Clade-specific differences between human immunodeficiency virus type 1 clades B and C: diversity and correlations in C3-V4 regions of gp120.

abstract：:Human bocavirus 1 (HBoV1) is a human parvovirus that causes acute respiratory tract infections in young children. In this study, we confirmed that, when polarized/well-differentiated human airway epithelia are infected with HBoV1 in vitro, they develop damage characterized by barrier function disruption and cell hypot...

journal_title：Journal of virology

authors： Deng X,Zou W,Xiong M,Wang Z,Engelhardt JF,Ye SQ,Yan Z,Qiu J

更新日期：2017-11-30 00:00:00

abstract：:T7 early mRNA's are generated from a high-molecular-weight precursor RNA by site-specific RNase III cleavage. When T7 DNA is transcribed in vitro by Escherichia coli RNA polymerase, the transcript is a large, single-piece RNA equivalent to the in vivo precursor RNA. The T7 RNA synthesized in vitro can be translated as...

journal_title：Journal of virology

authors： Yamada Y,Nakada D

更新日期：1976-06-01 00:00:00

abstract：:Using a method for freeze-drying intact cells, uninfected and murine leukemia virus (MuLV)-infected JLSV9 cell surfaces, as well as murine mammary tumor virus (MuMTV)-infected cell surfaces, were examined by electron microscopy. The 10-nm knobs of MuLV and the 5-nm spikes of MuMTV were clearly revealed on the surfaces...

journal_title：Journal of virology

authors： Demsey A,Kawka D,Stackpole CW

更新日期：1977-01-01 00:00:00

abstract：:Coupling of G proteins to ligand-engaged chemokine receptors is the paramount event in G-protein-coupled receptor signal transduction. Previously, we have demonstrated that the human cytomegalovirus-encoded chemokine receptor US28 mediates human vascular smooth muscle cell (SMC) migration in response to either RANTES ...

journal_title：Journal of virology

authors： Melnychuk RM,Streblow DN,Smith PP,Hirsch AJ,Pancheva D,Nelson JA

更新日期：2004-08-01 00:00:00

abstract：:Efforts to develop a vaccine against human immunodeficiency virus type 1 (HIV-1) are complicated by resistance of virus to neutralization. The neutralization resistance phenotype of HIV-1 has been linked to high infectivity. We studied the mechanisms determining this phenotype using clones of the T-cell-line-adapted (...

journal_title：Journal of virology

authors： Leavitt M,Park EJ,Sidorov IA,Dimitrov DS,Quinnan GV Jr

更新日期：2003-01-01 00:00:00

abstract：:Human immunodeficiency virus type 2 (HIV-2) strains vary widely in their abilities to grow in Old World monkey (OWM) cells such as those of cynomolgus monkeys (CM). We evaluated eight HIV-2 isolates for their sensitivities to CM TRIM5alpha, an anti-HIV factor in OWM cells. We found that different HIV-2 isolates showed...

journal_title：Journal of virology

authors： Song H,Nakayama EE,Yokoyama M,Sato H,Levy JA,Shioda T

更新日期：2007-07-01 00:00:00

abstract：:In vitro transcriptase activity of three group I temperature-sensitive (ts) mutants of vesicular stomatitis virus restricted at 39 C was restored by L-protein fractions derived from wild-type (wt) vesicular stomatitis virion nucleo-capsids. Soluble NS protein from wt nucleocapsids did not reconstitute restricted trans...

journal_title：Journal of virology

authors： Hunt DM,Emerson SU,Wagner RR

更新日期：1976-05-01 00:00:00

abstract：:HeLa cell nuclei, isolated 17 h after infection with human adenovirus type 2 (Ad2), were treated with 200 mM ammonium sulfate. The extract (S200 fraction) contained 50 to 70% of the nonintegrated Ad2 DNA, which was in the form of nucleoprotein complexes. These complexes contained native, intact Ad2 DNA (with the excep...

journal_title：Journal of virology

authors： Wilhelm J,Brison O,Kedinger C,Chambon P

更新日期：1976-07-01 00:00:00

abstract：:Molecularly cloned proviral DNA of avian oncogenic retrovirus CMII was isolated by screening a genomic library of a CMII-transformed quail cell line with a myc-specific probe. On a 10.4-kilobase EcoRI fragment, the cloned DNA contained 4.4 kilobases of CMII proviral sequences extending from the 5' long terminal repeat...

journal_title：Journal of virology

authors： Walther N,Lurz R,Patschinsky T,Jansen HW,Bister K

更新日期：1985-05-01 00:00:00

abstract：:Mice were infected with lymphocytic choriomeningitis virus and injected once 24 h later with a monoclonal antibody directed against gamma interferon. In comparison with controls, the increase of numbers of CD8+ T cells and the generation of virus-specific cytotoxic T lymphocytes in spleens and virus clearance from org...

