Transcriptional mapping of rabies virus in vivo.

abstract：:A human cytomegalovirus (CMV) UL54 pol exonuclease domain II mutation, D413A, found in a clinical specimen, conferred ganciclovir (GCV) and cidofovir resistance but not foscarnet resistance when incorporated into laboratory strain T2294. After several passages without drug, mutation was observed in five of eight plaqu...

journal_title：Journal of virology

authors： Chou S,Marousek GI

更新日期：2008-01-01 00:00:00

abstract：:The herpes simplex virus (HSV) capsid is released into the cytoplasm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along microtubules targets it to the nuclear envelope. Binding of the capsid to the nuclear pore complex (NPC) is mediated by the capsid protein pUL25 and the capsid-tet...

journal_title：Journal of virology

authors： Huffman JB,Daniel GR,Falck-Pedersen E,Huet A,Smith GA,Conway JF,Homa FL

更新日期：2017-07-12 00:00:00

abstract：:Western equine encephalitis virus (WEEV; Togaviridae, Alphavirus) is an enveloped RNA virus that is typically transmitted to vertebrate hosts by infected mosquitoes. WEEV is an important cause of viral encephalitis in humans and horses in the Americas, and infection results in a range of disease, from mild flu-like il...

journal_title：Journal of virology

authors： Sherman MB,Weaver SC

更新日期：2010-10-01 00:00:00

abstract：:Polyoma virus complementary RNA, synthesized in vitro by using highly purified Escherichia coli RNA polymerase and nondefective form I polyoma DNA, was translated in a wheat germ cell-free system. Polypeptides were synthesized that comigrated on sodium dodecyl sulfate-polyacrylamide gels with the polyoma capsid protei...

journal_title：Journal of virology

authors： Mangel WF,Hewick RM,Bayley ST,Wheeler T,Harvey R,Waterfield MD,Smith AE

更新日期：1978-02-01 00:00:00

abstract：:Adenovirus type 7 (Ad7) early region 1 mRNA species transcribed in rat cell lines transformed by the HindIII-I . J fragment (the left 7.8% of the viral genome) and in human KB cells infected with Ad7 were mapped on the viral genome, using S1 nuclease gel and diazobenzyloxymethyl paper hybridization techniques. At the ...

journal_title：Journal of virology

authors： Yoshida K,Fujinaga K

更新日期：1980-11-01 00:00:00

abstract：:Cell lines were generated by cotransfection of Vero cells with pSV2neo and a plasmid containing the herpes simplex virus type 1 (HSV-1) EcoRI D fragment (coordinates 0.086 to 0.194). One such cell line (S22) contained the genes for alkaline exonuclease and several uncharacterized functions. Three mutant isolates of HS...

journal_title：Journal of virology

authors： Carmichael EP,Kosovsky MJ,Weller SK

更新日期：1988-01-01 00:00:00

abstract：:The vif gene of human immunodeficiency virus type 1 is absolutely required for productive infection of primary cells derived from human blood and certain immortalized T lymphoid cells, for example, H9. Cells with this restrictive phenotype are termed nonpermissive, whereas cell lines in which vif-deficient virus can r...

journal_title：Journal of virology

authors： Simon JH,Malim MH

更新日期：1996-08-01 00:00:00

abstract：:Development of a vaccine for the common cold has been thwarted by the fact that there are more than 100 serotypes of human rhinovirus (HRV). We previously demonstrated that the HRV14 capsid is dynamic and transiently displays the buried N termini of viral protein 1 (VP1) and VP4. Here, further evidence for this "breat...

journal_title：Journal of virology

authors： Katpally U,Fu TM,Freed DC,Casimiro DR,Smith TJ

更新日期：2009-07-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) has a tropism for T lymphocytes and monocytes/macrophages, suggesting that HHV-6 infection affects the immunosurveillance system. In the present study, we investigated the HHV-6-induced phenotypic and functional alterations of dendritic cells (DCs), which are professional antigen-presenting...

journal_title：Journal of virology

authors： Kakimoto M,Hasegawa A,Fujita S,Yasukawa M

更新日期：2002-10-01 00:00:00

abstract：:We have previously described several human immunodeficiency virus type 1 (HIV-1) mutants that are characterized by an excessive-RNA-splicing phenotype and reduced virus particle production. In one of these mutants (NLD2up), the sequence of 5' splice site D2 was changed to a consensus splice donor site. This splice sit...

