The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex.

abstract：:After the contagion measles virus (MV) crosses the respiratory epithelium within myeloid cells that express the primary receptor signaling lymphocytic activation molecule (SLAM), it replicates briskly in SLAM-expressing cells in lymphatic organs. Later, the infection spreads to epithelia expressing nectin-4, an adhere...

journal_title：Journal of virology

authors： Frenzke M,Sawatsky B,Wong XX,Delpeut S,Mateo M,Cattaneo R,von Messling V

更新日期：2013-03-01 00:00:00

abstract：:Disease-associated PrP fragments produced upon in vitro or in vivo proteolysis can provide significant insight into the causal strain of prion disease. Here we describe a novel molecular strain typing assay that used thermolysin digestion of caudal medulla samples to produce PrPres signatures on Western blots that rea...

journal_title：Journal of virology

authors： Owen JP,Rees HC,Maddison BC,Terry LA,Thorne L,Jackman R,Whitelam GC,Gough KC

更新日期：2007-10-01 00:00:00

abstract：:Marek's disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas and tumors within 4 to 5 weeks of infection. Although the ability of MDV to induce tumors was demonstrated many years ago and although a number of viral oncogenic proteins have been identified, the mechanism by which the MDV is implicate...

journal_title：Journal of virology

authors： Fragnet L,Blasco MA,Klapper W,Rasschaert D

更新日期：2003-05-01 00:00:00

abstract：:Herpesvirus nucleocapsids are translocated from their assembly site in the nucleus to the cytosol by acquisition of a primary envelope at the inner nuclear membrane which subsequently fuses with the outer nuclear membrane. This transport through the nuclear envelope requires homologs of the conserved herpesviral pUL31...

journal_title：Journal of virology

authors： Grimm KS,Klupp BG,Granzow H,Müller FM,Fuchs W,Mettenleiter TC

更新日期：2012-06-01 00:00:00

abstract：:Dengue virus (DENV) is a major global pathogen that causes significant morbidity and mortality in tropical and subtropical areas worldwide. An improved understanding of the regions within the DENV genome and its encoded proteins that are required for the virus replication cycle will expedite the development of urgentl...

journal_title：Journal of virology

authors： Eyre NS,Johnson SM,Eltahla AA,Aloi M,Aloia AL,McDevitt CA,Bull RA,Beard MR

更新日期：2017-11-14 00:00:00

abstract：:In clinical trials, HIV-1 broadly neutralizing antibodies (bnAbs) effectively lower plasma viremia and delay virus reemergence. The presence of less neutralization-susceptible strains prior to treatment decreases the efficacy of these antibody-based treatments, but neutralization sensitivity often cannot be predicted ...

journal_title：Journal of virology

authors： Registre L,Moreau Y,Ataca ST,Pulukuri S,Henrich TJ,Lin N,Sagar M

更新日期：2020-01-06 00:00:00

abstract：:Here, we report that specific manipulations of the cellular response to virus infection can cause prevention of apoptosis and consequent establishment of persistent infection. Infection of several human cell lines with Sendai virus (SeV) or human parainfluenza virus 3, two prototypic paramyxoviruses, caused slow apopt...

journal_title：Journal of virology

authors： Peters K,Chattopadhyay S,Sen GC

更新日期：2008-04-01 00:00:00

abstract：:We investigated the effect of HLA class I alleles on clinical parameters for HIV-1 disease progression in the Japanese population, where two strongly protective alleles, HLA-B*57 and HLA-B*27, are virtually nonexistent. HLA-B alleles showed a dominant role, primarily through HLA-B*67:01 and the HLA-B*52:01-C*12:02 hap...

journal_title：Journal of virology

authors： Naruto T,Gatanaga H,Nelson G,Sakai K,Carrington M,Oka S,Takiguchi M

更新日期：2012-10-01 00:00:00

abstract：:The cellular protein bone marrow stromal antigen-2 (BST-2)/tetherin acts against a variety of enveloped viruses by restricting their release from the plasma membrane. The HIV-1 accessory protein Vpu counteracts BST-2 by downregulating it from the cell surface and displacing it from virion assembly sites. Previous comp...

journal_title：Journal of virology

authors： Sharma S,Jafari M,Bangar A,William K,Guatelli J,Lewinski MK

更新日期：2019-05-15 00:00:00

abstract：:Adenovirus type 19 is a major cause of epidemic keratoconjunctivitis, the only ocular adenoviral infection associated with prolonged corneal inflammation. In this study, we investigated the role of phosphoinositide 3-kinase (PI3K) and Akt and their downstream targets in adenovirus infection, and here we report the nov...

