Sendai virus targets inflammatory responses, as well as the interferon-induced antiviral state, in a multifaceted manner.

abstract：:The human immunodeficiency virus type 1 (HIV-1)-encoded RNA-binding protein Tat is known to play an essential role in viral gene expression. In the search for novel compounds to inhibit Tat transactivity, one coumarin derivative, BPRHIV001, was identified, with a 50% effective concentration (EC(50)) against HIV-1 at 1...

journal_title：Journal of virology

authors： Lin PH,Ke YY,Su CT,Shiao HY,Hsieh HP,Chao YK,Lee CN,Kao CL,Chao YS,Chang SY

更新日期：2011-09-01 00:00:00

abstract：:We studied the capacity of active immunization of rhesus monkeys with HIV-1 envelope protein (Env) to induce primary virus cross-reactive neutralizing antibodies to prevent infection following intravenous challenge with simian-human immunodeficiency virus (SHIV). Monkeys were immunized with the human immunodeficiency ...

journal_title：Journal of virology

authors： Quinnan GV Jr,Yu XF,Lewis MG,Zhang PF,Sutter G,Silvera P,Dong M,Choudhary A,Sarkis PT,Bouma P,Zhang Z,Montefiori DC,Vancott TC,Broder CC

更新日期：2005-03-01 00:00:00

abstract：:Cholesterol plays an essential role in the life cycle of several enveloped viruses. Many of these viruses manipulate host cholesterol metabolism to facilitate their replication. HIV-1 infection of CD4(+) T cells activates the sterol regulatory element-binding protein 2 (SREBP2) transcriptional program, which includes ...

journal_title：Journal of virology

authors： Taylor HE,Linde ME,Khatua AK,Popik W,Hildreth JE

更新日期：2011-08-01 00:00:00

abstract：:Adenovirus (Ad) entry into cells is initiated by the binding of the fiber knob to a cell surface receptor. The coxsackie- and adenovirus receptor (CAR) functions as the attachment receptor for many, but not all, Ad serotypes. Ad type 37 (Ad37), a subgroup D virus that causes keratoconjunctivitis in humans, does not in...

journal_title：Journal of virology

authors： Chiu CY,Wu E,Brown SL,Von Seggern DJ,Nemerow GR,Stewart PL

更新日期：2001-06-01 00:00:00

abstract：:Equine infectious anemia virus (EIAV) is an equine lentivirus similar to HIV-1, targets host immune cells, and causes a life-long infection in horses. The Chinese live EIAV vaccine is attenuated from long-term passaging of a highly virulent strain in vitro The parent pathogenic strain (EIAVDLV34) induces a host inflam...

journal_title：Journal of virology

authors： Du C,Duan Y,Wang XF,Lin Y,Na L,Wang X,Chen K,Wang X

更新日期：2019-10-15 00:00:00

abstract：:The interaction of the mouse hepatitis virus (MHV) nucleocapsid protein (N) and viral RNA was examined. Monoclonal antibody specific for N protein coimmunoprecipitated MHV genomic RNA as well as all six MHV subgenomic mRNAs found in MHV-infected cells. In contrast, monoclonal antibodies to the MHV E2 or E1 envelope gl...

journal_title：Journal of virology

authors： Baric RS,Nelson GW,Fleming JO,Deans RJ,Keck JG,Casteel N,Stohlman SA

更新日期：1988-11-01 00:00:00

abstract：:Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with the exacerbation of clinical symptoms and the induction of recurrences in humans and animal models. T...

journal_title：Journal of virology

authors： Ives AM,Bertke AS

更新日期：2017-06-09 00:00:00

abstract：:The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable region 1 (HVR1). We hypothesized that this genetic variability is driven by immune selection pressure, rather than representing the accumulation of random mutations in a region with relatively li...

journal_title：Journal of virology

authors： Ray SC,Mao Q,Lanford RE,Bassett S,Laeyendecker O,Wang YM,Thomas DL

更新日期：2000-04-01 00:00:00

abstract：:Today, global attention is focused on two influenza virus strains: the current pandemic strain, swine origin influenza virus (H1N1-2009), and the highly pathogenic avian influenza virus, H5N1. At present, the infection caused by the H1N1-2009 is moderate, with mortality rates of less <1%. In contrast, infection with t...

journal_title：Journal of virology

authors： Achdout H,Meningher T,Hirsh S,Glasner A,Bar-On Y,Gur C,Porgador A,Mendelson M,Mandelboim M,Mandelboim O

