Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2.

abstract：:Molecularly defined vaccine formulations capable of inducing antiviral CD8+ T-cell-specific immunity in a manner compatible with human delivery are limited. Few molecules achieve this target without the support of an appropriate immunological adjuvant. In this study, we investigate the potential of totally synthetic p...

journal_title：Journal of virology

authors： Zhang X,Issagholian A,Berg EA,Fishman JB,Nesburn AB,BenMohamed L

更新日期：2005-12-01 00:00:00

abstract：:Characterization of endogenous ecotropic Akv proviruses in DNA of low and high leukemic mouse strains revealed the presence of one to six copies of the Akv genome per haploid genome equivalent integrated in the germ line. Low leukemic strains analyzed so far contained only one complete copy of the Akv proviral DNA. Th...

journal_title：Journal of virology

authors： Quint W,van der Putten H,Janssen F,Berns A

更新日期：1982-03-01 00:00:00

abstract：:During ϕX174 morphogenesis, 240 copies of the external scaffolding protein D organize 12 pentameric assembly intermediates into procapsids, a reaction reconstituted in vitro In previous studies, ϕX174 strains resistant to exogenously expressed dominant lethal D genes were experimentally evolved. Resistance was achieve...

journal_title：Journal of virology

authors： Cherwa JE Jr.,,Tyson J,Bedwell GJ,Brooke D,Edwards AG,Dokland T,Prevelige PE,Fane BA

更新日期：2016-12-16 00:00:00

abstract：:The parameters governing the activity of the cloned T4 gene 23, which codes for the major T4 head protein, were analyzed. Suppressor-negative bacteria carrying wild-type T4 gene 23 cloned into plasmid pCR1 or pBR322 were infected with T4 gene 23 amber phage also carrying mutations in the following genes: (i) denA and ...

journal_title：Journal of virology

authors： Jacobs KA,Geiduschek EP

更新日期：1981-07-01 00:00:00

abstract：:Through their hemagglutinin-neuraminidase glycoprotein, parainfluenza viruses bind to sialic acid-containing glycoconjugates to initiate infection. Although the virus-receptor interaction is a key factor of infection, the exact nature of the receptors that human parainfluenza viruses recognize has not been determined....

journal_title：Journal of virology

authors： Suzuki T,Portner A,Scroggs RA,Uchikawa M,Koyama N,Matsuo K,Suzuki Y,Takimoto T

更新日期：2001-05-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) is a large (150-kb) double-stranded DNA virus that forms latent infections in neuronal cells of the human peripheral nervous system. Previous work determined that the HSV-1 genome is found in an ordered nucleosomal structure during latent infection. However, during lytic infection, ...

journal_title：Journal of virology

authors： Kent JR,Zeng PY,Atanasiu D,Gardner J,Fraser NW,Berger SL

更新日期：2004-09-01 00:00:00

abstract：:In December 2016, a low-pathogenic avian influenza (LPAI) A(H7N2) virus was identified to be the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in the states of New York and Pennsylvania. One person with occupational exposure to infected cats became in...

journal_title：Journal of virology

authors： Belser JA,Pulit-Penaloza JA,Sun X,Brock N,Pappas C,Creager HM,Zeng H,Tumpey TM,Maines TR

更新日期：2017-07-12 00:00:00

abstract：:The sequences of several hundred nucleotides around the junctions between the L and S components in concatemeric DNA and in mature virion DNA were ascertained. The two ends of the mature genome (which are joined in concatemeric DNA) show no sequence homology. Several directly repeated elements are present near both en...

journal_title：Journal of virology

authors： DeMarchi JM,Lu ZQ,Rall G,Kupershmidt S,Ben-Porat T

更新日期：1990-10-01 00:00:00

abstract：:The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motifs conserved in DEAD box proteins. In order to inspect the roles of in...

journal_title：Journal of virology

authors： Kim DW,Kim J,Gwack Y,Han JH,Choe J

更新日期：1997-12-01 00:00:00

abstract：:We have previously described the expression of the major nonstructural protein (NS-1) of Aleutian mink disease parvovirus (ADV) in insect cells by using a baculovirus vector (J. Christensen, T. Storgaard, B. Bloch, S. Alexandersen, and B. Aasted, J. Virol. 67:229-238, 1993). To study its biochemical properties, ADV NS...

