Differential antiviral effects of interferon in three murine cell lines.

abstract：:Human influenza viruses are more efficiently isolated by inoculating patient samples into the amniotic rather than the allantoic cavity of embryonated chicken eggs. This type of cultivation selects virus variants with mutations around the hemagglutinin (HA) receptor binding site. To understand the molecular basis of t...

journal_title：Journal of virology

authors： Ito T,Suzuki Y,Takada A,Kawamoto A,Otsuki K,Masuda H,Yamada M,Suzuki T,Kida H,Kawaoka Y

更新日期：1997-04-01 00:00:00

abstract：:Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu and Nef proteins of primate lentiviruses. Like other host genes subject to viral antagonism, primate Tetherin genes have evolved u...

journal_title：Journal of virology

authors： Lim ES,Malik HS,Emerman M

更新日期：2010-07-01 00:00:00

abstract：:We used the mammalian reoviruses to determine the molecular basis of the clearance of a virus from the bloodstream by specific organs. Reovirus serotypes 1 (T1) and 3 (T3) were radiolabeled with [35S]methionine or 125I, and the viruses were injected intravenously into weanling rats. The distribution of radioactivity w...

journal_title：Journal of virology

authors： Verdin EM,Lynn SP,Fields BN,Maratos-Flier E

更新日期：1988-02-01 00:00:00

abstract：:Influenza virus nucleoprotein (NP) is associated with the genome RNA, forming ribonucleoprotein cores. To identify the amino acid sequence involved in RNA binding, we performed Northwestern blot analysis with a set of N- and C-terminal deletion mutants of NP produced in Escherichia coli. The RNA binding region has bee...

journal_title：Journal of virology

authors： Kobayashi M,Toyoda T,Adyshev DM,Azuma Y,Ishihama A

更新日期：1994-12-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) is consistently found in Kaposi's sarcoma lesions and in body-cavity-based lymphomas. A 17-kb KSHV lambda clone was obtained directly from a Kaposi's sarcoma lesion. DNA sequence analysis of this clone identified an open reading frame whi...

journal_title：Journal of virology

authors： Li M,Lee H,Yoon DW,Albrecht JC,Fleckenstein B,Neipel F,Jung JU

更新日期：1997-03-01 00:00:00

abstract：:The NS5A protein of hepatitis C virus (HCV) plays an important but undefined role in viral RNA replication. NS5A has been proposed to be a three-domain protein, and the crystal structure of the well-conserved amino-terminal domain I has been determined. The remaining two domains of NS5A, designated domains II and III,...

journal_title：Journal of virology

authors： Tellinghuisen TL,Foss KL,Treadaway JC,Rice CM

更新日期：2008-02-01 00:00:00

abstract：:We have designed a DNA cassette to transcribe defective interfering (DI) RNAs of tomato bushy stunt virus (TBSV) and have investigated their potential to protect transgenic Nicotiana benthamiana plants from tombusvirus infections. To produce RNAs with authentic 5' and 3' termini identical to those of the native B10 DI...

journal_title：Journal of virology

authors： Rubio T,Borja M,Scholthof HB,Feldstein PA,Morris TJ,Jackson AO

更新日期：1999-06-01 00:00:00

abstract：:Human La protein has been implicated in facilitating internal ribosome entry site (IRES)-mediated translation of hepatitis C virus (HCV). Earlier, we demonstrated that the RNA recognition motif (RRM) encompassing residues 112 to 184 of La protein [La (112-184)] interacts with the HCV IRES near the initiator AUG codon....

journal_title：Journal of virology

authors： Mondal T,Ray U,Manna AK,Gupta R,Roy S,Das S

更新日期：2008-12-01 00:00:00

abstract：:Three monkeypox virus (MPV) antibody-secreting murine monoclones were characterized as being of the immunoglobulin G1 isotype, gave a 4+ reaction in the indirect fluorescent-antibody test, gave a positive reaction in the enzyme immunoassay, and did not neutralize MPV. These monoclonal antibodies were determined by the...

journal_title：Journal of virology

authors： Roumillat LF,Patton JL,Davis ML

更新日期：1984-10-01 00:00:00

abstract：:The small membrane glycoprotein (GS) of equine arteritis virus (EAV) is a minor virion component but is abundantly expressed in EAV-infected cells. In this study, we have analyzed its membrane topology, folding, oligomerization, and intracellular transport. We show that GS is a class I integral membrane protein with o...

