Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter.

abstract：:The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and consequent activatio...

journal_title：Journal of virology

authors： Beretta L,Svitkin YV,Sonenberg N

更新日期：1996-12-01 00:00:00

abstract：:Recent environmental and metagenomic studies have considerably increased the repertoire of archaeal viruses and suggested that they play important roles in nutrient cycling in the biosphere. However, very little is known about how they regulate their life cycles and interact with their hosts. Here, we report that the ...

journal_title：Journal of virology

authors： Chen B,Chen Z,Wang Y,Gong H,Sima L,Wang J,Ouyang S,Gan W,Krupovic M,Chen X,Du S

更新日期：2020-07-30 00:00:00

abstract：:Approximately 10% of gastric carcinomas (GC) are comprised of cells latently infected with Epstein-Barr virus (EBV); however, the mechanism by which EBV contributes to the development of this malignancy is unclear. We have investigated the cellular effects of the only EBV nuclear protein expressed in GC, EBNA1, focusi...

journal_title：Journal of virology

authors： Sivachandran N,Dawson CW,Young LS,Liu FF,Middeldorp J,Frappier L

更新日期：2012-01-01 00:00:00

abstract：:Vaccinia extracellular enveloped virus (EEV) is critical for cell-to-cell and long-range virus spread both in vitro and in vivo. The B5R gene encodes an EEV-specific type I membrane protein that is essential for efficient EEV formation. The majority of the B5R ectodomain consists of four domains with homology to short...

journal_title：Journal of virology

authors： Aldaz-Carroll L,Whitbeck JC,Ponce de Leon M,Lou H,Hirao L,Isaacs SN,Moss B,Eisenberg RJ,Cohen GH

更新日期：2005-05-01 00:00:00

abstract：:The hepatitis C virus (HCV) envelope proteins, E1 and E2, form noncovalent heterodimers and are leading candidate antigens for a vaccine against HCV. Studies in mammalian cell expression systems have focused primarily on E2 and its folding, whereas knowledge of E1 folding remains fragmentary. We used a cell-free in vi...

journal_title：Journal of virology

authors： Merola M,Brazzoli M,Cocchiarella F,Heile JM,Helenius A,Weiner AJ,Houghton M,Abrignani S

更新日期：2001-11-01 00:00:00

abstract：:During the S phase of the eukaryotic cell cycle and in virus-infected cells, DNA replication takes place at discrete sites in the nucleus, although it is not clear how the proteins involved in the replicative process are directed to these sites. Nuclear factor I is a cellular, sequence-specific DNA-binding protein uti...

journal_title：Journal of virology

authors： Bosher J,Dawson A,Hay RT

更新日期：1992-05-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) capsid is a T=16 icosahedral shell that forms in the nuclei of infected cells. Capsid assembly also occurs in vitro in reaction mixtures created from insect cell extracts containing recombinant baculovirus-expressed HSV-1 capsid proteins. During capsid formation, the major capsi...

journal_title：Journal of virology

authors： Spencer JV,Newcomb WW,Thomsen DR,Homa FL,Brown JC

更新日期：1998-05-01 00:00:00

abstract：:Replicase gene expression by the human coronavirus 229E involves the synthesis of two large polyproteins, pp1a and pp1ab. Experimental evidence suggests that these precursor molecules are subject to extensive proteolytic processing. In this study, we show that a chymotrypsin-like enzyme, the virus-encoded 3C-like prot...

journal_title：Journal of virology

authors： Ziebuhr J,Siddell SG

更新日期：1999-01-01 00:00:00

abstract：:Mice were infected with lymphocytic choriomeningitis virus and injected once 24 h later with a monoclonal antibody directed against gamma interferon. In comparison with controls, the increase of numbers of CD8+ T cells and the generation of virus-specific cytotoxic T lymphocytes in spleens and virus clearance from org...

journal_title：Journal of virology

authors： Utermöhlen O,Dangel A,Tárnok A,Lehmann-Grube F

更新日期：1996-03-01 00:00:00

abstract：:HVEM (for herpesvirus entry mediator) is a member of the tumor necrosis factor receptor superfamily and mediates entry of many strains of herpes simplex virus (HSV) into normally nonpermissive Chinese hamster ovary (CHO) cells. We used sucrose density centrifugation to demonstrate that purified HSV-1 KOS virions bind ...

