The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication.

abstract：:A novel species of 30S RNA has been detected in a variety of mouse cell lines. The 30S RNA is specifically packaged by helper-independent type C viruses propagated in such cells. Nucleic acid hybridization detects no homology between the 30SRNA and the genomic RNA of helper-independent mouse type C viruses. The proper...

journal_title：Journal of virology

authors： Howk RS,Troxler DH,Lowy D,Duesberg PH,Scolnick EM

更新日期：1978-01-01 00:00:00

abstract：:H5N1 highly pathogenic avian influenza virus (HPAIV) has continued to spread and poses a significant threat to both animal and human health. Current influenza vaccine strategies have limitations that prevent their effective use for widespread inoculation of animals in the field. Vaccine strains of Newcastle disease vi...

journal_title：Journal of virology

authors： Ge J,Deng G,Wen Z,Tian G,Wang Y,Shi J,Wang X,Li Y,Hu S,Jiang Y,Yang C,Yu K,Bu Z,Chen H

更新日期：2007-01-01 00:00:00

abstract：UNLABELLED:Human metapneumovirus (hMPV) is a respiratory paramyxovirus that is distributed worldwide and induces significant airway morbidity. Despite the relevance of hMPV as a pathogen, many aspects of the immune response to this virus are still largely unknown. In this report, we focus on the antiviral immune respon...

journal_title：Journal of virology

authors： Baños-Lara Mdel R,Harvey L,Mendoza A,Simms D,Chouljenko VN,Wakamatsu N,Kousoulas KG,Guerrero-Plata A

更新日期：2015-01-01 00:00:00

abstract：:Seneca Valley virus (SVV) is an oncolytic RNA virus belonging to the Picornaviridae family. Its nucleotide sequence is highly similar to those of members of the Cardiovirus genus. SVV is also a neuroendocrine cancer-selective oncolytic picornavirus that can be used for anticancer therapy. However, the interaction betw...

journal_title：Journal of virology

authors： Qian S,Fan W,Liu T,Wu M,Zhang H,Cui X,Zhou Y,Hu J,Wei S,Chen H,Li X,Qian P

更新日期：2017-07-27 00:00:00

abstract：:Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. BSE can be transmitted experimentally between cattle through the oral route, and in this study, brain tissue samples from animals at different time points postinoculation were analyzed for changes in gene expression....

journal_title：Journal of virology

authors： Tang Y,Xiang W,Hawkins SA,Kretzschmar HA,Windl O

更新日期：2009-09-01 00:00:00

abstract：UNLABELLED:PML is the organizer of cellular structures termed nuclear domain 10 (ND10) or PML-nuclear bodies (PML-NBs) that act as key mediators of intrinsic immunity against human cytomegalovirus (HCMV) and other viruses. The antiviral function of ND10 is antagonized by viral regulatory proteins such as the immediate ...

journal_title：Journal of virology

authors： Scherer M,Otto V,Stump JD,Klingl S,Müller R,Reuter N,Muller YA,Sticht H,Stamminger T

更新日期：2015-11-11 00:00:00

abstract：:In response to viral infection, reactive oxygen species (ROS) mediate innate immune signaling or generate danger signals to activate immune cells. The mechanisms of virally induced ROS are poorly defined, however. We demonstrate that ROS are produced within minutes of adenovirus type 5 (Ad5) infection of macrophages a...

journal_title：Journal of virology

authors： McGuire KA,Barlan AU,Griffin TM,Wiethoff CM

更新日期：2011-10-01 00:00:00

abstract：:A distinctive feature of chronic human immunodeficiency virus type 1 (HIV-1) infection is the presence of multiple coexisting genetic variants, or subpopulations, that comprise the HIV-1 population detected in the peripheral blood. Analysis of HIV-1 RNA decay dynamics during the initiation of highly active antiretrovi...

journal_title：Journal of virology

authors： Ince WL,Harrington PR,Schnell GL,Patel-Chhabra M,Burch CL,Menezes P,Price RW,Eron JJ Jr,Swanstrom RI

更新日期：2009-05-01 00:00:00

abstract：:Measles virus (MV) is the type species of the Morbillivirus genus and its RNA-dependent RNA polymerase complex is comprised of two viral polypeptides, the large (L) and the phospho- (P) proteins. Sequence alignments of morbillivirus L polymerases have demonstrated the existence of three well-conserved domains (D1, D2,...

journal_title：Journal of virology

authors： Duprex WP,Collins FM,Rima BK

更新日期：2002-07-01 00:00:00

abstract：:We have established a genetic assay for the multimerization of retroviral gag polyproteins. This assay is based on the GAL4 two-hybrid system for studying protein-protein interactions (S. Fields and O. Song, Nature (London) 340:245-246, 1989). In our initial experiments, we generated Saccharomyces cerevisiae plasmids ...