journal_title：Journal of virology

authors： Christensen J,Pedersen M,Aasted B,Alexandersen S

更新日期：1995-03-01 00:00:00

abstract：:The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...

journal_title：Journal of virology

authors： Naeve CW,Summers DF

更新日期：1980-06-01 00:00:00

abstract：:The XC rat cell line was found to support the replication of a strain of the Moloney murine sarcoma-leukemia virus. In growth curve experiments cytopathology was paralleled by the production of murine sarcoma virus and leukemia virus progeny having the biologic, antigenic, and biophysical properties of the infecting v...

journal_title：Journal of virology

authors： Trowbridge ST,Benyesh-Melnick M,Biswal N

更新日期：1973-01-01 00:00:00

abstract：UNLABELLED:HIV-1 Vpu decreases the exposure of epitopes within the viral envelope glycoprotein (Env) on the surface of infected cells by downregulating both BST2 and CD4. To test the hypothesis that inhibiting Vpu activity would increase the exposure of these epitopes and sensitize infected cells to antibody-dependent ...

journal_title：Journal of virology

authors： Tokarev A,Stoneham C,Lewinski MK,Mukim A,Deshmukh S,Vollbrecht T,Spina CA,Guatelli J

更新日期：2015-12-16 00:00:00

abstract：:A panel of murine monoclonal antibodies (MAbs) to the human immunodeficiency virus type 1 trans-activator tat protein were characterized. The anti-tat MAbs were mapped to the different domains of the tat protein by Western blot (immunoblot) and Pepscan analyses. One-half of the MAbs tested mapped to the amino-terminal...

journal_title：Journal of virology

authors： Brake DA,Goudsmit J,Krone WJ,Schammel P,Appleby N,Meloen RH,Debouck C

更新日期：1990-02-01 00:00:00

abstract：:Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication core origin sufficient for initiating eukaryotic DNA replication in the presence of wild-type MCV large T protein (LT). The origin includes a poly(T...

journal_title：Journal of virology

authors： Kwun HJ,Guastafierro A,Shuda M,Meinke G,Bohm A,Moore PS,Chang Y

更新日期：2009-12-01 00:00:00

abstract：:ev 2 is one of seven recently described genetic loci of chickens which contain structural genes for endogenous virus. ev 2 is present exclusively in line 72 chickens, an inbred strain of white Leghorns which is homozygous for the capacity to produce Rous-associated virus type 0 (RAV-0), a subgroup E virus. This phenot...

journal_title：Journal of virology

authors： Astrin SM,Crittenden LB,Buss EG

更新日期：1980-01-01 00:00:00

abstract：:We have been investigating the first viral genes to be transcribed in Spodoptera frugiperda cells after the infection with Autographa california nuclear polyhedrosis virus in order to identify regulatory proteins required for the activation of early and/or late gene transcription. By screening a cDNA library from poly...

journal_title：Journal of virology

authors： Knebel-Mörsdorf D,Kremer A,Jahnel F

更新日期：1993-02-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) gag polyprotein is processed by the viral protease to yield the structural proteins of the virus. One of these structural proteins, p15, and its protease cleavage products, p7 and p6, are believed to be responsible for the viral RNA binding which is prerequisite for assembly of i...

journal_title：Journal of virology

authors： Sheng N,Erickson-Viitanen S

更新日期：1994-10-01 00:00:00

abstract：:Adenovirus infection and expression of E1A induces both proliferation and apoptosis, the latter of which is blocked by the adenovirus Bcl-2 homologue E1B 19K. The mechanism of apoptosis induction and the role that it plays in productive infection are not known. Unlike apoptosis mediated by death receptors, infection w...

journal_title：Journal of virology

authors： Cuconati A,Degenhardt K,Sundararajan R,Anschel A,White E

更新日期：2002-05-01 00:00:00

abstract：:The segment of simian virus 40 (SV40) genome which is recognized as the BC domain encodes for the COOH-terminal end of the SV40 major capsid protein VP1. Mutations in this domain lead to the synthesis of a thermosensitive VP1 which fails to assemble mature SV40 at the nonpermissive temperature. We determined the DNA s...

