Bacteriophage T4 baseplate components. I. Binding and location of the folic acid.

abstract：:Herpes simplex virus type 1 (HSV-1) mutants impaired in the activities of the structural protein VP16 and the immediate-early (IE) proteins ICP0 and ICP4 establish a quiescent infection in human fibroblasts, with most cells retaining an inactive, repressed viral genome for sustained periods in culture. To date, the qu...

journal_title：Journal of virology

authors： Preston CM,Nicholl MJ

更新日期：2008-12-01 00:00:00

abstract：:ABT-378, a new human immunodeficiency virus type 1 (HIV-1) protease inhibitor which is significantly more active than ritonavir in cell culture, is currently under investigation for the treatment of AIDS. Development of viral resistance to ABT-378 in vitro was studied by serial passage of HIV-1 (pNL4-3) in MT-4 cells....

journal_title：Journal of virology

authors： Carrillo A,Stewart KD,Sham HL,Norbeck DW,Kohlbrenner WE,Leonard JM,Kempf DJ,Molla A

更新日期：1998-09-01 00:00:00

abstract：:Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; t...

journal_title：Journal of virology

authors： Luzuriaga K,Wu H,McManus M,Britto P,Borkowsky W,Burchett S,Smith B,Mofenson L,Sullivan JL

更新日期：1999-01-01 00:00:00

abstract：UNLABELLED:Since the 1960s, simian hemorrhagic fever virus (SHFV; Nidovirales, Arteriviridae) has caused highly fatal outbreaks of viral hemorrhagic fever in captive Asian macaque colonies. However, the source(s) of these outbreaks and the natural reservoir(s) of this virus remain obscure. Here we report the identifica...

journal_title：Journal of virology

authors： Bailey AL,Lauck M,Sibley SD,Pecotte J,Rice K,Weny G,Tumukunde A,Hyeroba D,Greene J,Correll M,Gleicher M,Friedrich TC,Jahrling PB,Kuhn JH,Goldberg TL,Rogers J,O'Connor DH

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often poorly managed with current treatments. Arthritic disease is usually characterized by high levels of the chemokine CCL2 and a...

journal_title：Journal of virology

authors： Poo YS,Nakaya H,Gardner J,Larcher T,Schroder WA,Le TT,Major LD,Suhrbier A

更新日期：2014-06-01 00:00:00

abstract：:We report the use of a HeLa whole cell extract (WCE) runoff transcription system for the study of cis- and trans-acting elements, participating in the regulation of transcription initiation from the P38 promoter of the parvovirus minute virus of mice (MVM). Our initial studies with HeLa WCE indicated that transcriptio...

journal_title：Journal of virology

authors： Krauskopf A,Resnekov O,Aloni Y

更新日期：1990-01-01 00:00:00

abstract：:Infectious leukemia virus production by two chronically infected NIH/MOL lines was strongly inhibited by interferon treatment of the cells. The corresponding degree of inhibition in JLSV-11 cells was much lower. Multiplication of encephalomyocarditis virus in all three cell lines was barely affected by interferon trea...

journal_title：Journal of virology

authors： Sen GC,Herz RE

更新日期：1983-03-01 00:00:00

abstract：:Viruses display a wide range of genomic profiles and, consequently, a variety of gene expression strategies. Specific sequences associated with transcriptional processes have been described in viruses, and putative promoter motifs have been elucidated for some nucleocytoplasmic large DNA viruses (NCLDV). Among NCLDV, ...

journal_title：Journal of virology

authors： Oliveira GP,Lima MT,Arantes TS,Assis FL,Rodrigues RAL,da Fonseca FG,Bonjardim CA,Kroon EG,Colson P,La Scola B,Abrahão JS

更新日期：2017-10-13 00:00:00

abstract：:Following infection by pairs of reovirus isolates consisting of combinations of reovirus T1 Lang, T2 Jones, or T3 Dearing, we found that one of the isolates interfered with the yield of progeny RNA derived from the other parents. The most significant interference was produced by T2 Jones or T3 Dearing, when mixed with...

journal_title：Journal of virology

authors： Rozinov MN,Fields BN

更新日期：1994-10-01 00:00:00

abstract：:Major neutralization antigenic sites have been previously mapped by us on VP1, the largest capsid protein of poliovirus type 1. Here we report the first identification of the primary sequence of a neutralization antigenic site on capsid protein VP2. Inspection of the amino acid sequence of VP2 led to the selection and...