journal_title：Journal of virology

authors： Utermöhlen O,Dangel A,Tárnok A,Lehmann-Grube F

更新日期：1996-03-01 00:00:00

abstract：:Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that has a worldwide distribution in the population of cattle. Many factors make human contamination by BoHV-4 likely to occur. In this study, we performed in vitro experiments to assess the risk and the consequences of human infection by BoHV-4. First, by using a re...

journal_title：Journal of virology

authors： Gillet L,Minner F,Detry B,Farnir F,Willems L,Lambot M,Thiry E,Pastoret PP,Schynts F,Vanderplasschen A

更新日期：2004-03-01 00:00:00

abstract：:Many viruses express inhibitors of programmed cell death (apoptosis), thereby countering host defenses that would otherwise rapidly clear infected cells. To counter this, viruses such as adenoviruses and herpesviruses express recognizable homologs of the mammalian prosurvival protein Bcl-2. In contrast, the majority o...

journal_title：Journal of virology

authors： Okamoto T,Campbell S,Mehta N,Thibault J,Colman PM,Barry M,Huang DC,Kvansakul M

更新日期：2012-11-01 00:00:00

abstract：:The DNA sensing pathway triggers innate immune responses against DNA virus infection, and NF-κB signaling plays a critical role in establishing innate immunity. We report here that the herpes simplex virus 1 (HSV-1) ubiquitin-specific protease (UL36USP), which is a deubiquitinase (DUB), antagonizes NF-κB activation, d...

journal_title：Journal of virology

authors： Ye R,Su C,Xu H,Zheng C

更新日期：2017-02-14 00:00:00

abstract：:Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Sa...

journal_title：Journal of virology

authors： Gori-Savellini G,Valentini M,Cusi MG

更新日期：2013-06-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) glycoprotein plays a critical role in parainfluenza virus replication. We recently found that in addition to the catalytic binding site, HN of human parainfluenza virus type 1 (hPIV-1) may have a second receptor-binding site covered by an N-linked glycan at residue 173, which is ne...

journal_title：Journal of virology

authors： Mishin VP,Watanabe M,Taylor G,Devincenzo J,Bose M,Portner A,Alymova IV

更新日期：2010-03-01 00:00:00

abstract：:Herpes simplex virus (HSV) virion host shutoff protein (vhs) destabilizes cellular and viral mRNAs. Previous work from several laboratories has indicated that vhs accelerates the turnover of most host mRNAs and provided evidence that at least some of these are degraded via endonucleolytic cleavage near regions of tran...

journal_title：Journal of virology

authors： Hsu WL,Saffran HA,Smiley JR

更新日期：2005-04-01 00:00:00

abstract：:Mutations introduced into the capsid gene of duck hepatitis B virus (DHBV) were tested for their effects on viral DNA synthesis and assembly of enveloped viruses. Four classes of mutant phenotypes were observed among a series of deletions of covering the 3' end of the capsid open reading frame. Class I mutant capsids ...

journal_title：Journal of virology

authors： Yu M,Summers J

更新日期：1991-05-01 00:00:00

abstract：:The investigation of papillomavirus chromatin has been hampered by the unavailability of a tissue culture system for vegetative growth of these viruses. We have used, therefore, bovine papillomavirus type 1-transformed hamster embryo fibroblasts containing 200 to 250 episomal genome equivalents per cell as a source of...

journal_title：Journal of virology

authors： Rösl F,Waldeck W,Sauer G

更新日期：1983-05-01 00:00:00

abstract：:To analyze the biological activities of the alphavirus glycoproteins, eight different monoclonal antibodies against the two glycoproteins of western equine encephalitis virus were isolated. Five of the eight monoclonal antibodies were shown to be specific for E1 and three for E2 protein by an enzyme-linked immunosorbe...

journal_title：Journal of virology

authors： Yamamoto K,Hashimoto K,Chiba J,Simizu B

更新日期：1985-09-01 00:00:00

abstract：UNLABELLED:Despite the nutritional and health benefits of breast milk, breast milk can serve as a vector for mother-to-child HIV transmission. Most HIV-infected infants acquire HIV through breastfeeding. Paradoxically, most infants breastfed by HIV-positive women do not become infected. This is potentially attributed t...

journal_title：Journal of virology

authors： Wahl A,Baker C,Spagnuolo RA,Stamper LW,Fouda GG,Permar SR,Hinde K,Kuhn L,Bode L,Aldrovandi GM,Garcia JV

