Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains.

abstract：:The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they mature...

journal_title：Journal of virology

authors： Klinken SP,Hartley JW,Fredrickson TN,Rapp UR,Morse HC 3rd

更新日期：1989-05-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：UNLABELLED:The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and cancer. It is unclear how DNA tumor viruses regulate these enzymes and how these interactions, in turn, impact the integrity of both the viral and cellular genomes. Polyomavirus (PyVs) are small DNA pathogens that contai...

journal_title：Journal of virology

authors： Verhalen B,Starrett GJ,Harris RS,Jiang M

更新日期：2016-06-24 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) ICP34.5 gene is a neurovirulence gene in mice. In addition, some ICP34.5 mutants have been reported to have a reduced efficiency of induced reactivation as measured by in vitro explantation of latently infected mouse ganglia. However, since spontaneous reactivation is almost non...

journal_title：Journal of virology

authors： Perng GC,Thompson RL,Sawtell NM,Taylor WE,Slanina SM,Ghiasi H,Kaiwar R,Nesburn AB,Wechsler SL

更新日期：1995-05-01 00:00:00

abstract：:The membrane-associated alphavirus RNA replication complex contains four virus-encoded subunits, the nonstructural proteins nsP1 to nsP4. Semliki Forest virus (SFV) nsP1 is hydrophobically modified by palmitoylation of cysteines 418 to 420. Here we show that Sindbis virus nsP1 is also palmitoylated on the same site (c...

journal_title：Journal of virology

authors： Ahola T,Kujala P,Tuittila M,Blom T,Laakkonen P,Hinkkanen A,Auvinen P

更新日期：2000-08-01 00:00:00

abstract：:The replication of many positive-strand RNA viruses [(+)RNA viruses] depends on the cellular protein GBF1, but its role in the replication process is not clear. In uninfected cells, GBF1 activates small GTPases of the Arf family and coordinates multiple steps of membrane metabolism, including functioning of the cellul...

journal_title：Journal of virology

authors： Viktorova EG,Gabaglio S,Meissner JM,Lee E,Moghimi S,Sztul E,Belov GA

更新日期：2019-10-15 00:00:00

abstract：:The ATP-dependent DNase activity of Escherichia coli disappeared or was markedly reduced after infection with double-stranded DNA phages, T2, T3, T4, T5, T6, T7, lambda, phi80, and P1, but not with the single-stranded DNA phage f1, or the RNA phage Qbeta. This DNase activity was not reduced when chloramphenicol was ad...

journal_title：Journal of virology

authors： Sakaki Y

更新日期：1974-12-01 00:00:00

abstract：:Three polyadenylated RNAs, 9, 7.3, and 3.5 kilobases long, of a human endogenous retrovirus, ERV3, are abundant in human placental chorion, representing about 0.03 to 0.05% of the total mRNA. We characterized the structure of these mRNAs by Northern blot and S1 nuclease mapping analyses. We found that all three RNAs w...

journal_title：Journal of virology

authors： Kato N,Pfeifer-Ohlsson S,Kato M,Larsson E,Rydnert J,Ohlsson R,Cohen M

更新日期：1987-07-01 00:00:00

abstract：:Viral protein genome-linked (VPg) plays a central role in several stages of potyvirus infection. This study sought to answer questions about the role of Potato virus A (PVA; genus Potyvirus) VPg in viral and host RNA expression. When expressed in Nicotiana benthamiana leaves in trans, a dual role of VPg in translation...

journal_title：Journal of virology

authors： Eskelin K,Hafrén A,Rantalainen KI,Mäkinen K

更新日期：2011-09-01 00:00:00

abstract：:Primary infection of a plant with a pathogen that causes high accumulation of salicylic acid in the plant typically via a hypersensitive response confers enhanced resistance against secondary infection with a broad spectrum of pathogens, including viruses. This phenomenon is called systemic acquired resistance (SAR), ...

journal_title：Journal of virology

authors： Jeon EJ,Tadamura K,Murakami T,Inaba JI,Kim BM,Sato M,Atsumi G,Kuchitsu K,Masuta C,Nakahara KS

