Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses.

abstract：:Human immunodeficiency virus type 1 (HIV-1) requires that its genome be reverse transcribed into double-stranded DNA for productive infection of cells. This process requires not only reverse transcriptase but also the nucleocapsid protein (NC), which functions as a nucleic acid chaperone. Reverse transcription general...

journal_title：Journal of virology

authors： Thomas JA,Bosche WJ,Shatzer TL,Johnson DG,Gorelick RJ

更新日期：2008-10-01 00:00:00

abstract：:To gain further insight on the function of the herpes simplex virus type 1 (HSV-1) packaging signal (a sequence), we constructed a recombinant virus containing a unique a sequence, which was flanked by two loxP sites in parallel orientation. The phenotype of this recombinant, named HSV-1 LaL, was studied in cell lines...

journal_title：Journal of virology

authors： Logvinoff C,Epstein AL

更新日期：2000-09-01 00:00:00

abstract：:Mutants of bacteriophage T4D that are defective in genes 42 (dCMP hydroxymethylase), 46 (DNA exonuclease), and 56 (dCTPase) produce limited amounts of phage DNA in Escherichia coli B. In this DNA, glucoylated 5-hydroxymethylcytosine is completely replaced by cytosine. We found that this DNA rapidly becomes fragmented ...

journal_title：Journal of virology

authors： Carlson K,Wiberg JS

更新日期：1983-10-01 00:00:00

abstract：:Human norovirus (HuNoV) is a major causative agent of food-borne gastroenteritis worldwide. Currently, there are no vaccines or effective therapeutic interventions for this virus. Development of an attenuated vaccine for HuNoV has been hampered by the inability to grow the virus in cell culture. Thus, a vector-based v...

journal_title：Journal of virology

authors： Ma Y,Li J

更新日期：2011-03-01 00:00:00

abstract：:Molluscs, comprising one of the most successful phyla, lack clear evidence of adaptive immunity and yet thrive in the oceans, which are rich in viruses. There are thought to be nearly 120,000 species of Mollusca, most living in marine habitats. Despite the extraordinary abundance of viruses in oceans, molluscs often h...

journal_title：Journal of virology

authors： Dang VT,Benkendorff K,Green T,Speck P

更新日期：2015-08-01 00:00:00

abstract：:Minute virus of canines (MVC) is a member of the genus Bocavirus in the family Parvoviridae. We have molecularly cloned and sequenced the 5'- and 3'-terminal palindromes of MVC. The MVC genome, 5,404 nucleotides (nt) in length, shared an identity of 52.6% and 52.1% with that of human bocavirus and bovine parvovirus, r...

journal_title：Journal of virology

authors： Sun Y,Chen AY,Cheng F,Guan W,Johnson FB,Qiu J

更新日期：2009-04-01 00:00:00

abstract：:Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. Although p40 and p23 are unrelated in amino acid sequence structure, cross-reactive antibodies are described. Protein fragments and synthetic peptides were analyzed to characterize the sp...

journal_title：Journal of virology

authors： Kliche S,Stitz L,Mangalam H,Shi L,Binz T,Niemann H,Briese T,Lipkin WI

更新日期：1996-11-01 00:00:00

abstract：:During Epstein-Barr virus (EBV) latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or Wp, whose activities have previously been shown to be mutually exclusive in established lymphoblastoid cell lines. Initially after infection, the EBNA genes are ...

journal_title：Journal of virology

authors： Yoo LI,Mooney M,Puglielli MT,Speck SH

更新日期：1997-12-01 00:00:00

abstract：:The key role of the mitochondria in the regulation of cellular Ca2+ led to a study of mitochondrial Ca2+ uptake during the infection of chicken embryo cells with Semliki Forest virus. Mitochondrial Ca2+ uptake was stimulated during the first 5 h of infection but declined later in infection. The early stimulation sugge...

journal_title：Journal of virology

authors： Peterhans E,Haenggeli E,Wild P,Wyler R

更新日期：1979-01-01 00:00:00

abstract：:Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...

journal_title：Journal of virology

authors： Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

更新日期：2018-08-29 00:00:00

abstract：:Previous studies have demonstrated that the genetic determinants of simian immunodeficiency virus (SIV) neurovirulence map to the env and nef genes. Recent studies from our laboratory demonstrated that SIV replication in primary rhesus macaque astrocyte cultures is dependent upon the nef gene. Here, we demonstrate tha...

