Modeling the acute and chronic phases of Theiler murine encephalomyelitis virus infection.

abstract：:The origin and role of the endonuclease activity associated with purified virions of simian virus 40, previously described by this and other laboratories, have been further investigated. We found that the enzymatic activity from virions of temperature-sensitive (ts) mutants is not more heat labile than that from wild-...

journal_title：Journal of virology

authors： Dooley DC,Ryzlak MT,Ozer HL

更新日期：1976-02-01 00:00:00

abstract：:Animal influenza viruses pose a clear threat to public health. Transmissibility among humans is a prerequisite for a novel influenza virus to cause a human pandemic. A novel reassortant swine influenza virus acquired sustained human-to-human transmissibility and caused the 2009 influenza pandemic. However, the molecul...

journal_title：Journal of virology

authors： Zhang Y,Zhang Q,Gao Y,He X,Kong H,Jiang Y,Guan Y,Xia X,Shu Y,Kawaoka Y,Bu Z,Chen H

更新日期：2012-09-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV), a double-stranded RNA (dsRNA) virus belonging to the Birnaviridae family, is an economically important avian pathogen. The IBDV capsid is based on a single-shelled T=13 lattice, and the only structural subunits are VP2 trimers. During capsid assembly, VP2 is synthesized as a pro...

journal_title：Journal of virology

authors： Luque D,Saugar I,Rodríguez JF,Verdaguer N,Garriga D,Martín CS,Velázquez-Muriel JA,Trus BL,Carrascosa JL,Castón JR

更新日期：2007-07-01 00:00:00

abstract：:Bats are the second largest group of mammals on earth and act as reservoirs of many emerging viruses. In this study, a novel bat adenovirus (AdV) (BtAdV-TJM) was isolated from bat fecal samples by using a bat primary kidney cell line. Infection studies indicated that most animal and human cell lines are susceptible to...

journal_title：Journal of virology

authors： Li Y,Ge X,Zhang H,Zhou P,Zhu Y,Zhang Y,Yuan J,Wang LF,Shi Z

更新日期：2010-04-01 00:00:00

abstract：:The v-src coding region was deleted from cloned Rous sarcoma virus DNA, and the deleted clones were tested for infectivity by transfection. All of the coding region, as well as most of the sequences lying between v-src and the unique 3' region (U3), could be deleted without affecting viability. However, at least 9 and...

journal_title：Journal of virology

authors： Sorge J,Hughes SH

更新日期：1982-08-01 00:00:00

abstract：:The papillomavirus (PV) E2 protein is a critical regulator of viral transcription and genome replication. We previously reported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by the fibroblast growth factor receptor 3 (FGFR3) kinase. In this study, we generated quasiviruses containing G418-selectable HPV-31 gen...

journal_title：Journal of virology

authors： Jose L,Androphy EJ,DeSmet M

更新日期：2020-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells re...

journal_title：Journal of virology

authors： Kitchen SG,Korin YD,Roth MD,Landay A,Zack JA

更新日期：1998-11-01 00:00:00

abstract：:We previously showed that the 93-bp region between the enhancer and promoter (named DEN for downstream of enhancer) of the long terminal repeat (LTR) of the MCF13 murine leukemia virus is an important determinant of the ability of this virus to induce thymic lymphoma. In this study we observed that DEN plays a role in...

journal_title：Journal of virology

authors： Yoshimura FK,Wang T,Cankovic M

更新日期：1999-06-01 00:00:00

abstract：:The potential role of T cells in the control of human papillomavirus type 6 (HPV-6) infections is an appealing premise, but their actual role has been sparsely investigated. Since HPV-6 infections are confined to the epithelium, such an investigation should focus on the T cells present at the site of infection (i.e., ...

journal_title：Journal of virology

authors： Hong K,Greer CE,Ketter N,Van Nest G,Paliard X

更新日期：1997-09-01 00:00:00

abstract：:We have synthesized 32P-labeled hybridization probes from a hyperdivergent region (nucleotides 51 to 392) of the rotavirus gene encoding the VP7 glycoprotein by using the polymerase chain reaction method. Both RNA (after an initial reverse transcription step) and cloned cDNA from human rotavirus serotypes 1 through 4 ...