更新日期：2010-04-01 00:00:00

abstract：:Poliovirus mutants in neutralizing antigenic site 3B were constructed by replacing the glutamic acid residue at amino acid 74 of capsid protein VP2 (VP2074E), using site-specific mutagenesis methods. All viable mutants display small-plaque phenotypes. Characterization of these mutants indicates that capsid assembly is...

journal_title：Journal of virology

authors： Reynolds C,Birnby D,Chow M

更新日期：1992-03-01 00:00:00

abstract：:The binding of cyclophilin A (CypA) to the human immunodeficiency virus type 1 (HIV-1) capsid protein (CA protein) is required soon after virus entry into natural target cells. In Jurkat T lymphocytes, disrupting CypA-CA interaction either by cyclosporine (Cs) treatment or by alteration (e.g., P90A) of the CA inhibits...

journal_title：Journal of virology

authors： Li Y,Kar AK,Sodroski J

更新日期：2009-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection has been shown to activate the mTORC1 signaling pathway. However, the phosphorylation of mTORC1 targets is differentially sensitive to the mTORC1 inhibitor rapamycin, and the drug inhibits HCMV replication to a modest extent. Using Torin1, a newly developed inhibitor that targets...

journal_title：Journal of virology

authors： Moorman NJ,Shenk T

更新日期：2010-05-01 00:00:00

abstract：:We have been investigating the first viral genes to be transcribed in Spodoptera frugiperda cells after the infection with Autographa california nuclear polyhedrosis virus in order to identify regulatory proteins required for the activation of early and/or late gene transcription. By screening a cDNA library from poly...

journal_title：Journal of virology

authors： Knebel-Mörsdorf D,Kremer A,Jahnel F

更新日期：1993-02-01 00:00:00

abstract：:The phosphoprotein pp65 (ppUL83) of human cytomegalovirus (HCMV) is abundantly synthesized during lytic infection in cultured fibroblasts. As a major constituent of extracellular particles, it gains entry to infected cells immediately after adsorption and subsequently translocates to the cell nucleus. This efficient t...

journal_title：Journal of virology

authors： Schmolke S,Kern HF,Drescher P,Jahn G,Plachter B

更新日期：1995-10-01 00:00:00

abstract：:Reduction of major histocompatibility complex class I cell surface expression occurs in adenovirus-, herpes simplex virus-, human cytomegalovirus (HCMV)-, and murine cytomegalovirus-infected cell systems. Recently, it was demonstrated that the down-regulation mediated by HCMV infection is posttranslational, as a resul...

journal_title：Journal of virology

authors： Jones TR,Hanson LK,Sun L,Slater JS,Stenberg RM,Campbell AE

更新日期：1995-08-01 00:00:00

abstract：:The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The re...

journal_title：Journal of virology

authors： Aubagnac S,Brahic M,Bureau JF

更新日期：2002-06-01 00:00:00

abstract：:The uncoating of adenovirus type 2 and a temperature-sensitive mutant, tsl, was studied. HEp-2 cells were infected with 32P- OR 125I-labeled purified virions for various lengths of time, and the nuclear and cytoplasmic fractions were analyzed by sucrose gradient velocity sedimentation and sodium dodecyl sulfate-polyac...

journal_title：Journal of virology

authors： Mirza MA,Weber J

更新日期：1979-05-01 00:00:00

abstract：UNLABELLED:Coronaviruses (CoVs) are unique in encoding a 3'→5' exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is required for high-fidelity replication, likely via proofreading. nsp14 associates with the CoV RNA-dependent RNA polymerase (nsp12-RdRp), and nsp14-ExoN activity is enhanced by binding nsp...

journal_title：Journal of virology

authors： Smith EC,Case JB,Blanc H,Isakov O,Shomron N,Vignuzzi M,Denison MR

更新日期：2015-06-01 00:00:00

abstract：:Mutants of bacteriophage T4D that are defective in genes 42 (dCMP hydroxymethylase), 46 (DNA exonuclease), and 56 (dCTPase) produce limited amounts of phage DNA in Escherichia coli B. In this DNA, glucoylated 5-hydroxymethylcytosine is completely replaced by cytosine. We found that this DNA rapidly becomes fragmented ...

journal_title：Journal of virology

authors： Carlson K,Wiberg JS

更新日期：1983-10-01 00:00:00

abstract：:A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 vir...

journal_title：Journal of virology

authors： Hellman A,Peebles PT,Strickland JE,Fowler AK,Kalter SS,Oroszlan KS,Gilden RV