journal_title：Journal of virology

authors： Overholser ED,Babas T,Zink MC,Barber SA,Clements JE

更新日期：2005-04-01 00:00:00

abstract：:The association between the level of class I major histocompatibility (MHC) antigen expression and the tumorigenic phenotype was determined for cells from a series of 15 lines of adenovirus type 2 (Ad2)-, Ad12-, and simian virus 40 (SV40)-transformed hamster cells and 16 lines of cells established from hamster tumors ...

journal_title：Journal of virology

authors： Haddada H,Sogn JA,Coligan JE,Carbone M,Dixon K,Levine AS,Lewis AM Jr

更新日期：1988-08-01 00:00:00

abstract：:Serial passage of reovirus temperature-sensitive (ts) mutant C(447) produced by passage 9 (P9) a heavily defective population of virus from which the double-stranded RNA genomic segments L(1), L(3), and M(1) were largely missing. Viral cores obtained from this P9 population were heterogeneous with respect to buoyant d...

journal_title：Journal of virology

authors： Ahmed R,Graham AF

更新日期：1977-08-01 00:00:00

abstract：:Deletion mutants of simian virus 40 (SV40) with lesions at the three DdeI sites near the 3' end of the early region were constructed. Mutants with deletions at 0.203 and 0.219 map units (mu) which did not change the large T antigen reading frame were viable. This extends slightly the upstream boundary for the location...

journal_title：Journal of virology

authors： Tornow J,Cole CN

更新日期：1983-09-01 00:00:00

abstract：:The presence of cycloheximide, an inhibitor of protein synthesis, during the period 30 to 60 min after vaccinia infection produced an irreversible block in virus replication. In contrast (i) cycloheximide given at earlier or later times, even for prolonged periods, did not prevent continuation of the infectious cycle ...

journal_title：Journal of virology

authors： Mss B,Filler R

更新日期：1970-02-01 00:00:00

abstract：:Influenza A virus (IAV) remains a global health concern despite the availability of a seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore, it is extremely challenging to test novel vaccines in the human population. To overcome this obstacle, new vaccines mus...

journal_title：Journal of virology

authors： Fay EJ,Aron SL,Stone IA,Waring BM,Plemper RK,Langlois RA

更新日期：2018-12-10 00:00:00

abstract：UNLABELLED:Capsid-associated tegument proteins have been identified in alpha- and betaherpesviruses to play an essential role in viral DNA packaging. Whether and how such tegument proteins exist in gammaherpesviruses have been mysteries. Here, we report a 6-Å-resolution cryo-electron microscopy (cryo-EM) structure of K...

journal_title：Journal of virology

authors： Dai X,Gong D,Wu TT,Sun R,Zhou ZH

更新日期：2014-11-01 00:00:00

abstract：:VP16-H is an essential structural protein of herpes simplex virus type 1 (HSV-1) and is also a potent activator of virus immediate-early (IE) gene expression. Current models of functional determinants within VP16-H indicate that it consists of two domains, an N-terminal domain involved in recruiting VP16-H to a multic...

journal_title：Journal of virology

authors： Grapes M,O'Hare P

更新日期：2000-11-01 00:00:00

abstract：:Toroviruses (family Coronaviridae, order Nidovirales) are enveloped, positive-stranded RNA viruses that have been implicated in enteric disease in cattle and possibly in humans. Despite their potential veterinary and clinical relevance, little is known about torovirus epidemiology and molecular genetics. Here, we pres...

journal_title：Journal of virology

authors： Smits SL,Lavazza A,Matiz K,Horzinek MC,Koopmans MP,de Groot RJ

更新日期：2003-09-01 00:00:00

abstract：:Nonglucosylated and fragmented T4 DNA shows a gene-specific variation in transformation efficiency. ...

journal_title：Journal of virology

authors： McNicol LA

更新日期：1973-08-01 00:00:00

abstract：:The goal of an effective AIDS vaccine is to generate immunity that will prevent human immunodeficiency virus 1 (HIV-1) acquisition. Despite limited progress toward this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial ...

journal_title：Journal of virology

authors： Yamamoto T,Johnson MJ,Price DA,Wolinsky DI,Almeida JR,Petrovas C,Nason M,Yeh WW,Shen L,Roederer M,Rao SS,McDermott AB,Lefebvre F,Nabel GJ,Haddad EK,Letvin NL,Douek DC,Koup RA

