Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.

abstract：:In intact Madin-Darby canine kidney (MDCK) cell monolayers, vesicular stomatitis virus (VSV) matures only at basolateral membranes beneath tight junctions, whereas influenza virus buds from apical cell surfaces. Early in the growth cycle, the viral glycoproteins are restricted to the membrane domain from which each vi...

journal_title：Journal of virology

authors： Roth MG,Compans RW

更新日期：1981-12-01 00:00:00

abstract：:A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between ex...

journal_title：Journal of virology

authors： Benson SJ,Ruis BL,Garbers AL,Fadly AM,Conklin KF

更新日期：1998-12-01 00:00:00

abstract：:Poliovirus infection of HeLa cells results in a rapid inhibition of host protein synthesis by a mechanism that does not affect the translation of poliovirus RNA. It has been suggested that this virus-induced translational control results from inactivation of the cap-binding protein complex, and it has been shown that ...

journal_title：Journal of virology

authors： Lloyd RE,Jense HG,Ehrenfeld E

更新日期：1987-08-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) has a tropism for T lymphocytes and monocytes/macrophages, suggesting that HHV-6 infection affects the immunosurveillance system. In the present study, we investigated the HHV-6-induced phenotypic and functional alterations of dendritic cells (DCs), which are professional antigen-presenting...

journal_title：Journal of virology

authors： Kakimoto M,Hasegawa A,Fujita S,Yasukawa M

更新日期：2002-10-01 00:00:00

abstract：:Mitochondria are crucial to proper neuronal function and overall brain health. Mitochondrial dysfunction within the brain has been observed in many neurodegenerative diseases, including prion disease. Several markers of decreased mitochondrial activity during prion infection have been reported, yet the bioenergetic re...

journal_title：Journal of virology

authors： Faris R,Moore RA,Ward A,Sturdevant DE,Priola SA

更新日期：2017-08-24 00:00:00

abstract：UNLABELLED:Influenza virus transcription requires functional coupling with cellular transcription for the cap-snatching process. Despite this fact, RNA polymerase II (RNAP II) is degraded during infection in a process triggered by the viral polymerase. Reassortant viruses from the A/PR/8/34 (PR8) strain that induce (hv...

journal_title：Journal of virology

authors： Llompart CM,Nieto A,Rodriguez-Frandsen A

更新日期：2014-03-01 00:00:00

abstract：:Varicella-zoster virus (VZV), an alphaherpesvirus restricted to humans, infects differentiated cells in vivo, including T lymphocytes, keratinocytes, and neurons, and spreads rapidly in confluent cultured dermal fibroblasts (HFFs). In VZV-infected HFFs, atypical expression of cyclins D3 and B1 occurs along with the in...

journal_title：Journal of virology

authors： Leisenfelder SA,Kinchington PR,Moffat JF

更新日期：2008-12-01 00:00:00

abstract：:Recombinant vaccinia viruses containing the 22-kilodalton protein (matrixlike or 22K protein) or phosphoprotein gene from respiratory syncytial virus were constructed. These recombinant viruses expressed proteins which were immunoprecipitated by appropriate respiratory syncytial virus antibodies and comigrated with au...

journal_title：Journal of virology

authors： Openshaw PJ,Anderson K,Wertz GW,Askonas BA

更新日期：1990-04-01 00:00:00

abstract：:Tegument is a unique structure of herpesvirus, which surrounds the capsid and interacts with the envelope. Morphogenesis of gammaherpesvirus is poorly understood due to lack of efficient lytic replication for Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, which are etiologically as...

journal_title：Journal of virology

authors： Guo H,Wang L,Peng L,Zhou ZH,Deng H

更新日期：2009-10-01 00:00:00

abstract：:Since human immunodeficiency virus (HIV)-specific cell-mediated immune (CMI) responses are critical in the early control and resolution of HIV infection and correlate with postchallenge outcomes in rhesus macaque challenge experiments, we sought to identify a plasmid DNA (pDNA) vaccine design capable of eliciting robu...

journal_title：Journal of virology

authors： Luckay A,Sidhu MK,Kjeken R,Megati S,Chong SY,Roopchand V,Garcia-Hand D,Abdullah R,Braun R,Montefiori DC,Rosati M,Felber BK,Pavlakis GN,Mathiesen I,Israel ZR,Eldridge JH,Egan MA

