Abstract:
:Analysis of the complete sequence of a human immunodeficiency virus (HIV) isolate (Ant70) obtained from a Cameroonian patient indicates that this virus is the most divergent strain within the HIV-1 family hitherto described. Comparison of the Pol protein, usually highly conserved within the HIV-1 family, shows only about 73% similarity with the HIVmm isolate, whereas for the more variable proteins such as envelope, similarities of 50% or lower are found. The principal neutralizing determinant (V3 loop) and the immunodominant region within gp41 also contain some unusual substitutions, which may have implications for protein function as well as for serological assays based on these regions. Phylogenetic analyses show that this isolate occupies a unique position relative to the human HIV-1 isolates and the recently described SIVcpz virus, indicating that this Cameroonian isolate may provide us with new insights into the origins of the HIV-1 family.
journal_name
J Viroljournal_title
Journal of virologyauthors
Vanden Haesevelde M,Decourt JL,De Leys RJ,Vanderborght B,van der Groen G,van Heuverswijn H,Saman Edoi
10.1128/JVI.68.3.1586-1596.1994subject
Has Abstractpub_date
1994-03-01 00:00:00pages
1586-96issue
3eissn
0022-538Xissn
1098-5514journal_volume
68pub_type
杂志文章abstract::Human herpesvirus 6 (HHV-6)-specific monoclonal antibody (Mab) 9A5D12 reacted with the nucleus of HHV-6 strain GS-infected cells and immunoprecipitated a phosphorylated polypeptide with an approximate size of 41 kDa, designated HHV-6 P41. A 110-kDa polypeptide was also immunoprecipitated by the MAb. These polypeptides...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.64.8.3635-3642.1990
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journal_title:Journal of virology
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journal_title:Journal of virology
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更新日期:1998-01-01 00:00:00