Abstract:
:Myeloblastosis-associated virus (MAV)-2(0), a virus which was derived from avian myeloblastosis virus and induced a high incidence of osteopetrosis, was compared with avian lymphomatosis virus 5938, a recent field isolate which induced a high incidence of lymphomatosis. The following information was obtained. (i) MAV-2(0) induced osteopetrosis, nephroblastoma, and a very low incidence of hepatocellular carcinoma. No difference was seen in the oncogenic spectrum of end point and plaque-purified MAV-2(0). (ii) 125I-labeled RNA sequences from MAV-2(0) formed hybrids with DNA extracted from osteopetrotic bone at a rate suggesting five proviral copies per haploid cell genome. The extent of hybridization of MAV-2(0) RNA with DNA from osteopetrotic tissue was more extensive (87%) than was observed in reactions with DNA from uninfected chicken embryos (52%). (iii) Competition of unlabeled viral RNA in hybridization reactions between the radioactive RNA from the two viruses and their respective proviral sequences present in tumor tissues showed that 15 to 20% of the viral sequences detected in these reactions were unshared. In contrast, no differences were detected in competition analyses of RNA sequences from the two viruses detected in DNA of normal chicken cells. (iv) MAV-2(0) 35S RNA was indistinguishable in size from avian lymphomatosis virus 5938 35S RNA by polyacrylamide gel electrophoresis.
journal_name
J Viroljournal_title
Journal of virologyauthors
Smith RE,Davids LJ,Neiman PEdoi
10.1128/JVI.17.1.160-167.1976subject
Has Abstractpub_date
1975-01-01 00:00:00pages
160-7issue
1eissn
0022-538Xissn
1098-5514journal_volume
17pub_type
杂志文章abstract::NK cells are key effectors of innate immunity and host survival during cytomegalovirus (CMV) infection. Innate murine CMV (MCMV) resistance in MA/My mice requires Ly49H/m157-independent H-2k-linked NK cell control. Here we show that replacement of MA/My H-2k with C57L H-2b susceptibility genes led to a remarkable loss...
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journal_title:Journal of virology
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pub_type: 杂志文章
doi:10.1128/JVI.66.9.5561-5568.1992
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pub_type: 杂志文章
doi:10.1128/JVI.33.1.438-448.1980
更新日期:1980-01-01 00:00:00
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更新日期:2000-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.8.4867-4874.1993
更新日期:1993-08-01 00:00:00
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更新日期:2014-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.31.2.334-340.1979
更新日期:1979-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.4.2.117-122.1969
更新日期:1969-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.12.5919-5926.1990
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.39.1.207-218.1981
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00644-10
更新日期:2010-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.9.6.938-945.1972
更新日期:1972-06-01 00:00:00
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更新日期:2009-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.33.3.1083-1096.1980
更新日期:1980-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.8.4038-4046.2006
更新日期:2006-04-01 00:00:00
abstract::Transcription and replication signals within the negative-sense genomic RNA of vesicular stomatitis virus (VSV) are located at the 3' terminus. To identify these signals, we have used a transcription- and replication-competent minigenome of VSV to generate a series of deletions spanning the first 47 nucleotides at the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.1.444-452.1999
更新日期:1999-01-01 00:00:00
abstract::Cowpox virus, in contrast to vaccinia virus, can multiply in Chinese hamster ovary cells. To study the genetic basis for this difference in host range, recombinants between vaccinia and cowpox viruses were isolated and their DNA restriction patterns were examined. The ability to multiply in Chinese hamster ovary cells...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.4.1297-1304.1988
更新日期:1988-04-01 00:00:00
abstract::Caprine arthritis encephalitis virus (CAEV) is a lentivirus closely related to visna virus and more distantly to other lentiviruses, such as human immunodeficiency virus. The genomes of visna virus and CAEV contain a tat gene encoding a protein able to weakly transactivate its own long terminal repeat, suggesting that...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.9.5445-5454.1995
更新日期:1995-09-01 00:00:00