journal_title：Journal of virology

authors： de Vries AA,Raamsman MJ,van Dijk HA,Horzinek MC,Rottier PJ

更新日期：1995-06-01 00:00:00

abstract：:Several aspects of the terminal stages of T4 head maturation were investigated using ts and am mutants blocked at single steps of the assembly pathway. We had previously found that cells infected with mutants of gene 13, e.g., tsN38 and amE609, accumulated both stable (10 to 20%)- and fragile (80%)-filled head precurs...

journal_title：Journal of virology

authors： Hamilton DL,Luftig RB

更新日期：1976-02-01 00:00:00

abstract：:The Ebola filoviruses are aggressive pathogens that cause severe and often lethal hemorrhagic fever syndromes in humans and nonhuman primates. To date, no effective therapies have been identified. To analyze the entry and fusion properties of Ebola virus, we adapted a human immunodeficiency virus type 1 (HIV-1) virion...

journal_title：Journal of virology

authors： Yonezawa A,Cavrois M,Greene WC

更新日期：2005-01-01 00:00:00

abstract：:A coxsackievirus B3 (CB3) isolate adapted to growth in RD cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kDa cell surface molecule expressed on these cells. We now show that this molecule is the complement regulatory protein, decay-accelerating factor (DAF) (CD55). Anti-DAF antibodi...

journal_title：Journal of virology

authors： Bergelson JM,Mohanty JG,Crowell RL,St John NF,Lublin DM,Finberg RW

更新日期：1995-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key regulators in many biological processes, from development to defense, at almost all organismal levels. Recently, their role has been highlighted in pathogen-host interactions. Emerging evidence from a variety of virus-host systems indicates that cellular as well as virally encode...

journal_title：Journal of virology

authors： Hussain M,Asgari S

更新日期：2010-01-01 00:00:00

abstract：UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...

journal_title：Journal of virology

authors： Liang EC,Sceats L,Bayless NL,Strauss-Albee DM,Kubo J,Grant PM,Furman D,Desai M,Katzenstein DA,Davis MM,Zolopa AR,Blish CA

更新日期：2014-08-01 00:00:00

abstract：:A total of 51 restriction sites were recognized within the BK virus genome by the combination of 10 different restriction endonucleases. These sites were mapped and oriented relative to one another as well as to the five fragments generated by the digestion of BK virus DNA with HindIII and EcoRI. The result was a comp...

journal_title：Journal of virology

authors： Freund J,di Mayorca G,Subramanian KN

更新日期：1979-03-01 00:00:00

abstract：:Autographa californica nuclear polyhedrosis virus late and very late mRNAs are transcribed by an RNA polymerase consisting of four virus-encoded polypeptides: LEF-8, LEF-9, LEF-4, and p47. The 464-amino-acid LEF-4 subunit contains the signature motifs of GTP:RNA guanylyltransferases (capping enzymes). Here, we show th...

journal_title：Journal of virology

authors： Gross CH,Shuman S

更新日期：1998-12-01 00:00:00

abstract：:Epstein-Barr virus is associated with several human malignancies including Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease (HD). To examine the effect of Epstein-Barr virus nuclear antigen 1 (EBNA-1) in the pathogenesis of HD, we transfected the gene into the HD cell line L428. EBNA-1 expression wa...

journal_title：Journal of virology

authors： Kube D,Vockerodt M,Weber O,Hell K,Wolf J,Haier B,Grässer FA,Müller-Lantzsch N,Kieff E,Diehl V,Tesch H

更新日期：1999-02-01 00:00:00

abstract：:Adaptation of field isolates of foot-and-mouth disease virus (FMDV) to grow in cells in culture can result in changes in viral properties that include acquisition of the ability to bind to cell surface heparan sulfate (HS). After 13 passages on BHK cells to produce a vaccine, a Cathay topotype isolate of FMDV serotype...

journal_title：Journal of virology

authors： Zhao Q,Pacheco JM,Mason PW

更新日期：2003-03-01 00:00:00

abstract：:The nucleoprotein (NP) of influenza B virus is 50 amino acids longer at the N-terminus than influenza A virus NP and lacks homology to the A virus protein over the first 69 residues. We have deleted the N-terminal 51 and 69 residues of the influenza B/Ann Arbor/1/66 virus NP and show that nuclear accumulation of the p...

