The caprine arthritis encephalitis virus tat gene is dispensable for efficient viral replication in vitro and in vivo.

abstract：:Herpes simplex virus type 1 (HSV-1) DNA replication is associated with nuclear domains called ND10, which contain host recombination proteins such as RPA, RAD51, and NBS1 and participate in the cell's response to DNA damage. The stages of HSV-1 infection have been described previously. Infected cells at stage IIIa are...

journal_title：Journal of virology

authors： Wilkinson DE,Weller SK

更新日期：2004-05-01 00:00:00

abstract：UNLABELLED:Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on characterizing its properties, in order to enable the development of prophylactic methods. We have sequenced the genom...

journal_title：Journal of virology

authors： Gandar F,Wilkie GS,Gatherer D,Kerr K,Marlier D,Diez M,Marschang RE,Mast J,Dewals BG,Davison AJ,Vanderplasschen AF

更新日期：2015-11-01 00:00:00

abstract：:We have analyzed the effects of reducing conditions on the folding of the spike (S) protein and on the intracellular transport of the membrane (M) protein of the mouse hepatitis coronavirus. These proteins differ in their potential to form disulfide bonds in the lumen of the endoplasmic reticulum (ER). Intrachain disu...

journal_title：Journal of virology

authors： Opstelten DJ,de Groote P,Horzinek MC,Vennema H,Rottier PJ

更新日期：1993-12-01 00:00:00

abstract：UNLABELLED:Barrier dysfunction of airway epithelium may increase the risk for acquiring secondary infections or allergen sensitization. Both rhinovirus (RV) and polyinosinic-polycytidilic acid [poly(I·C)], a double-stranded RNA (dsRNA) mimetic, cause airway epithelial barrier dysfunction, which is reactive oxygen speci...

journal_title：Journal of virology

authors： Unger BL,Ganesan S,Comstock AT,Faris AN,Hershenson MB,Sajjan US

更新日期：2014-04-01 00:00:00

abstract：:The therapeutic efficacy of direct drug infusion into the brain, the target organ of transmissible spongiform encephalopathies, was assessed in transgenic mice intracerebrally infected with 263K scrapie agent. Pentosan polysulfate (PPS) gave the most dramatic prolongation of the incubation period, and amphotericin B h...

journal_title：Journal of virology

authors： Doh-ura K,Ishikawa K,Murakami-Kubo I,Sasaki K,Mohri S,Race R,Iwaki T

更新日期：2004-05-01 00:00:00

abstract：:Viral protein R (Vpr) of human immunodeficiency virus type 1 has potent karyophilic properties, but details of the mechanism by which it enters the nucleus remain to be clarified. We reported previously that two regions, located between residues 17 and 34 (alphaH1) and between residues 46 and 74 (alphaH2), are indispe...

journal_title：Journal of virology

authors： Kamata M,Nitahara-Kasahara Y,Miyamoto Y,Yoneda Y,Aida Y

更新日期：2005-03-01 00:00:00

abstract：UNLABELLED:PD-1 is an inhibitory receptor that has a major role in T cell dysfunction during chronic infections and cancer. While demethylation of the PD-1 promoter DNA is observed in exhausted T cells isolated from chronically infected individuals, little is known about when this stable demethylation of PD-1 promoter ...

journal_title：Journal of virology

authors： Ahn E,Youngblood B,Lee J,Lee J,Sarkar S,Ahmed R

更新日期：2016-09-12 00:00:00

abstract：:The recent finding that the E1 glycoproteins of murine coronaviruses contain only O-linked oligosaccharides suggested that this unusual modification might be a distinguishing feature of coronaviruses and might play an essential role in the life cycle of this family of viruses. To examine these possibilities, we analyz...

journal_title：Journal of virology

authors： Stern DF,Sefton BM

更新日期：1982-12-01 00:00:00

abstract：:Interferon (IFN) signal transduction involves interferon regulatory factors (IRF). Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four IRF homologues: viral IRF 1 (vIRF-1) to vIRF-4. Previous functional studies revealed that the first exon of vIRF-2 inhibited alpha/beta interferon (IFN-alpha/beta) signaling. W...

journal_title：Journal of virology

authors： Fuld S,Cunningham C,Klucher K,Davison AJ,Blackbourn DJ

更新日期：2006-03-01 00:00:00

abstract：:Coxsackievirus B3 (CB3) firmly attaches to HeLa cells, forming a specific complex between the virus and its receptor on the cell surface. We extracted this virus-receptor complex (VRC) with the detergents sodium deoxycholate and Triton X-100. The VRC was identified by its sedimentation coefficient (140S), which was le...

