Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif.

abstract：:Chromatography of RNA polymerase purified from vaccinia virions and from vaccinia virus-infected HeLa cells resulted in the separation of populations active for early and late transcription. An RNA polymerase population immunodepleted for the vaccinia virus H4 gene peptide could support late transcription. ...

journal_title：Journal of virology

authors： Wright CF,Coroneos AM

更新日期：1995-04-01 00:00:00

abstract：:A recombinant vesicular stomatitis virus (VSV-PeGFP-M-MmRFP) encoding enhanced green fluorescent protein fused in frame with P (PeGFP) in place of P and a fusion matrix protein (monomeric red fluorescent protein fused in frame at the carboxy terminus of M [MmRFP]) at the G-L gene junction, in addition to wild-type (wt...

journal_title：Journal of virology

authors： Das SC,Panda D,Nayak D,Pattnaik AK

更新日期：2009-03-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) and the closely related simian immunodeficiency virus (SIV) induce profound immune dysfunction in primate species. The present studies show that cell populations infected in vitro with SIV exhibit increases in major histocompatibility complex (MHC) class II antigen expression. Ce...

journal_title：Journal of virology

authors： Kannagi M,Kiyotaki M,King NW,Lord CI,Letvin NL

更新日期：1987-05-01 00:00:00

abstract：:We have used cDNA arrays to compare the activation of various cellular genes in response to infection with Sendai viruses (SeV) that contain specific mutations. Three groups of cellular genes activated by mutant SeV infection, but not by wild-type SeV, were identified in this way. While some of these genes are well kn...

journal_title：Journal of virology

authors： Strähle L,Garcin D,Le Mercier P,Schlaak JF,Kolakofsky D

更新日期：2003-07-01 00:00:00

abstract：:A mutation that disrupts the interaction between the NS2 protein of minute virus of mice and the nuclear export factor Crm1 results in a block to egress of mutant-generated full virions from the nucleus of infected murine cells. These mutants produce wild-type levels of monomer and dimer replicative DNA forms but are ...

journal_title：Journal of virology

authors： Miller CL,Pintel DJ

更新日期：2002-04-01 00:00:00

abstract：:Tryptic digests of four polypeptides found in Kunjin virus-infected Vero cells, NV5, NV4, V3, and NV3, were compared by peptide mapping. The polypeptides to be analyzed were labeled with radioactive methionine and separated by electrophoresis through polyacrylamide gels containing sodium dodecyl sulfate. Because infec...

journal_title：Journal of virology

authors： Wright PJ,Bowden DS,Westaway EG

更新日期：1977-11-01 00:00:00

abstract：:Butyrate is an abundant metabolite produced by gut microbiota. While butyrate is a known histone deacetylase inhibitor that activates expression of many genes involved in immune system pathways, its effects on virus infections and on the antiviral type I interferon (IFN) response have not been adequately investigated....

journal_title：Journal of virology

authors： Chemudupati M,Kenney AD,Smith AC,Fillinger RJ,Zhang L,Zani A,Liu SL,Anderson MZ,Sharma A,Yount JS

更新日期：2020-07-30 00:00:00

abstract：:To investigate the genetic stability of vaccinia virus DNA, we have tested whether alterations occurred in the polypeptide composition of this complex virus during persistent infections. We found that variants isolated at various passages in Friend erythroleukemia cells persistently infected with vaccinia virus contai...

journal_title：Journal of virology

authors： Paez E,Dallo S,Esteban M

更新日期：1987-08-01 00:00:00

abstract：:Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-Å resolution, and the cryo-electron microscopy (cryo-EM) image reconstruction of a full-length PCV2 vir...

journal_title：Journal of virology

authors： Khayat R,Brunn N,Speir JA,Hardham JM,Ankenbauer RG,Schneemann A,Johnson JE

更新日期：2011-08-01 00:00:00

abstract：:Open reading frame P (ORF P), located at the 3' terminus of the 8.5-kb DNA sequence transcribed during latency and almost completely antisense to the gamma(1)34.5 gene, is naturally repressed by infected cell protein 4 (ICP4), the major herpes simplex virus 1 regulatory protein. Earlier studies on cells infected with ...

journal_title：Journal of virology

authors： Randall G,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:The zinc finger antiviral protein (ZAP) is a recently isolated host antiviral factor. It specifically inhibits the replication of Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing the accumulation of viral RNA in the cytoplasm. For this report, we mapped the viral sequences that are sensitive t...