journal_title：Journal of virology

authors： Flores J,Sears J,Schael IP,White L,Garcia D,Lanata C,Kapikian AZ

更新日期：1990-08-01 00:00:00

abstract：:Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing the receptor angiotensin-converting enzyme 2 (ACE2). Here we show that codon optimization of the SARS-CoV S-protein gene...

journal_title：Journal of virology

authors： Moore MJ,Dorfman T,Li W,Wong SK,Li Y,Kuhn JH,Coderre J,Vasilieva N,Han Z,Greenough TC,Farzan M,Choe H

更新日期：2004-10-01 00:00:00

abstract：:An in vitro method which led to the transformation of hamster embryo fibroblasts after exposure to herpes simplex virus type 2 (HSV-2) inactivated with ultraviolet irradiation is described. The transformed cells (333-8-9) produced tumors when inoculated into newborn Syrian hamsters but not when injected into weanling ...

journal_title：Journal of virology

authors： Duff R,Rapp F

更新日期：1971-10-01 00:00:00

abstract：:Luteoviruses and the luteovirus-like pea enation mosaic virus (PEMV; genus Enamovirus) are transmitted by aphids in a circulative, nonreplicative manner. Acquired virus particles persist for several weeks in the aphid hemolymph, in which a GroEL homolog, produced by the primary endosymbiont of the aphid, is abundantly...

journal_title：Journal of virology

authors： van den Heuvel JF,Bruyère A,Hogenhout SA,Ziegler-Graff V,Brault V,Verbeek M,van der Wilk F,Richards K

更新日期：1997-10-01 00:00:00

abstract：:Simian virus 40 (SV40)-transformed human cells (LN-SV) were fused with BALB/c peritoneal macrophages (BALB/c X LN-SV) and with C57BL peritoneal macrophages (C57BL X LN-SV) and hybrid clones, all of which had segregated human chromosomes and contained the entire complement of mouse chromosomes, were isolated. All 15 BA...

journal_title：Journal of virology

authors： Huebner K,Croce CM

更新日期：1976-06-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) G protein deletion mutants replicate effectively in vitro but have not been detected in nature. Subtyping of RSV strains in hospitalized children in South Africa identified G protein PCR amplicons significantly reduced in size in 2 out of 209 clinical specimens screened over 4 years. ...

journal_title：Journal of virology

authors： Venter M,van Niekerk S,Rakgantso A,Bent N

更新日期：2011-08-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) genome contains an open reading frame, BHRF1, that encodes a presumptive membrane protein with sequence similarity to the proto-oncogene bcl2, which is linked to human B-cell follicular lymphoma. Potential roles for BHRF1 in EBV's ability to growth transform human B cells and to replicate ...

journal_title：Journal of virology

authors： Lee MA,Yates JL

更新日期：1992-04-01 00:00:00

abstract：:Immediate-early viral gene products of human cytomegalovirus (HCMV) are derived from several genomic loci and largely serve to establish a cellular environment conducive to viral replication. We have further examined an unusual immediate-early transcript known as the 5-kb RNA, concluding that it is a stable intron enc...

journal_title：Journal of virology

authors： Kulesza CA,Shenk T

更新日期：2004-12-01 00:00:00

abstract：:Hepatitis delta virus (HDV) contains a circular RNA genome of 1.7 kb. HDV RNA replication is thought to proceed via a rolling-circle mechanism that is dependent on autocatalytic cleavage and ligation reactions. However, it has never been established that these ribozyme activities are indeed involved in HDV RNA replica...

journal_title：Journal of virology

authors： Macnaughton TB,Wang YJ,Lai MM

更新日期：1993-04-01 00:00:00

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：:The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein la...

journal_title：Journal of virology

authors： Tran EE,Simmons JA,Bartesaghi A,Shoemaker CJ,Nelson E,White JM,Subramaniam S

更新日期：2014-09-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) transmembrane glycoprotein has a 24-amino-acid cytoplasmic domain whose function in the viral life cycle is poorly understood. We introduced premature-stop mutations and 18 single-amino-acid substitutions into this domain and studied their effects on cell-to-cell transmi...

journal_title：Journal of virology

authors： Delamarre L,Pique C,Rosenberg AR,Blot V,Grange MP,Le Blanc I,Dokhélar MC