journal_title：Journal of virology

authors： Stevens MP,Barclay WS

更新日期：1998-06-01 00:00:00

abstract：:During the acute phase of infection with influenza A virus, the degree of lymphopenia correlates with severity of disease. Factors that contribute to T-cell activation during influenza virus infection may contribute to this observation. Since the immune response is initiated when dendritic cells (DC) interact with T c...

journal_title：Journal of virology

authors： Oh S,McCaffery JM,Eichelberger MC

更新日期：2000-06-01 00:00:00

abstract：UNLABELLED:Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukemia nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting viral genomes to cooperatively promote viral genome silencing...

journal_title：Journal of virology

authors： Brown JR,Conn KL,Wasson P,Charman M,Tong L,Grant K,McFarlane S,Boutell C

更新日期：2016-06-10 00:00:00

abstract：:Replication-defective vaccine vectors based on vesicular stomatitis virus (VSV) lacking its envelope glycoprotein gene (G) are highly effective in animal models. However, such ΔG vectors are difficult to grow because they require complementation with the VSV G protein. In addition, the complementing G protein induces ...

journal_title：Journal of virology

authors： Chattopadhyay A,Rose JK

更新日期：2011-03-01 00:00:00

abstract：:The Tf1 retrotransposon of Schizosaccharomyces pombe represents a group of eukaryotic long terminal repeat (LTR) retroelements that, based on their sequences, were predicted to use an RNA self-primer for initiating reverse transcription while synthesizing the negative-sense DNA strand. This feature is substantially di...

journal_title：Journal of virology

authors： Hizi A

更新日期：2008-11-01 00:00:00

abstract：:Type 3 reovirus inhibits L cell DNA synthesis, whereas type 1 reovirus exerts little or no effect on L cell DNA synthesis. By using recombinant viruses containing both type 1 and type 3 double-standard RNA segments, we determined that one double-stranded RNA segment, the reovirus type 3 S1 double-stranded RNA segment ...

journal_title：Journal of virology

authors： Sharpe AH,Fields BN

更新日期：1981-04-01 00:00:00

abstract：:Many complex viruses use an assembly pathway in which their genome is packaged into an empty procapsid which subsequently matures into its final expanded form. We utilized Pseudomonas phage 6, a well-established virus assembly model, to probe the plasticity of the procapsid maturation pathway. The 6 packaging nucleosi...

journal_title：Journal of virology

authors： Sun X,Pirttimaa MJ,Bamford DH,Poranen MM

更新日期：2013-12-01 00:00:00

abstract：:Major neutralization antigenic sites have been previously mapped by us on VP1, the largest capsid protein of poliovirus type 1. Here we report the first identification of the primary sequence of a neutralization antigenic site on capsid protein VP2. Inspection of the amino acid sequence of VP2 led to the selection and...

journal_title：Journal of virology

authors： Emini EA,Jameson BA,Wimmer E

更新日期：1984-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) has evolved multiple strategies for suppression of the antiviral response of the infected cell. DNA array technology has revealed that HCMV clearly regulates host gene expression during the course of a productive infection by enhancing, sustaining, or suppressing steady-state levels of cel...

journal_title：Journal of virology

authors： Gealy C,Denson M,Humphreys C,McSharry B,Wilkinson G,Caswell R

更新日期：2005-01-01 00:00:00

abstract：:Although monkey B virus (herpesvirus simiae; BV) is common in all macaque species, fatal human infections appear to be associated with exposure to rhesus macaques (Macaca mulatta), suggesting that BV isolates from rhesus monkeys may be more lethal to nonmacaques than are BV strains indigenous to other macaque species....

journal_title：Journal of virology

authors： Smith AL,Black DH,Eberle R

更新日期：1998-11-01 00:00:00

abstract：:The genome of infectious hematopoietic necrosis virus (IHNV), a salmonid novirhabdovirus, has been engineered to modify the gene order and to evaluate the impact on a possible attenuation of the virus in vitro and in vivo By reverse genetics, eight recombinant IHNVs (rIHNVs), termed NxGy according to the respective po...

journal_title：Journal of virology

authors： Rouxel RN,Tafalla C,Mérour E,Leal E,Biacchesi S,Brémont M

更新日期：2016-11-14 00:00:00