela A,Mäkinen P,Kakkola L,Marjomäki V,Vuento M

更新日期：1998-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) has two envelope proteins, E1 and E2, which form a heterooligomer. During dissection of interacting regions of HCV E1 and E2, we found the presence of an interfering compound or compounds in skim milk. Here we report that human as well as bovine lactoferrin, a multifunctional immunomodulator, b...

journal_title：Journal of virology

authors： Yi M,Kaneko S,Yu DY,Murakami S

更新日期：1997-08-01 00:00:00

abstract：:The Epstein-Barr Virus (EBV) immediate-early protein BRLF1 is one of two transactivators which mediate the switch from latent to lytic replication in EBV-infected cells. DNA viruses often modulate the function of critical cell cycle proteins to maximize the efficiency of virus replication. Here we have examined the ef...

journal_title：Journal of virology

authors： Swenson JJ,Mauser AE,Kaufmann WK,Kenney SC

更新日期：1999-08-01 00:00:00

abstract：:The multifunctional simian and human immunodeficiency virus (SIV and HIV) Nef proteins are important for virulence. We studied the importance of selected Nef functions using an SIV Nef with mutations in two regions that are required for CD4 downregulation. This Nef mutant is defective for downregulating CD4 and, in ad...

journal_title：Journal of virology

authors： Iafrate AJ,Carl S,Bronson S,Stahl-Hennig C,Swigut T,Skowronski J,Kirchhoff F

更新日期：2000-11-01 00:00:00

abstract：:Infectious pancreatic necrosis virus of fish, infectious bursal disease virus of chickens, Tellina virus and oyster virus of bivalve molluscs, and drosophila X virus of Drosophila melanogaster are naked icosahedral viruses with an electron microscopic diameter of 58 to 60 nm. The genome of each of these viruses consis...

journal_title：Journal of virology

authors： Dobos P,Hill BJ,Hallett R,Kells DT,Becht H,Teninges D

更新日期：1979-11-01 00:00:00

abstract：:The majority of T-cell clones derived from a donor who experienced dengue illness following receipt of a live experimental dengue virus type 3 (DEN3) vaccine cross-reacted with all four serotypes of dengue virus, but some were serotype specific or only partially cross-reactive. The nonstructural protein, NS3, was immu...

journal_title：Journal of virology

authors： Zeng L,Kurane I,Okamoto Y,Ennis FA,Brinton MA

更新日期：1996-05-01 00:00:00

abstract：:The use of adenovirus vectors for human gene therapy is limited by potent inflammatory responses that result in significant morbidity. In kidney-derived epithelial cells (REC), activation of extracellular signal-regulated kinase 1/2 (ERK) and p38 kinase (p38) pathways occurred within 20 min of transduction with the se...

journal_title：Journal of virology

authors： Tibbles LA,Spurrell JC,Bowen GP,Liu Q,Lam M,Zaiss AK,Robbins SM,Hollenberg MD,Wickham TJ,Muruve DA

更新日期：2002-02-01 00:00:00

abstract：:The vast majority of studies with candidate immunogens based on the human immunodeficiency virus envelope (Env) have been conducted with Env proteins derived from clade B viruses isolated during chronic infection. Whether non-clade B Env protein immunogens will elicit antibodies with epitope specificities that are sim...

journal_title：Journal of virology

authors： Kraft Z,Strouss K,Sutton WF,Cleveland B,Tso FY,Polacino P,Overbaugh J,Hu SL,Stamatatos L

更新日期：2008-06-01 00:00:00

abstract：:The contribution of the hepatitis B virus enhancers I and II in the regulation of the activity of the core and the X promoters was assessed in transgenic mice. Surprisingly, despite the presence of heterologous promoters linked 5' of the X gene, the transgene expression is mostly due to core promoter (Cp) activity pre...

journal_title：Journal of virology

authors： Billet O,Grimber G,Levrero M,Seye KA,Briand P,Joulin V

更新日期：1995-09-01 00:00:00

abstract：:Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (p...

journal_title：Journal of virology

authors： Van Poucke S,Doedt J,Baumann J,Qiu Y,Matrosovich T,Klenk HD,Van Reeth K,Matrosovich M

更新日期：2015-12-01 00:00:00

abstract：:A well-characterized mechanism by which anti-HLA class I monoclonal antibodies (MAb) inhibit human immunodeficiency virus type 1 (HIV-1) propagation in in vitro cell cultures is the neutralization of the virus through interactions with HLA molecules associated with the virion envelope. Yet, the possibility that anothe...