更新日期：1999-11-01 00:00:00

abstract：:Virion protein 16 (VP16) of herpes simplex virus type 1 (HSV-1) is a potent transcriptional activator of viral immediate-early (IE) genes. The VP16 activation domain can recruit various transcriptional coactivators to target gene promoters. However, the role of transcriptional coactivators in HSV-1 IE gene expression ...

journal_title：Journal of virology

authors： Kutluay SB,DeVos SL,Klomp JE,Triezenberg SJ

更新日期：2009-04-01 00:00:00

abstract：:The Roseobacter clade has been recognized as one of the abundant bacterial lineages in marine environments, which makes the characterization of bacteriophages infecting members of the clade important. Here we report the complete genome sequence of bacteriophage P12053L, which infects Celeribacter sp. strain IMCC12053,...

journal_title：Journal of virology

authors： Kang I,Jang H,Oh HM,Cho JC

更新日期：2012-08-01 00:00:00

abstract：:The papillomavirus E2 gene product plays a pivotal role in viral replication. E2 has multiple functions, including (i) transcriptional activation and repression of viral promoters and (ii) the enhancement of viral DNA replication. It was previously reported that E2 suppressed the growth of papillomavirus-positive cerv...

journal_title：Journal of virology

authors： Nishimura A,Ono T,Ishimoto A,Dowhanick JJ,Frizzell MA,Howley PM,Sakai H

更新日期：2000-04-01 00:00:00

abstract：:Pseudorabies virus (PRV), a member of the Alphaherpesvirinae, has a complex multilayered extracellular virion that is structurally conserved among other herpesviruses. PRV virions contain a double-stranded DNA genome within a proteinaceous capsid surrounded by the tegument, a layer of viral and cellular proteins. The ...

journal_title：Journal of virology

authors： Kramer T,Greco TM,Enquist LW,Cristea IM

更新日期：2011-07-01 00:00:00

abstract：:All positive-strand RNA viruses reorganize host intracellular membranes to assemble their replication complexes. Similarly, brome mosaic virus (BMV) induces two alternate forms of membrane-bound RNA replication complexes: vesicular spherules and stacks of appressed double-membrane layers. The mechanisms by which these...

journal_title：Journal of virology

authors： Zhang J,Diaz A,Mao L,Ahlquist P,Wang X

更新日期：2012-05-01 00:00:00

abstract：:Experimental reverse genetic replacement of Epstein-Barr virus nuclear antigen 3A (EBNA3A) with a conditional mutant EBNA3A revealed that EBNA3A is critical for continued lymphoblastoid cell (LCL) growth. Wild-type (wt) EBNA3A expressed in the LCLs specifically sustained growth under nonpermissive conditions, whereas ...

journal_title：Journal of virology

authors： Maruo S,Johannsen E,Illanes D,Cooper A,Zhao B,Kieff E

更新日期：2005-08-01 00:00:00

abstract：:A streptomycin-resistant Escherichia coli mutant has been isolated that is temperature sensitive for Qbeta phage, but not for the group I RNA phages f2, MS2, and R17. The growth of Qbeta in the mutant at the nonpermissive temperature (42 degrees C) results in the release of a near-normal burst of noninfectious particl...

journal_title：Journal of virology

authors： Engelberg-Kulka H,Dekel L,Israeli-Reches M

更新日期：1977-01-01 00:00:00

abstract：:Friend virus induces an erythroleukemia in susceptible mice that is initiated by the interaction of the Friend virus-encoded glycoprotein gp55 with the erythropoietin (Epo) receptor and the product of the host Fv2 gene, a naturally occurring truncated form of the Stk receptor tyrosine kinase (Sf-Stk). We have previous...

journal_title：Journal of virology

authors： He S,Ni S,Hegde S,Wang X,Sharda DR,August A,Paulson RF,Hankey PA

更新日期：2010-03-01 00:00:00

abstract：:The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection. The temporal and spatial distribution of viral antigen, known as the transneuronal spread phenotype, has not previously been described; nor is it ...

journal_title：Journal of virology

authors： Engel JP,Madigan TC,Peterson GM

更新日期：1997-03-01 00:00:00