Abstract:
:Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional partner of HTLV-1 envelope (Env) proteins. HTLV-1 Env and NRP1 complexes are formed in cotransfected cells, and endogenous NRP1 contributes to the binding of HTLV-1 Env to target cells. NRP1 overexpression increases HTLV-1 Env-dependent syncytium formation. Moreover, overexpression of NRP1 increases both HTLV-1 and HTLV-2 Env-dependent infection, whereas down-regulation of endogenous NRP1 has the opposite effect. Finally, overexpressed GLUT1, NRP1, and Env form ternary complexes in transfected cells, and endogenous NRP1 and GLUT1 colocalize in membrane junctions formed between uninfected and HTLV-1-infected T cells. These data show that NRP1 is involved in HTLV-1 and HTLV-2 entry, suggesting that the HTLV receptor has a multicomponent nature.
journal_name
J Viroljournal_title
Journal of virologyauthors
Ghez D,Lepelletier Y,Lambert S,Fourneau JM,Blot V,Janvier S,Arnulf B,van Endert PM,Heveker N,Pique C,Hermine Odoi
10.1128/JVI.02719-05subject
Has Abstractpub_date
2006-07-01 00:00:00pages
6844-54issue
14eissn
0022-538Xissn
1098-5514pii
80/14/6844journal_volume
80pub_type
杂志文章abstract::The sequence of the S RNA of La Crosse bunyavirus was deduced from analyses of DNA copies cloned in the Escherichia coli plasmid pBR322. The S RNA is 984 nucleotides in length, has a base ratio of 31.8% U, 27.0% A, 23.2% C, and 18.0% G, and codes for two distinct gene products that are read from overlapping reading fr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.45.3.1155-1158.1983
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.11.7309-7314.1995
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/jvi.77.24.13232-13247.2003
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.8.4914-4923.1995
更新日期:1995-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.1.143-152.1979
更新日期:1979-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.9.4759-4768.1991
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.2.3.178-181.1968
更新日期:1968-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.11.7517-7526.1996
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.44.3.877-881.1982
更新日期:1982-12-01 00:00:00
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.3.739-747.1984
更新日期:1984-06-01 00:00:00
abstract::Herpesvirus saimiri (HVS) is the prototype gamma-2 herpesvirus, which naturally infects the squirrel monkey Saimiri sciureus, causing an asymptomatic but persistent infection. The latent phase of gamma-2 herpesviruses is characterized by their ability to persist in a dividing cell population while expressing a limited...
journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.2.916-922.1995
更新日期:1995-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00