Polyoma virus complementary RNA directs the in vitro synthesis of capsid proteins VP1 and VP2.

abstract：:The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the vir...

journal_title：Journal of virology

authors： Moller-Tank S,Kondratowicz AS,Davey RA,Rennert PD,Maury W

更新日期：2013-08-01 00:00:00

abstract：:Here we show that the adenovirus early region 4 (E4) open reading frame 4 (ORF4) protein autoregulates its own transcription by inhibiting adenovirus E1A-induced activation of E4 transcription both in transient transfection experiments and during lytic virus growth. The inhibitory activity of E4-ORF4 was selective for...

journal_title：Journal of virology

authors： Bondesson M,Ohman K,Manervik M,Fan S,Akusjärvi G

更新日期：1996-06-01 00:00:00

abstract：:Superinfection of Corynebacterium diphtheriae C7(beta) by heteroimmune phage gamma is productive, whereas superinfection by gamma-bin mutants is for the most part nonproductive. Exclusion of gamma-bin phage occurred after its DNA had penetrated and was partially expressed in the heteroimmune lysogen. All of the infect...

journal_title：Journal of virology

authors： Groman NB,Rabin M

更新日期：1980-11-01 00:00:00

abstract：:Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise epitopes targeted by this response remain to be defined. In this study, we generated CD4(+) T-cell clones specific for ...

journal_title：Journal of virology

authors： Norris PJ,Sumaroka M,Brander C,Moffett HF,Boswell SL,Nguyen T,Sykulev Y,Walker BD,Rosenberg ES

更新日期：2001-10-01 00:00:00

abstract：:The RNA genome of influenza virus is transcribed and replicated by the viral RNA polymerase complex in the cell nucleus. We have generated green fluorescent protein (GFP)-tagged polymerase subunits to study the assembly of the polymerase complex. Our results show that individually expressed polymerase basic protein 1 ...

journal_title：Journal of virology

authors： Fodor E,Smith M

更新日期：2004-09-01 00:00:00

abstract：:In vitro replication of coxsackievirus B3 (CVB3) in cells of the immune system derived from uninfected adolescent A/J and C57BL/6J mice and replication of CVB3 in and association with immune cells from spleens of infected animals in vivo were assessed. Nonstimulated or mitogen-stimulated spleen cells were minimally pe...

journal_title：Journal of virology

authors： Anderson DR,Wilson JE,Carthy CM,Yang D,Kandolf R,McManus BM

更新日期：1996-07-01 00:00:00

abstract：:We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells. Mmut virus propagated to significantly lower titers than did wild-type virus in cells infected at low multiplicity. By contrast, virion morphology and incorporation of viral proteins and vRNAs...

journal_title：Journal of virology

authors： Bourmakina SV,García-Sastre A

更新日期：2005-06-01 00:00:00

abstract：:The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motifs conserved in DEAD box proteins. In order to inspect the roles of in...

journal_title：Journal of virology

authors： Kim DW,Kim J,Gwack Y,Han JH,Choe J

更新日期：1997-12-01 00:00:00

abstract：UNLABELLED:Despite encoding multiple viral proteins that modulate the retinoblastoma (Rb) protein in a manner classically defined as inactivation, human cytomegalovirus (HCMV) requires the presence of the Rb protein to replicate efficiently. In uninfected cells, Rb controls numerous pathways that the virus also command...

journal_title：Journal of virology

authors： VanDeusen HR,Kalejta RF

更新日期：2015-12-01 00:00:00

abstract：:Virus was isolated from the lumen of the calyx region of ovaries in the parasitoid wasp Campoletis sonorensis (Hymenoptera: Ichneumonidae), and the nature of the viral DNA was analyzed. DNA purified from a homogeneous band of virus contained double-stranded superhelical molecules which were polydisperse in molecular w...

journal_title：Journal of virology

authors： Krell PJ,Summers MD,Vinson SB

更新日期：1982-09-01 00:00:00

abstract：:Five urea-resistant and two heat-resistant mutants of poliovirus types 1 and 2 were isolated and their structural and nonstructural polypeptides compared to those of their wild-type, parental strains in an attempt to correlate mutant phenotypes with alterations in specific capsid polypeptides. Four of the seven mutant...