journal_title：Journal of virology

authors： Emini EA,Jameson BA,Wimmer E

更新日期：1984-11-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen 3B (EBNA-3B) is considered nonessential for EBV-mediated B-cell growth transformation in vitro based on three virus isolates with EBNA-3B mutations. Two of these isolates could potentially express truncated EBNA-3B products, and, similarly, we now show that the third isolat...

journal_title：Journal of virology

authors： Chen A,Divisconte M,Jiang X,Quink C,Wang F

更新日期：2005-04-01 00:00:00

abstract：:Removal of nucleoside triphosphates from extracts prepared from bacteriophage T7-infected Escherichia coli results in a stringent requirement for added ATP to form infective phage particles by in vitro packaging of bacteriophage T7 DNA. Optimal packaging efficiency was achieved at a concentration of about 1.25 mM. Oth...

journal_title：Journal of virology

authors： Masker WE

更新日期：1982-07-01 00:00:00

abstract：:Mice infected with myopathic coxsackievirus B1 Tucson (CVB1(T)) develop chronic inflammatory myopathy (CIM) consisting of hind limb weakness and inflammation. Amyopathic virus variants are infectious but attenuated for CIM. In this report, viral clones, chimeras, and sequencing were used to identify viral determinants...

journal_title：Journal of virology

authors： Tam PE,Weber-Sanders ML,Messner RP

更新日期：2003-11-01 00:00:00

abstract：:Two defective RNAs (designated D RNA 3 alpha and D RNA 3 beta) were found to be associated with the Fny strain of cucumber mosaic cucumovirus but not with the Sny strain after serial passages in a tobacco host. The D RNAs were derived from RNA 3 by single, in-frame deletions within the 3a open reading frame. A full-le...

journal_title：Journal of virology

authors： Graves MV,Roossinck MJ

更新日期：1995-08-01 00:00:00

abstract：:We have recovered a virion from defective cDNA of Sendai virus (SeV) that is capable of self-replication but incapable of transmissible-virion production. This virion delivers and expresses foreign genes in infected cells, and this is the first report of a gene expression vector derived from a defective viral genome o...

journal_title：Journal of virology

authors： Li HO,Zhu YF,Asakawa M,Kuma H,Hirata T,Ueda Y,Lee YS,Fukumura M,Iida A,Kato A,Nagai Y,Hasegawa M

更新日期：2000-07-01 00:00:00

abstract：:Engineered alphavirus vectors expressing reporters of infection have been used for a number of years due to their relatively low costs for analysis of virus replication and the capacity to utilize imaging systems for longitudinal measurements of growth within single animals. In general, these vectors have been derived...

journal_title：Journal of virology

authors： Sun C,Gardner CL,Watson AM,Ryman KD,Klimstra WB

更新日期：2014-02-01 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) encodes several MIE proteins (MIEPs) produced as a result of alternative splicing and polyadenylation of the primary transcript. Previously we demonstrated that the HCMV MIEPs expressed from the entire MIE gene could rescue the temperature-sensitive ...

journal_title：Journal of virology

authors： Lukac DM,Alwine JC

更新日期：1999-04-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells have recently been used for identification of receptors for several alphaherpesviruses, including pseudorabies virus (PrV) (R. J. Geraghty, C. Krummenacher, G. H. Cohen, R. J. Eisenberg, and P. G. Spear, Science 280:1618-1620, 1998). The experiments were based on the fact that CHO cel...

journal_title：Journal of virology

authors： Nixdorf R,Schmidt J,Karger A,Mettenleiter TC

更新日期：1999-10-01 00:00:00

abstract：:Herpesvirus lytic DNA replication requires both the cis-acting element, the origin, and trans-acting factors, including virally encoded origin-binding protein, DNA replication enzymes, and auxiliary factors. Two lytic DNA replication origins (ori-Lyt) of Kaposi's sarcoma-associated herpesvirus (KSHV) have been identif...

journal_title：Journal of virology

authors： Wang Y,Li H,Tang Q,Maul GG,Yuan Y

更新日期：2008-03-01 00:00:00

abstract：:The hepatitis B virus X protein acts as a transcriptional transactivator in vitro. To elucidate possible biological effects of X protein on liver cells in vivo, we generated four lines of transgenic mice carrying the X gene open reading frame under the control of the human alpha-1-antitrypsin regulatory region. The pl...