更新日期：2007-05-01 00:00:00

abstract：:Cytotoxic-T-lymphocyte (CTL) escape mutations undermine the durability of effective human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) T cell responses. The rate of CTL escape from a given response is largely governed by the net of all escape-associated viral fitness costs and benefits. The observation that C...

journal_title：Journal of virology

authors： Boutwell CL,Carlson JM,Lin TH,Seese A,Power KA,Peng J,Tang Y,Brumme ZL,Heckerman D,Schneidewind A,Allen TM

更新日期：2013-04-01 00:00:00

abstract：:The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the type species of alphabaculoviruses, is an enveloped DNA virus that infects lepidopteran insects and is commonly known as a vector for protein expression and cell transduction. AcMNPV belongs to a diverse group of viral and bacterial pat...

journal_title：Journal of virology

authors： Hepp SE,Borgo GM,Ticau S,Ohkawa T,Welch MD

更新日期：2018-05-14 00:00:00

abstract：:Human papillomavirus type 18 (HPV18) and HPV45 account for approximately 20% of all cervix cancers. We show that HPV18, HPV45, and the recently discovered HPV97 comprise a clade sharing a most recent common ancestor within HPV alpha7 species. Variant lineages of these HPV types were classified by sequence analysis of ...

journal_title：Journal of virology

authors： Chen Z,DeSalle R,Schiffman M,Herrero R,Burk RD

更新日期：2009-02-01 00:00:00

abstract：:We developed a mouse model of Borna disease to facilitate immunopathogenesis research by adaptation of Borna disease virus to mice through serial passage in mouse brain tissue. Borna disease virus replication, antibody production, inflammation, and Borna disease expression in several different strains of mice were exa...

journal_title：Journal of virology

authors： Rubin SA,Waltrip RW 2nd,Bautista JR,Carbone KM

更新日期：1993-01-01 00:00:00

abstract：:Adenovirus infections cause significant morbidity and mortality in immunocompromised patients, yet little is known about the immune response to adenovirus infections. We established a system for the generation of a cytotoxic immune response to adenovirus in vitro. Cytotoxic T cells (CTLs) were derived from normal dono...

journal_title：Journal of virology

authors： Smith CA,Woodruff LS,Kitchingman GR,Rooney CM

更新日期：1996-10-01 00:00:00

abstract：:Chronic hepatitis B affects over 300 million people who are at risk of developing liver cancer. The basis for the persistence of hepatitis B virus (HBV) in hepatocytes, even in the presence of available antiviral therapies, lies in the accumulation of covalently closed circular DNA (cccDNA) in nuclei of infected cells...

journal_title：Journal of virology

authors： Li M,Sohn JA,Seeger C

更新日期：2017-12-14 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Tat is a mediator of viral transcription and is involved in the control of virus replication. However, associations between HIV-1 Tat diversity and functional effects during primary HIV-1 infection are still unclear. We estimated selection pressures in tat exon 1 using the m...

journal_title：Journal of virology

authors： Rossenkhan R,MacLeod IJ,Sebunya TK,Castro-Nallar E,McLane MF,Musonda R,Gashe BA,Novitsky V,Essex M

更新日期：2013-05-01 00:00:00

abstract：:The segment of simian virus 40 (SV40) genome which is recognized as the BC domain encodes for the COOH-terminal end of the SV40 major capsid protein VP1. Mutations in this domain lead to the synthesis of a thermosensitive VP1 which fails to assemble mature SV40 at the nonpermissive temperature. We determined the DNA s...

journal_title：Journal of virology

authors： Ng SC,Behm M,Bina M

更新日期：1985-05-01 00:00:00

abstract：:A closed circular, double-stranded infectious DNA of Moloney leukemia virus has been described previously. The present report characterizes a second type of infectious, unintegrated viral DNA which is linear, largely double stranded, and of mass comparable to that of the closed circular viral DNA. The linear form is o...

journal_title：Journal of virology

authors： Smotkin D,Yoshimura FK,Weinberg RA

更新日期：1976-12-01 00:00:00

abstract：:Bacteriophage with linear, double-stranded DNA genomes package DNA into preassembled protein shells called procapsids. Located at one vertex in the procapsid is a portal complex composed of a ring of 12 subunits of portal protein. The portal complex serves as a docking site for the DNA packaging enzymes, a conduit for...

journal_title：Journal of virology

authors： Moore SD,Prevelige PE Jr

更新日期：2002-10-01 00:00:00

abstract：UNLABELLED:Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and the leading cause of infant hospitalization worldwide. Uncontrolled response to RSV is mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses anti-RSV activ...