journal_title：Journal of virology

authors： Fennell R,Phillips BA

更新日期：1974-10-01 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are being considered for in vivo applications of gene therapy in the treatment of a variety of disorders. This study evaluates the biology of second-generation vectors based on the novel serotypes AAV7 and AAV8 and containing self-complementary genomes in the nonhuman primate liver...

journal_title：Journal of virology

authors： Gao GP,Lu Y,Sun X,Johnston J,Calcedo R,Grant R,Wilson JM

更新日期：2006-06-01 00:00:00

abstract：:Antibody was raised against purified vaccinia virus RNA polymerase and used to screen a recombinant vaccinia virus-lambda gt11 library. The DNA from several immunopositive clones was shown by Southern hybridization to originate from the vaccinia virus HindIII E fragment. The nucleotide sequence of the RNA polymerase s...

journal_title：Journal of virology

authors： Broyles SS,Pennington MJ

更新日期：1990-11-01 00:00:00

abstract：:The genome RNA and six mRNA species of infectious hematopoietic necrosis virus were analyzed by denaturing gel electrophoresis. The following molecular weights were determined: genome RNA, 3.7 X 10(6); mRNA 1, 2.26 X 10(6); mRNA 2, 5.63 X 10(5); mRNA 3, 4.84 X 10(5); mRNA 4 (containing two different mRNA species), 3.0...

journal_title：Journal of virology

authors： Kurath G,Leong JC

更新日期：1985-02-01 00:00:00

abstract：:The contributions of the glycoproteins gI (ORF67) and gE (ORF68) to varicella-zoster virus (VZV) replication were investigated in deletion mutants made by using cosmids with VZV DNA derived from the Oka strain. Deletion of both gI and gE prevented virus replication. Complete deletion of gI or deletions of 60% of the N...

journal_title：Journal of virology

authors： Mallory S,Sommer M,Arvin AM

更新日期：1997-11-01 00:00:00

abstract：UNLABELLED:Bean pod mottle virus (BPMV) is a bipartite, positive-sense (+) RNA plant virus in the Secoviridae family. Its RNA1 encodes proteins required for genome replication, whereas RNA2 primarily encodes proteins needed for virion assembly and cell-to-cell movement. However, the function of a 58-kDa protein (P58) e...

journal_title：Journal of virology

authors： Lin J,Guo J,Finer J,Dorrance AE,Redinbaugh MG,Qu F

更新日期：2014-03-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) infects >90% of the population and establishes a latent infection with asymptomatic episodes of reactivation. However, HHV-6 reactivation is associated with morbidity and sometimes mortality in immunocompromised patients. To date, control of the virus in healthy virus carriers and the failu...

journal_title：Journal of virology

authors： Fastenackels S,Bayard C,Larsen M,Magnier P,Bonnafous P,Seddiki N,Appay V,Gautheret-Dejean A,Sauce D

更新日期：2019-06-14 00:00:00

abstract：:BST-2/CD317/tetherin is a host factor that inhibits the release of HIV-1 and other unrelated viruses. A current model proposes that BST-2 physically tethers virions to the surface of virus-producing cells. The HIV-1-encoded Vpu protein effectively antagonizes the activity of BST-2. How Vpu accomplishes this task remai...

journal_title：Journal of virology

authors： Andrew AJ,Miyagi E,Strebel K

更新日期：2011-03-01 00:00:00

abstract：:In this study, we show that replication-competent subgenomic hepatitis C virus (HCV) RNA can be transferred to permissive Huh7 cells, leading to the establishment of viral RNA replication. Further, we show that these events are mediated by exosomes rather than infectious virus particles. If similar events occur in viv...

journal_title：Journal of virology

authors： Longatti A,Boyd B,Chisari FV

更新日期：2015-03-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a herpesvirus and is the causative agent of chicken pox (varicella) and shingles (herpes zoster). Active immunization against varicella became possible with the development of live attenuated varicella vaccine. The Oka vaccine strain was isolated in Japan from a child who had typical va...