journal_title：Journal of virology

authors： Mandal D,Feng Z,Stoltzfus CM

更新日期：2008-02-01 00:00:00

abstract：:ETnII elements are mobile members of the repetitive early transposon family of mouse long terminal repeat (LTR) retroelements and have caused a number of mutations by inserting into genes. ETnII sequences lack retroviral genes, but the recent discovery of related MusD retroviral elements with regions similar to gag, p...

journal_title：Journal of virology

authors： Baust C,Gagnier L,Baillie GJ,Harris MJ,Juriloff DM,Mager DL

更新日期：2003-11-01 00:00:00

abstract：:Northern (RNA) blot analysis was used to determine the spatial and temporal distribution of bovine herpesvirus 1 (BHV-1) transcripts. Total RNA was isolated from Madin-Darby bovine kidney cells which had been infected with BHV-1.2b strain K22 or BHV-1.1 strain Jura in the presence or absence of metabolic inhibitors. C...

journal_title：Journal of virology

authors： Wirth UV,Gunkel K,Engels M,Schwyzer M

更新日期：1989-11-01 00:00:00

abstract：:Enviroxime is an antienterovirus compound that targets viral protein 3A and/or 3AB and suppresses a step in enterovirus replication by unknown mechanism. To date, four antienterovirus compounds, i.e., GW5074, Flt3 inhibitor II, TTP-8307, and AN-12-H5, are known to have similar mutations in the 3A protein-encoding regi...

journal_title：Journal of virology

authors： Arita M,Kojima H,Nagano T,Okabe T,Wakita T,Shimizu H

更新日期：2011-03-01 00:00:00

abstract：:The papillomavirus (PV) E2 protein is a critical regulator of viral transcription and genome replication. We previously reported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by the fibroblast growth factor receptor 3 (FGFR3) kinase. In this study, we generated quasiviruses containing G418-selectable HPV-31 gen...

journal_title：Journal of virology

authors： Jose L,Androphy EJ,DeSmet M

更新日期：2020-07-01 00:00:00

abstract：:A new group of nucleocytoplasmic shuttling proteins has recently been identified in the structural proteins encoded by several alphaherpesvirus UL47 genes. Nuclear import and export signals for the bovine herpesvirus type 1 UL47 protein (VP8 or bUL47) have been described previously. Here, we study the trafficking of b...

journal_title：Journal of virology

authors： Verhagen J,Donnelly M,Elliott G

更新日期：2006-10-01 00:00:00

abstract：:The effect of guanidine on the replication of the group A arboviruses, Sindbis virus, and Semliki Forest virus (SFV) was studied. Guanidine rapidly, but reversibly, inhibited SFV ribonucleic acid (RNA) synthesis. The synthesis of all species of viral RNA was inhibited, but that of ribonuclease-resistant forms was leas...

journal_title：Journal of virology

authors： Friedman RM

更新日期：1970-11-01 00:00:00

abstract：:Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing the receptor angiotensin-converting enzyme 2 (ACE2). Here we show that codon optimization of the SARS-CoV S-protein gene...

journal_title：Journal of virology

authors： Moore MJ,Dorfman T,Li W,Wong SK,Li Y,Kuhn JH,Coderre J,Vasilieva N,Han Z,Greenough TC,Farzan M,Choe H

更新日期：2004-10-01 00:00:00

abstract：:The P4 promoter of the parvovirus minute virus of mice contains a single degenerate GC box sequence which binds the transcription factor Sp1 with high affinity. The two promoters of murine Sp1 were affinity purified, and their interactions with the P4 promoter were examined. Several unusual features were observed. Met...

journal_title：Journal of virology

authors： Pitluk ZW,Ward DC

更新日期：1991-12-01 00:00:00

abstract：UNLABELLED:Many murine leukemia viruses (MLVs) are partially resistant to restriction by mouse APOBEC3 (mA3) and essentially fully resistant to induction of G-to-A mutations by mA3. In contrast, Vif-deficient HIV-1 (ΔVif HIV-1) is profoundly restricted by mA3, and the restriction includes high levels of G-to-A mutation...

journal_title：Journal of virology

authors： Nair S,Sanchez-Martinez S,Ji X,Rein A

更新日期：2014-04-01 00:00:00

abstract：:We investigated the synergism between influenza virus and Streptococcus pneumoniae, particularly the role of deletions in the stalk region of the neuraminidase (NA) of H2N2 and H9N2 avian influenza viruses. Deletions in the NA stalk (ΔNA) had no effect on NA activity or on the adherence of S. pneumoniae to virus-infec...

journal_title：Journal of virology

authors： Chockalingam AK,Hickman D,Pena L,Ye J,Ferrero A,Echenique JR,Chen H,Sutton T,Perez DR

