Abstract:
:GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely with heparan sulfate proteoglycan (HSPG) expression on target cells. Moreover, since activated CD4+ T cells and cord blood lymphocytes that are susceptible to HTLV-1 infection expressed undetectable levels of surface GLUT1, these results indicate that GLUT1 and HSPGs are important for efficient cell-to-cell transmission of HTLV-1 but raise concerns on the role of GLUT1 as the HTLV-1 primary binding receptor.
journal_name
J Viroljournal_title
Journal of virologyauthors
Takenouchi N,Jones KS,Lisinski I,Fugo K,Yao K,Cushman SW,Ruscetti FW,Jacobson Sdoi
10.1128/JVI.01522-06subject
Has Abstractpub_date
2007-02-01 00:00:00pages
1506-10issue
3eissn
0022-538Xissn
1098-5514pii
JVI.01522-06journal_volume
81pub_type
杂志文章abstract::Purified avian myeloblastosis virus was iodinated by the lactoperoxidase method. Disruption of the labeled virions and chromatography of the viral proteins showed that radioiodine was associated only with the glycoproteins of the viral envelope. Reaction of the radiolabeled virus with antiviral antibody followed by mi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.1.42-45.1974
更新日期:1974-01-01 00:00:00
abstract::High rates of genetic variation ensure the survival of RNA viruses. Although this variation is thought to result from error-prone replication, RNA viruses must also maintain highly conserved genomic segments. A balance between conserved and variable viral elements is especially important in order for viruses to avoid ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.17.8505-8517.2002
更新日期:2002-09-01 00:00:00
abstract::A human endogenous retrovirus-like element (HERV), flanked by long terminal repeats of 502 and 495 nucleotides is inserted into the human pleiotrophin (PTN) gene upstream of the open reading frame. Based on its Glu-tRNA primer binding site specificity and the location within the PTN gene, we named this element HERV-E....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.7.6065-6072.1998
更新日期:1998-07-01 00:00:00
abstract::Transcription of herpesviral late genes is stimulated after the onset of viral DNA replication but otherwise restricted. Late gene expression in gammaherpesviruses requires the coordination of six early viral proteins, termed viral transactivation factors (vTFs). Here, we mapped the organization of this protein comple...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02157-15
更新日期:2015-10-14 00:00:00
abstract::Cytotoxic T lymphocyte (CTL) activity was assessed in mice immunized with DNA plasmids containing the human immunodeficiency virus type 1 (HIV-1) gp120 envelope (pTMIgp120) or p55gag (pTMIgag) gene regulated by the bacteriophage T7 promoter. Immunization with either plasmid resulted in CTL activity against class I maj...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.10.7827-7831.1997
更新日期:1997-10-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A to PPP2R5E). While APOBEC3 antagonism is the canonical function of HIV-1 Vif, this viral accessory protein is also known to trigger G2/...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00631-20
更新日期:2020-10-14 00:00:00
abstract::Cell-to-cell movement of beet yellows closterovirus requires four structural proteins and a 6-kDa protein (p6) that is a conventional, nonstructural movement protein. Here we demonstrate that either virus infection or p6 overexpression results in association of p6 with the rough endoplasmic reticulum. The p6 protein p...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.7.3704-3709.2004
更新日期:2004-04-01 00:00:00
abstract::Rhesus rhadinovirus (RRV) is a gammaherpesvirus closely related to Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic virus linked to the development of Kaposi's sarcoma and several other lymphoproliferative diseases, including primary effusion lymphoma and multicentric Castleman's disease. RRV naturally inf...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01429-10
更新日期:2010-11-01 00:00:00
abstract::Treatment of purified simian virus 40 large T antigen (LT) with protein phosphatase 2A stimulates LT-dependent DNA unwinding and replication (D. M. Virshup, M. G. Kauffman, and T. J. Kelly, EMBO J. 8: 3891-3898, 1989). The specificity of the catalytic subunit of protein phosphatase 2A toward LT was investigated by two...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.4.2098-2101.1991
更新日期:1991-04-01 00:00:00
abstract::Retroviruses and retrotransposons insert into the host genome with no obvious sequence specificity. We examined the target sites of the retroelement ZAM by sequencing each host-ZAM junction in the genome of Drosophila melanogaster. Our overall data provide compelling evidence that ZAM integration machinery recognizes ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.8.7061-7064.1999
更新日期:1999-08-01 00:00:00
abstract::To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminu...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.9.7703-7706.1998
更新日期:1998-09-01 00:00:00
abstract::The production and selection of infectious vaccinia virus recombinants expressing foreign genes was facilitated by the construction of plasmid vectors. These vectors contain all or part of the vaccinia virus thymidine kinase (TK) gene interrupted by multiple unique restriction endonuclease sites placed adjacent to the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.49.3.857-864.1984
更新日期:1984-03-01 00:00:00
abstract::The filoviruses Ebola Zaire virus and Marburg virus are believed to infect target cells through endocytic vesicles, but the details of this pathway are unknown. We used a pseudotyping strategy to investigate the cell biology of filovirus entry. We observed that specific inhibitors of the caveola system, including chol...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.10.5266-5270.2002
更新日期:2002-05-01 00:00:00
abstract::Influenza causes significant morbidity in tropical regions; however, unlike in temperate zones, influenza in the tropics is not strongly associated with a given season. We have recently shown that influenza virus transmission in the guinea pig model is most efficient under cold, dry conditions, which are rare in the t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00325-08
更新日期:2008-06-01 00:00:00
