Abstract:
:Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the persistence of the viral genome during latent infection. It has been suggested that LANA1 tethers the viral genome to the host chromosome and also participates actively in DNA replication from the terminal repeat of KSHV. Here we show by mutational analysis that the mitotic chromosome-binding activity of LANA1 is tightly coupled to its replication activity. Thus, KSHV appears to have evolved a unique tactic for its stable maintenance.
journal_name
J Viroljournal_title
Journal of virologyauthors
Lim C,Choi C,Choe Jdoi
10.1128/JVI.78.13.7248-7256.2004subject
Has Abstractpub_date
2004-07-01 00:00:00pages
7248-56issue
13eissn
0022-538Xissn
1098-5514pii
78/13/7248journal_volume
78pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00