journal_title：Journal of virology

authors： Briant L,Benkirane M,Girard M,Hirn M,Iosef C,Devaux C

更新日期：1996-08-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) alkaline nuclease, encoded by the UL12 gene, plays an important role in HSV-1 replication, as a UL12 null mutant displays a severe growth defect. The HSV-1 alkaline exonuclease UL12 interacts with the viral single-stranded DNA binding protein ICP8 and promotes strand exchange in...

journal_title：Journal of virology

authors： Balasubramanian N,Bai P,Buchek G,Korza G,Weller SK

更新日期：2010-12-01 00:00:00

abstract：:A number of eucaryotic viruses have devised strategies to minimize the deleterious effects on protein synthesis caused by activation of the interferon-induced, double-stranded-RNA-activated protein kinase, P68. In a recent report, we described the down regulation of the P68 protein kinase in cells infected by human im...

journal_title：Journal of virology

authors： Roy S,Agy M,Hovanessian AG,Sonenberg N,Katze MG

更新日期：1991-02-01 00:00:00

abstract：:Infection by viruses depends on a balance between capsid stability and dynamics. This study investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability and between thermostability and infectivity. In the FMDV ...

journal_title：Journal of virology

authors： López-Argüello S,Rincón V,Rodríguez-Huete A,Martínez-Salas E,Belsham GJ,Valbuena A,Mateu MG

更新日期：2019-05-01 00:00:00

abstract：:The NS5A nonstructural protein of hepatitis C virus (HCV) has been shown to inhibit the cellular interferon (IFN)-induced protein kinase R (PKR). PKR mediates the host IFN-induced antiviral response at least in part by inhibiting mRNA translation initiation through phosphorylation of the alpha subunit of eukaryotic in...

journal_title：Journal of virology

authors： He Y,Tan SL,Tareen SU,Vijaysri S,Langland JO,Jacobs BL,Katze MG

更新日期：2001-06-01 00:00:00

abstract：:Disruption of Epstein-Barr virus (EBV) latency is mediated by ZEBRA, the protein product of the immediate-early EBV gene, BZLF1. In vitro, phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), induces reactivation of EBV. However, the physiological stimuli responsible for the disruption ...

journal_title：Journal of virology

authors： Fahmi H,Cochet C,Hmama Z,Opolon P,Joab I

更新日期：2000-07-01 00:00:00

abstract：:An immunocompetent, permissive, small-animal model would be valuable for the study of human immunodeficiency virus type 1 (HIV-1) pathogenesis and for the testing of drug and vaccine candidates. However, the development of such a model has been hampered by the inability of primary rodent cells to efficiently support s...

journal_title：Journal of virology

authors： Tervo HM,Keppler OT

更新日期：2010-12-01 00:00:00

abstract：:Six overlapping viral RNAs are synthesized in cells infected with the avian coronavirus infectious bronchitis virus (IBV). These RNAs contain a 3'-coterminal nested sequence set and were assumed to be viral mRNAs. The seven major IBV virion proteins are all produced by processing of three polypeptides of ca. 23, 51, a...

journal_title：Journal of virology

authors： Stern DF,Sefton BM

更新日期：1984-04-01 00:00:00

abstract：:We report the identification of a functional nuclear localization signal (NLS) in the human cytomegalovirus (HCMV) large tegument protein pUL48 that is required for nuclear localization in transfected cells and is essential for viral growth. The NLS was mapped to pUL48 amino acid residues 284 to 302. This sequence con...

journal_title：Journal of virology

authors： Brock I,Krüger M,Mertens T,von Einem J

更新日期：2013-05-01 00:00:00

abstract：:Moloney murine leukemia virus (M-MuLV) IN-IN protein interactions important for catalysis of strand transfer and unimolecular and bimolecular disintegration reactions were investigated by using a panel of chemically modified M-MuLV IN proteins. Functional complementation of an HHCC-deleted protein (Ndelta105) by an in...

journal_title：Journal of virology

authors： Donzella GA,Leon O,Roth MJ

更新日期：1998-02-01 00:00:00

abstract：:Equine infectious anemia virus (EIAV) is an equine lentivirus similar to HIV-1, targets host immune cells, and causes a life-long infection in horses. The Chinese live EIAV vaccine is attenuated from long-term passaging of a highly virulent strain in vitro The parent pathogenic strain (EIAVDLV34) induces a host inflam...

