Maintenance of an intact human immunodeficiency virus type 1 vpr gene following mother-to-infant transmission.


:The vpr sequences from six human immunodeficiency virus type 1 (HIV-1)-infected mother-infant pairs following perinatal transmission were analyzed. We found that 153 of the 166 clones analyzed from uncultured peripheral blood mononuclear cell DNA samples showed a 92.17% frequency of intact vpr open reading frames. There was a low degree of heterogeneity of vpr genes within mothers, within infants, and between epidemiologically linked mother-infant pairs. The distances between vpr sequences were greater in epidemiologically unlinked individuals than in epidemiologically linked mother-infant pairs. Moreover, the infants' sequences displayed patterns similar to those seen in their mothers. The functional domains essential for Vpr activity, including virion incorporation, nuclear import, and cell cycle arrest and differentiation were highly conserved in most of the sequences. Phylogenetic analyses of 166 mother-infant pairs and 195 other available vpr sequences from HIV databases formed distinct clusters for each mother-infant pair and for other vpr sequences and grouped the six mother-infant pairs' sequences with subtype B sequences. A high degree of conservation of intact and functional vpr supports the notion that vpr plays an important role in HIV-1 infection and replication in mother-infant isolates that are involved in perinatal transmission.


J Virol


Journal of virology


Yedavalli VR,Chappey C,Ahmad N




Has Abstract


1998-08-01 00:00:00












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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

    更新日期:2018-08-29 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Nuss DL,Koch G

    更新日期:1975-01-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Shestakova E,Bandu MT,Doly J,Bonnefoy E

    更新日期:2001-04-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Farr GA,Cotmore SF,Tattersall P

    更新日期:2006-01-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Naeve CW,Summers DF

    更新日期:1980-06-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


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    更新日期:2019-10-15 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Denesvre C,Blondeau C,Lemesle M,Le Vern Y,Vautherot D,Roingeard P,Vautherot JF

    更新日期:2007-11-01 00:00:00

  • The polymerase-like core of brome mosaic virus 2a protein, lacking a region interacting with viral 1a protein in vitro, maintains activity and 1a selectivity in RNA replication.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Smirnyagina E,Lin NS,Ahlquist P

    更新日期:1996-07-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Gretch DR,Kari B,Gehrz RC,Stinski MF

    更新日期:1988-06-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: O'Connor CM,Vanicek J,Murphy EA

    更新日期:2014-05-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Lin J,Cheng N,Chow M,Filman DJ,Steven AC,Hogle JM,Belnap DM

    更新日期:2011-10-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Jing X,Cerveny M,Yang K,He B

    更新日期:2004-07-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Song S,Pitot HC,Lambert PF

    更新日期:1999-07-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Flores J,Sears J,Schael IP,White L,Garcia D,Lanata C,Kapikian AZ

    更新日期:1990-08-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Yen HL,Lipatov AS,Ilyushina NA,Govorkova EA,Franks J,Yilmaz N,Douglas A,Hay A,Krauss S,Rehg JE,Hoffmann E,Webster RG

    更新日期:2007-07-01 00:00:00

  • The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation.

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    journal_title:Journal of virology

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    authors: Valle C,Martin B,Debart F,Vasseur JJ,Imbert I,Canard B,Coutard B,Decroly E

    更新日期:2020-06-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Men R,Bray M,Clark D,Chanock RM,Lai CJ

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Bigornia L,Lockridge KM,Sparger EE

    更新日期:2001-01-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Bakker AB,Marissen WE,Kramer RA,Rice AB,Weldon WC,Niezgoda M,Hanlon CA,Thijsse S,Backus HH,de Kruif J,Dietzschold B,Rupprecht CE,Goudsmit J

    更新日期:2005-07-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Jeang KT,Boros I,Brady J,Radonovich M,Khoury G

    更新日期:1988-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Winkler M,Rice SA,Stamminger T

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Pilon AA,Desjardins P,Hassell JA,Mes-Masson AM

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ortin J,Vińuela E

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    journal_title:Journal of virology

    pub_type: 杂志文章


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    更新日期:2018-07-17 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Bale JF Jr,O'Neil ME

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Honda-Okubo Y,Barnard D,Ong CH,Peng BH,Tseng CT,Petrovsky N

    更新日期:2015-03-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Dobie K,Barron R

    更新日期:2013-05-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Levin JG,Hu SC,Rein A,Messer LI,Gerwin BI

    更新日期:1984-08-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Komuro A,Horvath CM

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Tvarogová J,Madhugiri R,Bylapudi G,Ferguson LJ,Karl N,Ziebuhr J

    更新日期:2019-05-29 00:00:00