journal_title：Journal of virology

authors： Rajala MS,Rajala RV,Astley RA,Butt AL,Chodosh J

更新日期：2005-10-01 00:00:00

abstract：:Pancreatic islets from DBA/2 mice infected with the D variant of encephalomyocarditis (EMC-D) virus revealed lymphocytic infiltration with moderate to severe destruction of pancreatic beta cells. Our previous studies showed that the major population of infiltrating cells at the early stages of infection is macrophages...

journal_title：Journal of virology

authors： Hirasawa K,Jun HS,Maeda K,Kawaguchi Y,Itagaki S,Mikami T,Baek HS,Doi K,Yoon JW

更新日期：1997-05-01 00:00:00

abstract：:The establishment of de novo-generated patterns of DNA methylation is characterized by the gradual spreading of DNA methylation (I. Kuhlmann and W. Doerfler, J. Virol. 47:631-636, 1983; M. Toth, U. Lichtenberg, and W. Doerfler, Proc. Natl. Acad. Sci. USA 86:3728-3732, 1989; M. Toth, U. Müller, and W. Doerfler J. Mol. ...

journal_title：Journal of virology

authors： Orend G,Kuhlmann I,Doerfler W

更新日期：1991-08-01 00:00:00

abstract：:The flavivirus dengue virus (DV) infects cells through a low-pH-triggered membrane fusion reaction mediated by the viral envelope protein E. E is an elongated transmembrane protein with three domains and is organized as a homodimer on the mature virus particle. During fusion, the E protein homodimer dissociates, inser...

journal_title：Journal of virology

authors： Liao M,Sánchez-San Martín C,Zheng A,Kielian M

更新日期：2010-06-01 00:00:00

abstract：:Enveloped virus vectors are used in a wide variety of applications. We have discovered that treatment of cultured cells with phosphatidylserine (PS) liposomes can increase virus vector infection by up to 20-fold. This effect does not abrogate virus receptor requirements, is specific to PS compared to other phospholipi...

journal_title：Journal of virology

authors： Coil DA,Miller AD

更新日期：2005-09-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) remains latent throughout the life of the carrier, with cells containing the provirus and viral gene expression efficiently down-regulated. On a molecular level, exactly how viruses are down-regulated in vivo remains unresolved. We described here the possibility that down-re...

journal_title：Journal of virology

authors： Saiga A,Orita S,Minoura-Tada N,Maeda M,Aono Y,Asakawa M,Nakahara K,Kubota R,Osame M,Igarashi H

更新日期：1997-06-01 00:00:00

abstract：:Cytomegaloviruses (CMVs) colonize blood-borne myeloid cells. Murine CMV (MCMV) spreads from the lungs via infected CD11c+ cells, consistent with an important role for dendritic cells (DC). We show here that MCMV entering via the olfactory epithelium, a natural transmission portal, also spreads via infected DC. They re...

journal_title：Journal of virology

authors： Farrell HE,Bruce K,Lawler C,Stevenson PG

更新日期：2019-07-17 00:00:00

abstract：:Herpes B virus (BV) naturally infects macaque monkeys and is genetically similar to herpes simplex virus (HSV). Zoonotic infection of humans can cause encephalitis and if untreated has a fatality rate of ∼80%. The frequent use of macaques in biomedical research emphasizes the need to understand the molecular basis of ...

journal_title：Journal of virology

authors： Amen MA,Griffiths A

更新日期：2011-07-01 00:00:00

abstract：:The TAATGARAT motif in the herpes simplex virus (HSV) immediate-early (IE) gene promoters plays a key role in their activation by the Oct-1-Vmw65 complex, but its role in mediating inhibitory effects of cellular octamer-binding proteins is less clear. We have used indicator viruses containing reporter constructs with ...

journal_title：Journal of virology

authors： Thomas S,Coffin RS,Watts P,Gough G,Latchman DS

更新日期：1998-04-01 00:00:00

abstract：:We applied deep sequencing technology to small RNA fractions from cells lytically infected with murine gammaherpesvirus 68 (gammaHV68) in order to define in detail small RNAs generated from a cluster of tRNA-related polycistronic structures located at the left end of the viral genome. We detected 10 new candidate micr...

journal_title：Journal of virology

authors： Reese TA,Xia J,Johnson LS,Zhou X,Zhang W,Virgin HW

更新日期：2010-10-01 00:00:00

abstract：:The phosphoprotein pp65 (ppUL83) of human cytomegalovirus (HCMV) is abundantly synthesized during lytic infection in cultured fibroblasts. As a major constituent of extracellular particles, it gains entry to infected cells immediately after adsorption and subsequently translocates to the cell nucleus. This efficient t...