journal_title：Journal of virology

authors： Mapoles JE,Krah DL,Crowell RL

更新日期：1985-09-01 00:00:00

abstract：:The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in pho...

journal_title：Journal of virology

authors： Dackiw AP,Zakrzewski K,Nathens AB,Cheung PY,Fingerote R,Levy GA,Rotstein OD

更新日期：1995-09-01 00:00:00

abstract：:The small envelope protein of hepatitis B virus is the major component of the viral coat and is also secreted from cells as a 20-nm subviral particle, even in the absence of other viral proteins. Such empty envelope particles are composed of approximately 100 copies of this polypeptide and host-derived lipids and are ...

journal_title：Journal of virology

authors： Mangold CM,Streeck RE

更新日期：1993-08-01 00:00:00

abstract：:The inducible transcription factor NF-kappaB is commonly activated upon RNA virus infection and is a key player in the induction and regulation of the innate immune response. Borna disease virus (BDV) is a neurotropic negative-strand RNA virus, which replicates in the nucleus of the infected cell and causes a persiste...

journal_title：Journal of virology

authors： Bourteele S,Oesterle K,Pleschka S,Unterstab G,Ehrhardt C,Wolff T,Ludwig S,Planz O

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentric Castleman disease (MCD). The KSHV life cycle has two principal gene repertoires, latent and lytic. KSHV viral interleukin-6 (vIL-6), an analog of human ...

journal_title：Journal of virology

authors： Hu D,Wang V,Yang M,Abdullah S,Davis DA,Uldrick TS,Polizzotto MN,Veeranna RP,Pittaluga S,Tosato G,Yarchoan R

更新日期：2015-10-21 00:00:00

abstract：:Two serologically distinguishable primate herpesviruses, Herpesvirus aotus type 1 and type 3, were examined with regard to their genomes and structural polypeptides. The duplex DNA genomes of these two viruses were found to be essentially identical in molecular weight (Mr approximately equal to 145 X 10(6)) and guanin...

journal_title：Journal of virology

authors： Ebeling A,Keil G,Nowak B,Fleckenstein B,Berthelot N,Sheldrick P

更新日期：1983-02-01 00:00:00

abstract：:A variant of human T-cell leukemia virus subgroup I (HTLV-I), designated HTLV-Ib, has been isolated from a transformed T-lymphocytic cell line established from a Zairian patient with adult T-cell lymphoma. A recombinant phage clone of the variant provirus, denoted lambda MC-1, hybridizes under high stringency to HTLV-...

journal_title：Journal of virology

authors： Ratner L,Josephs SF,Starcich B,Hahn B,Shaw GM,Gallo RC,Wong-Staal F

更新日期：1985-06-01 00:00:00

abstract：:The mechanism by which bovine herpesvirus 1 (BHV-1) predisposes cattle to bacterial pneumonia was investigated by using an in vitro system to demonstrate immunosuppression. At a multiplicity of infection of 0.001, live or inactivated BHV-1 induced a 50% inhibition of the proliferative response of peripheral blood mono...

journal_title：Journal of virology

authors： Hutchings DL,Campos M,Qualtiere L,Babiuk LA

更新日期：1990-09-01 00:00:00

abstract：:The TAATGARAT motif in the herpes simplex virus (HSV) immediate-early (IE) gene promoters plays a key role in their activation by the Oct-1-Vmw65 complex, but its role in mediating inhibitory effects of cellular octamer-binding proteins is less clear. We have used indicator viruses containing reporter constructs with ...

journal_title：Journal of virology

authors： Thomas S,Coffin RS,Watts P,Gough G,Latchman DS

更新日期：1998-04-01 00:00:00

abstract：:Hepatitis C virus core protein forms the viral nucleocapsid and plays a critical role in the formation of infectious particles. In this study, we demonstrate that the highly conserved residue G33, located within domain 1 of the core protein, is important for the production of cell culture-infectious virus (HCVcc). Ala...

journal_title：Journal of virology

authors： Angus AG,Loquet A,Stack SJ,Dalrymple D,Gatherer D,Penin F,Patel AH

更新日期：2012-01-01 00:00:00

abstract：:Infectious hematopoietic necrosis virus (IHNV) is a rhabdovirus that produces an acute, lethal infection in rainbow trout (Oncorhynchus mykiss). Fish that survive infection cease to produce detectable infectious virus at approximately 46 days after infection, yet there is evidence that survivor fish continue to harbor...