journal_title：Journal of virology

authors： Nicola AV,Ponce de Leon M,Xu R,Hou W,Whitbeck JC,Krummenacher C,Montgomery RI,Spear PG,Eisenberg RJ,Cohen GH

更新日期：1998-05-01 00:00:00

abstract：:In 2010 and 2011, several devastating Newcastle disease (ND) outbreaks occurred in China, affecting broilers, layers, and breeders. The CK-JSX1-201005 virus was isolated from broiler breeder flocks vaccinated with the classical ND virus (NDV) vaccine program, but laying rate decreased from 80% to 30 to 40% in the clin...

journal_title：Journal of virology

authors： Chen F,Liu J,Liu D,Yan Z,Ji J,Qin J,Li H,Ma J,Bi Y,Xie Q

更新日期：2012-11-01 00:00:00

abstract：:Phosphorylation of viral proteins plays important roles in the influenza A virus (IAV) life cycle. By using mass spectrometry, we identified tyrosine 132 (Y132) as a phosphorylation site of the matrix protein (M1) of the influenza virus A/WSN/1933(H1N1). Phosphorylation at this site is essential to the process of viru...

journal_title：Journal of virology

authors： Wang S,Zhao Z,Bi Y,Sun L,Liu X,Liu W

更新日期：2013-06-01 00:00:00

abstract：:The phosphoprotein (P) of the nonsegmented negative-sense RNA viruses is a multimeric modular protein that is essential for RNA transcription and replication. Despite great variability in length and sequence, the architecture of this protein is conserved among the different viral families, with a long N-terminal intri...

journal_title：Journal of virology

authors： Gérard FCA,Jamin M,Blackledge M,Blondel D,Bourhis JM

更新日期：2020-02-28 00:00:00

abstract：:The coding region for the hepatitis B virus surface antigens contains three in-phase ATG codons which direct the synthesis of three related polypeptides. The 24-kilodalton major surface (or S) glycoprotein is initiated at the most distal ATG and is a transmembrane protein whose translocation across the bilayer is medi...

journal_title：Journal of virology

authors： Eble BE,Lingappa VR,Ganem D

更新日期：1990-03-01 00:00:00

abstract：:The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses ...

journal_title：Journal of virology

authors： Kim J,Zhang X,Centonze VE,Bowman VD,Noble S,Baker TS,Nibert ML

更新日期：2002-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) and woolly monkey hepatitis B virus (WMHBV) are primate hepadnaviruses that display restricted tissue and host tropisms. Hepatitis D virus (HDV) particles pseudotyped with HBV and WMHBV envelopes (HBV-HDV and WM-HDV) preferentially infect human and spider monkey hepatocytes, respectively, there...

journal_title：Journal of virology

authors： Barrera A,Guerra B,Notvall L,Lanford RE

更新日期：2005-08-01 00:00:00

abstract：:Mitochondrial DNA synthesis in adenovirus type 2-infected HeLa cells was measured at various times from 0 to 24 h postinfection. Although viral infection effectively turned off host chromosomal DNA synthesis, mitochondrial DNA synthesis was not inhibited. These findings indicate a dissociation between the regulation o...

journal_title：Journal of virology

authors： Fisher PB,Horwitz MS

更新日期：1977-05-01 00:00:00

abstract：:Alphaherpesviruses are parasites of the peripheral nervous system in their natural hosts. After the initial infection of peripheral tissues such as mucosal cells, these neurotropic viruses will invade the peripheral nervous system that innervates the site of infection via long-distance axonal transport of the viral ge...

journal_title：Journal of virology

authors： Ch'ng TH,Enquist LW

更新日期：2005-09-01 00:00:00

abstract：:Immune responses to vector-corrected cells have limited the application of gene therapy for treatment of chronic disorders such as inherited deficiency states. We have found that recombinant adeno-associated virus (AAV) efficiently transduces muscle fibers in vivo without activation of cellular and humoral immunity to...

journal_title：Journal of virology

authors： Jooss K,Yang Y,Fisher KJ,Wilson JM

更新日期：1998-05-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. How HSV evolves within an infected individual experiencing multiple episodes of recurrent disease over time is not known. We determined...

