Maintenance of an intact human immunodeficiency virus type 1 vpr gene following mother-to-infant transmission.

abstract：:Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...

journal_title：Journal of virology

authors： Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

更新日期：2018-08-29 00:00:00

abstract：:Synthesis of the vesicular stomatitis virus membrane matrix protein and the glycoprotein is inhibited to a greater extent than the synthesis of the nucleocapsid protein, the nonstructural protein, and the large protein when the rate of peptide chain initiation is reduced by exposure of vesicular stomatitis virus-infec...

journal_title：Journal of virology

authors： Nuss DL,Koch G

更新日期：1975-01-01 00:00:00

abstract：:The induction of alpha/beta interferon (IFN-alpha/beta) genes constitutes one of the first responses of the cell to virus infection. The IFN-beta gene is constitutively repressed in uninfected cells and is transiently activated after virus infection. In this work we demonstrate that histone deacetylation regulates the...

journal_title：Journal of virology

authors： Shestakova E,Bandu MT,Doly J,Bonnefoy E

更新日期：2001-04-01 00:00:00

abstract：:Cylindrical projections surrounding the fivefold-symmetry axes in minute virus of mice (MVM) harbor central pores that penetrate through the virion shell. In newly released DNA-containing particles, these pores contain residues 28 to 38 belonging to a single copy of VP2, disposed so that its extreme N-terminal domain ...

journal_title：Journal of virology

authors： Farr GA,Cotmore SF,Tattersall P

更新日期：2006-01-01 00:00:00

abstract：:The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...

journal_title：Journal of virology

authors： Naeve CW,Summers DF

更新日期：1980-06-01 00:00:00

abstract：:Dengue virus (DENV) infection causes serious clinical symptoms, including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular permeability change is the main feature of the diseases, and the abnormal expression of proinflammatory cytokines is the important cause of vascular permeability change. Ho...

journal_title：Journal of virology

authors： Pan P,Zhang Q,Liu W,Wang W,Lao Z,Zhang W,Shen M,Wan P,Xiao F,Liu F,Zhang W,Tan Q,Liu X,Wu K,Liu Y,Li G,Wu J

更新日期：2019-10-15 00:00:00

abstract：:Marek's disease virus (MDV) is an alphaherpesvirus for which infection is strictly cell associated in permissive cell culture systems. In contrast to most other alphaherpesviruses, no comprehensive ultrastructural study has been published to date describing the different stages of MDV morphogenesis. To circumvent prob...

journal_title：Journal of virology

authors： Denesvre C,Blondeau C,Lemesle M,Le Vern Y,Vautherot D,Roingeard P,Vautherot JF

更新日期：2007-11-01 00:00:00

abstract：:Brome mosaic virus (BMV), a member of the alphavirus-like super-family of positive-strand RNA viruses, encodes two proteins required for viral RNA replication: 1a and 2a. 1a contains m7G methyltransferase- and helicase-like domains, while 2a contains a polymerase (pol)-like core flanked by N- and C-terminal extensions...

journal_title：Journal of virology

authors： Smirnyagina E,Lin NS,Ahlquist P

更新日期：1996-07-01 00:00:00

abstract：:The HXLF (HindIII-X left reading frame) gene family is a group of five genes that share one or two regions of homology and are arranged in tandem within the short unique component of the human cytomegalovirus genome (K. Weston and B.G. Barrell, J. Mol. Biol. 192:177-208, 1986). These genes were cloned into an SP6 expr...

journal_title：Journal of virology

authors： Gretch DR,Kari B,Gehrz RC,Stinski MF

更新日期：1988-06-01 00:00:00

abstract：UNLABELLED:Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients, underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular microRNAs (miRNAs) in cells that promote latency to regulate exp...

journal_title：Journal of virology

authors： O'Connor CM,Vanicek J,Murphy EA

更新日期：2014-05-01 00:00:00

abstract：:During cell entry, native poliovirus (160S) converts to a cell-entry intermediate (135S) particle, resulting in the externalization of capsid proteins VP4 and the amino terminus of VP1 (residues 1 to 53). Externalization of these entities is followed by release of the RNA genome (uncoating), leaving an empty (80S) par...