journal_title：Journal of virology

authors： Kim CH,Dummer DM,Chiou PP,Leong JA

更新日期：1999-01-01 00:00:00

abstract：:The expression of interleukin-2 (IL-2) has been implicated in the modulation of the outcome of ocular infection with herpes simplex virus type 1 (HSV-1); however, its effects remain controversial. To clarify the role of IL-2, we constructed a recombinant HSV-1 (HSV-IL-2) that expresses two copies of the murine IL-2 ge...

journal_title：Journal of virology

authors： Ghiasi H,Osorio Y,Perng GC,Nesburn AB,Wechsler SL

更新日期：2002-09-01 00:00:00

abstract：:New zonal centrifuges can conveniently process as much as five orders of magnitude (10(5)) greater sample volumes than conventional swinging-bucket rotors. The continuous-sample-flow-with-banding versions may be used in series with ancillary purification procedures. Here we have studied the combined process: absorptio...

journal_title：Journal of virology

authors： Reimer CB,Baker RS,Van Frank RM,Newlin TE,Cline GB,Anderson NG

更新日期：1967-12-01 00:00:00

abstract：:The herpes simplex virus type 1 UL6 protein forms a 12-subunit ring structure at a unique capsid vertex which functions as a conduit for encapsidation of the viral genome. To characterize UL6 protein domains that are involved in intersubunit interactions and interactions with other capsid proteins, we engineered a set...

journal_title：Journal of virology

authors： Nellissery JK,Szczepaniak R,Lamberti C,Weller SK

更新日期：2007-09-01 00:00:00

abstract：:Coronavirus subgenomic mRNA possesses a 5'-end leader sequence which is derived from the 5' end of genomic RNA and is linked to the mRNA body sequence. This study examined whether coronavirus transcription involves a discontinuous transcription step; the possibility that a leader sequence from mouse hepatitis virus (M...

journal_title：Journal of virology

authors： Jeong YS,Makino S

更新日期：1994-04-01 00:00:00

abstract：:We have evaluated the physical state and infectious nature of Kaposi's sarcoma-associated herpesvirus (KSHV) in the saliva of nine persons with past or current Kaposi's sarcoma (KS). KSHV DNA in saliva had the physical characteristics of DNA present in virions. Inoculation of 293 cells with cell-free saliva fluid resu...

journal_title：Journal of virology

authors： Vieira J,Huang ML,Koelle DM,Corey L

更新日期：1997-09-01 00:00:00

abstract：:Mature nonstructural protein-15 (nsp15) from the severe acute respiratory syndrome coronavirus (SARS-CoV) contains a novel uridylate-specific Mn2+-dependent endoribonuclease (NendoU). Structure studies of the full-length form of the obligate hexameric enzyme from two CoVs, SARS-CoV and murine hepatitis virus, and its ...

journal_title：Journal of virology

authors： Joseph JS,Saikatendu KS,Subramanian V,Neuman BW,Buchmeier MJ,Stevens RC,Kuhn P

更新日期：2007-06-01 00:00:00

abstract：:The influenza A virus (IAV) M2 protein is a multifunctional protein with critical roles in virion entry, assembly, and budding. M2 is targeted to the apical plasma membrane of polarized epithelial cells, and the interaction of the viral proteins M2, M1, HA, and NA near glycolipid rafts in the apical plasma membrane is...

journal_title：Journal of virology

authors： Wohlgemuth N,Lane AP,Pekosz A

更新日期：2018-10-29 00:00:00

abstract：:The relatively small package capacity (less than 5 kb) of adeno-associated virus (AAV) vectors has been effectively doubled with the development of dual-vector heterodimerization approaches. However, the efficiency of such dual-vector systems is limited not only by the extent to which intermolecular recombination occu...

journal_title：Journal of virology

authors： Yan Z,Zak R,Zhang Y,Engelhardt JF

更新日期：2005-01-01 00:00:00

abstract：:Eucaryotic, viral, and bacteriophage DNA polymerases of the alpha-like family share blocks of sequence similarity, the most conserved of which has been designated region I. Region I includes a YGDTDS motif that is almost invariant within the alpha-like family and that is similar to a motif conserved among RNA-directed...

journal_title：Journal of virology

authors： Marcy AI,Hwang CB,Ruffner KL,Coen DM

更新日期：1990-12-01 00:00:00

abstract：:The majority of HIV-1 infections around the world result from non-B clade HIV-1 strains. The CRF01_AE (AE) strain is seen principally in Southeast Asia. AE protease differs by approximately 10% in amino acid sequence from clade B protease and carries several naturally occurring polymorphisms that are associated with d...

journal_title：Journal of virology

authors： Bandaranayake RM,Kolli M,King NM,Nalivaika EA,Heroux A,Kakizawa J,Sugiura W,Schiffer CA

更新日期：2010-10-01 00:00:00