更新日期：2012-05-01 00:00:00

abstract：:Two murine leukemia viruses were isolated from JLS-V9 cells which had been infected with Rauscher plasma virus. One virus was XC positive and failed to grow on mink or cat cells and thus was an ecotropic virus. The other virus formed cytopathic foci on mink cells, was XC negative, and fell into the mink cell focus-for...

journal_title：Journal of virology

authors： Schultz A,Rein A,Henderson L,Oroszlan S

更新日期：1983-03-01 00:00:00

abstract：:The hemagglutinin of fowl plague virus has been expressed in Spodoptera frugiperda (Sf9) cells and in Estigmene acrea cells by using a baculovirus vector. Structural analysis revealed that the endo-H-resistant N-glycans of HA from Sf9 cells were predominantly trimannosyl core oligosaccharides, whereas in E. acrea cell...

journal_title：Journal of virology

authors： Wagner R,Geyer H,Geyer R,Klenk HD

更新日期：1996-06-01 00:00:00

abstract：:The emergence of drug resistance-conferring mutations can severely compromise the success of chemotherapy directed against human immunodeficiency virus type 1 (HIV-1). The M184V and/or L74V mutation in the reverse transcriptase (RT) gene are frequently found in viral isolates from patients treated with the nucleoside ...

journal_title：Journal of virology

authors： Diallo K,Marchand B,Wei X,Cellai L,Götte M,Wainberg MA

更新日期：2003-08-01 00:00:00

abstract：:Herpesviruses encode an essential, maturational serine protease whose catalytic domain, assemblin (28 kDa), is released by self-cleavage from a 74-kDa precursor (pPR, pUL80a). Although there is considerable information about the structure and enzymatic characteristics of assemblin, a potential pharmacologic target, co...

journal_title：Journal of virology

authors： Brignole EJ,Gibson W

更新日期：2007-04-01 00:00:00

abstract：:Most retroviral packaging cell lines were established by a helper virus plasmid cotransfected with a separate plasmid encoding a selection marker. Since this selection marker coexisted in trans with the helper virus sequence, helper virus gene expression could be inactivated by host DNA methylation despite selection f...

journal_title：Journal of virology

authors： Young WB,Link CJ Jr

更新日期：2000-06-01 00:00:00

abstract：:Autophagy is an intracellular degradation pathway that provides a host defense mechanism against intracellular pathogens. However, many viruses exploit this mechanism to promote their replication. This study shows that lytic induction of Epstein-Barr virus (EBV) increases the membrane-bound form of LC3 (LC3-II) and LC...

journal_title：Journal of virology

authors： Hung CH,Chen LW,Wang WH,Chang PJ,Chiu YF,Hung CC,Lin YJ,Liou JY,Tsai WJ,Hung CL,Liu ST

更新日期：2014-10-01 00:00:00

abstract：:Human adenovirus 41 (HAdV-41) causes acute gastroenteritis in young children. The main characteristics of HAdV-41 infection are diarrhea and vomiting. Nevertheless, the precise mechanism of HAdV-41-induced diarrhea is unknown, as a suitable small-animal model has not been described. In this study, we used the human mi...

journal_title：Journal of virology

authors： Westerberg S,Hagbom M,Rajan A,Loitto V,Persson BD,Allard A,Nordgren J,Sharma S,Magnusson KE,Arnberg N,Svensson L

更新日期：2018-03-14 00:00:00

abstract：:Aphid transmission of poleroviruses is highly specific, but the viral determinants governing this specificity are unknown. We used a gene exchange strategy between two poleroviruses with different vectors, Beet western yellows virus (BWYV) and Cucurbit aphid-borne yellows virus (CABYV), to analyze the role of the majo...

journal_title：Journal of virology

authors： Brault V,Périgon S,Reinbold C,Erdinger M,Scheidecker D,Herrbach E,Richards K,Ziegler-Graff V

更新日期：2005-08-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) downregulates major histocompatibility complex (MHC) class I complexes from the plasma membrane via two of its genes, K3 and K5. The N termini of K3 and K5 contain a plant homeodomain (PHD) predicted to be structurally similar to RING domains found in E3 ubiquitin ligases. In view of the imp...

journal_title：Journal of virology

authors： Lorenzo ME,Jung JU,Ploegh HL

更新日期：2002-06-01 00:00:00