journal_title：Journal of virology

authors： Ng SC,Behm M,Bina M

更新日期：1985-05-01 00:00:00

abstract：:HTG2 hamster cells produce a defective murine sarcoma virus lacking gp70 and, consequently, viral surface projections (knobs), but the lack of knobs appears to have no effect on intramembrane particle distribution. In addition, it has been noted that the core of the virus remains in the "immature" form as a result of ...

journal_title：Journal of virology

authors： Demsey A,Collins F,Kawka D

更新日期：1980-12-01 00:00:00

abstract：:A limited period of chemotherapy during primary immunodeficiency virus infection might provide a long-term clinical benefit even if treatment is initiated at a time point when virus is already detectable in plasma. To evaluate this strategy, we infected rhesus macaques with the pathogenic simian/human immunodeficiency...

journal_title：Journal of virology

authors： Rosenwirth B,ten Haaft P,Bogers WM,Nieuwenhuis IG,Niphuis H,Kuhn EM,Bischofberger N,Heeney JL,Uberla K

更新日期：2000-02-01 00:00:00

abstract：:Infection of human dermal microvascular endothelial (HMVEC-d) cells and human foreskin fibroblast (HFF) cells in vitro by Kaposi's sarcoma-associated herpesvirus (KSHV) provides an excellent in vitro model system to study viral latency. KSHV infection is characterized by the induction of preexisting host signal cascad...

journal_title：Journal of virology

authors： Sharma-Walia N,Raghu H,Sadagopan S,Sivakumar R,Veettil MV,Naranatt PP,Smith MM,Chandran B

更新日期：2006-07-01 00:00:00

abstract：:We generated Chinese hamster ovary cell lines that stably express wild-type, secreted, and glycosylphosphatidylinositol (GPI)-anchored envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1). The cells expressing wild-type Env (WT cells) express both the precursor gp160 and the mature gp120/gp41 and readi...

journal_title：Journal of virology

authors： Weiss CD,White JM

更新日期：1993-12-01 00:00:00

abstract：UNLABELLED:Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing mumps cases. However, rece...

journal_title：Journal of virology

authors： Pickar A,Xu P,Elson A,Li Z,Zengel J,He B

更新日期：2014-04-01 00:00:00

abstract：:When herpes simplex virus was inoculated into the flank of a BALB/c mouse by scarification, the local replication of virus was followed by the establishment of an acute ganglionic infection. The subsequent centrifugal spread of this virus along nerves to the skin of the whole dermatome led to the development of a band...

journal_title：Journal of virology

authors： Simmons A,Nash AA

更新日期：1985-03-01 00:00:00

abstract：:Coinfection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) often leads to AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The interaction between HIV and KSHV plays a pivotal role in the progression of these malignancies. We have previously demonstrated th...

journal_title：Journal of virology

authors： Yan Q,Zhao R,Shen C,Wang F,Li W,Gao SJ,Lu C

更新日期：2018-08-29 00:00:00

abstract：:Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu and Nef proteins of primate lentiviruses. Like other host genes subject to viral antagonism, primate Tetherin genes have evolved u...

journal_title：Journal of virology

authors： Lim ES,Malik HS,Emerman M

更新日期：2010-07-01 00:00:00

abstract：:In 2010 and 2011, several devastating Newcastle disease (ND) outbreaks occurred in China, affecting broilers, layers, and breeders. The CK-JSX1-201005 virus was isolated from broiler breeder flocks vaccinated with the classical ND virus (NDV) vaccine program, but laying rate decreased from 80% to 30 to 40% in the clin...

journal_title：Journal of virology

authors： Chen F,Liu J,Liu D,Yan Z,Ji J,Qin J,Li H,Ma J,Bi Y,Xie Q

更新日期：2012-11-01 00:00:00

abstract：:We sequenced the genes coding for the two neutralization proteins, VP4 and VP7, of human rotavirus strains L26 and L27 with subgroup I specificity but the long RNA pattern. The deduced VP7 amino acid sequence of strains L26 and L27 showed a low homology (73.6 to 81.9%) to those of rotavirus strains of the established ...

journal_title：Journal of virology

authors： Taniguchi K,Urasawa T,Kobayashi N,Gorziglia M,Urasawa S

更新日期：1990-11-01 00:00:00