Superinfection exclusion by heteroimmune corynebacteriophages.


:Superinfection of Corynebacterium diphtheriae C7(beta) by heteroimmune phage gamma is productive, whereas superinfection by gamma-bin mutants is for the most part nonproductive. Exclusion of gamma-bin phage occurred after its DNA had penetrated and was partially expressed in the heteroimmune lysogen. All of the infected cells were killed, and lysis was observed. The beta inhibitor causing exclusion was produced during the prophage state and appeared to be distinct from immune repressor. The ability of gamma-bin phage to superinfect C7(beta) productively could be restored by recombination with beta phage, indicating that both beta and gamma phages contain either indentical or similar alleles of the bin gene. The bin gene was mapped by vegetative and prophage crosses and found to be located in the region of the phage genome concerned with regulation. Both beta and gamma wild-type phages induced the resident prophage in a significant fraction of superinfeted heteroimmune lysogens. This, coupled with the fact that induction of C7(beta) abolished exclusion, suggests that the bin gene product acts as antirepressor, i.e., it reduces the level of heteroimmune repressor either directly or indirectly. The gamma-bin mutants either failed to produce antirepressor or did so with reduced efficiency. Antirepressor activity was negatively controlled by homoimmune repressor. The isolation of beta mutants that appeared bin-like suggests that beta and gamma phages contain homologous systems of exclusion and antiexclusion. Exclusion of gamm-bin by beta phage in gram-positive C. diphtheriae exhibited striking parallels to the sieB exclusion described for phages P22 and lambda in gram-negative organisms. The extended similarities of these coryngephages to lambda bacteriophage is noted.


J Virol


Journal of virology


Groman NB,Rabin M




Has Abstract


1980-11-01 00:00:00












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    journal_title:Journal of virology

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    更新日期:2021-01-28 00:00:00

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    journal_title:Journal of virology

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    authors: Mohr I,Sternberg D,Ward S,Leib D,Mulvey M,Gluzman Y

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  • In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins.

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    journal_title:Journal of virology

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    authors: Kang Y,Stein CS,Heth JA,Sinn PL,Penisten AK,Staber PD,Ratliff KL,Shen H,Barker CK,Martins I,Sharkey CM,Sanders DA,McCray PB Jr,Davidson BL

    更新日期:2002-09-01 00:00:00

  • Human immunodeficiency virus type 2 produces a defect in CD3-gamma gene transcripts similar to that observed for human immunodeficiency virus type 1.

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    authors: Segura I,Delmelle-Wibaut C,Janssens M,Cleuter Y,van den Broeke A,Kettmann R,Willard-Gallo KE

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  • Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein.

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    authors: Okamoto K,Moriishi K,Miyamura T,Matsuura Y

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  • Transcription of hepatitis delta antigen mRNA continues throughout hepatitis delta virus (HDV) replication: a new model of HDV RNA transcription and replication.

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  • Identification of novel positive-strand RNA viruses by metagenomic analysis of archaea-dominated Yellowstone hot springs.

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  • Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.

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    更新日期:2009-10-01 00:00:00

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    更新日期:2007-03-01 00:00:00

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    更新日期:2001-09-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Zimmer G,Zimmer KP,Trotz I,Herrler G

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    pub_type: 杂志文章


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    更新日期:2010-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Court D,Campbell A

    更新日期:1972-06-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2006-04-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Barbacid M

    更新日期:1981-01-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2017-07-27 00:00:00