Rotavirus-induced structural and functional alterations in tight junctions of polarized intestinal Caco-2 cell monolayers.

abstract：:Viruses cause about 15% of the cancers that are still the leading causes of human mortality. The discovery of viral oncogenes has enhanced our understanding of viral oncogenesis. However, the underlying molecular mechanisms of virus-induced cancers are complex and require further investigation. The present study has a...

journal_title：Journal of virology

authors： Xu S,Xue C,Li J,Bi Y,Cao Y

更新日期：2011-01-01 00:00:00

abstract：:In the search for effective immunologic interventions to prevent and treat HIV-1 infection, standardized reference reagents are a cost-effective way to maintain robustness and reproducibility among immunological assays. To support planned and ongoing studies where clade C predominates, here we describe three virus pan...

journal_title：Journal of virology

authors： Hraber P,Rademeyer C,Williamson C,Seaman MS,Gottardo R,Tang H,Greene K,Gao H,LaBranche C,Mascola JR,Morris L,Montefiori DC,Korber B

更新日期：2017-09-12 00:00:00

abstract：:The gB glycoprotein of herpes simplex virus type 1 is involved in viral entry and fusion and contains a predicted membrane-anchoring sequence of 69 hydrophobic amino acids, which can span the membrane three times, near the carboxy terminus. To define the membrane-anchoring sequence and the role of this hydrophobic str...

journal_title：Journal of virology

authors： Rasile L,Ghosh K,Raviprakash K,Ghosh HP

更新日期：1993-08-01 00:00:00

abstract：:Major neutralization antigenic sites have been previously mapped by us on VP1, the largest capsid protein of poliovirus type 1. Here we report the first identification of the primary sequence of a neutralization antigenic site on capsid protein VP2. Inspection of the amino acid sequence of VP2 led to the selection and...

journal_title：Journal of virology

authors： Emini EA,Jameson BA,Wimmer E

更新日期：1984-11-01 00:00:00

abstract：:A gene encoding the large T antigen of polyomavirus was inserted into the baculovirus Autographa californica nuclear polyhedrosis virus so that gene expression was under the control of the strong, very late polyhedrin gene promoter. Significantly more large T antigen was produced in recombinant virus-infected insect c...

journal_title：Journal of virology

authors： Rice WC,Lorimer HE,Prives C,Miller LK

更新日期：1987-05-01 00:00:00

abstract：:We describe initial genetic and structural characterizations of HK97, a temperate bacteriophage of Escherichia coli. We isolated 28 amber mutants, characterized them with respect to what phage-related structures they make, and mapped many of them to restriction fragments of genomic DNA. Sodium dodecyl sulfate-polyacry...

journal_title：Journal of virology

authors： Popa MP,McKelvey TA,Hempel J,Hendrix RW

更新日期：1991-06-01 00:00:00

abstract：:Retroviruses, as a result of the presence of two identical genomic RNA molecules in their virions, recombine at a high rate. When nonhomologous RNA is present in the dimer RNA molecules, nonhomologous recombination can occur, although the rate is very low, only 0.1% of the rate of essentially homologous recombination ...

journal_title：Journal of virology

authors： Zhang J,Temin HM

更新日期：1994-04-01 00:00:00

abstract：:We isolated a simian virus 40 mutant, dl2194, which carried deletions in both early genes. One deletion removed 234 base pairs in the 54/59 region within the small-t-antigen coding sequence and the large-T-antigen gene intron. The second deletion removed 57 base pairs at the C terminus of the large-T-antigen coding se...

journal_title：Journal of virology

authors： Feunteun J,Carmichael G,Nicolas JC,Kress M

更新日期：1981-12-01 00:00:00

abstract：:Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that has a worldwide distribution in the population of cattle. Many factors make human contamination by BoHV-4 likely to occur. In this study, we performed in vitro experiments to assess the risk and the consequences of human infection by BoHV-4. First, by using a re...

journal_title：Journal of virology

authors： Gillet L,Minner F,Detry B,Farnir F,Willems L,Lambot M,Thiry E,Pastoret PP,Schynts F,Vanderplasschen A

更新日期：2004-03-01 00:00:00

abstract：:T-cell responses of pigs to hog cholera virus (HCV) have reportedly been absent or difficult to detect. Therefore, little is known about cellular immunity to HCV. In this study, we used an attenuated strain of pseudorabies virus expressing the envelope glycoprotein E1 of HCV and purified recombinant E1 to examine whet...