journal_title：Journal of virology

authors： Tillieux SL,Halsey WS,Thomas ES,Voycik JJ,Sathe GM,Vassilev V

更新日期：2008-11-01 00:00:00

abstract：:A more complete assessment of ovine prion strain diversity will be achieved by complementing biological strain typing in conventional and ovine PrP transgenic mice with a biochemical analysis of the resultant PrPSc. This will provide a correlation between ovine prion strain phenotype and the molecular nature of differ...

journal_title：Journal of virology

authors： Thackray AM,Hopkins L,Spiropoulos J,Bujdoso R

更新日期：2008-11-01 00:00:00

abstract：:A porcine rotavirus (prv), variant 4F, isolated in tissue culture from the feces of a Chinese pig with diarrhea, was found to have become highly pathogenic when passaged in gnotobiotic piglets (J. C. Bridger, B. Burke, G. M. Beards, and U. Desselberger, J. Gen. Virol. 73:3011-3015, 1992). Comparison with the closely r...

journal_title：Journal of virology

authors： Tauscher GI,Desselberger U

更新日期：1997-01-01 00:00:00

abstract：:Viral protein genome-linked (VPg) plays a central role in several stages of potyvirus infection. This study sought to answer questions about the role of Potato virus A (PVA; genus Potyvirus) VPg in viral and host RNA expression. When expressed in Nicotiana benthamiana leaves in trans, a dual role of VPg in translation...

journal_title：Journal of virology

authors： Eskelin K,Hafrén A,Rantalainen KI,Mäkinen K

更新日期：2011-09-01 00:00:00

abstract：:Differentiating infected from vaccinated animals (DIVA) strategies have been central enabling techniques in several successful viral disease elimination programs. However, owing to their long and uncertain development process, no DIVA-compatible vaccines are available for many important diseases. We report herein a ne...

journal_title：Journal of virology

authors： Xue Q,Xu H,Liu H,Pan J,Yang J,Sun M,Chen Y,Xu W,Cai X,Ma H

更新日期：2020-02-28 00:00:00

abstract：:The p24 protein, one of the three proteins implicated in local movement of potato virus X (PVX), was expressed in transgenic tobacco plants (Nicotiana tabacum Xanthi D8 NN). Plants with the highest level of p24 accumulation exhibited a stunted and slightly chlorotic phenotype. These transgenic plants facilitate the ce...

journal_title：Journal of virology

authors： Ares X,Calamante G,Cabral S,Lodge J,Hemenway P,Beachy RN,Mentaberry A

更新日期：1998-01-01 00:00:00

abstract：:Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the persistence of the viral genome during latent infection. It has been suggested that LANA1 tethers the viral genome to the host chromosome and also participates actively in DNA replication from the termin...

journal_title：Journal of virology

authors： Lim C,Choi C,Choe J

更新日期：2004-07-01 00:00:00

abstract：:We have examined EcoRI-restricted cellular DNA from BALB/c mouse-hamster somatic cell hybrids by blot hybridization for the presence of mouse mammary tumor virus-related sequences. Results of this analysis show that mouse mammary tumor virus-related proviral copies are located on chromosomes 16 (16-kilobase-pair fragm...

journal_title：Journal of virology

authors： Callahan R,Gallahan D,Kozak C

更新日期：1984-03-01 00:00:00

abstract：:Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells. ...

journal_title：Journal of virology

authors： Flomenberg PR,Chen M,Horwitz MS

更新日期：1987-12-01 00:00:00

abstract：:Massive infection of memory CD4 T cells is a hallmark of early simian immunodeficiency virus (SIV) infection, with viral infection peaking at day 10 postinfection (p.i.), when a majority of memory CD4 T cells in mucosal and peripheral tissues are infected. It is not clear if mononuclear cells from the monocyte and mac...

journal_title：Journal of virology

authors： Moore AC,Bixler SL,Lewis MG,Verthelyi D,Mattapallil JJ

更新日期：2012-01-01 00:00:00

abstract：:In vitro transcription by vesicular stomatitis virus nucleocapsids is inhibited by enzymatic dephosphorylation of the NS protein. We provide evidence that specific, partial dephosphorylation of NS molecules is the only detectable change in nucleocapsids treated with bacterial alkaline phosphatase under conditions that...

journal_title：Journal of virology

authors： Hsu CH,Morgan EM,Kingsbury DW

更新日期：1982-07-01 00:00:00