abstract::The small and middle T (tumor) antigens of polyomavirus have been shown previously to associate with the 36-kDa catalytic subunit and the 63-kDa regulatory subunit of protein phosphatase type 2A, apparently substituting for a normal third 55-kDa regulatory subunit (D.C. Pallas, L.K. Shahrik, B.L. Martin, S. Jaspers, T...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.2.886-893.1992
更新日期:1992-02-01 00:00:00
abstract::Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 H1N1 pandemic. This pathology is induced by IAV-specific memory CD8(+) T cells cr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00936-13
更新日期:2013-12-01 00:00:00
abstract::All known DNA tumor viruses are known to target and inactivate two main cell cycle regulatory proteins, retinoblastoma protein (pRb) and p53. Inactivation of pRb promotes host cell cycle progression into S phase, and inactivation of p53 promotes cell immortalization. The DNA tumor virus Kaposi's sarcoma associated her...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.19.10336-10347.2004
更新日期:2004-10-01 00:00:00
abstract::We have examined EcoRI-restricted cellular DNA from BALB/c mouse-hamster somatic cell hybrids by blot hybridization for the presence of mouse mammary tumor virus-related sequences. Results of this analysis show that mouse mammary tumor virus-related proviral copies are located on chromosomes 16 (16-kilobase-pair fragm...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.49.3.1005-1008.1984
更新日期:1984-03-01 00:00:00
abstract::Growth of phage phi105 and its deoxyribonucleic acid (DNA) was studied in radiation-sensitive mutants of Bacillus subtilis. The recA gene is required for optimal prophage induction with mitomycin C and for infectivity of prophage DNA. rec B gene is required for marker rescue from mature DNA. The importance of bacteria...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.8.6.919-921.1971
更新日期:1971-12-01 00:00:00
abstract::Poliovirus-infected cells undergo an increase in cytoplasmic calcium concentrations from the 4th h postinfection. The protein responsible for this effect was identified by the expression of different poliovirus nonstructural proteins in HeLa cells by using a recombinant vaccinia virus system. Synthesis of protein 2BC ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.8.6214-6217.1997
更新日期:1997-08-01 00:00:00
abstract::Six overlapping viral RNAs are synthesized in cells infected with the avian coronavirus infectious bronchitis virus (IBV). These RNAs contain a 3'-coterminal nested sequence set and were assumed to be viral mRNAs. The seven major IBV virion proteins are all produced by processing of three polypeptides of ca. 23, 51, a...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.1.22-29.1984
更新日期:1984-04-01 00:00:00
abstract::Kilham rat virus (KRV) contains linear, single-stranded DNA in the virion. The fate of radioactive viral DNA was followed after infection of monolayer cells. Within 60 min after infection of cells, 28 to 42% of the parental viral DNA is converted to a new form. This new DNA form is believed to be double stranded and l...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.11.2.299-305.1973
更新日期:1973-02-01 00:00:00
abstract:UNLABELLED:To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) tegument protein UL51 promotes viral replication, we screened for viral proteins that interact with UL51 in infected cells. Affinity purification of tagged UL51 in HSV-1-infected Vero cells was coupled with immunoblotting of th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01258-16
更新日期:2016-09-12 00:00:00
abstract::Differential effect of various metabolic inhibitors on the development of hemadsorption activity and virus formation in cells infected with Newcastle disease virus (NDV) was investigated. It was found that, in BHK-21 cells infected with NDV, cycloheximide did not prevent the development of hemadsorption activity, wher...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.11.4.479-486.1973
更新日期:1973-04-01 00:00:00
abstract::Inhibition of hepatitis B virus (HBV) replication and viral clearance from an infected host requires both the innate and adaptive immune responses. Expression of interferon (IFN)-inducible proteasome catalytic and regulatory subunits correlates with the IFN-alpha/beta- and IFN-gamma-mediated noncytopathic inhibition o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01779-06
更新日期:2007-01-01 00:00:00
abstract::Glycoprotein B (gB) is a conserved herpesvirus virion component implicated in membrane fusion. As with many-but not all-herpesviruses, the gB of murid herpesvirus 4 (MuHV-4) is cleaved into disulfide-linked subunits, apparently by furin. Preventing gB cleavage for some herpesviruses causes minor infection deficits in ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00709-13
更新日期:2013-10-01 00:00:00
abstract::Interaction of the C-terminal domains of Sendai virus (SeV) P and N proteins is crucial for RNA synthesis by correctly positioning the polymerase complex (L+P) onto the nucleocapsid (N/RNA). To better understand this mechanism within the paramyxovirus family, we have studied the complex formed by the SeV C-terminal do...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00338-07
更新日期:2007-07-01 00:00:00
abstract::Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role in more-significant respiratory illnesses, including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respirato...
journal_title:Journal of virology
pub_type: 杂志文章,评审
doi:10.1128/JVI.02290-09
更新日期:2010-08-01 00:00:00
abstract::The fusion (F) protein of simian virus 5 (strain W3A) induced extensive cell fusion in BHK cells when expressed alone, while that of strain WR did not. Mutational analysis demonstrated that the fusing activity can be transferred to the WR F protein by a proline residue at position 22 of subunit W3A F2. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.12.9855-9858.1997
更新日期:1997-12-01 00:00:00
abstract::Growth of bacteriophage T7 is inhibited by the antibiotic coumermycin A1, an inhibitor of the Escherichia coli DNA gyrase. Since growth of the phage is insensitive to the antibiotic in strains containing a coumermycin-resistant DNA gyrase, this enzyme appears to be required for phage growth. We have investigated the e...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.2.529-535.1979
更新日期:1979-02-01 00:00:00