更新日期：2015-11-01 00:00:00

abstract：:Enterovirus 71 (EV71) (genus Enterovirus, family Picornaviridae), a common cause of hand, foot, and mouth disease (HFMD), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. To examine the genetic diversity and rate of evolution of EV71, we have determined and analyzed c...

journal_title：Journal of virology

authors： Brown BA,Oberste MS,Alexander JP Jr,Kennett ML,Pallansch MA

更新日期：1999-12-01 00:00:00

abstract：:The flavivirus dengue virus (DV) infects cells through a low-pH-triggered membrane fusion reaction mediated by the viral envelope protein E. E is an elongated transmembrane protein with three domains and is organized as a homodimer on the mature virus particle. During fusion, the E protein homodimer dissociates, inser...

journal_title：Journal of virology

authors： Liao M,Sánchez-San Martín C,Zheng A,Kielian M

更新日期：2010-06-01 00:00:00

abstract：:The binding of cyclophilin A (CypA) to the human immunodeficiency virus type 1 (HIV-1) capsid protein (CA protein) is required soon after virus entry into natural target cells. In Jurkat T lymphocytes, disrupting CypA-CA interaction either by cyclosporine (Cs) treatment or by alteration (e.g., P90A) of the CA inhibits...

journal_title：Journal of virology

authors： Li Y,Kar AK,Sodroski J

更新日期：2009-11-01 00:00:00

abstract：:We established a system for propagation of Sindbis virus (SIN)-based replicons in tissue culture in the form of a tricomponent genome virus. Three RNA fragments containing complementing genetic information required for virus replication are packaged into separate viral particles, and each cell produces at least 1,000 ...

journal_title：Journal of virology

authors： Fayzulin R,Gorchakov R,Petrakova O,Volkova E,Frolov I

更新日期：2005-01-01 00:00:00

abstract：:Defining a macrophage-tropic phenotype for HIV-1 to assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary continuously in their ability to enter monocyte-derived macrophages (MDMs) in vitro, and MDMs vary in their ability to support HIV-1 entry. To overcome these limitations, we identified ...

journal_title：Journal of virology

authors： Joseph SB,Arrildt KT,Swanstrom AE,Schnell G,Lee B,Hoxie JA,Swanstrom R

更新日期：2014-02-01 00:00:00

abstract：:The epithelium plays a key role in the spread of Lassa virus. Transmission from rodents to humans occurs mainly via inhalation or ingestion of droplets, dust, or food contaminated with rodent urine. Here, we investigated Lassa virus infection in cultured epithelial cells and subsequent release of progeny viruses. We s...

journal_title：Journal of virology

authors： Schlie K,Maisa A,Freiberg F,Groseth A,Strecker T,Garten W

更新日期：2010-04-01 00:00:00

abstract：:In intact Madin-Darby canine kidney (MDCK) cell monolayers, vesicular stomatitis virus (VSV) matures only at basolateral membranes beneath tight junctions, whereas influenza virus buds from apical cell surfaces. Early in the growth cycle, the viral glycoproteins are restricted to the membrane domain from which each vi...

journal_title：Journal of virology

authors： Roth MG,Compans RW

更新日期：1981-12-01 00:00:00

abstract：:All presently available replication-competent proviral clones of human immunodeficiency virus type 1 (HIV-1) are derived from cell culture-amplified virus. Since tissue culture is highly selective for viral strains with an in vitro growth advantage, such clones may not be representative of the biologically relevant vi...

journal_title：Journal of virology

authors： Li Y,Kappes JC,Conway JA,Price RW,Shaw GM,Hahn BH

更新日期：1991-08-01 00:00:00

abstract：:In resting CD4(+) T lymphocytes harboring human immunodeficiency virus type 1 (HIV-1), replication-competent virus persists in patients responding to highly active antiretroviral therapy (HAART). This small latent reservoir represents between 10(3) and 10(7) cells per patient. However, the efficiency of HIV-1 DNA-posi...

journal_title：Journal of virology

authors： Fondere JM,Petitjean G,Huguet MF,Salhi SL,Baillat V,Macura-Biegun A,Becquart P,Reynes J,Vendrell JP

更新日期：2004-10-01 00:00:00

abstract：:The hepatitis C virus (HCV) core protein is known to be a multifunctional protein, besides being a component of viral nucleocapsids. Previously, we have shown that the core protein binds to the cytoplasmic domain of lymphotoxin beta receptor, which is a member of tumor necrosis factor receptor (TNFR) family. In this s...

journal_title：Journal of virology

authors： Zhu N,Khoshnan A,Schneider R,Matsumoto M,Dennert G,Ware C,Lai MM

更新日期：1998-05-01 00:00:00