journal_title：Journal of virology

authors： Du C,Duan Y,Wang XF,Lin Y,Na L,Wang X,Chen K,Wang X

更新日期：2019-10-15 00:00:00

abstract：:The chimeric recombinant virus rHPIV3-N(B), a version of human parainfluenza virus type 3 (HPIV3) that is attenuated due to the presence of the bovine PIV3 nucleocapsid (N) protein open reading frame (ORF) in place of the HPIV3 ORF, was modified to encode the measles virus hemagglutinin (HA) inserted as an additional,...

journal_title：Journal of virology

authors： Skiadopoulos MH,Surman SR,Riggs JM,Collins PL,Murphy BR

更新日期：2001-11-01 00:00:00

abstract：:Reactivations of persistent viral infections pose a significant medical problem in immunocompromised cancer, transplant, and AIDS patients, yet little is known about how persistent viral infections are immunologically controlled. Here we describe a mouse model for investigating the role of the immune response in contr...

journal_title：Journal of virology

authors： Hasenkrug KJ,Brooks DM,Dittmer U

更新日期：1998-08-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) and the closely related simian immunodeficiency virus (SIV) induce profound immune dysfunction in primate species. The present studies show that cell populations infected in vitro with SIV exhibit increases in major histocompatibility complex (MHC) class II antigen expression. Ce...

journal_title：Journal of virology

authors： Kannagi M,Kiyotaki M,King NW,Lord CI,Letvin NL

更新日期：1987-05-01 00:00:00

abstract：:Mosquito-borne alphaviruses, which replicate alternately and obligately in mosquitoes and vertebrates, appear to experience lower rates of evolution than do many RNA viruses that replicate solely in vertebrates. This genetic stability is hypothesized to result from the alternating host cycle, which constrains evolutio...

journal_title：Journal of virology

authors： Greene IP,Wang E,Deardorff ER,Milleron R,Domingo E,Weaver SC

更新日期：2005-11-01 00:00:00

abstract：:Hepatitis A virus (HAV) 3C proteinase expressed in Escherichia coli was purified to homogeneity, and its cleavage specificity towards various parts of the viral polyprotein was analyzed. Intermolecular cleavage of the P2-P3 domain of the HAV polyprotein gave rise to proteins 2A, 2B, 2C, 3ABC, and 3D, suggesting that i...

journal_title：Journal of virology

authors： Schultheiss T,Sommergruber W,Kusov Y,Gauss-Müller V

更新日期：1995-03-01 00:00:00

abstract：:Duck hepatitis B virus mutants containing frameshift or stop codon mutations in a portion of the viral pol gene separating the terminal protein and reverse transcriptase domains had a leaky phenotype and, depending on the location and type of mutation, synthesized up to 10% as much viral DNA as did the wild type. This...

journal_title：Journal of virology

authors： Wu TT,Condreay LD,Coates L,Aldrich C,Mason W

更新日期：1991-05-01 00:00:00

abstract：:The tax gene of the human T-cell leukemia virus types I and II (HTLV-I and HTLV-II) is essential for viral replication and acts by increasing the level of RNA transcription. The tax genes of HTLV-I and HTLV-II encode proteins of 40 and 37 kilodaltons, respectively. By in vitro mutagenesis of the tax gene, we have inve...

journal_title：Journal of virology

authors： Cann AJ,Rosenblatt JD,Wachsman W,Chen IS

更新日期：1989-03-01 00:00:00

abstract：:The alternating host cycle and persistent vector infection may constrain the evolution of arboviruses. To test this hypothesis, eastern equine encephalitis virus was passaged in BHK or mosquito cells, as well as in alternating (both) host cell passages. High and low multiplicities were used to examine the effect of de...

journal_title：Journal of virology

authors： Weaver SC,Brault AC,Kang W,Holland JJ

更新日期：1999-05-01 00:00:00

abstract：:FeLV-FAIDS, an immunodeficiency-inducing isolate of feline leukemia virus, is composed of a pathogenic but replication-defective genome (molecular clone 61C) and a replication-competent but non-immunodeficiency-inducing variant genome (molecular clone 61E). The chimeric virus EECC, composed of the 5' gag-pol of 61E fu...

journal_title：Journal of virology

authors： Poss ML,Quackenbush SL,Mullins JI,Hoover EA

更新日期：1990-09-01 00:00:00