更新日期：2012-04-01 00:00:00

abstract：:It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin. Therefore, the antiviral activities of (i) ribavirin, (ii) its 5-ethynyl analogue, 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), and (iii) mycophenolic acid (MPA) (a compound t...

journal_title：Journal of virology

authors： Leyssen P,Balzarini J,De Clercq E,Neyts J

更新日期：2005-02-01 00:00:00

abstract：:The glycan shield of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) protein serves as a barrier to antibody-mediated neutralization and plays a critical role in transmission and infection. One of the few broadly neutralizing HIV-1 antibodies, 2G12, binds to a carbohydrate epitope consisting of an array...

journal_title：Journal of virology

authors： Luallen RJ,Lin J,Fu H,Cai KK,Agrawal C,Mboudjeka I,Lee FH,Montefiori D,Smith DF,Doms RW,Geng Y

更新日期：2008-07-01 00:00:00

abstract：:We analyzed xenotropic murine leukemia virus-related virus (XMRV) integration site sequences previously identified from human prostate tissues for single-nucleotide polymorphisms (SNPs) to discriminate between patient and potential cell line sources of the proviruses. The SNPs of two integration sites were identical t...

journal_title：Journal of virology

authors： Rusmevichientong A,Das Gupta J,Elias PS,Silverman RH,Chow SA

更新日期：2011-12-01 00:00:00

abstract：:Apoptosis of virus-infected cells occurs either as a direct response to viral infection or upon recognition of infection by the host immune response. Apoptosis reduces production of new virus from these cells, and therefore viruses have evolved inhibitory mechanisms. We previously showed that laboratory strains of her...

journal_title：Journal of virology

authors： Jerome KR,Fox R,Chen Z,Sears AE,Lee Hy,Corey L

更新日期：1999-11-01 00:00:00

abstract：:Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are encapsidated by assembling HIV-1 virions and edit viral cDNA in the next round of infection. Using alpha interferon (IFN-α)-treated monocyte-derived macrophages, we show that infrequent editing of HIV-1 reverse transcripts can als...

journal_title：Journal of virology

authors： Koning FA,Goujon C,Bauby H,Malim MH

更新日期：2011-12-01 00:00:00

abstract：:During the course of experiments designed to isolate deletion mutants of herpes simplex virus type 1 in the gene encoding the major DNA-binding protein, ICP8, a mutant, d61, that grew efficiently in ICP8-expressing Vero cells but not in normal Vero cells was isolated (P. K. Orberg and P. A. Schaffer, J. Virol. 61:1136...

journal_title：Journal of virology

authors： Polvino-Bodnar M,Orberg PK,Schaffer PA

更新日期：1987-11-01 00:00:00

abstract：:We previously reported that a recombinant pantothenate auxotroph of Mycobacterium bovis BCG expressing human immunodeficiency virus type 1 (HIV-1) subtype C Gag (rBCGpan-Gag) efficiently primes the mouse immune system for a boost with a recombinant modified vaccinia virus Ankara (rMVA) vaccine. In this study, we furth...

journal_title：Journal of virology

authors： Chege GK,Burgers WA,Stutz H,Meyers AE,Chapman R,Kiravu A,Bunjun R,Shephard EG,Jacobs WR Jr,Rybicki EP,Williamson AL

更新日期：2013-05-01 00:00:00

abstract：:The pathway of envelopment and egress of the varicella-zoster virus (VZV) and the primary site of viral production within the epidermal layer of the skin are not fully understood. There are several hypotheses to explain how the virus may receive an envelope as it travels to the surface of the monolayer. In this study,...

journal_title：Journal of virology

authors： Harson R,Grose C

更新日期：1995-08-01 00:00:00

abstract：:In addition to encoding the structural and regulatory proteins, many viruses encode auxiliary proteins, some of which have been shown to play important roles in lytic and latent states of the viruses. The human neurotropic JC virus (JCV) genome encodes an auxiliary protein called Agno whose function remains unknown. H...

journal_title：Journal of virology

authors： Safak M,Barrucco R,Darbinyan A,Okada Y,Nagashima K,Khalili K

更新日期：2001-02-01 00:00:00

abstract：:A variant of human T-cell leukemia virus subgroup I (HTLV-I), designated HTLV-Ib, has been isolated from a transformed T-lymphocytic cell line established from a Zairian patient with adult T-cell lymphoma. A recombinant phage clone of the variant provirus, denoted lambda MC-1, hybridizes under high stringency to HTLV-...

journal_title：Journal of virology

authors： Ratner L,Josephs SF,Starcich B,Hahn B,Shaw GM,Gallo RC,Wong-Staal F

更新日期：1985-06-01 00:00:00