HLA class I-mediated control of HIV-1 in the Japanese population, in which the protective HLA-B*57 and HLA-B*27 alleles are absent.

Abstract:

:We investigated the effect of HLA class I alleles on clinical parameters for HIV-1 disease progression in the Japanese population, where two strongly protective alleles, HLA-B*57 and HLA-B*27, are virtually nonexistent. HLA-B alleles showed a dominant role, primarily through HLA-B*67:01 and the HLA-B*52:01-C*12:02 haplotype. Neither a rare-allele nor a heterozygote advantage was found, suggesting that the effect of HLA alleles in the Japanese population is either different from those observed in Africans and Caucasians or undetectable due to limited power.

journal_name

J Virol

journal_title

Journal of virology

authors

Naruto T,Gatanaga H,Nelson G,Sakai K,Carrington M,Oka S,Takiguchi M

doi

10.1128/JVI.00689-12

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

10870-2

issue

19

eissn

0022-538X

issn

1098-5514

pii

JVI.00689-12

journal_volume

86

pub_type

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