journal_title：Journal of virology

authors： Lee TH,Finegold MJ,Shen RF,DeMayo JL,Woo SL,Butel JS

更新日期：1990-12-01 00:00:00

abstract：:Infectious poxvirus particles are unusual in that they are brick shaped and lack symmetry. Nevertheless, an external honeycomb lattice comprised of a capsid-like protein dictates the spherical shape and size of immature poxvirus particles. In the case of vaccinia virus, trimers of 63-kDa D13 polypeptides form the buil...

journal_title：Journal of virology

authors： Bisht H,Weisberg AS,Szajner P,Moss B

更新日期：2009-09-01 00:00:00

abstract：:Glycoprotein B (gB) is the most highly conserved of the envelope glycoproteins of human herpesviruses. The gB protein of human cytomegalovirus (CMV) serves multiple roles in the life cycle of the virus. To investigate structural properties of gB that give rise to its function, we sought to determine the disulfide bond...

journal_title：Journal of virology

authors： Lopper M,Compton T

更新日期：2002-06-01 00:00:00

abstract：UNLABELLED:In a genome-wide small interfering RNA (siRNA) screen, we recently identified the interferon (IFN)-inducible protein 35 (IFI35; also known as IFP35) as a factor required for vesicular stomatitis virus (VSV) infection. Studies reported here were conducted to further understand the role and requirement of IFI3...

journal_title：Journal of virology

authors： Das A,Dinh PX,Panda D,Pattnaik AK

更新日期：2014-03-01 00:00:00

abstract：:Hantaviruses replicate primarily in the vascular endothelium and cause two human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). In this report, we demonstrate that the cellular entry of HFRS-associated hantaviruses is facilitated by specific integrins expressed on plate...

journal_title：Journal of virology

authors： Gavrilovskaya IN,Brown EJ,Ginsberg MH,Mackow ER

更新日期：1999-05-01 00:00:00

abstract：:We previously reported that nucleolin, a representative nucleolar marker, interacts with nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) through two independent regions of NS5B, amino acids 208 to 214 and 500 to 506. We also showed that truncated nucleolin that harbors the NS5B-binding region inhibited the ...

journal_title：Journal of virology

authors： Shimakami T,Honda M,Kusakawa T,Murata T,Shimotohno K,Kaneko S,Murakami S

更新日期：2006-04-01 00:00:00

abstract：:Harvard Medical School convened a meeting of biomedical and clinical experts on 5 March 2015 on the topic of "Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era," with the goals of discussing the lessons from the recent Ebola outbreak and using those lessons as a case study to aid...

journal_title：Journal of virology

authors： Knipe DM,Whelan SP

更新日期：2015-08-01 00:00:00

abstract：:The parameters governing the activity of the cloned T4 gene 23, which codes for the major T4 head protein, were analyzed. Suppressor-negative bacteria carrying wild-type T4 gene 23 cloned into plasmid pCR1 or pBR322 were infected with T4 gene 23 amber phage also carrying mutations in the following genes: (i) denA and ...

journal_title：Journal of virology

authors： Jacobs KA,Geiduschek EP

更新日期：1981-07-01 00:00:00

abstract：:Infection of domestic rabbits with cottontail rabbit papillomavirus (CRPV) causes local papillomas which progress to carcinomas in more than 80% of cases. This animal model system therefore allows the identification of molecular mechanisms required for the induction and progression of epithelial tumors. The viral E2 p...

journal_title：Journal of virology

authors： Jeckel S,Huber E,Stubenrauch F,Iftner T

更新日期：2002-11-01 00:00:00

abstract：:Myeloblastosis-associated virus type 1 (MAV1) derived from a molecular clone of infectious proviral DNA (B. Perbal, J. S. Lipsick, J. Svoboda, R. F. Silva, and M. A. Baluda, J. Virol. 56:240-244, 1985) was shown to specifically induce nephroblastoma in chickens and therefore belongs to the MAV-N class. We show that ne...

journal_title：Journal of virology

authors： Soret J,Dambrine G,Perbal B

更新日期：1989-04-01 00:00:00

abstract：:SF162 is a primary (PR), non-syncytium-inducing, macrophagetropic human immunodeficiency virus type 1 (HIV-1) clade B isolate which is resistant to antibody-mediated neutralization. Deletion of the first or second hypervariable envelope gp120 region (V1 or V2 loop, respectively) of this virus does not abrogate its abi...

journal_title：Journal of virology

authors： Stamatatos L,Cheng-Mayer C

更新日期：1998-10-01 00:00:00