Abstract:
:Transcription of herpesviral late genes is stimulated after the onset of viral DNA replication but otherwise restricted. Late gene expression in gammaherpesviruses requires the coordination of six early viral proteins, termed viral transactivation factors (vTFs). Here, we mapped the organization of this protein complex for Kaposi's sarcoma-associated herpesvirus. Disruption of this complex via point mutation of the interaction interface between the open reading frame 24 (ORF24) and ORF34 vTFs ablated both late gene expression and viral replication.
journal_name
J Viroljournal_title
Journal of virologyauthors
Davis ZH,Hesser CR,Park J,Glaunsinger BAdoi
10.1128/JVI.02157-15subject
Has Abstractpub_date
2015-10-14 00:00:00pages
599-604issue
1eissn
0022-538Xissn
1098-5514pii
JVI.02157-15journal_volume
90pub_type
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