更新日期：1974-07-01 00:00:00

abstract：:Accurate and sensitive quantitation of infectious human immunodeficiency virus (HIV) has been difficult to achieve. In this report, a quantitative focal immunoassay (FIA) for HIV was developed using human HeLa cells rendered susceptible to HIV infection by introduction of the CD4 gene via a retrovirus vector. Infected...

journal_title：Journal of virology

authors： Chesebro B,Wehrly K

更新日期：1988-10-01 00:00:00

abstract：:The EICP0 protein of equine herpesvirus 1 (EHV-1) is an early, viral regulatory protein that independently trans-activates EHV-1 immediate-early (IE), early, gamma1 late, and gamma2 late promoters. To assess whether this powerful trans-activator functions in conjunction with three other EHV-1 regulatory proteins to ac...

journal_title：Journal of virology

authors： Bowles DE,Kim SK,O'Callaghan DJ

更新日期：2000-02-01 00:00:00

abstract：:Analyses of the breadth and specificity of virus-specific CD8(+) T cell responses associated with control of HIV have largely relied on measurement of cytokine secretion by effector T cells. These have resulted in the identification of HIV elite controllers with low or absent responses in which non-T-cell mechanisms o...

journal_title：Journal of virology

authors： Ndhlovu ZM,Proudfoot J,Cesa K,Alvino DM,McMullen A,Vine S,Stampouloglou E,Piechocka-Trocha A,Walker BD,Pereyra F

更新日期：2012-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) R5 isolates that predominantly use CCR5 as a coreceptor are frequently described as macrophage tropic. Here, we compare macrophage tropism conferred by HIV-1 R5 envelopes that were derived directly by PCR from patient tissue. This approach avoids potentially selective cultur...

journal_title：Journal of virology

authors： Peters PJ,Sullivan WM,Duenas-Decamp MJ,Bhattacharya J,Ankghuambom C,Brown R,Luzuriaga K,Bell J,Simmonds P,Ball J,Clapham PR

更新日期：2006-07-01 00:00:00

abstract：:Hantaviruses are rodent-borne agents that cause hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome in humans. The nucleocapsid protein (N) is relatively conserved among hantaviruses and highly immunogenic in both laboratory animals and humans, and it has been shown to induce efficient protective im...

journal_title：Journal of virology

authors： de Carvalho Nicacio C,Gonzalez Della Valle M,Padula P,Björling E,Plyusnin A,Lundkvist A

更新日期：2002-07-01 00:00:00

abstract：:The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin (HA) vaccine-mediated protection after vaccination. Using a C3 knockout (C3 KO) mouse model, we found that ...

journal_title：Journal of virology

authors： Kim YJ,Kim KH,Ko EJ,Kim MC,Lee YN,Jung YJ,Lee YT,Kwon YM,Song JM,Kang SM

更新日期：2018-09-26 00:00:00

abstract：:Affinity-purified medium T antigen encoded by NG59, a nontransforming mutant of polyomavirus, is specifically associated with a protein of 72,000 daltons (72K protein). Medium T antigens of wild-type polyomavirus and the transformation-competent mutant dl8 are not associated with the 72K protein. Instead, they form a ...

journal_title：Journal of virology

authors： Walter G,Carbone A,Welch WJ

更新日期：1987-02-01 00:00:00

abstract：:Intranuclear and intracytoplasmic inclusions in monkey kidney cells infected with African horsesickness virus were studied with the aid of electron microscopy. ...

journal_title：Journal of virology

authors： Breese SS Jr,Ozawa Y

更新日期：1969-07-01 00:00:00

abstract：:The African swine fever virus protein A238L inhibits activation of NFAT transcription factor by binding calcineurin and inhibiting its phosphatase activity. NFAT controls the expression of many immunomodulatory proteins. Here we describe a 14-amino-acid region of A238L that is needed and sufficient for binding to calc...

journal_title：Journal of virology

authors： Miskin JE,Abrams CC,Dixon LK

更新日期：2000-10-01 00:00:00

abstract：:We have used deletion and recombinant long terminal repeat (LTR) mutants to examine enhancer activity differences between LTRs of the nonpathogenic Akv and the thymus lymphomagenic MCF13 murine retroviruses. Deletion mutant analysis revealed that major control regions for MCF13 and Akv LTR enhancer activity were simil...

journal_title：Journal of virology

authors： Hollon T,Yoshimura FK

更新日期：1989-08-01 00:00:00