journal_title：Journal of virology

authors： Luban J,Alin KB,Bossolt KL,Humaran T,Goff SP

更新日期：1992-08-01 00:00:00

abstract：:Influenza virus enters its host cell by receptor-mediated endocytosis followed by acid-activated membrane fusion in endosomes. The viral ribonucleoprotein particles (vRNPs) delivered into the cytosol then dissociate from the matrix protein, M1, and from each other, after which they are individually imported into the n...

journal_title：Journal of virology

authors： Bui M,Whittaker G,Helenius A

更新日期：1996-12-01 00:00:00

abstract：:Unintegrated linear and closed circular DNAs of B- and N-tropic endogenous BALB/c murine leukemia virus (MuLV) were extracted from newly infected mouse cells and cleaved with EcoRI, XhoI, PvuI, HindIII, SalI, XbaI, KpnI, SmaI, and PstI restriction endonucleases. The DNA fragments were separated by electrophoresis and ...

journal_title：Journal of virology

authors： Rassart E,Jolicoeur P

更新日期：1980-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) exhibits a high level of genetic variation generated by frequent mutation and genetic recombination during reverse transcription. We have measured HIV-1 recombination rates in T cells in one round of virus replication. It was recently proposed that HIV-1 recombines far more ...

journal_title：Journal of virology

authors： Chen J,Rhodes TD,Hu WS

更新日期：2005-07-01 00:00:00

abstract：:Vif counteracts the host restriction factor APOBEC3G (A3G) and other APOBEC3s by preventing the incorporation of A3G into progeny virions. We previously identified Vif mutants with a dominant-negative (D/N) phenotype that interfered with the function of wild-type Vif, inhibited the degradation of A3G, and reduced the ...

journal_title：Journal of virology

authors： Miyagi E,Welbourn S,Sukegawa S,Fabryova H,Kao S,Strebel K

更新日期：2020-03-17 00:00:00

abstract：:Molluscum contagiosum virus (MCV), the only member of the Molluscipoxvirus genus, causes benign papules in healthy people but disfiguring lesions in immunocompromised patients. The sequence of MCV has been completed, revealing that MCV encodes a probable type I topoisomerase enzyme. All poxviruses sequenced to date al...

journal_title：Journal of virology

authors： Hwang Y,Wang B,Bushman FD

更新日期：1998-04-01 00:00:00

abstract：:Adaptation of field isolates of foot-and-mouth disease virus (FMDV) to grow in cells in culture can result in changes in viral properties that include acquisition of the ability to bind to cell surface heparan sulfate (HS). After 13 passages on BHK cells to produce a vaccine, a Cathay topotype isolate of FMDV serotype...

journal_title：Journal of virology

authors： Zhao Q,Pacheco JM,Mason PW

更新日期：2003-03-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates the HTLV-1 long terminal repeat and key regulatory proteins involved in inflammation, activation, and proliferation and may induce cell transformation. Tax is also the immunodominant target antigen for cytotoxic T cells in HTLV-1 infection. We found...

journal_title：Journal of virology

authors： Hemelaar J,Bex F,Booth B,Cerundolo V,McMichael A,Daenke S

更新日期：2001-11-01 00:00:00

abstract：UNLABELLED:Human cytomegalovirus (hCMV) infection is characterized by a vast expansion of resting effector-type virus-specific T cells in the circulation. In mice, interleukin-7 receptor α (IL-7Rα)-expressing cells contain the precursors for long-lived antigen-experienced CD8(+) T cells, but it is unclear if similar me...

journal_title：Journal of virology

authors： Remmerswaal EB,Klarenbeek PL,Alves NL,Doorenspleet ME,van Schaik BD,Esveldt RE,Idu MM,van Leeuwen EM,van der Bom-Baylon N,van Kampen AH,Koch SD,Pircher H,Bemelman FJ,Ten Brinke A,Baas F,Ten Berge IJ,van Lier RA,de Vries

更新日期：2015-01-01 00:00:00

abstract：:The structure of Bacillus subtilis bacteriophage phi25 and phi25 deoxyribonucleic acid (DNA) were studied by electron microscopy. The head of phi25 is a regular polyhedron measuring 75 nm in diameter. The uncontracted tail of phi25 is 130 nm in length and includes a large, complex tail plate. Phage phi25 DNA is double...