journal_title：Journal of virology

authors： Guo X,Carroll JW,Macdonald MR,Goff SP,Gao G

更新日期：2004-12-01 00:00:00

abstract：:PCR amplification of baboon endogenous virus (BaEV) long terminal repeat, reverse transcriptase gene, and env fragments from 24 different species of African monkeys indicates that BaEV is less widespread than was formerly thought. Instead of being present in every species of African primates, BaEV can be found only in...

journal_title：Journal of virology

authors： van der Kuyl AC,Dekker JT,Goudsmit J

更新日期：1995-12-01 00:00:00

abstract：:A gene encoding the large T antigen of polyomavirus was inserted into the baculovirus Autographa californica nuclear polyhedrosis virus so that gene expression was under the control of the strong, very late polyhedrin gene promoter. Significantly more large T antigen was produced in recombinant virus-infected insect c...

journal_title：Journal of virology

authors： Rice WC,Lorimer HE,Prives C,Miller LK

更新日期：1987-05-01 00:00:00

abstract：:Polyomaviruses are small nonenveloped particles with a circular double-stranded genome, approximately 5 kbp in size. The mammalian polyomaviruses mainly cause persistent subclinical infections in their natural nonimmunocompromised hosts. In contrast, the polyomaviruses of birds--avian polyomavirus (APV) and goose hemo...

journal_title：Journal of virology

authors： Johne R,Wittig W,Fernández-de-Luco D,Höfle U,Müller H

更新日期：2006-04-01 00:00:00

abstract：:We have examined the relative ability of Sendai virus M (matrix) protein to associate with membranes containing viral glycoproteins at three distinct stages of the exocytic pathway prior to cell surface appearance. By the use of selective low-temperature incubations or the ionophore monensin, the transport of newly sy...

journal_title：Journal of virology

authors： Sanderson CM,McQueen NL,Nayak DP

更新日期：1993-02-01 00:00:00

abstract：UNLABELLED:The distribution of vesicular stomatitis virus (VSV) nucleocapsids in the cytoplasm of infected cells was analyzed by scanning confocal fluorescence microscopy using a newly developed quantitative approach called the border-to-border distribution method. Nucleocapsids were located near the cell nucleus at ea...

journal_title：Journal of virology

authors： Yacovone SK,Smelser AM,Macosko JC,Holzwarth G,Ornelles DA,Lyles DS

更新日期：2016-06-10 00:00:00

abstract：:Immune responses to vector-corrected cells have limited the application of gene therapy for treatment of chronic disorders such as inherited deficiency states. We have found that recombinant adeno-associated virus (AAV) efficiently transduces muscle fibers in vivo without activation of cellular and humoral immunity to...

journal_title：Journal of virology

authors： Jooss K,Yang Y,Fisher KJ,Wilson JM

更新日期：1998-05-01 00:00:00

abstract：:Monoclonal antibody vpg15 detects a 24-kDa cell surface protein on feline cells permissive for infection with feline immunodeficiency virus (FIV). The antibody blocks infection of FIV-susceptible cells, and expression of the vpg15 marker is decreased in FIV-infected cells in vitro. These results suggest that the antib...

journal_title：Journal of virology

authors： Hosie MJ,Willett BJ,Dunsford TH,Jarrett O,Neil JC

更新日期：1993-03-01 00:00:00

abstract：:Initiation of the Epstein-Barr virus (EBV) lytic cycle is dependent on expression of the viral transactivator Zta, which is encoded by the BZLF1 gene. Described here is an initial mapping of the regions of Zta involved in activating transcription. The data indicate that the amino-terminal 153 amino acids of Zta are im...

journal_title：Journal of virology

authors： Flemington EK,Borras AM,Lytle JP,Speck SH

更新日期：1992-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a ubiquitously distributed pathogen that causes severe disease in immunosuppressed patients and newborn infants infected in utero. The viral envelope glycoprotein B (gB) is an attractive molecule for active vaccination and passive immunoprophylaxis and therapy. Using human monoclonal an...

journal_title：Journal of virology

authors： Spindler N,Rücker P,Pötzsch S,Diestel U,Sticht H,Martin-Parras L,Winkler TH,Mach M

更新日期：2013-08-01 00:00:00

abstract：:The genome of influenza A virus consists of eight single-strand negative-sense RNA segments, each comprised of a coding region and a noncoding region. The noncoding region of the NS segment is thought to provide the signal for packaging; however, we recently showed that the coding regions located at both ends of the h...

