Clade-specific differences between human immunodeficiency virus type 1 clades B and C: diversity and correlations in C3-V4 regions of gp120.

abstract：:The development of antiviral drug resistance is an important problem in the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Potent antiretroviral therapy is currently used for treatment, and typically consists of at least two reverse transcriptase (RT) inhibitors. We have previously reported that b...

journal_title：Journal of virology

authors： Chen R,Yokoyama M,Sato H,Reilly C,Mansky LM

更新日期：2005-09-01 00:00:00

abstract：:The genome of a human papillomavirus (HPV) found in a patient with Bowen's disease of the skin was molecularly cloned. Blot hybridization experiments, performed under stringent conditions, revealed no cross-hybridization between this HPV DNA and the other known HPV DNAs, showing that this HPV represents a new type, te...

journal_title：Journal of virology

authors： Kawashima M,Jablonska S,Favre M,Obalek S,Croissant O,Orth G

更新日期：1986-02-01 00:00:00

abstract：:The vast majority of people already have preexisting immune responses to influenza viruses from one or more subtypes. However, almost all preclinical studies evaluate new influenza vaccine candidates in immunologically naive animals. Recently, our group demonstrated that priming naive ferrets with broadly reactive H1 ...

journal_title：Journal of virology

authors： Allen JD,Jang H,DiNapoli J,Kleanthous H,Ross TM

更新日期：2019-01-17 00:00:00

abstract：:The human immunodeficiency virus (HIV) and the closely related simian immunodeficiency virus (SIV) induce profound immune dysfunction in primate species. The present studies show that cell populations infected in vitro with SIV exhibit increases in major histocompatibility complex (MHC) class II antigen expression. Ce...

journal_title：Journal of virology

authors： Kannagi M,Kiyotaki M,King NW,Lord CI,Letvin NL

更新日期：1987-05-01 00:00:00

abstract：:Natural killer (NK) cells serve as a crucial first-line defense against tumors and virus-infected cells. We previously showed that lysis of influenza virus (IV)-infected cells is mediated by the interaction between the NK receptor, NKp46, and the IV hemagglutinin (HA) type 1 expressed by the infected cells. This inter...

journal_title：Journal of virology

authors： Mendelson M,Tekoah Y,Zilka A,Gershoni-Yahalom O,Gazit R,Achdout H,Bovin NV,Meningher T,Mandelboim M,Mandelboim O,David A,Porgador A

更新日期：2010-04-01 00:00:00

abstract：:Chinese hamster X mouse somatic cell hybrids were analyzed by Southern blot hybridization with a probe specific for the cellular c-fms proto-oncogene. Results demonstrate that Fms, the genetic locus containing this sequence, maps to mouse chromosome 18. Mouse Fms is thus not linked to the same set of genes involved in...

journal_title：Journal of virology

authors： Hoggan MD,Halden NF,Buckler CE,Kozak CA

更新日期：1988-03-01 00:00:00

abstract：:Recombinant adeno-associated virus (rAAV) vectors have been shown to be useful for efficient gene delivery to a variety of dividing and nondividing cells. Mechanisms responsible for the long-term, persistent expression of the rAAV transgene are not well understood. In this study we investigated the kinetics of rAAV-me...

journal_title：Journal of virology

authors： Malik AK,Monahan PE,Allen DL,Chen BG,Samulski RJ,Kurachi K

更新日期：2000-04-01 00:00:00

abstract：:Corneal infection with herpes simplex virus 1 (HSV-1) leads to infection of trigeminal ganglia (TG), typically followed by the establishment of latency in the infected neurons. When latency is disrupted, the virus reactivates and migrates back to the cornea, where it restimulates the immune response, leading to lesion...

journal_title：Journal of virology

authors： Yin XT,Baugnon NK,Potter CA,Tai S,Keadle TL,Stuart PM

更新日期：2019-07-30 00:00:00

abstract：:During paramyxovirus entry into a host cell, receptor engagement by a specialized binding protein triggers conformational changes in the adjacent fusion protein (F), leading to fusion between the viral and cell membranes. According to the existing paradigm of paramyxovirus membrane fusion, the initial activation of F ...

journal_title：Journal of virology

authors： Porotto M,Devito I,Palmer SG,Jurgens EM,Yee JL,Yokoyama CC,Pessi A,Moscona A

更新日期：2011-12-01 00:00:00

abstract：:The bovine papillomavirus E5 gene encodes a 44-amino-acid, homodimeric transmembrane protein that is the smallest known transforming protein. The E5 protein transforms cultured fibroblasts by forming a stable complex with the endogenous platelet-derived growth factor (PDGF) beta receptor through transmembrane and juxt...