更新日期：2017-09-12 00:00:00

abstract：:The virion host shutoff protein (vhs) of herpes simplex virus (HSV) triggers global shutoff of host protein synthesis and accelerated mRNA turnover during virus infection and induces endoribonucleolytic cleavage of exogenous RNA substrates when it is produced in a rabbit reticulocyte (RRL) in vitro translation system....

journal_title：Journal of virology

authors： Lu P,Jones FE,Saffran HA,Smiley JR

更新日期：2001-02-01 00:00:00

abstract：:Human norovirus (HuNoV) is a leading cause of acute gastroenteritis in both developed and developing countries. Studies of HuNoV host cell interactions are limited by the lack of a simple, robust cell culture system. Due to their diverse HuNoV-like biological features, including histo-blood group antigen (HBGA) bindin...

journal_title：Journal of virology

authors： Farkas T,Yang K,Le Pendu J,Baines JD,Cardin RD

更新日期：2019-10-29 00:00:00

abstract：:The human cytomegalovirus UL4 gene encodes a 48-kDa glycoprotein, expression of which is repressed at the translational level by a short upstream open reading frame (uORF2) within the UL4 transcript leader. Mutation of the uORF2 initiation codon in the viral genome eliminates ribosomal stalling at the uORF2 terminatio...

journal_title：Journal of virology

authors： Alderete JP,Child SJ,Geballe AP

更新日期：2001-08-01 00:00:00

abstract：:Differentiating infected from vaccinated animals (DIVA) strategies have been central enabling techniques in several successful viral disease elimination programs. However, owing to their long and uncertain development process, no DIVA-compatible vaccines are available for many important diseases. We report herein a ne...

journal_title：Journal of virology

authors： Xue Q,Xu H,Liu H,Pan J,Yang J,Sun M,Chen Y,Xu W,Cai X,Ma H

更新日期：2020-02-28 00:00:00

abstract：:The poliovirus (PV) genome was manipulated by replacing its 2A-encoding sequence with the corresponding sequence of coxsackie B4 virus (CBV4) or human rhinovirus type 2 (HRV2). In vitro translation of the resulting chimeric PV genomes revealed a normal cis-cleavage activity for both heterologous 2A(pro) proteinases in...

journal_title：Journal of virology

authors： Lu HH,Li X,Cuconati A,Wimmer E

更新日期：1995-12-01 00:00:00

abstract：:The binding of tail parts to the head of phage P22 is normally irreversible, but after adsorption to host cells sonication releases many of the tail parts intact. This release is dependent on the power of sonication, but is independent of the length of sonication from 2 to 32 s. This phenomenon has been used to show t...

journal_title：Journal of virology

authors： Ruddel M,Israel V

更新日期：1976-02-01 00:00:00

abstract：:Effectively recognizing invading viruses and subsequently inducing innate antiviral immunity are essential for host antiviral defense. Although these processes are closely regulated by the host to maintain immune balance, viruses have evolved the ability to downregulate or upregulate these processes for their survival...

journal_title：Journal of virology

authors： Xu T,Chu Q,Cui J,Bi D

更新日期：2018-01-02 00:00:00

abstract：:A technique of continuous filtration of T4-infected Escherichia coli has been devised to study the phenomenon of lysis inhibition. Studies using this technique revealed that the length of the lysis delay caused by superinfection can attain only certain discrete values, which for low average multiplicity of superinfect...

journal_title：Journal of virology

authors： Bode W

更新日期：1967-10-01 00:00:00

abstract：:The nature of the lesions involved in producing the fusiform phenotype of three mutants (WO101, WO201, and tsST529) of the Schmidt-Ruppin A strain of Rous sarcoma virus (RSV) was determined by molecular cloning and DNA sequencing. WO101 and WO201 contained an in-frame deletion of the v-src region coding for amino acid...