journal_title：Journal of virology

authors： Kimman TG,Bianchi AT,Wensvoort G,de Bruin TG,Meliefste C

更新日期：1993-05-01 00:00:00

abstract：:The purpose of this study was to determine whether a cell surface protein that can serve as coreceptor for herpes simplex virus type 1 (HSV-1) entry, herpesvirus entry mediator (previously designated HVEM but renamed HveA), also mediates HSV-1-induced cell-cell fusion. We found that transfection of DNA from KOS-804, a...

journal_title：Journal of virology

authors： Terry-Allison T,Montgomery RI,Whitbeck JC,Xu R,Cohen GH,Eisenberg RJ,Spear PG

更新日期：1998-07-01 00:00:00

abstract：:We have studied protein synthesis in cultured cells infected with the six noncytopathic (nc) mutants of the Australia-Victoria strain (AV-WT) of Newcastle disease virus and their plaque-forming revertants. Virus-specific polypeptides accumulated at 30 to 63% of wild-type levels in nc mutant-infected cells and between ...

journal_title：Journal of virology

authors： Madansky CH,Bratt MA

更新日期：1981-12-01 00:00:00

abstract：:The ascomycete Botrytis porri causes clove rot and leaf blight of garlic worldwide. We report here the biological and molecular features of a novel bipartite double-stranded RNA (dsRNA) mycovirus named Botrytis porri RNA virus 1 (BpRV1) from the hypovirulent strain GarlicBc-72 of B. porri. The BpRV1 genome comprises t...

journal_title：Journal of virology

authors： Wu M,Jin F,Zhang J,Yang L,Jiang D,Li G

更新日期：2012-06-01 00:00:00

abstract：:Nonpermissive 3T3 cells were infected with purified superhelical simian virus 40 (SV40) deoxyribonucleic acid I (DNA I). One hour after infection, approximately 60% of the intracellular SV40 DNA was converted to relaxed forms. One day after infection, all intracellular SV40 DNA was present as slow-sedimenting material...

journal_title：Journal of virology

authors： Collins CJ,Sauer G

更新日期：1972-09-01 00:00:00

abstract：:Physiological microenvironments such as blood, seminal plasma, mucosal secretions, or lymphatic fluids may influence the biology of the virus-host cell and immune interactions for human immunodeficiency virus type 1 (HIV-1). Relative to media, physiological levels of human plasma were found to enhance the infectivity ...

journal_title：Journal of virology

authors： Wu SC,Spouge JL,Conley SR,Tsai WP,Merges MJ,Nara PL

更新日期：1995-10-01 00:00:00

abstract：:GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely wi...

journal_title：Journal of virology

authors： Takenouchi N,Jones KS,Lisinski I,Fugo K,Yao K,Cushman SW,Ruscetti FW,Jacobson S

更新日期：2007-02-01 00:00:00

abstract：:The human cytomegalovirus UL47 open reading frame encodes a 110-kDa protein that is a component of the virion tegument. We have constructed a cytomegalovirus mutant, ADsubUL47, in which the central portion of the UL47 open reading frame has been replaced by two marker genes. The mutant replicated to titers 100-fold lo...

journal_title：Journal of virology

authors： Bechtel JT,Shenk T

更新日期：2002-02-01 00:00:00

abstract：:We recently discovered an expanded family of adeno-associated viruses (AAVs) that show promise as improved gene therapy vectors. In this study we evaluated the potential of vectors based on several of these novel AAVs as vaccine carriers for human immunodeficiency virus type 1 Gag. Studies with mice indicated that vec...

journal_title：Journal of virology

authors： Lin J,Zhi Y,Mays L,Wilson JM

更新日期：2007-11-01 00:00:00

abstract：:Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mic...

journal_title：Journal of virology

authors： Yoshikai Y,Kidokoro H,Kimura K,Aoki Y,Makino M,Hiromatsu K

更新日期：1997-01-01 00:00:00

abstract：:The bacteriophage PRD1 is a lipid-bearing phage that infects a wide variety of gram-negative bacteria, including Escherichia coli and Salmonella typhimurium when they contain the appropriate plasmid. It contains a linear duplex DNA molecule that is covalently bound by its 5' ends to a terminal protein. We report here ...

