Abstract:
:Human cytomegalovirus (HCMV) encodes several proteins that inhibit major histocompatibility complex (MHC) class I-dependent antigen presentation. The HCMV products US2 and US11 are each sufficient for causing the dislocation of human and murine MHC class I heavy chains from the lumen of the endoplasmic reticulum to the cytosol, where the heavy chains are readily degraded. The apparent redundancy of US2 and US11 has been probed predominantly in cultured cell lines, where differences in their specificities were shown for murine and human MHC class I locus products. Here, we expressed US11 and US2 via adenovirus vectors and show that US11 exhibits a superior ability to degrade MHC class I molecules in primary human dendritic cells. MHC class II complexes are unaffected by US2- and US11-mediated attack. We suggest that multiple HCMV-encoded immunoevasions have evolved complementary functions in response to diverse host cell types and tissues.
journal_name
J Viroljournal_title
Journal of virologyauthors
Rehm A,Engelsberg A,Tortorella D,Körner IJ,Lehmann I,Ploegh HL,Höpken UEdoi
10.1128/jvi.76.10.5043-5050.2002subject
Has Abstractpub_date
2002-05-01 00:00:00pages
5043-50issue
10eissn
0022-538Xissn
1098-5514journal_volume
76pub_type
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