journal_title：Journal of virology

authors： Fujii K,Fujii Y,Noda T,Muramoto Y,Watanabe T,Takada A,Goto H,Horimoto T,Kawaoka Y

更新日期：2005-03-01 00:00:00

abstract：:Current knowledge of human immunodeficiency virus type 1 envelope (Env) glycoprotein structure and function is based on studies of clade B viruses. We present evidence of sequence and structural differences in viral glycoprotein gp120 between clades B and C. In clade C, the C3 region alpha2-helix exhibits high sequenc...

journal_title：Journal of virology

authors： Gnanakaran S,Lang D,Daniels M,Bhattacharya T,Derdeyn CA,Korber B

更新日期：2007-05-01 00:00:00

abstract：:The interaction of simian virus 40 (SV40) T antigen (T-ag) with the viral origin has served as a model for studies of site-specific recognition of a eukaryotic replication origin and the mechanism of DNA unwinding. These studies have revealed that a motif termed the "beta-hairpin" is necessary for assembly of T-ag on ...

journal_title：Journal of virology

authors： Kumar A,Meinke G,Reese DK,Moine S,Phelan PJ,Fradet-Turcotte A,Archambault J,Bohm A,Bullock PA

更新日期：2007-05-01 00:00:00

abstract：:Interleukin-15 (IL-15), natural killer (NK) cells, and NK T (NKT) cells, components of the innate immune system, are known to contribute to defense against pathogens, including viruses. Here we report that IL-15(-/-) (NK(-) and NKT(-/+)) mice and RAG-2(-/-)/gamma(c)(-/-) (NK(-) and NKT(-)) mice that lack all lymphoid ...

journal_title：Journal of virology

authors： Ashkar AA,Rosenthal KL

更新日期：2003-09-01 00:00:00

abstract：:Scrapie-associated fibrils (SAFs) are abnormal filamentous structures that are uniquely associated with unconventional slow virus diseases. The antigenic relationships of SAFs from animals infected with four biologically distinct scrapie strains were investigated by using antisera raised to purified SAF proteins. Rabb...

journal_title：Journal of virology

authors： Kascsak RJ,Rubenstein R,Merz PA,Carp RI,Robakis NK,Wisniewski HM,Diringer H

更新日期：1986-09-01 00:00:00

abstract：:A second nonstructural protein of the Aleutian disease parvovirus was predicted from nucleotide sequence analysis and a detailed transcription map. Western immunoblotting analysis showed that infected mink and ferrets show an antibody response to this predicted protein. ...

journal_title：Journal of virology

authors： Porter DD,Porter HG,Larsen AE

更新日期：1990-04-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect keratinocytes of skin and mucosa. Homeostasis of these constantly renewing, stratified epithelia is maintained by balanced keratinocyte proliferation and terminal differentiation. Instructions from the extracellular matrix engaging integrins strongly regulate these keratinocyte fun...

journal_title：Journal of virology

authors： Oldak M,Smola H,Aumailley M,Rivero F,Pfister H,Smola-Hess S

更新日期：2004-10-01 00:00:00

abstract：:Human immunodeficiency virus type 2 (HIV-2), like other lentiviruses, is capable of infecting nondividing T cells and macrophages. The present work shows that in HIV-2-infected cells, Vpx is necessary for efficient nuclear import of the preintegration complex. In agreement with this finding, the subcellular localizati...

journal_title：Journal of virology

authors： Pancio HA,Vander Heyden N,Ratner L

更新日期：2000-07-01 00:00:00

abstract：:We have proposed a general algorithm for identification of potential immunoprotective domains (cassettes) on the envelope E2 polypeptide of alphaviruses (H. Grosfeld, B. Velan, M. Leitner, S. Cohen, S. Lustig, B.E. Lachmi, and A. Shafferman, J. Virol. 63:3416-3422, 1989). To assess the generality of our approach, we c...

journal_title：Journal of virology

authors： Grosfeld H,Lustig S,Gozes Y,Velan B,Cohen S,Leitner M,Lachmi B,Katz D,Olshevski U,Shafferman A

更新日期：1992-02-01 00:00:00

abstract：:Open reading frame 45 (ORF45) of Kaposi's sarcoma-associated herpesvirus 8 (KSHV) is an immediate-early phosphorylated tegument protein and has been shown to play important roles at both early and late stages of viral infection. Homologues of ORF45 exist only in gammaherpesviruses, and their homology is limited. These...

journal_title：Journal of virology

authors： Li X,Zhu F

更新日期：2009-03-01 00:00:00