journal_title：Journal of virology

authors： Gerendasy DD,Ito J

更新日期：1987-02-01 00:00:00

abstract：:The membrane-associated alphavirus RNA replication complex contains four virus-encoded subunits, the nonstructural proteins nsP1 to nsP4. Semliki Forest virus (SFV) nsP1 is hydrophobically modified by palmitoylation of cysteines 418 to 420. Here we show that Sindbis virus nsP1 is also palmitoylated on the same site (c...

journal_title：Journal of virology

authors： Ahola T,Kujala P,Tuittila M,Blom T,Laakkonen P,Hinkkanen A,Auvinen P

更新日期：2000-08-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor/transcription factor that modulates several cellular and immunological processes following activation by pathogen-associated stimuli, though its role during virus infection is largely unknown. Here, we show that AhR is activated in cells infected with mouse...

journal_title：Journal of virology

authors： Grunewald ME,Shaban MG,Mackin SR,Fehr AR,Perlman S

更新日期：2020-01-17 00:00:00

abstract：UNLABELLED:Due to a scarcity of immunocompetent animal models for viral hepatitis, little is known about the early innate immune responses in the liver. In various hepatotoxic models, both pro- and anti-inflammatory activities of recruited monocytes have been described. In this study, we compared the effect of liver in...

journal_title：Journal of virology

authors： Movita D,van de Garde MD,Biesta P,Kreefft K,Haagmans B,Zuniga E,Herschke F,De Jonghe S,Janssen HL,Gama L,Boonstra A,Vanwolleghem T

更新日期：2015-05-01 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are being considered for in vivo applications of gene therapy in the treatment of a variety of disorders. This study evaluates the biology of second-generation vectors based on the novel serotypes AAV7 and AAV8 and containing self-complementary genomes in the nonhuman primate liver...

journal_title：Journal of virology

authors： Gao GP,Lu Y,Sun X,Johnston J,Calcedo R,Grant R,Wilson JM

更新日期：2006-06-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to currently available therapies and has a very poor prognosis. To prevent the development of ATL among carriers, it is important to control HTLV-1-infected cells in infected individuals. Therefore, ...

journal_title：Journal of virology

authors： Tezuka K,Okuma K,Kuramitsu M,Matsuoka S,Tanaka R,Tanaka Y,Hamaguchi I

更新日期：2018-01-30 00:00:00

abstract：:The segment of simian virus 40 (SV40) genome which is recognized as the BC domain encodes for the COOH-terminal end of the SV40 major capsid protein VP1. Mutations in this domain lead to the synthesis of a thermosensitive VP1 which fails to assemble mature SV40 at the nonpermissive temperature. We determined the DNA s...

journal_title：Journal of virology

authors： Ng SC,Behm M,Bina M

更新日期：1985-05-01 00:00:00

abstract：:The entire genome of the reference strain of bluetongue virus (BTV) serotype 16 (strain RSArrrr/16) was sequenced (a total of 23,518 base pairs). The virus was obtained from the Orbivirus Reference Collection (ORC) at IAH, Pirbright, United Kingdom. The virus strain, which was previously provided by the Onderstepoort ...

journal_title：Journal of virology

authors： Maan S,Maan NS,Singh KP,Belaganahalli MN,Guimera M,Pullinger G,Nomikou K,Mertens PP

更新日期：2012-09-01 00:00:00

abstract：:Marek's disease virus DNA appears to be wound around a central structure connecting the two inner poles of the capsid. Based on electron micrographs of Marek's disease virions, a diagram of spatial configuration of virus DNA is presented. This diagram may explain the pleomorphic character of the herpesvirus core obser...

journal_title：Journal of virology

authors： Nazerian K

更新日期：1974-05-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus (SARS-CoV) encodes numerous accessory proteins whose importance in the natural infection process is currently unclear. One of these accessory proteins is set apart by its function in the context of a related murine hepatitis virus (MHV) infection. SARS-CoV protein 6 in...

journal_title：Journal of virology

authors： Hussain S,Perlman S,Gallagher TM

更新日期：2008-07-01 00:00:00

abstract：:The distribtuion of various amino acid tRNA's in the 4S RNA components of avian myeloblastosis virus (AMV) and in 4S RNA prepared from chicken cmbryo cells, chicken myeloblasts, and chicken livers was determined. This was done by aminoacylating the 4S RNA samples with a mixture of 17 radioactive amino acids and subseq...

journal_title：Journal of virology

authors： Waters LC,Mullin BC,Bailiff EG,Popp RA

更新日期：1975-12-01 00:00:00