journal_title：Journal of virology

authors： Liljemark WF,Anderson DL

更新日期：1970-07-01 00:00:00

abstract：:A system has been developed for generating chimeric yellow fever/Japanese encephalitis (YF/JE) viruses from cDNA templates encoding the structural proteins prM and E of JE virus within the backbone of a molecular clone of the YF17D strain. Chimeric viruses incorporating the proteins of two JE strains, SA14-14-2 (human...

journal_title：Journal of virology

authors： Chambers TJ,Nestorowicz A,Mason PW,Rice CM

更新日期：1999-04-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) envelope protein is required for virus spread. This study further characterizes the role of the envelope protein in HTLV-1 immortalization. Viruses with single amino acid substitutions within the SU protein at residue 75, 81, 95, 101, 105, or 195 or with a C-terminal cyt...

journal_title：Journal of virology

authors： Tsukahara T,Wielgosz MM,Ratner L

更新日期：2001-10-01 00:00:00

abstract：:The full-length viral RNA of human immunodeficiency virus type 1 (HIV-1) functions both as the mRNA for the viral structural proteins Gag and Gag/Pol and as the genomic RNA packaged within viral particles. The packaging signal which Gag recognizes to initiate genome encapsidation is in the 5' untranslated region (UTR)...

journal_title：Journal of virology

authors： Anderson EC,Lever AM

更新日期：2006-11-01 00:00:00

abstract：:Virions produced by cells in the presence of actinomycin D (Act D virions) contain reverse transcriptase but are deficient in 70S genomic RNA. To assess the role of genomic RNA in encapsidation of a functional reverse transcriptase and to study the interaction of the enzyme and its template in the cores of intact viri...

journal_title：Journal of virology

authors： Gerwin BI,Levin JG

更新日期：1977-11-01 00:00:00

abstract：:The baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) initiates apoptosis in diverse insects through events triggered by virus DNA (vDNA) replication. To define the proapoptotic pathway and its role in antivirus defense, we investigated the link between the host's DNA damage response (DDR) a...

journal_title：Journal of virology

authors： Mitchell JK,Friesen PD

更新日期：2012-12-01 00:00:00

abstract：:During infection, adenovirus-associated virus (AAV) undergoes microtubule-dependent retrograde transport as part of a program of vectorial transport of viral genome to the nucleus. A microtubule binding assay was used to evaluate the hypothesis that cytoplasmic dynein mediates AAV interaction with microtubules. Bindin...

journal_title：Journal of virology

authors： Kelkar S,De BP,Gao G,Wilson JM,Crystal RG,Leopold PL

更新日期：2006-08-01 00:00:00

abstract：:It is generally accepted that the fitness cost of resistance mutations plays a role in the persistence of transmitted drug-resistant human immunodeficiency virus type 1 and that mutations that confer a high fitness cost are less able to persist in the absence of drug pressure. Here, we show that the fitness cost of re...

journal_title：Journal of virology

authors： Cong ME,Heneine W,García-Lerma JG

更新日期：2007-03-01 00:00:00

abstract：:The vaccinia virus Western Reserve A38L protein is a hydrophobic integral membrane glycoprotein with amino acid similarity to mammalian integrin-associated protein. The protein has an N-terminal immunoglobulin superfamily domain, followed by five membrane-spanning domains and a short cytoplasmic tail. Deletion of the ...

journal_title：Journal of virology

authors： Sanderson CM,Parkinson JE,Hollinshead M,Smith GL

更新日期：1996-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection causes substantial morbidity and some deaths in the young and elderly worldwide. There is no safe and effective vaccine available, although it is possible to reduce the hospitalization rate for high-risk children by anti-RSV antibody prophylaxis. RSV has been shown to modify...

journal_title：Journal of virology

authors： Zhang W,Choi Y,Haynes LM,Harcourt JL,Anderson LJ,Jones LP,Tripp RA

更新日期：2010-01-01 00:00:00

abstract：:Poliovirus-infected cells undergo an increase in cytoplasmic calcium concentrations from the 4th h postinfection. The protein responsible for this effect was identified by the expression of different poliovirus nonstructural proteins in HeLa cells by using a recombinant vaccinia virus system. Synthesis of protein 2BC ...

journal_title：Journal of virology

authors： Aldabe R,Irurzun A,Carrasco L

更新日期：1997-08-01 00:00:00

abstract：:The glycosylated Gag protein (gPr80) of murine leukemia viruses (MLVs) has been shown to exhibit multiple roles in facilitating retrovirus release, infection, and resistance to host-encoded retroviral restriction factors, such as APOBEC3, SERINC3, and SERINC5. One way in which gPr80 helps MLVs to escape host innate im...

journal_title：Journal of virology

authors： Renner TM,Bélanger K,Lam C,Gerpe MCR,McBane JE,Langlois MA

更新日期：2018-02-26 00:00:00