journal_title：Journal of virology

authors： Schmolke S,Kern HF,Drescher P,Jahn G,Plachter B

更新日期：1995-10-01 00:00:00

abstract：:Bicistronic RNAs containing the 373-nucleotide-long 5' nontranslated region (NTR) of the classical swine fever virus (CSFV) genome as intercistronic spacer were used to show the presence of an internal ribosome entry site (IRES) in the 5' end of the CSFV genome. By coexpression of the poliovirus 2A protease it was dem...

journal_title：Journal of virology

authors： Rijnbrand R,van der Straaten T,van Rijn PA,Spaan WJ,Bredenbeek PJ

更新日期：1997-01-01 00:00:00

abstract：:Viruses display a wide range of genomic profiles and, consequently, a variety of gene expression strategies. Specific sequences associated with transcriptional processes have been described in viruses, and putative promoter motifs have been elucidated for some nucleocytoplasmic large DNA viruses (NCLDV). Among NCLDV, ...

journal_title：Journal of virology

authors： Oliveira GP,Lima MT,Arantes TS,Assis FL,Rodrigues RAL,da Fonseca FG,Bonjardim CA,Kroon EG,Colson P,La Scola B,Abrahão JS

更新日期：2017-10-13 00:00:00

abstract：:Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ass...

journal_title：Journal of virology

authors： Brass V,Pal Z,Sapay N,Deléage G,Blum HE,Penin F,Moradpour D

更新日期：2007-03-01 00:00:00

abstract：:Although hepatitis A virus (HAV) is typically transmitted by the fecal-oral route, little is known of its interactions with cells of the gastrointestinal tract. We studied the replication of HAV in polarized cultures of Caco-2 cells, a human cell line which retains many differentiated functions of small intestinal epi...

journal_title：Journal of virology

authors： Blank CA,Anderson DA,Beard M,Lemon SM

更新日期：2000-07-01 00:00:00

abstract：:Type III interferons (IFNs) (interleukin-28/29 or lambda interferon [IFN-lambda]) are cytokines with IFN-like activities. Here we show that several classes of viruses induce expression of IFN-lambda1 and -lambda2/3 in similar patterns. The IFN-lambdas were-unlike alpha/beta interferon (IFN-alpha/beta)-induced directly...

journal_title：Journal of virology

authors： Ank N,West H,Bartholdy C,Eriksson K,Thomsen AR,Paludan SR

更新日期：2006-05-01 00:00:00

abstract：:The relative antigenicity of the individual herpes simplex virus type 1 (KOS) glycoproteins gC and gB was analyzed in BALB/c mice by using KOS mutants altered in their ability to present these antigens on cell surface membranes during infection. The mutants employed were as follows: syn LD70 , a non-temperature-sensit...

journal_title：Journal of virology

authors： Glorioso J,Schröder CH,Kumel G,Szczesiul M,Levine M

更新日期：1984-06-01 00:00:00

abstract：:Further advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations requi...

journal_title：Journal of virology

authors： Dale CJ,De Rose R,Stratov I,Chea S,Montefiori DC,Thomson S,Ramshaw IA,Coupar BE,Boyle DB,Law M,Kent SJ

更新日期：2004-12-01 00:00:00

abstract：:A mutation (asparagine 815 to serine 815) was introduced into the herpes simplex virus type 1 (HSV-1) DNA polymerase (pol). The HSV-1 pol enzyme in lysates of Saccharomyces cerevisiae cells expressing the mutant protein showed increased resistance to acyclovir triphosphate and increased sensitivity to phosphonoacetate...

journal_title：Journal of virology

authors： Matthews JT,Carroll RD,Stevens JT,Haffey ML

更新日期：1989-11-01 00:00:00

abstract：:Incubation of highly purified adeno-associated virus (AAV) capsids in vitro at pH 5.5 induced significant autocleavage of capsid proteins at several amino acid positions. No autocleavage was seen at pH 7.5. Examination of other AAV serotypes showed at least two different pH-induced cleavage patterns, suggesting that d...

journal_title：Journal of virology

authors： Salganik M,Venkatakrishnan B,Bennett A,Lins B,Yarbrough J,Muzyczka N,Agbandje-McKenna M,McKenna R

更新日期：2012-11-01 00:00:00

abstract：:A panel of monoclonal antibodies that recognize the two major glycoproteins of bovine viral diarrhea virus (BDV) was used to evaluate the antigenic relationship between cytopathic (CP) and noncytopathic (NCP) viruses isolated from cattle dead or dying from fatal BDV infections. Various unrelated BDV isolates were init...

journal_title：Journal of virology

authors： Corapi WV,Donis RO,Dubovi EJ

更新日期：1988-08-01 00:00:00