journal_title：Journal of virology

authors： Klein O,Kegler-Ebo D,Su J,Smith S,DiMaio D

更新日期：1999-04-01 00:00:00

abstract：:The antibiotic tunicamycin, which blocks the synthesis of glycoproteins, inhibited the production of infectious herpes simplex virus. In the presence of this drug, [14C]glucosamine and [3H]mannose incorporation was reduced in infected cells, whereas total protein synthesis was not affected. Gel electrophoresis of [2-3...

journal_title：Journal of virology

authors： Pizer LI,Cohen GH,Eisenberg RJ

更新日期：1980-04-01 00:00:00

abstract：:The binding specificities of a panel of avian influenza virus subtype H5 hemagglutinin (HA) proteins bearing mutations at key residues in the receptor binding site were investigated. The results demonstrate that two simultaneous mutations in the receptor binding site resulted in H5 HA binding in a pattern similar to t...

journal_title：Journal of virology

authors： Harvey R,Martin AC,Zambon M,Barclay WS

更新日期：2004-01-01 00:00:00

abstract：:Recently, it was demonstrated that the coxsackievirus B3 variant PD (CVB3 PD) is able to infect coxsackievirus-adenovirus receptor (CAR)-lacking cells by using heparan sulfates (HS) as additional receptors (A. E. Zautner, U. Korner, A. Henke, C. Badorff, and M. Schmidtke, J. Virol. 77:10071-10077, 2003). For this stud...

journal_title：Journal of virology

authors： Zautner AE,Jahn B,Hammerschmidt E,Wutzler P,Schmidtke M

更新日期：2006-07-01 00:00:00

abstract：:We investigated the primary cellular immune responses to human immunodeficiency virus type 1 (HIV-1) Env and Gag proteins elicited by recombinant vesicular stomatitis viruses (rVSVs). The primary response to Env peaked 5 to 7 days after intraperitoneal vaccination, at which time 40% of CD8(+) cells were Env tetramer p...

journal_title：Journal of virology

authors： Haglund K,Leiner I,Kerksiek K,Buonocore L,Pamer E,Rose JK

更新日期：2002-03-01 00:00:00

abstract：UNLABELLED:Tetherin (BST2, CD317, or HM1.24) is a host cellular restriction factor that prevents the release of enveloped viruses by mechanically linking virions to the plasma membrane. The precise arrangement of tetherin molecules at the plasma membrane site of HIV-1 assembly, budding, and restriction is not well unde...

journal_title：Journal of virology

authors： Strauss JD,Hammonds JE,Yi H,Ding L,Spearman P,Wright ER

更新日期：2015-11-18 00:00:00

abstract：:A procedure incorporating the use of heparin was developed to purify Herpesvirus ovis. The viral DNA has a buoyant density of 1.706 +/- 0.001 g/cm3, and the sedimentation constant was estimated to be 47.5 +/- 1.5S; from the latter, the molecular weight was calculated as 67.3 +/- 5.4 X 10(6). Estimates of the guanine-p...

journal_title：Journal of virology

authors： De Villiers EM

更新日期：1979-12-01 00:00:00

abstract：:Bacteriophage CL31 was isolated on a Corynebacterium lilium strain. Out of 30 strains tested, only CL31 was able to form plaques on Corynebacterium glutamicum ATCC 13287, Brevibacterium lactofermentum ATCC 21086, and Arthrobacter sp. strain SI55, but at a very low frequency. This phage belongs to group B of Bradley's ...

journal_title：Journal of virology

authors： Trautwetter A,Blanco C,Sicard AM

更新日期：1987-05-01 00:00:00

abstract：:Viral attenuation may be due to lowered efficiency of certain steps essential for viral multiplication. For the construction of less neurovirulent strains of poliovirus in vitro, we introduced deletions into the 5' noncoding sequence (742 nucleotides long) of the genomes of the Mahoney and Sabin 1 strains of polioviru...

journal_title：Journal of virology

authors： Iizuka N,Kohara M,Hagino-Yamagishi K,Abe S,Komatsu T,Tago K,Arita M,Nomoto A

更新日期：1989-12-01 00:00:00

abstract：:Hepatitis delta virus (HDV) replicates by RNA-dependent RNA synthesis according to a double rolling circle model. Also synthesized during replication is a 0.8-kb, polyadenylated mRNA encoding the hepatitis delta antigen (HDAg). It has been proposed that this mRNA species represents the initial product of HDV RNA repli...