journal_title：Journal of virology

authors： Minaya MA,Jensen TL,Goll JB,Korom M,Datla SH,Belshe RB,Morrison LA

更新日期：2017-11-14 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein US2 increases the proteasome-mediated degradation of major histocompatibility complex (MHC) class I heavy chain (HC), class II DR-alpha and DM-alpha proteins, and HFE, a nonclassical MHC protein. US2-initiated degradation of MHC proteins apparently involves the recruitment of ...

journal_title：Journal of virology

authors： Chevalier MS,Johnson DC

更新日期：2003-04-01 00:00:00

abstract：:Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray...

journal_title：Journal of virology

authors： Singh BK,Koromyslova A,Hefele L,Gürth C,Hansman GS

更新日期：2015-12-23 00:00:00

abstract：:The relationship between virus-specific CD8(+)-T-cell responses and viral persistence was studied in mice by using Hantaan virus (HTNV). We first established a simple method for measuring levels of virus-specific CD8(+) T cells by flow cytometry. Next, to produce a mouse model of persistent HTNV infection, newborn mic...

journal_title：Journal of virology

authors： Araki K,Yoshimatsu K,Lee BH,Kariwa H,Takashima I,Arikawa J

更新日期：2003-08-01 00:00:00

abstract：:Human oncolytic adenoviruses have been used in clinical trials targeting cancers of epithelial origin. To gain a better understanding of the infectious cycle of adenovirus in normal human squamous tissues, we examined the viral infection process in organotypic cultures of primary human keratinocytes. We show that for ...

journal_title：Journal of virology

authors： Noya F,Balagué C,Banerjee NS,Curiel DT,Broker TR,Chow LT

更新日期：2003-06-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three discrete activities that each affect the ability of HN to promote viral fusion and entry: receptor binding, receptor cleaving (neuraminidase), and triggering of the fusion protein. The interrelationship between the receptor binding and f...

journal_title：Journal of virology

authors： Porotto M,Fornabaio M,Kellogg GE,Moscona A

更新日期：2007-04-01 00:00:00

abstract：:The morphology of Safferman's virus of blue-green algae (phycovirus LPP-1) has been studied by electron microscopy and physicochemical methods. The virion has a short (100 to 200 A long, 150 A in diameter) forked tail, with an outer sheath, an inner core, and a capital attached to one of the vertices of a polyhedral h...

journal_title：Journal of virology

authors： Luftig R,Haselkorn R

更新日期：1967-04-01 00:00:00

abstract：:Preclinical studies have shown that gene transfer following readministration of viral vectors is often inefficient due to the presence of neutralizing antibodies. Vectors derived from ubiquitous human adenoviruses may have limited clinical use because preexisting humoral and cellular immunity is found in 90% of the po...

journal_title：Journal of virology

authors： Kremer EJ,Boutin S,Chillon M,Danos O

更新日期：2000-01-01 00:00:00

abstract：:Transient transfection assays indicated that A2L is one of three vaccinia virus intermediate genes that are required for the transcriptional transactivation of viral late genes. We have expressed the A2L open reading frame in Escherichia coli and shown by blotting experiments that the 26-kDa protein binds zinc, a prop...

journal_title：Journal of virology

authors： Keck JG,Feigenbaum F,Moss B

更新日期：1993-10-01 00:00:00

abstract：:A promoter-trap retrovirus has been constructed in which a promoterless polyomavirus middle T antigen gene was inserted in the U3 region of the long terminal repeat of a replication-competent Moloney murine leukemia virus. The resulting virus, designated PyT, was used to infect mouse mammary glands in situ. As expecte...

journal_title：Journal of virology

authors： Coulombe J,Avis Y,Gray DA

更新日期：1996-10-01 00:00:00

abstract：UNLABELLED:Nonhuman primates (NHPs) are a historically important source of zoonotic viruses and are a gold-standard model for research on many human pathogens. However, with the exception of simian immunodeficiency virus (SIV) (family Retroviridae), the blood-borne viruses harbored by these animals in the wild remain i...

journal_title：Journal of virology

authors： Bailey AL,Lauck M,Ghai RR,Nelson CW,Heimbruch K,Hughes AL,Goldberg TL,Kuhn JH,Jasinska AJ,Freimer NB,Apetrei C,O'Connor DH

更新日期：2016-07-11 00:00:00