journal_title：Journal of virology

authors： Liu T,Zang N,Zhou N,Li W,Xie X,Deng Y,Ren L,Long X,Li S,Zhou L,Zhao X,Tu W,Wang L,Tan B,Liu E

更新日期：2014-04-01 00:00:00

abstract：:We previously showed that the 93-bp region between the enhancer and promoter (named DEN for downstream of enhancer) of the long terminal repeat (LTR) of the MCF13 murine leukemia virus is an important determinant of the ability of this virus to induce thymic lymphoma. In this study we observed that DEN plays a role in...

journal_title：Journal of virology

authors： Yoshimura FK,Wang T,Cankovic M

更新日期：1999-06-01 00:00:00

abstract：:Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectru...

journal_title：Journal of virology

authors： O'Keefe BR,Giomarelli B,Barnard DL,Shenoy SR,Chan PK,McMahon JB,Palmer KE,Barnett BW,Meyerholz DK,Wohlford-Lenane CL,McCray PB Jr

更新日期：2010-03-01 00:00:00

abstract：:Entry of the budded virus form of baculoviruses into insect and mammalian cells is generally thought to occur through a low-pH-dependent endocytosis pathway, possibly through clathrin-coated pits. This insight is primarily based on (immuno)electron microscopy studies but requires biochemical support to exclude the use...

journal_title：Journal of virology

authors： Long G,Pan X,Kormelink R,Vlak JM

更新日期：2006-09-01 00:00:00

abstract：:Simian virus 40 mutants lacking sequences in the late leader region are viable but produce smaller plaques than does wild-type virus. Within three passages at low multiplicities of infection, virus stocks of several such mutants accumulated variants that synthesized an altered form of the major virion protein, VP1, ha...

journal_title：Journal of virology

authors： Barkan A,Welch RC,Mertz JE

更新日期：1987-10-01 00:00:00

abstract：:Infectious hematopoietic necrosis virus (IHNV) is a rhabdovirus that produces an acute, lethal infection in rainbow trout (Oncorhynchus mykiss). Fish that survive infection cease to produce detectable infectious virus at approximately 46 days after infection, yet there is evidence that survivor fish continue to harbor...

journal_title：Journal of virology

authors： Kim CH,Dummer DM,Chiou PP,Leong JA

更新日期：1999-01-01 00:00:00

abstract：:Production of a vesicular stomatitis virus spike protein G (VSVG)-pseudotyped lentiviral expression vector in HEK293 cells decreased on overexpression of low-density lipoprotein receptor (LDLR) but not that of ICAM1 or TfR1. Reverse transcription-quantitative PCR (RT-qPCR) revealed a reduction in vector RNA as a funct...

journal_title：Journal of virology

authors： Otahal A,Fuchs R,Al-Allaf FA,Blaas D

更新日期：2015-11-01 00:00:00

abstract：:Genetic and phylogenetic analyses suggest that the pandemic H1N1/2009 virus was derived from well-established swine influenza lineages; however, there is no convincing evidence that the pandemic virus was generated from a direct precursor in pigs. Furthermore, the evolutionary dynamics of influenza virus in pigs have ...

journal_title：Journal of virology

authors： Wei K,Sun H,Sun Z,Sun Y,Kong W,Pu J,Ma G,Yin Y,Yang H,Guo X,Chang KC,Liu J

更新日期：2014-10-01 00:00:00

abstract：:Klebsiella pneumoniae is a member of the family Enterobacteriaceae, opportunistic pathogens that are among the eight most prevalent infectious agents in hospitals. The emergence of multidrug-resistant strains of K. pneumoniae has became a public health problem globally. To develop an effective antimicrobial agent, we ...

journal_title：Journal of virology

authors： Cui Z,Shen W,Wang Z,Zhang H,Me R,Wang Y,Zeng L,Zhu Y,Qin J,He P,Guo X

更新日期：2012-12-01 00:00:00

abstract：:Mycophenolic acid (MPA), an inhibitor of IMP dehydrogenase, inhibits reovirus replication and viral RNA and protein production. In mouse L929 cells, antiviral effects were greatest at 30 microg of MPA/ml. At this dosage, MPA inhibited replication of reovirus strain T3D more than 1,000-fold and inhibited replication of...

journal_title：Journal of virology

authors： Hermann LL,Coombs KM

更新日期：2004-06-01 00:00:00