journal_title：Journal of virology

authors： Lin J,Cheng N,Chow M,Filman DJ,Steven AC,Hogle JM,Belnap DM

更新日期：2011-10-01 00:00:00

abstract：:The ability of the gamma(1)34.5 protein to suppress the PKR response plays a crucial role in herpes simplex virus pathogenesis. In this process, the gamma(1)34.5 protein associates with protein phosphatase 1 to form a large complex that dephosphorylates eIF-2alpha and thereby prevents translation shutoff mediated by P...

journal_title：Journal of virology

authors： Jing X,Cerveny M,Yang K,He B

更新日期：2004-07-01 00:00:00

abstract：:High-risk human papillomaviruses (HPVs) are the causative agents of certain human cancers. HPV type 16 (HPV16) is the papillomavirus most frequently associated with cervical cancer in women. The E6 and E7 genes of HPV are expressed in cells derived from these cancers and can transform cells in tissue culture. Animal e...

journal_title：Journal of virology

authors： Song S,Pitot HC,Lambert PF

更新日期：1999-07-01 00:00:00

abstract：:We have synthesized 32P-labeled hybridization probes from a hyperdivergent region (nucleotides 51 to 392) of the rotavirus gene encoding the VP7 glycoprotein by using the polymerase chain reaction method. Both RNA (after an initial reverse transcription step) and cloned cDNA from human rotavirus serotypes 1 through 4 ...

journal_title：Journal of virology

authors： Flores J,Sears J,Schael IP,White L,Garcia D,Lanata C,Kapikian AZ

更新日期：1990-08-01 00:00:00

abstract：:The abilities to infect and transmit efficiently among humans are essential for a novel influenza A virus to cause a pandemic. To evaluate the pandemic potential of widely disseminated H5N1 influenza viruses, a ferret contact model using experimental groups comprised of one inoculated ferret and two contact ferrets wa...

journal_title：Journal of virology

authors： Yen HL,Lipatov AS,Ilyushina NA,Govorkova EA,Franks J,Yilmaz N,Douglas A,Hay A,Krauss S,Rehg JE,Hoffmann E,Webster RG

更新日期：2007-07-01 00:00:00

abstract：:The large (L) protein of Ebola virus is a key protein for virus replication. Its N-terminal region harbors the RNA-dependent RNA polymerase activity, and its C terminus contains a cap assembling line composed of a capping domain and a methyltransferase domain (MTase) followed by a C-terminal domain (CTD) of unknown fu...

journal_title：Journal of virology

authors： Valle C,Martin B,Debart F,Vasseur JJ,Imbert I,Canard B,Coutard B,Decroly E

更新日期：2020-06-01 00:00:00

abstract：:The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3' noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne fl...

journal_title：Journal of virology

authors： Men R,Bray M,Clark D,Chanock RM,Lai CJ

更新日期：1996-06-01 00:00:00

abstract：:AP-1- and ATF-binding sites are cis-acting transcriptional elements within the U3 domain of the feline immunodeficiency virus (FIV) long terminal repeat (LTR) that serve as targets for cellular activation pathways and may regulate virus replication. We report that FIV LTR mutant proviruses encoding U3 deletions of the...

journal_title：Journal of virology

authors： Bigornia L,Lockridge KM,Sparger EE

更新日期：2001-01-01 00:00:00

abstract：:The need to replace rabies immune globulin (RIG) as an essential component of rabies postexposure prophylaxis is widely acknowledged. We set out to discover a unique combination of human monoclonal antibodies (MAbs) able to replace RIG. Stringent criteria concerning neutralizing potency, affinity, breadth of neutraliz...

journal_title：Journal of virology

authors： Bakker AB,Marissen WE,Kramer RA,Rice AB,Weldon WC,Niezgoda M,Hanlon CA,Thijsse S,Backus HH,de Kruif J,Dietzschold B,Rupprecht CE,Goudsmit J

更新日期：2005-07-01 00:00:00

abstract：:Transcriptional activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) by viral protein p40x requires a 21-base-pair (bp) sequence which is repeated three times within the LTR. This sequence contains a core octanucleotide (TGACGTCT) which has been attributed to be a cyclic-AMP (cAMP)-...

journal_title：Journal of virology

authors： Jeang KT,Boros I,Brady J,Radonovich M,Khoury G

更新日期：1988-12-01 00:00:00

abstract：:The UL69 open reading frame of human cytomegalovirus (HCMV) is homologous to the immediate-early protein ICP27 of herpes simplex virus, an essential viral regulatory protein involved in the transition from early to late gene expression. Genes with homology to ICP27 have been detected in all subclasses of herpesviruses...