journal_title：Journal of virology

authors： Anderson SK,Fujita DJ

更新日期：1987-06-01 00:00:00

abstract：:The S2 gene of bluetongue virus, serotype 17, has been cloned, and the nonstructural protein NS2 has been expressed. Synthetic peptides matching regions within the amino acid sequence of NS2 were used to map three single-stranded RNA (ssRNA)-binding regions within the protein. A prokaryotic expression system was then ...

journal_title：Journal of virology

authors： Fillmore GC,Lin H,Li JK

更新日期：2002-01-01 00:00:00

abstract：:Electron micrographic studies of neuronal axons have produced contradictory conclusions on how alphaherpesviruses are transported from neuron cell bodies to axon termini. Some reports have described unenveloped capsids transported on axonal microtubules with separate transport of viral glycoproteins within membrane ve...

journal_title：Journal of virology

authors： Snyder A,Wisner TW,Johnson DC

更新日期：2006-11-01 00:00:00

abstract：:Infection and transformation of chondrocytes by Rous sarcoma viruses (RSVs) (Schmidt-Ruppin, Prague) stimulated the rate of cell growth. In contrast, several transformation-defective (td) mutants (tdPRA, tdNY105, tdNY106, tdNY107, and tdNY108) retaining various sizes of the src gene did not stimulate cell growth, indi...

journal_title：Journal of virology

authors： Tanaka A,Parker C,Kaji A

更新日期：1980-08-01 00:00:00

abstract：:Of the numerous endogenous retroviral elements that are present in the human genome, the abundant HERV-K family is distinct because several members are transcriptionally active and coding for biologically active proteins. A detailed phylogeny of the HERV-K family based on the partial sequence of the reverse transcript...

journal_title：Journal of virology

authors： Berkhout B,Jebbink M,Zsíros J

更新日期：1999-03-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) capsids leave the nucleus by a process of envelopment and de-envelopment at the nuclear envelope (NE) that is accompanied by structural alterations of the NE. As capsids translocate across the NE, transient primary enveloped virions form in the perinuclear space. Here, we provide evidenc...

journal_title：Journal of virology

authors： Maric M,Shao J,Ryan RJ,Wong CS,Gonzalez-Alegre P,Roller RJ

更新日期：2011-10-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) is an oncogenic human herpesvirus. EBV latent membrane protein 1 (LMP-1) is a viral oncogene that manifests its oncogenic phenotype through activation of cellular signaling pathways involved in cell growth, survival, differentiation, and transformation. Lytic LMP-1 (lyLMP-1) is a related E...

journal_title：Journal of virology

authors： Pandya J,Walling DM

更新日期：2006-08-01 00:00:00

abstract：:CaM kinase-Gr is a multifunctional Ca2+/calmodulin-dependent protein kinase which is enriched in neurons and T lymphocytes. The kinase is absent from primary human B lymphocytes but is expressed in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cell lines, suggesting that expression of the kinase can be upregul...

journal_title：Journal of virology

authors： Mosialos G,Hanissian SH,Jawahar S,Vara L,Kieff E,Chatila TA

更新日期：1994-03-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:Two different proteins with high affinities for the pteridine ring of folic acid have been used to determine the location of this portion of the folate molecule in the tail plate of T4D and other T-even bacteriophage particles. The two proteins used were (i) antibody specific for folic acid and (ii) the folate-binding...

journal_title：Journal of virology

authors： Kozloff LM,Lute M,Crosby LK

更新日期：1975-12-01 00:00:00

abstract：:We analyzed the susceptibility of 10 AKXD recombinant inbred (RI) mouse strains to lymphomas. These strains were derived from crosses of AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 10 strains analyzed, nine showed a high incidence of lymphoma development. As with the other 13 ...

journal_title：Journal of virology

authors： Gilbert DJ,Neumann PE,Taylor BA,Jenkins NA,Copeland NG

更新日期：1993-04-01 00:00:00

abstract：:HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that...

journal_title：Journal of virology

authors： Kløverpris HN,Stryhn A,Harndahl M,Payne R,Towers GJ,Chen F,Riddell L,Walker BD,Ndung'u T,Leslie A,Buus S,Goulder P

更新日期：2013-10-01 00:00:00