journal_title：Journal of virology

authors： Modahl LE,Lai MM

更新日期：1998-07-01 00:00:00

abstract：:This study examines the persistence and fitness of multidrug-resistant (MDR) viruses acquired during primary human immunodeficiency virus infection (PHI). In four individuals, MDR infections persisted over the entire study period, ranging from 36 weeks to 5 years, in the absence of antiretroviral therapy. In stark con...

journal_title：Journal of virology

authors： Brenner BG,Routy JP,Petrella M,Moisi D,Oliveira M,Detorio M,Spira B,Essabag V,Conway B,Lalonde R,Sekaly RP,Wainberg MA

更新日期：2002-02-01 00:00:00

abstract：:The novel low-pathogenic avian influenza A H7N9 viruses (LPAI H7N9 viruses) have been a threat to public health since their emergence in 2013 because of the high rates of mortality and morbidity that they cause. Recently, highly pathogenic variants of these avian influenza A H7N9 viruses (HPAI H7N9 viruses) have emerg...

journal_title：Journal of virology

authors： Yang L,Zhu W,Li X,Chen M,Wu J,Yu P,Qi S,Huang Y,Shi W,Dong J,Zhao X,Huang W,Li Z,Zeng X,Bo H,Chen T,Chen W,Liu J,Zhang Y,Liang Z,Shi W,Shu Y,Wang D

更新日期：2017-11-14 00:00:00

abstract：:Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products al...

journal_title：Journal of virology

authors： Maruo S,Nanbo A,Takada K

更新日期：2001-10-01 00:00:00

abstract：:West Nile virus (WNV) is a neurotropic flavivirus and the leading cause of mosquito-borne encephalitis in the United States. Recent studies in humans have found that dysfunctional T cell responses strongly correlate with development of severe WNV neuroinvasive disease. However, the contributions of human dendritic cel...

journal_title：Journal of virology

authors： Zimmerman MG,Bowen JR,McDonald CE,Pulendran B,Suthar MS

更新日期：2019-11-13 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection of the human thymus results in depletion of CD4-bearing thymocytes. This depletion is initially manifested in the immature CD4+/CD8+ thymocyte subset. To determine cellular factors involved in HIV infection in the thymus, we examined the expression of the recently ...

journal_title：Journal of virology

authors： Kitchen SG,Zack JA

更新日期：1997-09-01 00:00:00

abstract：:Prior to the introduction of live-attenuated vaccines, mumps virus (MuV) was the leading cause of virus-induced meningitis. Although vaccination has been effective at controlling the disease, the use of insufficiently attenuated strains has been associated with high rates of aseptic meningitis in vaccinees. The molecu...

journal_title：Journal of virology

authors： Lemon K,Rima BK,McQuaid S,Allen IV,Duprex WP

更新日期：2007-08-01 00:00:00

abstract：:The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection. The temporal and spatial distribution of viral antigen, known as the transneuronal spread phenotype, has not previously been described; nor is it ...

journal_title：Journal of virology

authors： Engel JP,Madigan TC,Peterson GM

更新日期：1997-03-01 00:00:00

abstract：:Cytolytic T-lymphocyte (CTL) activity specific for respiratory syncytial (RS) virus was investigated after intranasal infection of mice with RS virus, after intraperitoneal infection of mice with a recombinant vaccinia virus expressing the F glycoprotein, and after intramuscular vaccination of mice with Formalin-inact...

journal_title：Journal of virology

authors： Nicholas JA,Rubino KL,Levely ME,Adams EG,Collins PL

更新日期：1990-09-01 00:00:00

abstract：:Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial ...

journal_title：Journal of virology

authors： Huang Y,Kong WP,Nabel GJ

更新日期：2001-05-01 00:00:00

abstract：:Autographa californica nuclear polyhedrosis virus (AcMNPV) is a double-stranded DNA virus that expresses several immediate-early genes under the control of different promoters. The expression of one of these transcription units, IE-N, is shown here, by a transient expression assay, to be regulated by both cis- and tra...

journal_title：Journal of virology

authors： Carson DD,Summers MD,Guarino LA

更新日期：1991-02-01 00:00:00

abstract：UNLABELLED:The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use to prevent or to treat HIV-1 infection. Due to the antigenically diverse nature of the HIV-1 envelope (Env), no single antibody is highly active against all viral strains. ...

journal_title：Journal of virology

authors： Asokan M,Rudicell RS,Louder M,McKee K,O'Dell S,Stewart-Jones G,Wang K,Xu L,Chen X,Choe M,Chuang G,Georgiev IS,Joyce MG,Kirys T,Ko S,Pegu A,Shi W,Todd JP,Yang Z,Bailer RT,Rao S,Kwong PD,Nabel GJ,Mascola JR

更新日期：2015-12-01 00:00:00