journal_title：Journal of virology

authors： Winkler M,Rice SA,Stamminger T

更新日期：1994-06-01 00:00:00

abstract：:In this study, we have extensively modified the Rb-binding domain of polyomavirus large T antigen. Mutant polyomavirus large T antigens were tested for their ability to bind pRb and p107 in vitro and assayed for their capacity to immortalize primary rat embryo fibroblasts in vivo. Polyomavirus large T antigen bound pR...

journal_title：Journal of virology

authors： Pilon AA,Desjardins P,Hassell JA,Mes-Masson AM

更新日期：1996-07-01 00:00:00

abstract：:The role of the cell nucleus in the development of African swine fever virus in Vero cells has been studied. No viral growth could be detected in enucleated cells under conditions that allow normal development of Sindbis virus. Furthermore, African swine fever virus DNA synthesis was inhibited more than 95% after infe...

journal_title：Journal of virology

authors： Ortin J,Vińuela E

更新日期：1977-03-01 00:00:00

abstract：:The members of Flaviviridae utilize several endocytic pathways to enter a variety of host cells. Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and Rab7. The entry mechanism for CSFV into other cell lines rema...

journal_title：Journal of virology

authors： Zhang YN,Liu YY,Xiao FC,Liu CC,Liang XD,Chen J,Zhou J,Baloch AS,Kan L,Zhou B,Qiu HJ

更新日期：2018-07-17 00:00:00

abstract：:We used virus assay and in situ hybridization with a cloned fragment of the murine cytomegalovirus (MCMV) genome to study MCMV infection of circulating leukocytes harvested from 3-week-old BALB/c, C57BL/6, and C3H mice infected with MCMV intraperitoneally. Infectious virus or MCMV DNA was detected in leukocytes on day...

journal_title：Journal of virology

authors： Bale JF Jr,O'Neil ME

更新日期：1989-06-01 00:00:00

abstract：UNLABELLED:Although the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvaccine measures, coronaviruses remain a major threat to human health. The design of optimal coronavirus vaccines therefore remains a priority. Such vaccines present major challenges: coronavirus im...

journal_title：Journal of virology

authors： Honda-Okubo Y,Barnard D,Ong CH,Peng BH,Tseng CT,Petrovsky N

更新日期：2015-03-01 00:00:00

abstract：:Most current diagnostic tests for transmissible spongiform encephalopathies (TSE) rely on the presence of proteinase K (PK)-resistant PrP(Sc) (PrP-res) in postmortem tissues as an indication of TSE disease. However, a number of studies have highlighted a discrepancy between TSE infectivity and PrP-res levels in both n...

journal_title：Journal of virology

authors： Dobie K,Barron R

更新日期：2013-05-01 00:00:00

abstract：:The molecular defect in the nonconditional B-tropic MuLV pol mutant, clone 23 (Gerwin et al., J. Virol. 31:741-751, 1979), has been characterized by recombinant DNA technology. The entire mutant genome was cloned from an EcoRI digest of integrated cellular DNA into bacteriophage lambda Charon 4A and then subcloned at ...

journal_title：Journal of virology

authors： Levin JG,Hu SC,Rein A,Messer LI,Gerwin BI

更新日期：1984-08-01 00:00:00

abstract：:Antiviral innate immune responses can be triggered by accumulation of intracellular nucleic acids resulting from virus infections. Double-stranded RNA (dsRNA) can be detected by the cytoplasmic RNA helicase proteins RIG-I and MDA5, two proteins that share sequence similarities within a caspase recruitment domain (CARD...

journal_title：Journal of virology

authors： Komuro A,Horvath CM

更新日期：2006-12-01 00:00:00

abstract：:Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities, including noncanonical template-dependent polymerase activities. Here, we characterized a recombinant form of the human coronavirus 229E (HCoV-229E) nsp8 and found that the protein has metal ion-dependent RNA 3'-terminal adenylyl...

journal_title：Journal of virology

authors： Tvarogová J,Madhugiri R,Bylapudi G,Ferguson LJ,Karl N,Ziebuhr J

更新日期：2019-05-29 00:00:00